Osteogenic protein-1: Biology and applications

Clinical Orthopaedics and Related Research

Volumn 324, Issue , 1996, Pages 29-38

  Cook, Stephen D ^a   Rueger, David C ^b  

^a TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CURIS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

OSTEOGENIC PROTEIN 1; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; BONE ATROPHY; BONE DEVELOPMENT; CARBOXY TERMINAL SEQUENCE; CELL MATURATION; CELL PROLIFERATION; CELL SURVIVAL; CONFERENCE PAPER; DIAPHYSIS; FRACTURE HEALING; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; SPINE FUSION;

EID: 0030070358     PISSN: 0009921X     EISSN: 15281132     Source Type: Journal    
DOI: 10.1097/00003086-199603000-00005     Document Type: Conference Paper

References (45)

1. Celeste AJ, Lannazzi JA, Taylor RC, et al: Identification of transforming growth factor-β superfamily members present in bone-inductive protein purified from bovine bone. Proc Natl Acad Sci 87:9843-9847, 1990.
2. Cook SD, Baffes GC, Wolfe MW, Sampath TK, Rueger DC: Recombinant human bone morphogenetic protein-7 induces healing in a canine long bone segmental defect model. Clin Orthop 301:302-312, 1994.
3. Cook SD, Baffes GC, Wolfe MW, et al: The effect of recombinant human osteogenic protein-1 on healing of large segmental bone defects. J Bone Joint Surg 76A:827-838, 1994.
4. Cook SD, Dalton JE, Tan EH, Whitecloud TS, Rueger DC: In vivo evaluation of recombinant human osteogenic protein (rhOP-1) implants as bone graft substitute for spinal fusions. Spine 19(IS): 1655-1663, 1994.
5. Cook SD, Salkeld SL, Rueger DC: Evaluation of osteogenic protein-1 to aid in the initial fixation of implants. J Oral Implantol 21:1-6, 1996.
6. Cook SD, Salkeld SL, Rueger DC: Use of recombinant human osteogenic protein-1 for repair of osteochondral defects. J Long-Term Effects Med Implants 1996 (In press).
7. Cook SD, Wolfe MW, Salkeld SL, Rueger DC: Recombinant human osteogenic protein-1 (rhOP-1) heals segmental defects in nonhuman primates. J Bone Joint Surg 77A:734-750, 1995.
8. Hiroshi N, Yoshihiro O, Oohira A: Bioassay of chondrocyte differentiation by bone morphogenetic protein. Clin Orthop 258:295-299, 1990.
9. Jones WK, Richmond EA, White K, et al: Osteogenic protein-1 expression and processing in Chinese hamster ovary cells: Isolation of a soluble complex containing the mature and pro-domains of OP-1. Growth Factors 11:215-225, 1994.
10. Kingsley DM: The TGF-β Superfamily: New members, new receptors, and new genetic tests of function in different organisms. Genes Dev 8:133-146, 1994.
11. Knutsen R, Honda Y, Strong DD: Regulation of insulin like growth factor (IGF) system components by osteogenic protein (OP-1) in human bone cells. Endocrinology 1995 (In press).
12. Maliakal JC, Asahina I, Hauschka PV, Sampath TK: Osteogenic protein-1 (BMP7) inhibits cell proliferation and stimulates the expression of markers characteristic of osteoblast phenotype in rat osteosarcoma cells. Growth Factors 11:227-234, 1994.
13. Mizutani H, Urist MR: The nature of bone morphogenetic protein (BMP) fractions derived from bovine bone matrix gelatin. Clin Orthop 171:213-223, 1982.
14. Moran ME, Kim HK, Salter RB: Biological resurfacing of full-thickness detects in patellar articular cartilage of the rabbit. J Bone Joint Surg 74B:659-667, 1992.
15. Nakagawa M, Urist MR: Chondrogenesis in tissue cultures of muscle under the influence of diffusible component of bone matrix. Proc Soc Exp Biol Med 154:568-572, 1977.
16. Nathanson MA: Proteoglycan synthesis by skeletal muscle undergoing bone matrix-directed transfermation into cartilage in vitro. J Biol Chem 258:10325-10334, 1983.
17. Özkaynak E, Jin DF, Dorai H, et al: Regulation of OP-1 mRNA expression in vivo; Structure of OP-3, a new member of the TGF-β superfamily. J Bone Miner Res Suppl 1:1040, 1993 (Abstract).
18. Özkaynak E, Rueger DC, Droer EA: OP-1 cDNA encodes an osteogenic protein in TGF-β family. EMBO J 9:2085-2093, 1990.
19. Özkaynak E, Schnegelsberg PNJ, Jin DF, et al: Osteogenic protein-2: A new member of the transforming growth factor-β superfamily expressed in early embryogenesis. J Biol Chem 267:25220-25227, 1992.
20. Özkaynak E, Schnegelsberg PNJ, Oppermann H: Murine osteogenic protein-1 (OP-1): High levels of mRNA in kidney. Biochem Biophys Res Commun 179:116-123, 1991.
