New insights into obesity genes

Diabetologia

Volumn 39, Issue 12, 1996, Pages 1528-1531

  Guerre Millo, M ^a   Staels, B ^b   Auwerx, J ^b  

^a INSERM   (France)

^b INSTITUT PASTEUR DE LILLE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL MODEL; CELL DIFFERENTIATION; GENE; GENE MUTATION; HUMAN; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; SHORT SURVEY;

ADIPOSE TISSUE; ANIMALS; CCAAT-ENHANCER-BINDING PROTEINS; CELL DIFFERENTIATION; DISEASE MODELS, ANIMAL; DNA-BINDING PROTEINS; HIGH MOBILITY GROUP PROTEINS; HUMANS; LEPTIN; MICE; NUCLEAR PROTEINS; OBESITY; PROTEINS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; TRANSCRIPTION FACTORS;

EID: 0029951730     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001250050609     Document Type: Short Survey

References (45)

1. Warden CH, Fisler JS, Shoemaker SM, et al. (1995) Identification of four chromosomal loci determining obesity in a multifactorial mouse model. J Clin Invest 95: 1545-1552
2. West DB, Waguespack J, York B, Goudey-Lefevre J, Price RA (1994) Genetics of dietary obesity in AKR/J x SWR/J mice: segregation of the trait and identification of a linked locus on chromosome 4. Mammalian Genome 5: 546-552
3. West DB, Goudey-Lefevre J, York B, Truett GE (1994) Dietary obesity linked to genetic loci on chromosomes 9 and 15 in a polygenic mouse model. J Clin Invest 94: 1410-1416
4. Bultman SJ, Michaud EJ, Woychik RP (1992) Molecular characterization of the mouse agouti locus. Cell 71: 1195-1204
5. Miller MW, Duhl DMJ, Vrieling H et al. (1993) Cloning of the mouse agouti gene predicts a secreted protein ubiquitously expressed in mice carrying the lethal yellow mutation. Genes Dev 7: 454-467
6. γ) mutation. Proc Natl Acad Sci USA 91: 2562-2566
7. Perry WL, Hustad CM, Swing DA, Jenkin NA, Copeland NG (1995) A transgenic mouse assay for agouti protein activity. Genetics 140: 267-274
8. Kleibig ML, Wilkinson JG, Geisler JG, Woychik RP (1995) Ectopic expression of the agouti gene in transgenic mice causes obesity, features of type II diabetes and yellow fur. Proc Natl Acad Sci USA 92: 4728-4732
9. Zemel MB, Han Kim J, Woychik RP, et al. (1995) Agouti regulation of intracellular calcium: role in the insulin resistance of viable yellow mice. Proc Natl Acad Sci USA 92: 4733-4737
10. Jones BH, Kim JH, Zemel MB, et al. (1996) Upregulation of adipocyte metabolism by agouti protein: possible paracrine actions in yellow mouse obesity. Am J Physiol 270: E192-E196
11. Lu D, Willard D, Patel IR, et al. (1994) Agouti protein is an antagonist of the melanocyte-stimulating hormone receptor. Nature 371: 799-802
12. Wilson BD, Ollmann MM, Kang L, Stoffel M, Bell GI, Barsh GS (1995) Structure and function of ASP, the human homolog of the mouse agouti gene. Hum Mol Genet 4: 223-230
13. Kwon HY, Bultman SJ, Löffler C, et al. (1994) Moecular structure and chromosomal mapping of the human homolog of the agouti gene. Proc Natl Acad Sci USA 91: 9760-9764
14. Naggert JK, Fricker LD, Varlamov O, et al. (1995) Hyperproinsulinemia in obese fat/fat mice associated with a carboxypeptidase E mutation which reduces enzyme activity. Nature Genet 10: 135-142
15. Noben-Trauth K, Naggert JK, North MA, Nishina PM (1996) A candidate gene for the mouse mutation tubby. Nature 380: 534-538
16. Kleyn PW, Fan W, Kovats SG, et al. Identification and characterization of the mouse obesity gene tubby: a member of a novel gene family. Cell 85: 281-290
17. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L. Friedman JM (1994) Positional cloning of the mouse obese gene and its human homologue. Nature 372: 425-432
18. Pelleymounter MA, Cullen MJ, Baker MB, et al. (1995) Effects of the obese gene product on body weight regulation in ob/ob mice. Science 269: 540-543
19. Halaas JL, Gajiwala KS, Maffei M, et al. (1995) Weight-reducing effects of the plasma protein encoded by the obese gene. Science 269: 543-546
20. Campfield LA, Smith FJ, Guisez Y, Devos R, Burn P (1995) Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science 269: 546-549
21. Coleman DL (1978) Obese and diabetes: two mutant genes causing diabetes-obesity syndromes in mice. Diabetologia 14: 141-148
