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Volumn , Issue 4, 1998, Pages 77-94

Importance of TNF-α and leptin in obesity and insulin resistance: A hypothesis on the impact of physical exercise

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE TRANSPORTER; INSULIN; LEPTIN; LIPOPROTEIN LIPASE; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROTEIN TYROSINE KINASE; TUMOR NECROSIS FACTOR ALPHA;

EID: 0031862996     PISSN: 10775552     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (88)

References (114)
  • 1
    • 0030975615 scopus 로고    scopus 로고
    • Production of plasminogen activator inhibitor 1 by human adipose tissue: Possible link between visceral fat accumulation and vascular disease
    • Alessi, M.C., Peiretti, P. Morange, M. Henry, G. Nalbone, and I. Juhan-Vague. Production of plasminogen activator inhibitor 1 by human adipose tissue: Possible link between visceral fat accumulation and vascular disease. Diabetes 46:860-867, 1997.
    • (1997) Diabetes , vol.46 , pp. 860-867
    • Alessi, M.C.1    Peiretti2    Morange, P.3    Henry, M.4    Nalbone, G.5    Juhan-Vague, I.6
  • 3
    • 0029894219 scopus 로고    scopus 로고
    • Tumor necrosis factor: Function, release and clearance
    • Bemelmans, M.H., J. van Tits, and W.A. Buurman. Tumor necrosis factor: Function, release and clearance [Review]. Crit. Rev. Immunol. 16:1-11, 1996.
    • (1996) Crit. Rev. Immunol. , vol.16 , pp. 1-11
    • Bemelmans, M.H.1    Van Tits, J.2    Buurman, W.A.3
  • 4
    • 0030049616 scopus 로고    scopus 로고
    • Spontaneously low LDL cholesterol and relation to exercise-induced stress
    • Berg, A., Halle, M.W. Baumstark, J. Keul, and H. Northoff. Spontaneously low LDL cholesterol and relation to exercise-induced stress. Lancet 347:405, 1996.
    • (1996) Lancet , vol.347 , pp. 405
    • Berg, A.1    Halle2    Baumstark, M.W.3    Keul, J.4    Northoff, H.5
  • 5
    • 0024405827 scopus 로고
    • The biology of cachectin/TNF - A primary mediator of the host response
    • Beutler, B., and A. Cerami. The biology of cachectin/TNF - A primary mediator of the host response [Review]. Ann. Rev. Immunol. 7:625-655, 1989.
    • (1989) Ann. Rev. Immunol. , vol.7 , pp. 625-655
    • Beutler, B.1    Cerami, A.2
  • 7
    • 0022367616 scopus 로고
    • Regional patterns of fat distribution
    • Björntorp, P. Regional patterns of fat distribution. Ann. Intern. Med. 103:994-995, 1985.
    • (1985) Ann. Intern. Med. , vol.103 , pp. 994-995
    • Björntorp, P.1
  • 8
    • 0031014830 scopus 로고    scopus 로고
    • Role of fatty acids in the pathogenesis of insulin resistance and NIDDM
    • Boden, G. Role of fatty acids in the pathogenesis of insulin resistance and NIDDM [Review]. Diabetes 46:3-10, 1997.
    • (1997) Diabetes , vol.46 , pp. 3-10
    • Boden, G.1
  • 9
    • 0029844267 scopus 로고    scopus 로고
    • Effect of fasting on serum leptin in normal human subjects
    • Boden, G., Chen, M. Mozzoli, and I. Ryan. Effect of fasting on serum leptin in normal human subjects. J. Clin. Endocrinol. Metab. 81:3419-3423, 1996.
    • (1996) J. Clin. Endocrinol. Metab. , vol.81 , pp. 3419-3423
    • Boden, G.1    Chen2    Mozzoli, M.3    Ryan, I.4
  • 10
    • 0027395358 scopus 로고
    • The relation between insulin sensitivity and the fatty-acid composition of skeletal-muscle phospholipids
    • Borkman, M., H. Storlien, D.A. Pan, A.B. Jenkins, D.J. Chisholm, and L.V. Campbell. The relation between insulin sensitivity and the fatty-acid composition of skeletal-muscle phospholipids. N. Engl. J. Med. 328:238-244, 1993.
