Regulation of adipose cell number in man

Clinical Science

Volumn 92, Issue 1, 1997, Pages 3-11

  Prins, Johannes B ^a   O'Rahilly, Stephen ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Adipocyte; Apoptosis; Differentiation; Obesity; Preadipocyte

Indexed keywords

GLUCAGON LIKE PEPTIDE 1; INSULIN; LEPTIN; LIGAND; NEUROPEPTIDE Y; PEROXISOME PROLIFERATOR; TUMOR NECROSIS FACTOR ALPHA;

ADIPOCYTE; ADIPOSE TISSUE CELL; APOPTOSIS; APPETITE; AUTOCRINE EFFECT; BODY MASS; CELL COUNT; CELL DIFFERENTIATION; CELL DIVISION; CELL LOSS; CELL VOLUME; ENDOCRINE SYSTEM; HUMAN; HUMAN CELL; HYPOTHALAMUS; METABOLIC RATE; PRIORITY JOURNAL; PROADIPOCYTE; REGULATORY MECHANISM; REVIEW;

EID: 0031037111     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/cs0920003     Document Type: Review

References (101)

1. Smith EL, Hill RL, Lehman IR, Lefkowitz RJ, Handler P, White A. Principles of biochemistry. General aspects. 7th edn. Sydney: McGraw-Hill, 1983.
2. Stunkard AJ, Sorensen TIA, Hanis C, Teasdale TW, Chakroborty R. An adoption study of human obesity. N Engl J Med 1986; 314: 193-8.
3. Carey D, Campbell L, Chisholm D, Jenkins A, Kelly P. Genetic influences on central abdominal fat: a twin study. Int J Obes 1994; 18 (Suppl. 2): 116.
4. Coleman DL. Obese and diabetes: two mutant genes causing diabetes-obesity syndromes in mice. Diabetologia 1978; 14: 141-8.
5. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. Positional cloning of the mouse obese gene and its human homologue. Nature (London) 1994; 372: 425-32.
6. Chen H, Charlat O, Tartaglia LA, et al. Evidence that the diabetes gene encodes the leptin receptor; identification of a mutation in the leptin receptor gene in db/db mice. Cell 1996; 84: 491-5.
7. Lee G-H, Proenca R, Montez JM, et al. Abnormal splicing of the leptin receptor in diabetic mice. Nature (London) 1996; 379: 632-5.
8. Levin N, Nelson C, Gurney A, Vandlen R, de Sauvage F. Decreased food intake does not completely account for adiposity reduction after ob protein infusion. Proc Natl Acad Sci USA 1996; 93: 1726-30.
9. Pelleymounter MA, Cullen MJ, Baker MB, et al. Effects of the obese gene product on body weight regulation in ob/ob mice. Science (Washington DC) 1995; 269: 540-3.
10. Halaas JL, Gajiwala KS, Maffei M, et al. Weight-reducing effects of the plasma protein encoded by the obese gene. Science (Washington DC) 1995; 269: 543-6.
11. Campfield LA, Smith FJ, Giesez Y, Devos R, Burn P. Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science (Washington DC) 1995; 269: 546-9.
12. Ahima RS, Prabakaran D, Mantzoros C, et al. Role of leptin in the neuroendocrine response to fasting. Nature (London) 1996; 382: 250-2.
13. Chehab FF, Lim ME, Lu R. Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin. Nat Genet 1996; 12: 318-20.
14. Rohner-Jeanrenaud F, Jeanrenaud B. Obesity, leptin, and the brain. N Engl J Med 1996; 334: 324-5.
15. 3 adrenoreceptors. J Clin Invest 1995; 95: 923.
16. 3-adrenoceptor agonists in the treatment of obesity and diabetes. Int J Obes 1996; 20: 191-9.
17. Hirsch J. Adipose cellularity in relation to human obesity. In: Stollerman GH, ed. Advances in internal medicine. vol. 17. Chicago: Year Book Medical Publishers, 1971: 289-300.
18. Rodbell M. Metabolism of isolated fat cells. I. Effects of hormones on glucose metabolism and lipolysis. J Biol Chem 1964; 239: 375-80.
19. Arner P. Control of lipolysis and its relevance to development of obesity in man. Diabetes Metab Rev 1988; 4: 507-15.