22. Tartaglia LA, Dembski M, Weng X, et al. (1995) Identification and expression cloning of a leptin receptor. OB-R. Cell 83: 1263-1271
23. Chen H, Charlat O, Tartaglia LA, et al. (1996) Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice. Cell 84: 491-495
24. Lee G-H, Proenca R, Montez, JM, et al. (1996) Abnormal splicing of the leptin receptor in diabetic mice. Nature 379: 632-635
25. Ghilardi N, Ziegler S, Wiestner A, Stoffel R, Heim MH, Skoda RC (1996) Defective STAT signaling by the leptin receptor in diabetic mice. Proc Natl Acad Sci USA 93: 6231-6235
26. Baumann H, Morella KK, White DW, et al. (1996) The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors. Proc Natl Acad Sci USA 93: 8374-8378
27. Stephens TW, Basinski M, Bristow PK, et al. (1995) The role of neuropeptide Y in the antiobesity action of the obese gene product. Nature 377: 530-532
28. Clement K, Garner C, Hager J, et al. (1996) Indication for linkage of the human OB gene region with extreme obesity. Diabetes 45: 687-690
29. Reed DR, Ding Y, Xu W, Cather C, Green ED, Price RA (1996) Extreme obesity may be linked to markers flanking the human OB gene. Diabetes 45: 691-694
30. Considine RV, Considine EL, Williams CJ, Hyde TM, Caro JF (1996) The hypothalamic leptin receptor in humans. Identification of incidental sequence polymorphisms and absence of the db/db mouse and fa/fa rat mutation. Diabetes 19: 992-994
31. Schoonjans K, Staels B, Auwerx J (1996) Role of the peroxisomal proliferator activated receptors (PPAR) in mediating effects of fibrates and fatty acids on gene expression. J Lipid Res 37: 907-925
32. Tontonoz P, Hu E, Spiegelman BM (1994) Stimulation of adipogenesis in fibroblasts by PPAR γ 2, a lipid-activated transcription factor. Cell 79: 1147-1156
33. Hu EP, Tontonoz P, Spiegelman BM (1995) Transdifferentiation of myoblasts by the adipogenic transcription factors PPARγ and C/EBPα Proc Natl Acad Sci USA 92: 9856-9860
34. Yu K, Bayona CB, Kallen HP, et al. (1995) Differential activation of peroxisome proliferator-activated receptors by eicosanoids. J Biol Chem 270: 23975-23983
35. Lehmann JM, Moore LB, Smith-Oliver TA, Wilkinson WO, Willson TM, Kliewer SA (1995) An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor γ (PPARγ). J Biol Chem 270: 12953-12956
36. Forman BM, Tontonoz P, Chen J, Brun RP, Spiegelman BM, Evans RM (1995) 15-Deoxy-Δ 12,14 prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ. Cell 83: 803-812
37. Kliewer SA, Lenhard JM, Willson TM, Patel I, Morris DC, Lehman JM (1995) A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation. Cell 83: 813-819
38. Christy RJ, Yang VW, Ntambi JM, et al. (1989) Differentiation-induced gene expression in 3T3-L1 preadipocytes: CCAAT/enhancer binding protein interacts with and activates the promoters of two adipocytc-specific genes. Genes Dev 3: 1323-1335
39. Lin FT, Lane MD (1992) Antisense CCAAT/enhancer binding protein RNA supresses coordinate gene expression and triglyceride accumulation during differentiation of 3T3-L1 adipocytes. Genes Dev 6: 533-544
40. Freytag SO, Paielli DL, Gilbert DJ (1994) Ectopic expression of the CCAAT/enhancer-binding protein α promotes the adipogenic program in a variety of mouse fibroblastic cells. Genes Dev 8: 1654-1663
41. Lin FT, Lane MD (1994) CCAAT/enhancer binding protein is sufficient to initiate the 3T3-L1 adipocyte differentiation program. Proc Natl Acad Sci USA 91: 8757-8761
42. Wang N, Finegold MJ, Bradley A et al. (1995) Impaired energy homeostasis in C/EBPα knockout mice. Science 269: 1108-1112
43. Ashar HR, Schoenberg Fejzo M, Tkachenko A, et al. (1995) Disruption of the architectural factor HMGI-C: DNA-binding AT hook motif fused in lipomas to distinct transcriptional regulatory domains. Cell 82: 57-65
44. Schoenmakers EFPM, Wanschura S, Mols R, Bullerdiek J, Van den Berghe H, Van de Ven WJW (1995) Recurrent rearrangements in the high mobility group protein gene, HMGI-C, in benign mesenchymal tumours. Nature Genet 10: 436-443
45. Zhou X, Benson KF, Ashar HR, Chada K (1995) Mutation responsible for the mouse pygmy phenotype in the developmentally regulated factor HMGI-C. Nature 376: 771-774