    • (1993) N. Engl. J. Med. , vol.328 , pp. 238-244
    • Borkman, M.1    Storlien, H.2    Pan, D.A.3    Jenkins, A.B.4    Chisholm, D.J.5    Campbell, L.V.6
  • 11
    • 0030928160 scopus 로고    scopus 로고
    • Genetics of human obesity: Recent results from linkage studies
    • Bouchard, C. Genetics of human obesity: Recent results from linkage studies. [Review]. J. Nutr. 127:1887S-1890S, 1997.
    • (1997) J. Nutr. , vol.127
    • Bouchard, C.1
  • 12
    • 0029048408 scopus 로고
    • Recombinant mouse OB protein: Evidence for a peripheral signal linking adiposity and central neural networks
    • Campfield, L.A., J. Smith, Y. Guisez, R. Devos, and P. Burn. Recombinant mouse OB protein: Evidence for a peripheral signal linking adiposity and central neural networks. Science 269:546-549, 1995.
    • (1995) Science , vol.269 , pp. 546-549
    • Campfield, L.A.1    Smith, J.2    Guisez, Y.3    Devos, R.4    Burn, P.5
  • 14
    • 0030038986 scopus 로고    scopus 로고
    • The effect on human tumor necrosis factor-alpha and interleukin 1-beta production of diets enriched in n-3 fatty acids from vegetable oil or fish oil
    • Caughey, G.E., Mantzioris, R.A. Gibson, L.G. Cleland, and M.J. James. The effect on human tumor necrosis factor-alpha and interleukin 1-beta production of diets enriched in n-3 fatty acids from vegetable oil or fish oil. Am. J. Clin. Nutr. 63:116-122, 1996.
    • (1996) Am. J. Clin. Nutr. , vol.63 , pp. 116-122
    • Caughey, G.E.1    Mantzioris2    Gibson, R.A.3    Cleland, L.G.4    James, M.J.5
  • 15
    • 0030865242 scopus 로고    scopus 로고
    • The reproductive side of leptin
    • Chehab, F.F. The reproductive side of leptin. Nature Med. 3:952-953, 1997.
    • (1997) Nature Med. , vol.3 , pp. 952-953
    • Chehab, F.F.1
  • 16
    • 0030010388 scopus 로고    scopus 로고
    • Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin
    • Chehab, F.F., E. Lim, and R. Lu. Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin. Nat. Genet. 12:318-320, 1996.
    • (1996) Nat. Genet. , vol.12 , pp. 318-320
    • Chehab, F.F.1    Lim, E.2    Lu, R.3
  • 19
    • 0030012248 scopus 로고    scopus 로고
    • Plasma leptin and insulin relationships in obese and nonobese humans
    • Dagogo-Jack, S., Fanelli, D. Paramore, J. Brothers, and M. Landt. Plasma leptin and insulin relationships in obese and nonobese humans. Diabetes 45:695-698, 1996.
    • (1996) Diabetes , vol.45 , pp. 695-698
    • Dagogo-Jack, S.1    Fanelli2    Paramore, D.3    Brothers, J.4    Landt, M.5
  • 21
    • 0023683874 scopus 로고    scopus 로고
    • An in vitro human muscle preparation suitable for metabolic studies. Decreased insulin stimulation of glucose transport in muscle from morbidly obese and diabetic subjects
    • Dohm, G.L., B. Tapscott, W.J. Pories, D.J. Dabbs, E.G. Flickinger, D. Meelheim, T. Fushiki, S.M. Atkinson, C.W. Elton, and J.F. Caro. An in vitro human muscle preparation suitable for metabolic studies. Decreased insulin stimulation of glucose transport in muscle from morbidly obese and diabetic subjects. J. Clin. Invest. 82:486-494. 1998.
    • (1998) J. Clin. Invest. , vol.82 , pp. 486-494
    • Dohm, G.L.1    Tapscott, B.2    Pories, W.J.3    Dabbs, D.J.4    Flickinger, E.G.5    Meelheim, D.6    Fushiki, T.7    Atkinson, S.M.8    Elton, C.W.9    Caro, J.F.10
  • 23
    • 0026660277 scopus 로고
    • Role of cytokines in inducing hyperlipidemia
    • Feingold, K.R., and C. Grunfeld. Role of cytokines in inducing hyperlipidemia [Review]. Diabetes 41(Suppl 2): 97-101, 1992.