20. Baldo A, Sniderman AD, St-Luce S, et al. The adipsin-acylation stimulating protein system and regulation of intracellular triglyceride synthesis. J Clin Invest 1993; 92: 1543-7.
21. Salans L, Cushman SW, Weissman RE. Studies of human adipose tissue: adipose cell size and number in nonobese and obese patients. J Clin Invest 1973; 52: 929-41.
22. Bjorntorp B. Adipose tissue distribution and function. Int J Obes 1991; 15: 67-81.
23. Vague J, ed. Obesities. 1st edn. London: John Libbey and Company Ltd, 1991: 20.
24. Ng CW, Poznanski WJ, Borowieki M, Reimer G. Differences in growth in vitro of adipose cells from normal and obese patients. Nature (London) 1971; 231: 445.
25. Van RLR, Roncari AK. Complete differentiation of adipocyte precursors. Cell Tissue Res 1978; 195: 317-29.
26. Poznanski WJ, Waheed I, Van R. Human fat cell precursors. Lab Invest 1973; 29: 570-6.
27. Ailhaud G, Barbaras R, Castiella L, et al. Adipose cell differentiation: differential expression of specific mRNAs and protein markers in cells from white and brown adipose tissue. Recent Adv Obesity Res 1980; 5: 174-80.
28. Ailhaud G, Amri E, Bardon S, et al. Growth and differentiation of regional adipose tissue: molecular and hormonal mechanisms. Int J Obes 1991; 15: 87-90.
29. Geloen A, Roy PE, Bukowiecki LJ. Regression of white adipose tissue in diabetic rats. Am J Physiol 1989; 257: E547-53.
30. Sjöström. Can the relapsing patient be identified? In: Björntorp P, Cairella M, Howard AN, eds. Recent advances in obesity research: III. London: John Libbey, 1981: 392.
31. Miller WHJ, Faust IM, Goldberger AC, Hirsch J. Effects of severe long-term food deprivation and refeeding on adipose tissue cells in the rat. Am J Physiol 1983; 245: E74-80.
32. Prins JB, Walker NI, Winterford CM, Cameron DP. Human adipocyte apoptosis occurs in malignancy. Biochem Biophys Res Commun 1994; 205: 625-30.
33. Roncari DAK, Van RLR. Promotion of human adipocyte precursor replication by 17β-estradiol in culture. J Clin Invest 1978; 9: 503-8.
34. Roncari DAK, Lau DCW, Kindler S. Exaggerated replication in culture of adipocyte precursors from massively obese persons. Metabolism 1981; 30: 425-7.
35. Deslex S, Negrel R, Vannier C, Wabitsch M, Gaillard D, Ailhaud G. Differentiation of human adipocyte precursors in a chemically defined, serum-free medium. Int J Obes 1987; 11: 19.
36. Kuo PT, Conn HL, DeFelice EA, eds. Health and Obesity. New York: Raven Press, 1983: 27.
37. Ailhaud G. Adipose cell differentiation in culture. Mol Cell Biochem 1982; 49: 17-31.
38. Smyth MJ, Sparks RL, Wharton W. Proadipocyte cell lines: models of cellular proliferation and differentiation. J Cell Sci 1993; 106: 1-9.
39. Krawisz BR, Scott RE. Coupling of proadipocyte growth arrest and differentiation. I. Induction by heparinized medium containing human plasma. J Cell Biol 1982; 94: 394-9.
40. Teichert-Kuliszewska K, Hamilton BS, Deitel M, Roncari DAK. Augmented production of heparin-binding mitogenic proteins by preadipocytes from massively obese persons. J Clin Invest 1992; 90: 1226-31.
41. Hauner H, Entenmann G, Wabitsch M, et al. Promoting effect of glucocorticoids on the differentiation of human adipocyte precursor cells cultured in a chemically defined medium. J Clin Invest 1989; 84: 1663-70.
42. Dixon-Shanies D, Rudick J, Knittle JL. Observations on the growth and metabolic functions of cultured cells derived from human adipose tissue (38846). Proc Soc Exp Biol Med 1975; 149: 541-5.
