Fibroblasts of spinal ligaments pathologically differentiate into chondrocytes induced by recombinant human bone morphogenetic protein-2: Morphological examinations for ossification of spinal ligaments

Bone

Volumn 21, Issue 2, 1997, Pages 155-162

  Hoshi, K ^a,b   Amizuka, N ^a   Sakou, T ^c   Kurokawa, T ^b   Ozawa, H ^a  

^a NIIGATA UNIVERSITY   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c KAGOSHIMA UNIVERSITY   (Japan)

Author keywords

Bone morphogenetic protein type I receptor; Bone morphogenetic protein type II receptor; Bone morphogenetic protein 2; Ossification; Spinal ligament

Indexed keywords

ALKALINE PHOSPHATASE; BONE MORPHOGENETIC PROTEIN; BONE MORPHOGENETIC PROTEIN RECEPTOR; CELL RECEPTOR; COLLAGEN; COLLAGEN TYPE 1; COLLAGEN TYPE 2; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CARTILAGE CELL; CELL DIFFERENTIATION; CELL MIGRATION; CELL STRUCTURE; CONTROLLED STUDY; ENCHONDRAL OSSIFICATION; EXTRACELLULAR MATRIX; FIBROBLAST; LIGAMENT; MALE; MOUSE; NONHUMAN; OSSIFICATION; OSTEOBLAST; PROTEIN LOCALIZATION; RECEPTOR UPREGULATION; SPINE;

ACID PHOSPHATASE; ANIMALS; BIOLOGICAL MARKERS; BONE MORPHOGENETIC PROTEIN RECEPTORS, TYPE I; BONE MORPHOGENETIC PROTEIN RECEPTORS, TYPE II; BONE MORPHOGENETIC PROTEINS; CALCINOSIS; CARTILAGE; CELL DIFFERENTIATION; COLLAGEN; EXTRACELLULAR MATRIX; FIBROBLASTS; HUMANS; IMMUNOHISTOCHEMISTRY; ISOENZYMES; LIGAMENTUM FLAVUM; LUMBAR VERTEBRAE; MALE; MICE; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, GROWTH FACTOR; RECOMBINANT PROTEINS; RIBONUCLEASES; TRANSFORMING GROWTH FACTOR BETA;

EID: 0030823929     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/S8756-3282(97)00106-3     Document Type: Article

References (31)