    • (1992) Diabetes , vol.41 , Issue.2 SUPPL. , pp. 97-101
    • Feingold, K.R.1    Grunfeld, C.2
  • 24
    • 0027332738 scopus 로고
    • Tumor necrosis factor-alpha suppresses insulin-induced tyrosine phosphorylation of insulin receptor and its substrates
    • Feinstein, R., Kanety, M.Z. Papa, B. Lunenfeld, and A. Karasik. Tumor necrosis factor-alpha suppresses insulin-induced tyrosine phosphorylation of insulin receptor and its substrates. J. Biol. Chem. 268:26055-26058, 1993.
    • (1993) J. Biol. Chem. , vol.268 , pp. 26055-26058
    • Feinstein, R.1    Kanety2    Papa, M.Z.3    Lunenfeld, B.4    Karasik, A.5
  • 25
    • 0030863239 scopus 로고    scopus 로고
    • The TNF-alpha gene Nco I polymorphism influences the relationship among insulin resistance, percent body fat, and increased serum leptin levels
    • Fernandez-Real, J.M., Gutierrez, W. Ricart, R. Casamitjana, M. Fernandez-Castaner, J. Vendrell, C. Richart, and J. Soler. The TNF-alpha gene Nco I polymorphism influences the relationship among insulin resistance, percent body fat, and increased serum leptin levels. Diabetes 46:1468-1472, 1997.
    • (1997) Diabetes , vol.46 , pp. 1468-1472
    • Fernandez-Real, J.M.1    Gutierrez2    Ricart, W.3    Casamitjana, R.4    Fernandez-Castaner, M.5    Vendrell, J.6    Richart, C.7    Soler, J.8
  • 26
    • 0028793697 scopus 로고
    • Leptin levels reflect body lipid content in mice: Evidence for diet-induced resistance to leptin action
    • Frederich, R.C., Hamann, S. Anderson, B. Lollmann, B.B. Lowell, and J.S. Flier. Leptin levels reflect body lipid content in mice: Evidence for diet-induced resistance to leptin action. Nature Med. 1:1311-1314, 1995,
    • (1995) Nature Med. , vol.1 , pp. 1311-1314
    • Frederich, R.C.1    Hamann2    Anderson, S.3    Lollmann, B.4    Lowell, B.B.5    Flier, J.S.6
  • 27
    • 0023893104 scopus 로고
    • Role of glucose transporters in the cellular insulin resistance of type II non-insulin-dependent diabetes mellitus
    • Garvey, W.T., P, Huecksteadt, S. Matthaei, and J.M. Olefsky. Role of glucose transporters in the cellular insulin resistance of type II non-insulin-dependent diabetes mellitus. J. Clin. Invest. 81:1528-1536, 1988.
    • (1988) J. Clin. Invest. , vol.81 , pp. 1528-1536
    • Garvey, W.T.1    Huecksteadt, P.2    Matthaei, S.3    Olefsky, J.M.4
  • 28
    • 0026032419 scopus 로고
    • The metabolic effects of tumor necrosis factor and other cytokines
    • Grunfeld, C., and K.R. Feingold. The metabolic effects of tumor necrosis factor and other cytokines [Review]. Biotherapy 3:143-158, 1991,
    • (1991) Biotherapy , vol.3 , pp. 143-158
    • Grunfeld, C.1    Feingold, K.R.2
  • 31
    • 0029083859 scopus 로고
    • Increased obese mRNA expression in omental fat cells from massively obese humans
    • Hamilton, B.S., Paglia, A.Y. Kwan, and M. Deitel. Increased obese mRNA expression in omental fat cells from massively obese humans. Nature Med. 1:953-956, 1995.
    • (1995) Nature Med. , vol.1 , pp. 953-956
    • Hamilton, B.S.1    Kwan, P.A.Y.2    Deitel, M.3
  • 33
    • 0022354051 scopus 로고
    • Increased plasma levels of a rapid inhibitor of tissue plasminogen activator in young survivors of myocardial infarction
    • Hamsten, A., Wiman, U. De Faire, and M. Blombäck. Increased plasma levels of a rapid inhibitor of tissue plasminogen activator in young survivors of myocardial infarction. N. Engl. J. Med. 313:1557-1563, 1985.