43. Tontonoz P, Hu E, Graves RA, Budavari AI, Spiegelman BM. mPPARγ2: tissue-specific regulator of an adipocyte enhancer. Genes Dev 1994; 8: 1224-34.
44. Tontonoz P, Hu E, Spiegelman BM. Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor. Cell 1994; 79: 1147-56.
45. Sugihara H, Yonemitsu N, Miyabara S, Yum K. Primary cultures of unilocular fat cells: characteristics of growth in vitro and changes in differentiation properties. Differentiation 1986; 31: 42-9.
46. Loffler G, Mirter G, Hartrampf R. Culture of mature adipocytes: evidence for cell division induced by growth factors. Int J Obes 1994; 18 (Suppl.): 88.
47. Negrel R. Fat cells cannot divide. Int J Obes 1994; 18 (Suppl.): 88.
48. Cheng AYM, Deitel M, Roncari DAK. The biochemistry and molecular biology of human adipocyte reversion. Int J Obes 1994; 18 (Suppl. 2): 112.
49. Van RLR, Bayliss CE, Roncari DAK. Cytological and enzymological characterization of adult human adipocyte precursors in culture. J Clin Invest 1976; 58: 699-704.
50. Hauner H. Prevention of adipose tissue growth. Int J Obes 1994; 18 (Suppl. 2): 147.
51. Petruschke TH, Hauner H. Tumor necrosis factor-α prevents the differentiation of human adipocyte precursor cells and causes delipidation of newly developed fat cells. J Clin Endocrinol Metab 1993; 76: 742-7.
52. Prins JB, Walker NI, Winterford CM, Cameron DP. Apoptosis of human adipocytes in vitro. Biochem Biophys Res Commun 1994; 201: 500-7.
53. Denton R, Brownsey RW, Belsham GJ. A partial view of the mechanism of insulin action. Diabetologia 1981; 21: 347-62.
54. Geloen A, Collet AJ, Guay G, Bukowiecki LJ. Insulin stimulates in vivo cell proliferation in white adipose tissue. Am J Physiol 1989; 256: C190-6.
55. Reaven G. The fourth Musketeer - from Alexandre Dumas to Claude Bernard. Diabetologia 1995; 38: 3-13.
56. Inadera H, Ito S, Ishikawa Y, et al. Visceral fat deposition is seen in patients with insulinoma. Diabetologia 1993; 36: 91-2.
57. Sahu A, Dube MG, Phelps CP, Sninsky CA, Kalra PS, Kalra SP. Insulin and insulin-like growth factor II suppress neuropeptide Y release from the nerve terminals in the paraventricular nucleus: a putative hypothalamic site for energy homeostasis. Endocrinology (Baltimore) 1995; 136: 5718-24.
58. Rentsch J, Chiesi M. Regulation of ob mRNA levels in cultured adipocytes. FEBS Lett 1996; 379: 55-9.
59. Leroy P, Dessolin S, Villageois P, et al. Expression of ob gene in adipose cells. Regulation by insulin. J Biol Chem 1996; 271: 2365-8.
60. Cusin I, Sainsbury A, Doyle P, Rohner-Jeanrenaud F, Jeanrenaud B. The ob gene and insulin. A relationship leading to clues to the understanding of obesity. Diabetes 1995; 44: 1467-70.
61. Kolaczynski JW, Nyce MR, Considine RV, et al. Acute and chronic effect of insulin on leptin production in humans. Studies in vivo and in vitro. Diabetes 1996; 45: 699-701.
62. Dagogo-Jack S, Fanelli C, Paramore D, Brothers J, Landt M. Plasma leptin and insulin relationships in obese and nonobese humans. Diabetes 1996; 45: 695-8.
63. Oomura Y, Tarui S, Inoue S, Shimazu T, eds. Progress in obesity research 1990. 1st edn. London: John Libby, 1991: 213.
64. Dreyer C, Krey G, Keller H, Givel F, Helftenbein G, Wahli W. Control of the peroxisomal β-oxidation pathway by a novel family of nuclear hormone receptors. Cell 1992; 68: 879-87.