1. Alpaslan, C., Irie, K., Takahashi, K., Ohashi, N., Sakai, H., Nakajima, T., and Ozawa, H. Long-term evaluation of recombinant human bone morphogenetic protein-2 induced bone formation with a biologic and synthetic delivery system. Br J Oral Maxillofac Surg 34:414-418; 1996.
2. Amizuka, N., Karaplis, A. C., Henderson, J. E., Warshawsky, H., Lipman, M. L., Matsuki, Y., Ejiri, S., Tanaka, M., Izumi, N., Ozawa, H., and Goltzman, D. Haploinsufficiency of parathyroid hormone-related peptide (PTHrP) results in abnormal postnatal bone development. Dev Biol 175:166-176; 1996.
3. Bassett, C. A. L. Current concepts of bone formation. J Bone Jt Surg 44A: 1217-1244; 1962.
4. Burstone, M. S. Alkaline phosphatase, naphthol AS phosphate method. In: Burstone, M. S., Ed. Enzyme Histochemistry and Its Application on the Study of Neoplasms. New York: Academic; 1962; 275-276.
5. Cooper, R. R. and Misol, S. Tendon and ligament insertion: A light and electron microscopic study. J Bone Jt Surg 52A:1-20; 1970.
6. Fujimura, K., Bessho, K., Kusumoto, K., Ogawa, Y., and Iizuka, T. Experimental studies on bone inducing activity of composites of atelopeptide type I collagen as a carrier for ectopic osteoinduction by rhBMP-2. Biochem Biophys Res Commun 208:316-322; 1995.
7. Hattori, A., Endoh, H., Suzuki, K., and Kaneda, M. Ossification of the thoracic ligamentum flavum with compression of the spinal cord: A report of six cases. J Jpn Orthop Assoc 50:1141-1146; 1976.
8. Hoshi, K., Amizuka, N., Oda, K., Ikehara, Y., and Ozawa. H. Immunolocalization of tissue non-specific alkaline phosphatase in mice. Histochem Cell Biol 107:283-292; 1997.
9. Ishidou, U., Kitajima, I., Obama, H., Maruyama, I., Murata, F., Imamura, T., ten Dijke, P., Miyazono, K., and Sakou, T. Enhanced expression of type I receptor for bone morphogenetic proteins during bone formation. J Bone Miner Res 10:1651-1659; 1995.
10. Katagiri, T., Yamaguchi, A., Ikeda, T., Yoshiki, S., Wozney, J. M., Rosen, V., Wang, E. A., Tanaka, H., Omura, S., and Suda, T. The non-osteogenic mouse pluripotent cell line, C3H10T1/2, is induced to differentiate into osteoblastic cells by recombinant human bone morphogenetic protein-2. Biochem Biophys Res Commun 172:295-299; 1990.
11. Katagiri, T., Yamaguchi, A., Komaki, M., Abe, E., Takahashi, N., Ikeda, T., Rosen, V., Wozney, J. M., Fujisawa Sehara, A., and Suda, T. Bone morphogenetic protein-2 converts the differentiation pathway of C2C12 myoblasts into the osteoblast lineage. J Cell Biol 127:1755-1766; 1994.
12. Kawaguchi, H., Kurokawa, T., Hoshino, Y., Kawahara, H., Ogata, E., and Matsumoto, T. Immunohistochemical demonstration of bone morphogenetic protein-2 and transforming growth factor-β in the ossification of the posterior longitudinal ligament of the cervical spine. Spine 17:S33-S36; 1992.
13. Kenley, R., Marden, L., Jin, L., Ron, E., and Hollinger, J. O. Osseous regeneration in the rat calvarium using novel delivery systems for recombinant human bone morphogenetic protein-2 (rhBMP-2). J Biomed Mater Res 28: 1139-1147; 1994.
14. Koenig, B. B., Cook, J. S., Wolsing, D. H., Ting, J., Tiesman, J. P., Correa, P. E., Olson, C. A., Pecquet, A. L., Ventura, F., Grant, R. A., Chen, G. X., and Wrana, J. L. Characterization and cloning of a receptor for BMP-2 and BMP-4 from NIH 3T3 cells. Mol Cell Biol 14:5961-5974; 1994.
15. Lee, S. C., Shea, M., Battle, M. A., Kozitza, K., Ron, E., Turek, T., Schaub, R. G., and Hayes, W. C. Healing of large segmental defects in rat femurs is aided by RhBMP-2 in PLGA matrix. J Biomed Mater Res 28:1149-1156; 1994.
16. Marden, L. J., Hollinger, J. O., Chaudhari, A., Turek, T., Schaub, R. G., and Ron, E. Recombinant human bone morphogenetic protein-2 is superior to demineralized bone matrix in repairing craniotomy defects in rats. J Biomed Mater Res 28:1127-1138; 1994.
17. Miyamoto, S., Takaoka, K., Yonenobu, K., and Ono, K. Ossification of the ligamentum flavum induced by bone morphogenetic protein: An experimental study in mice. J Bone Jt Surg 746:279-283; 1992.
18. Ohashi, N., Ejiri, S., Kanada, K., and Ozawa, H. Changes in type I, II and X collagen immunoreactivity of the mandibular condylar cartilage in a naturally aging rat model. J Bone Miner Metab. In press.
19. Okada, K., Oka, S., Tohge, K., Ono, K., Yonenobu, K., and Hosoya, T. Thoracic myelopathy caused by ossification of the ligamentum flavum: Clinicopathologic study and surgical treatment. Spine 16:280-287; 1991.
20. Ono, K., Ota, H., Tada, K., Hamada, H., and Takaoka, K. Ossified posterior longitudinal ligament: A clinicopathologic study. Spine 2:126-138; 1977.
21. Rosenzweig, B. L., Imamura, T., Okadome, T., Cox, G. N., Yamashita, H., ten Dijke, P., Heldin, C. H., and Miyazono, K. Cloning and characterization of a human type II receptor for bone morphogenetic proteins. Proc Natl Acad Sci USA 92:7632-7636; 1995.
22. ten Dijke, P., Yamashita, H., Sampath, T. K., Reddi, A. H., Estevez, M., Riddle, D. L., Ichijo, H., Heldin, C. H., and Miyazono, K. Identification of type I receptors for osteogenic protein-1 and bone morphogenetic protein-4. J Biol Chem 269:16985-16988; 1994.
23. Thies, R. S., Bauduy, M., Ashton, B. A., Kurtzberg, L., Wozney, J. M., and Rosen, V. Recombinant human bone morphogenetic protein-2 induces osteoblastic differentiation in W-20-17 stromal cells. Endocrinology 130:1318-1324; 1992.
24. van de Wijingaert, F. P. and Burger, E. H. Demonstration of tartrate-resistant acid phosphate in undecalcified, glycolmethacrylate-embedded mouse bone: A possible marker for (pre)osteoclast identification. J Histochem Cytochem 34:1317-1323; 1986.
25. Wood, G. W. II, Spinal stenosis, In: Crenshaw, A. H., Ed. Campbell's Operative Orthopaedics, 8th ed., Vol. 5. St. Louis, MO: Mosby Year Book; 1992; 3836-3845.
26. Wrana, J. L., Attisano, L., Carcarno, J., Zentella, A., Doody, J., Laiho, M., Wang, X. F., and Massague, J. TGF beta signals through a heteromeric protein kinase receptor complex. Cell 71:1003-1014; 1992.
27. Yahia, L. H., Garzon, S., Strykowski, H., and Rivard, C. H. Ultrastructure of the human interspinous ligament and ligamentum flavum: A preliminary study. Spine 15:262-268; 1990.
28. Yamada, M. Ultrastructural and cytochemical studies on the calcification of the tendon-bone joint. Arch Histol Jpn 39:347-378; 1976.
29. Yamaguchi, A., Katagiri, T., Ikeda, T., Wozney, J. M., Rosen, V., Wang, E. A., Kahn, A. J., Suda, T., and Yoshiki, S. Recombinant human bone morphogenetic protein-2 stimulates osteoblastic maturation and inhibits myogenic differentiation in vitro. J Cell Biol 113:681-687; 1991.
30. Yasko, A. W., Lane, J. M., Fellinger, E. J., Rosen, V., Wozney, J. M., and Wang, E. A. The healing of segmental bone defects, induced by recombinant human bone morphogenetic protein (rhBMP-2): A radiographic, histological, and biomechanical study in rats. J Bone Jt Surg 74A:659-670; 1992.
31. Yasui, N., Ono, K., Yamaura, I., Konomi, H., and Nagai, Y. Immunohistochemical localization of types I, II, and III collagens in the ossified posterior longitudinal ligament of the human cervical spine. Calcif Tissue Int 35:159-163; 1983.