    • (1985) N. Engl. J. Med. , vol.313 , pp. 1557-1563
    • Hamsten, A.1    De Faire, W.U.2    Blombäck, M.3
  • 34
    • 0024347501 scopus 로고
    • Insulin receptor kinase defects in insulin-resistant tissues and their role in the pathogenesis of NIDDM
    • Haring, H., and B. Obermaier-Kusser. Insulin receptor kinase defects in insulin-resistant tissues and their role in the pathogenesis of NIDDM [Review]. Diabetes Metab. Rev. 5:431-441, 1989,
    • (1989) Diabetes Metab. Rev. , vol.5 , pp. 431-441
    • Haring, H.1    Obermaier-Kusser, B.2
  • 35
    • 0028127942 scopus 로고
    • Fibrinogen and factor VII in the prediction of coronary risk. Results from the PROCAM study in healthy men
    • Heinrich, J., Balleisen, H. Schulte, G. Assmann, and J. van de Loo. Fibrinogen and factor VII in the prediction of coronary risk. Results from the PROCAM study in healthy men. Arterioscler. Thromb. 14:54-59, 1994.
    • (1994) Arterioscler. Thromb. , vol.14 , pp. 54-59
    • Heinrich, J.1    Balleisen2    Schulte, H.3    Assmann, G.4    Van De Loo, J.5
  • 36
    • 0025820742 scopus 로고
    • Physical activity and reduced occurrence of non-insulin-dependent diabetes mellitus
    • Helmrich, S.P., R. Ragland, R.W. Leung, and R.S. Paffenbarger, Jr. Physical activity and reduced occurrence of non-insulin-dependent diabetes mellitus. N. Engl. J. Med. 325:147-152, 1991.
    • (1991) N. Engl. J. Med. , vol.325 , pp. 147-152
    • Helmrich, S.P.1    Ragland, R.2    Leung, R.W.3    Paffenbarger Jr., R.S.4
  • 38
    • 0026604774 scopus 로고
    • A clinical perspective on peptides and food intake
    • Hirsch, J., L. Leibel, and S.C. Chua. A clinical perspective on peptides and food intake [Review]. Am. J. Clin. Nutr. 55:296S-298S, 1992.
    • (1992) Am. J. Clin. Nutr. , vol.55
    • Hirsch, J.1    Leibel, L.2    Chua, S.C.3
  • 39
    • 0027972524 scopus 로고
    • Altered gene expression for tumor necrosis factor-alpha and its receptors during drug and dietary modulation of insulin resistance
    • Hofmann, C., Lorenz, S.S. Braithwaite, J.R. Colea, B.J. Palazuk, G.S. Hotamisligil, and B.M. Spiegelman. Altered gene expression for tumor necrosis factor-alpha and its receptors during drug and dietary modulation of insulin resistance. Endocrinol. 134:264-270, 1994.
    • (1994) Endocrinol. , vol.134 , pp. 264-270
    • Hofmann, C.1    Lorenz2    Braithwaite, S.S.3    Colea, J.R.4    Palazuk, B.J.5    Hotamisligil, G.S.6    Spiegelman, B.M.7
  • 40
    • 0031053823 scopus 로고    scopus 로고
    • Differential regulation of the p80 tumor necrosis factor receptor in human obesity and insulin resistance
    • Hotamisligil, G.S., Arner, R.L. Atkinson, and B.M. Spiegelman. Differential regulation of the p80 tumor necrosis factor receptor in human obesity and insulin resistance. Diabetes 46:451-455, 1997.
    • (1997) Diabetes , vol.46 , pp. 451-455
    • Hotamisligil, G.S.1    Atkinson, A.R.L.2    Spiegelman, B.M.3
  • 41
    • 0028931724 scopus 로고
    • Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance
    • Hotamisligil, G.S., Amer, J.F. Caro, R.L. Atkinson, and B.M. Spiegelman. Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance. J. Clin. Invest. 95:2409-2415, 1995.
    • (1995) J. Clin. Invest. , vol.95 , pp. 2409-2415
    • Hotamisligil, G.S.1    Amer2    Caro, J.F.3    Atkinson, R.L.4    Spiegelman, B.M.5
  • 42
    • 0028031569 scopus 로고
    • Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes. Central role of tumor necrosis factor-alpha
    • Hotamisligil, G.S., Budavari, D. Murray, and B.M. Spiegelman. Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes. Central role of tumor necrosis factor-alpha. J. Clin. Invest. 94:1543-1549, 1994.