21. Reddi AH, Huggins CB: Biochemical sequences in the transformation of normal fibroblasts in adolescent rats. Proc Natl Acad Sci 69:1601-1605, 1972.
22. Reddi AH, Weintroub S, Muthukumaran N: Biological principles of bone induction. Orthop Clin North Am 18:207-212, 1987.
23. Rutherford RB, Sampath TK, Rueger DC, Taylor TD: Use of bovine osteogenic protein to promote rapid osseointegration of endosseous dental implants. J Oral Maxillofac Impl 7:297-301, 1992.
24. Sampath TK, Coughlin JE, Whetstone RM, et al: Bovine osteogenic protein is composed of dimers of OP-1 and BMP-2 A, two members of the transforming growth factor-B superfamily. J Biol Chem 265:13198-13205, 1990.
25. Sampath TK, DeSimone DP, Reddi AH: Extracellular bone matrix-derived growth factor. Exper Cell Res 142:460-464, 1982.
26. Sampath TK, Maliakal JC, Hauschka PV, et al: Recombinant human osteogenic protein-1 (hOP-1) induces new bone formation in vivo with a specific activity comparable with natural bovine osteogenic protein and stimulates osteoblast proliferation and differentiation in vitro. J Biol Chem 267: 20352-20362, 1992.
27. Sampath TK, Muthukumaran N, Reddi AH: Isolation of osteogenin, an extracellular matrix-associated bone inductive protein by heparin affinity chromatography. Proc Natl Acad Sci 84:7109-7113, 1987.
28. Sampath K, Nathanson MA, Reddi AH: In vitro transformation of mesenchymal cells derived from embryonic muscle into cartilage in response to extracellular matrix components of bone. Proc Natl Acad Sci USA 81:3419-3423, 1984.
29. Sampath TK, Rashka KE, Doctor JS, Tucker RF, Hoffmann FM: Drosophila TGF-β superfamily proteins induce endochondral bone formation in mammals. Proc Natl Acad Sci USA 90:6004-6008, 1993.
30. Sampath TK, Reddi AH: Dissociative extraction and reconstitution of extracellular matrix components involved in local bone differentiation. Proc Natl Acad Sci 78:7599-7602, 1981.
31. Sampath TK, Reddi AH: Homology of bone-inductive proteins from human monkey, bovine, and rat extracellular matrix. Proc Natl Acad Sci 80:6591-6595, 1983.
32. Sampath TK, Rueger DC: Structure, function, and orthopaedic applications of osteogenic protein (OP-1). Complications Orthopaed Winter 101-107, 1994.
33. Sato K, Miura T, Iwata H: Cartilaginous transdifferentiation of rat tenosynovial cells under the influence of bone morphogenetic protein in tissue culture. Clin Orthop 236:233-239, 1988.
34. Sato K, Urist MR: Bone morphogenetic protein-induced cartilage development in tissue culture. Clin Orthop 183:180-187, 1984.
35. Seyedin SM, Thompson AY, Rosen DM, Piez KA: In vitro induction of cartilage-specific macromolecules by a bone extract. J Cell Biol 97:1950-1953, 1983.
36. Takaoka K, Yoshikawa H, Masuhara K, et al: Establishment of a cell line producing bone morphogenetic protein from a human osteosarcoma. Clin Orthop 244:258-264, 1989.
37. Tsuda T, Masuhara K, Yoshikawa H, Shimuzu N, Takaoka K: Establishment of an osteoinductive murine osteosarcoma clonal cell line showing osteoblast phenotypic traits. Bone 10:195-200, 1989.
38. Urist MR, DeLange R, Finerman GAM:Bone cell differentiation and growth factors. Science 220: 680-686, 1983.
39. Urist MR: Bone:Formation by autoinduction. Science 150:893-899, 1965.
40. Urist MR: Practical application of basic research on bone graft physiology. Instr Course Lect 25:1-26, 1976.
41. Urist MR, Iwata H: Preservation and biodegradation of morphogenetic property of bone matrix. J Theor Biol 38:155-167, 1973.
42. Vukicevic S, Latin V, Chen P, Batorsky R, et al: Localization of osteogenic protein-1 (bone morphogenetic protein-7) during human embryonic development: High affinity binding to basement membranes. Biochem Biophys Res Commun 198::693-700, 1994.
43. Wang EA, Rosen V, Cordes P, et al: Purification and characterization of other distinct bone-inducing proteins. Proc Natl Acad Sci USA 85:9484-9488, 1988.
44. Wang EA, Rosen V, D'Alessandro S, et al: Recombinant human bone morphogenetic protein induces bone formation. Proc Natl Acad Sci 87:2220-2224, 1990.
45. Wozney JM, Rosen V, Celeste AJ, et al: Novel regulators of bone formation: Molecular clones and activities. Science 242:1526-1534, 1988.