Tubulin from paclitaxel-resistant cells as a probe for novel antimicrotubule agents

Cancer Chemotherapy and Pharmacology

Volumn 40, Issue 3, 1997, Pages 228-232

  Sackett, Dan L ^a,b   Giannakakou, Paraskevi ^a   Poruchynsky, Marianne ^a   Fojo, Antonio ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

Drug resistance; Microtubules; Paclitaxel; Taxol; Tubulin

Indexed keywords

PACLITAXEL; PACLITAXEL DERIVATIVE; TUBULIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CYTOTOXICITY; DRUG RESISTANCE; ELECTRON MICROSCOPY; FEMALE; HUMAN; HUMAN CELL; MICROTUBULE ASSEMBLY; NONHUMAN; OVARY CARCINOMA; PRIORITY JOURNAL; PROTEIN FOLDING; RAT;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; BRAIN; CARCINOMA; DRUG RESISTANCE, NEOPLASM; FEMALE; HUMANS; MICROTUBULES; OVARIAN NEOPLASMS; PACLITAXEL; POLYMERS; RATS; RATS, SPRAGUE-DAWLEY; TUBULIN; TUMOR CELLS, CULTURED;

EID: 0031010084     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002800050651     Document Type: Article

References (15)

1. Fojo A (1996) Taxanes. Cancer Chemother Biol Response Modif 16: 501-511
2. Rowinsky EK, Donehower RC (1991) The clinical pharmacology and use of antimicrotubule agents in cancer chemotherapeutics. Pharmacol Ther 52: 35-84
3. Georg GI, Cheruvallath ZS, Himes RH, Mejillano MR, Burke CT (1992) Synthesis of biologically active taxol analogues with modified phenylisoserine side chains. J Med Chem 35: 4230-4237
4. Duanmu C, Shahrik LK, Ho HH. Hamel E (1989) Tubulin-dependent hydrolysis of guanosine triphosphate as a screening test to identify new antitubulin compounds with potential as antimitotic agents: application to carbamates of aromatic amines. Cancer Res 49: 1344-1348
5. Lataste H, Senilh V, Wright M, Guenard D, Potier P (1984) Relationships between the structures of taxol and baccatine III derivatives and their in vitro action on the disassembly of mammalian brain and Physarum amoebal microtubules. Proc Natl Acad Sci USA 81: 4090-4094
6. Lin CM, Jiang YQ, Chaudhary AG, Rimoldi JM, Kingston DGI, Hamel E (1996) Cancer Chemother Pharmacol 38: 136-140
7. Eva A, Robbins KC, Anderson PR, Srinivasan A, Tronick SR, Reddy EP, Ellmore NW, Galen AT, Lautenberger JA, Papas TS, Westin EH, Wong-Stahl F, Gallo RC, Aaronson SA (1982) Cellular genes analogous to retroviral one genes are transcribed in human tumor cells. Nature 295: 116-119
8. Giannakakou P, Sackett DL, Mickley L, Kang Y-K, Fojo AT (1995) Characterization of non-Pgp paclitaxel (PTX) resistance in the human ovarian cancer cell line A2780. Proc Am Assoc Cancer Res 36: 456
9. Sackett DL, Knipling L, Wolff J (1991) Isolation of microtubule protein from mammalian brain frozen for extended periods of time. Protein Expr Purif 2: 390-393
10. Sackett DL (1995) Rapid purification of tubulin from tissue and tissue culture cells using solid-phase ion exchange. Anal Biochem 228: 343-348
11. Chaudhary AG, Gharpure MM, Rimoldi JM, Chordia MD, Gunatilaka AAL, Kingston DGI, Grover S, Lin CM, Hamel E (1994) Unexpectedly facile hydrolysis of the 2-benzoate group of taxol and synthesis of analogs with increased activities. J Am Chem Soc 116: 4097-4098
12. Sackett DL, Wolff J (1986) Proteolysis of tubulin and the substructure of the tubulin dimer. J Biol Chem 261: 9070-9076
13. Sackett DL, Bhattacharyya B, Wolff J (1994) Local unfolding and the stepwise loss of functional properties of tubulin. Biochemistry 33: 12868-12878
14. Grover S, Rimoldi JM, Molinero AA, Chaudhary AG, Kingston DG, Hamel E (1995) Differential effects of paclitaxel (Taxol) analogs modified at positions C-2, C-7, and C-3′ on tubulin polymerization and polymer stabilization: identification of a hyperactive paclitaxel derivative. Biochemistry 34: 3927-3934
15. Bollag DM, McQueney PA, Zhu J, Hensens O, Koupal L, Liesch J, Goetz M, Lazarides E, Woods CM (1995) Epothilones, a new class of microtubule-stabilizing agents with a taxol-like mechanism of action. Cancer Res 55: 2325-2333