    • (1994) J. Clin. Invest. , vol.94 , pp. 1543-1549
    • Hotamisligil, G.S.1    Murray, B.D.2    Spiegelman, B.M.3
  • 43
    • 0029847504 scopus 로고    scopus 로고
    • Uncoupling of obesity from insulin resistance through a targeted mutation in aP2, the adipocyte fatty acid binding protein
    • Hotamisligil, G.S., S. Johnson, R.J. Distel, R. Ellis, V.E. Papaioannou, and B.M. Spiegelman. Uncoupling of obesity from insulin resistance through a targeted mutation in aP2, the adipocyte fatty acid binding protein. Science 274:1377-1379, 1996.
    • (1996) Science , vol.274 , pp. 1377-1379
    • Hotamisligil, G.S.1    Johnson, S.2    Distel, R.J.3    Ellis, R.4    Papaioannou, V.E.5    Spiegelman, B.M.6
  • 45
    • 0030061922 scopus 로고    scopus 로고
    • IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha-and obesity-induced insulin resistance
    • Hotamisligil, G.S., Peraldi, A. Budavari, R. Ellis, M.F. White, and B.M. Spiegelman. IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha-and obesity-induced insulin resistance. Science 271:665-668, 1996.
    • (1996) Science , vol.271 , pp. 665-668
    • Hotamisligil, G.S.1    Peraldi2    Budavari, A.3    Ellis, R.4    White, M.F.5    Spiegelman, B.M.6
  • 46
    • 0027459878 scopus 로고
    • Adipose expression of tumor necrosis factor-alpha: Direct role in obesity-linked insulin resistance
    • Hotamisligil, G.S., S. Shargill, and B.M. Spiegelman. Adipose expression of tumor necrosis factor-alpha: Direct role in obesity-linked insulin resistance. Science 259:87-91, 1993.
    • (1993) Science , vol.259 , pp. 87-91
    • Hotamisligil, G.S.1    Shargill, S.2    Spiegelman, B.M.3
  • 47
    • 0028587742 scopus 로고
    • Tumor necrosis factor alpha: A key component of the obesity-diabetes link
    • Hotamisligil, G.S., and B.M. Spiegelman. Tumor necrosis factor alpha: A key component of the obesity-diabetes link [Review]. Diabetes 43:1271-1278, 1994.
    • (1994) Diabetes , vol.43 , pp. 1271-1278
    • Hotamisligil, G.S.1    Spiegelman, B.M.2
  • 48
    • 0028073850 scopus 로고
    • Regulatory elements and transcription factors controlling basal and cytokine-induced expression of the gene encoding intercellular adhesion molecule 1
    • Hou, J., Baichwal, and Z. Cao. Regulatory elements and transcription factors controlling basal and cytokine-induced expression of the gene encoding intercellular adhesion molecule 1. Proc. Natl. Acad. Sci. USA 91:11641-11645, 1994.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 11641-11645
    • Hou, J.1    Baichwal2    Cao, Z.3
  • 49
    • 0030764551 scopus 로고    scopus 로고
    • PAI-1, obesity, insulin resistance and risk of cardiovascular events
    • Juhan-Vague, I., and M.C. Alessi. PAI-1, obesity, insulin resistance and risk of cardiovascular events [Review]. Thromb. Haemost. 78:656-660, 1997.
    • (1997) Thromb. Haemost. , vol.78 , pp. 656-660
    • Juhan-Vague, I.1    Alessi, M.C.2
  • 50
    • 0000072070 scopus 로고
    • Lipoprotein lipase suppression in 3T3-L1 cells by an endotoxin-induced mediator from exudate cells
    • Kawakmi, M., H. Pekala, M.D. Lane, and A. Cerami. Lipoprotein lipase suppression in 3T3-L1 cells by an endotoxin-induced mediator from exudate cells. Proc. Natl. Acad. Sci. USA 79:912-916, 1982.
    • (1982) Proc. Natl. Acad. Sci. USA , vol.79 , pp. 912-916
    • Kawakmi, M.1    Pekala, H.2    Lane, M.D.3    Cerami, A.4
  • 51
    • 0028968879 scopus 로고
    • The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase
    • Kern, P.A., Saghizadeh, J.M. Ong, R.J. Bosch, R. Deem, and R.B. Simsolo. The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase. J. Clin. Invest. 95:2111-2119, 1995.