65. Schmidt A, Endo N, Rutledge SJ, Vogel R, Shinar D, Rodan GA. Identification of a new member of the steroid hormone receptor superfamily that is activated by a peroxisome proliferator and fatty acids. Mol Endocrinol 1992; 6: 1634-41.
66. Issemann I, Green S. Activation of a member of the steroid hormone superfamily by peroxisome proliferators. Nature (London) 1990; 347: 645-50.
67. 2 is a ligand for the adipocyte determination factor PPARγ. Cell 1995; 83: 803-12.
68. 2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation. Cell 1995; 83: 813-19.
69. Lehmann JM, Moore LB, Smith-Oliver TA, Wilkinson WO, Willson TM, Kliewer SA. An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor γ (PPARγ). J Clin Invest 1995; 270: 12953-6.
70. Keller H, Dreyer C, Medin J, Mahfoudi A, Ozato K, Wahli W. Fatty acids and retinoids control lipid metabolism through activation of peroxisome proliferator-activated receptor-retinoid X receptor heterodimers. Proc Natl Acad Sci USA 1993; 90: 2160-4.
71. Kletzien RF, Clarke SD, Ulrich RG. Enhancement of adipocyte differentiation by an insulin-sensitizing agent. Mol Pharmacol 1992; 41: 393-8.
72. Jetten AM. Modulation of cell growth by retinoids and their possible mechanisms of action. Fed Proc 1984; 43: 134-9.
73. Safanova I, Reichert U, Shroot B, Ailhaud G, Grimaldi P. Fatty acids and retinoids act synergistically on adipose cell differentiation. Biochem Biophys Res Commun 1994; 204: 498-504.
74. Chawla A, Lazar MA. Peroxisome proliferator and retinoid signaling pathways co-regulate preadipocyte phenotype and survival. Proc Natl Acad Sci USA 1994; 91: 1786-90.
75. Mayo Smith W, Hayes C, Biller B, Klibanski A, Rosenthal H, Rosenthal D. Body fat distribution measured with CT: correlations in healthy subjects, patients with anorexia nervosa, and patients with Cushing syndrome. Radiology 1989; 170: 515-18.
76. Marin P, Darin N, Amemiya T, Andersson B, Jern S, Bjorntorp P. Cortisol secretion in relation to body fat distribution in obese premenopausal women. Metabolism 1992; 41: 882-6.
77. Rebuffe-Scrive M, Walsh UA, McEwan B, Rodin J. Effect of chronic stress and exogenous glucocorticoids on regional fat distribution and metabolism. Physiol Behav 1992; 52: 583-90.
78. Pasquali R, Cantobelli S, Casimirri F, et al. The hypothalamic-pituitary-adrenal axis in obese women with different patterns of body fat distribution. J Clin Endocrinol Metab 1993; 77: 341-6.
79. Ottosson M, Vikman-Adolfsson K, Enerbäck S, Olivecrona G, Björntorp P. The effects of cortisol on the regulation of lipoprotein lipase activity in human adipose tissue. J Clin Endocrinol Metab 1994; 79: 820-5.
80. Rizza RA, Mandarine LJ, Gerich JE. Cortisol-induced insulin resistance in man: impaired suppression of glucose production and stimulation of glucose utilization due to a postreceptor defect of insulin action. J Clin Endocrinol Metab 1982; 54: 131-8.
81. Hajduch E, Hainault I, Meunier C, et al. Regulation of glucose transporters in cultured rat adipocytes: synergistic effect of insulin and dexamethasone on GLUT4 gene expression through promoter activation. Endocrinology (Baltimore) 1995; 136: 4782-9.
82. DeVos P, Saladin R, Auwerx J, Staels B. Induction of ob gene expression by corticosteroids is accompanied by body weight loss and reduced food intake. J Biol Chem 1995; 270: 15958-61.