    • (1995) J. Clin. Invest. , vol.95 , pp. 2111-2119
    • Kern, P.A.1    Saghizadeh2    Ong, J.M.3    Bosch, R.J.4    Deem, R.5    Simsolo, R.B.6
  • 52
    • 0028117163 scopus 로고
    • Cytokine signal transduction
    • Kishimoto, T., Taga, and S. Akira. Cytokine signal transduction [Review]. Cell 76:253-262, 1994.
    • (1994) Cell , vol.76 , pp. 253-262
    • Kishimoto, T.1    Taga2    Akira, S.3
  • 53
    • 0029795319 scopus 로고    scopus 로고
    • Serum leptin levels are reduced in response to exercise training, but not hormone replacement therapy, in older women
    • Kohrt, W.M., Landt, and S.J. Birge. Serum leptin levels are reduced in response to exercise training, but not hormone replacement therapy, in older women. J. Clin. Endocrinol. 81:3980-3985, 1996.
    • (1996) J. Clin. Endocrinol. , vol.81 , pp. 3980-3985
    • Kohrt, W.M.1    Landt2    Birge, S.J.3
  • 54
    • 0029964871 scopus 로고    scopus 로고
    • Responses of leptin to short-term fasting and refeeding in humans: A link with ketogenesis but not ketones themselves
    • Kolaczynski, J.W., V. Considine, J. Ohannesian, C. Marco, I. Opentanova, M.R. Nyce, M. Myint, and J.F. Caro. Responses of leptin to short-term fasting and refeeding in humans: A link with ketogenesis but not ketones themselves. Diabetes 45:1511-1515, 1996.
    • (1996) Diabetes , vol.45 , pp. 1511-1515
    • Kolaczynski, J.W.1    Considine, V.2    Ohannesian, J.3    Marco, C.4    Opentanova, I.5    Nyce, M.R.6    Myint, M.7    Caro, J.F.8
  • 60
    • 0029050937 scopus 로고
    • Overexpression of the obese (ob) gene in adipose tissue of human obese subjects
    • Lonnqvist, F., Arner, L. Nordfors, and M. Schalling. Overexpression of the obese (ob) gene in adipose tissue of human obese subjects. Nature Med. 1:950-953, 1995.
    • (1995) Nature Med. , vol.1 , pp. 950-953
    • Lonnqvist, F.1    Nordfors, A.L.2    Schalling, M.3
  • 61
    • 0031963703 scopus 로고    scopus 로고
    • The adipocyte and hemostatic balance in obesity: Studies of PAI-1. Arterioscler
    • Loskutoff, D.J., and F. Samad. The adipocyte and hemostatic balance in obesity: Studies of PAI-1. Arterioscler. Thromb. Vasc. Biol. 18:1-6, 1998,
    • (1998) Thromb. Vasc. Biol. , vol.18 , Issue.1-6
    • Loskutoff, D.J.1    Samad, F.2
  • 62
    • 0029922704 scopus 로고    scopus 로고
    • Moderately intense physical activities and high levels of cardiorespiratory fitness reduce the risk of non-insulin-dependent diabetes mellitus in middle-aged men
    • Lynch, J., P. Helmrich, T.A. Lakka, G.A. Kaplan, R.D. Cohen, R. Salonen, and J.T. Salonen. Moderately intense physical activities and high levels of cardiorespiratory fitness reduce the risk of non-insulin-dependent diabetes mellitus in middle-aged men. Arch. Intern. Med. 156:1307-1314, 1996.
    • (1996) Arch. Intern. Med. , vol.156 , pp. 1307-1314
    • Lynch, J.1    Helmrich, P.2    Lakka, T.A.3    Kaplan, G.A.4    Cohen, R.D.5    Salonen, R.6    Salonen, J.T.7
  • 64
    • 0031036351 scopus 로고    scopus 로고
    • A protein-counting mechanism for telomere length regulation in yeast
    • Marcand, S., Gilson, and D. Shore. A protein-counting mechanism for telomere length regulation in yeast. Science 275:986-990, 1997.