83. Abrahamsen N, Nishimura E. Regulation of glucagon and glucagon-like peptide-1 receptor messenger ribonucleic acid expression in cultured rat pancreatic islets by glucose, cyclic adenosine 3′,5′-monophosphate, and glucocorticoids. Endocrinology (Baltimore) 1995; 136: 1572-8.
84. Hotamisligil GS, Spiegelman BM. Tumor necrosis factor alpha: a key component of the obesity-diabetes link. Diabetes 1994; 43: 1271-8.
85. Hotamisligil GS, Arner P, Caro JF, Atkinson RL, Spiegelman BM. Increased adipose tissue expression of tumor necrosis factor-α in human obesity and insulin resistance. J Clin Invest 1995; 95: 2409-15.
86. Dandona P, Weinstock R, Love J, Thusu K, Aljada A, Wadden T. Elevated tumor necrosis factor a in sera of obese patients: fall with weight loss. Diabetes 1996; 45 (Suppl.) 173A.
87. Hotamisligil GS, Budavari A, Murray D, Spiegelman B. Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes. Central role of tumor necrosis factor alpha. J Clin Invest 1994; 94: 1543-9.
88. Hotamisligil GS, Peraldi P, Budavari A, Ellis R, White MF, Spiegelman BM. IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-α-and obesity-induced insulin resistance. Science (Washington DC) 1996; 271: 665-B.
89. Hauner H, Petruschke T, Russ M, Röhrig K, Eckel J. Effects of tumour necrosis factor alpha (TNFα) on glucose transport and lipid metabolism of newly-differentiated human fat cells in culture. Diabetologia 1995; 38: 764-71.
90. Szalkowski D, White-Carrington S, Berger J, Zhang B. Antidiabetic thiazolidinediones block the inhibitory effect of tumor necrosis factor-α on differentiation, insulin-stimulated glucose uptake, and gene expression in 3T3-L1 cells. Endocrinology (Baltimore) 1995; 136: 1474-81.
91. Stephens TW, Basinski M, Bristow PK, et al. The role of neuropeptide Y in the antiobesity action of the obese gene product. Nature (London) 1995; 377: 530-2.
92. Funahashi T, Shimomura I, Hiraoka H, et al. Enhanced expression of rat obese (ob) gene in adipose tissues of ventromedial hypothalamus (VMH)-lesioned rats. Biochem Biophys Res Commun 1995; 211: 469-75.
93. Maffei M, Fei H, Lee G-H, et al. Increased expression in adipocytes of ob RNA in mice with lesions of the hypothalamus and with mutations at the db locus. Proc Natl Acad Sci USA 1995; 92: 6957-60.
94. Tartaglia LA, Dembski M, Weng X, et al. Identification and expression cloning of a leptin receptor, OB-R. Cell 1995; 83: 1263-71.
95. Chua SCJ, Chung WK, Wu-Peng XS, et al. Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor. Science (Washington DC) 1996; 271: 994-6.
96. Orskov C. Glucagon-like peptide-1, a new hormone of the entero-insular axis. Diabetologia 1992; 35: 701-11.
97. Gutniak M, Orskov C, Hoist JJ, Ahrén B, Efendic S. Antidiabetic effect of glucagon-like peptide-1 (7-36)amide in normal subjects and patients with diabetes mellitus. N Engl J Med 1992; 326: 1316-22.
98. Spedding M, Ouvry C, Millan M, Duhault J, Dacquet C. Neural control of dieting. Nature (London) 1996; 380: 488.
99. Tecott LH, Sun LM, Akana SF, et al. Eating disorder and epilepsy in mice lacking 5-HT 2c serotonin receptors. Nature (London) 1995; 374: 542-6.
100. Rebuffe-Scrive M, Bronnegard M, Nillson A, Eldh J, Gustafsson J-A, Bjorntorp P. Steroid hormone receptors in human adipose tissue. J Clin Endocrinol Metab 1990; 71: 1215-19.
101. Montague CT, Prins JB, Sanders L, Digby JE, O'Rahilly S. Depot and sex specific differences in human leptin mRNA expression: implications for the control of regional fat distribution. Diabetes (In press).