    • (1997) Science , vol.275 , pp. 986-990
    • Marcand, S.1    Gilson2    Shore, D.3
  • 65
    • 0030984583 scopus 로고    scopus 로고
    • Inflammation, atherosclerosis, and ischemic events-Exploring the hidden side of the moon
    • Maseri, A. Inflammation, atherosclerosis, and ischemic events-Exploring the hidden side of the moon [Editorial; comment]. N. Engl. J. Med. 336:1014-1016, 1997.
    • (1997) N. Engl. J. Med. , vol.336 , pp. 1014-1016
    • Maseri, A.1
  • 66
    • 0027978071 scopus 로고
    • Coagulation/fibrinolysis balance in septic shock related to cytokines and clinical state
    • Massignon, D., Lepape, J. Bienvenu, Y. Barbier, C. Boileau, and P. Coeur. Coagulation/fibrinolysis balance in septic shock related to cytokines and clinical state Haemostasis 24:36-48, 1994.
    • (1994) Haemostasis , vol.24 , pp. 36-48
    • Massignon, D.1    Lepape2    Bienvenu, J.3    Barbier, Y.4    Boileau, C.5    Coeur, P.6
  • 67
    • 0028008336 scopus 로고
    • Factors responsible for impaired fibrinolysis in obese subjects and NIDDM patients
    • McGill, J.B., J. Schneider, C.L. Arfken, C.L. Lucore, and B.E. Sobel. Factors responsible for impaired fibrinolysis in obese subjects and NIDDM patients. Diabetes 43:104-109, 1994.
    • (1994) Diabetes , vol.43 , pp. 104-109
    • McGill, J.B.1    Schneider, J.2    Arfken, C.L.3    Lucore, C.L.4    Sobel, B.E.5
  • 68
    • 0025945012 scopus 로고
    • Insulin resistance - Mechanisms, syndromes, and implications
    • Moller, D.E., and J.S. Flier. Insulin resistance - Mechanisms, syndromes, and implications [Review]. N. Engl. J. Med. 325:938-948, 1991.
    • (1991) N. Engl. J. Med. , vol.325 , pp. 938-948
    • Moller, D.E.1    Flier, J.S.2
  • 69
    • 0030862338 scopus 로고    scopus 로고
    • High fat diets elevate adipose tissue-derived tumor necrosis factor-alpha activity
    • Morin, C.L., H. Eckel, T. Marcel, and M.J. Pagliassotti. High fat diets elevate adipose tissue-derived tumor necrosis factor-alpha activity. Endocrinol. 138:4665-4671, 1997.
    • (1997) Endocrinol. , vol.138 , pp. 4665-4671
    • Morin, C.L.1    Eckel, H.2    Marcel, T.3    Pagliassotti, M.J.4
  • 70
    • 0030912144 scopus 로고    scopus 로고
    • Immune response to heavy exertion
    • Nieman, D.C. Immune response to heavy exertion [Review]. J. Appl. Physiol. 82:1385-1394, 1997.
    • (1997) J. Appl. Physiol. , vol.82 , pp. 1385-1394
    • Nieman, D.C.1
  • 71
    • 0029795431 scopus 로고    scopus 로고
    • Effect of troglitazone on leptin production. Studies in vitro and in human subjects
    • Nolan, J.J., M. Olefsky, M.R. Nyce, R.V, Considine, and J.F. Caro. Effect of troglitazone on leptin production. Studies in vitro and in human subjects. Diabetes 45:1276-1278, 1996.
    • (1996) Diabetes , vol.45 , pp. 1276-1278
    • Nolan, J.J.1    Olefsky, M.2    Nyce, M.R.3    Considine, R.V.4    Caro, J.F.5
  • 73
    • 0028073768 scopus 로고
    • The cytokine response to strenuous exercise
    • Northoff, H., Weinstock, and A. Berg. The cytokine response to strenuous exercise [Review]. Int. J. Sports Med. 15(Suppl 3): 167-171, 1994.
    • (1994) Int. J. Sports Med. , vol.15 , Issue.3 SUPPL. , pp. 167-171
    • Northoff, H.1    Weinstock2    Berg, A.3
  • 74
    • 0022369998 scopus 로고
    • Tumor necrosis factor (TNF)
    • Old, L.J. Tumor necrosis factor (TNF). Science 230:630-632, 1985.
    • (1985) Science , vol.230 , pp. 630-632
    • Old, L.J.1
  • 75
    • 0019829781 scopus 로고
    • Lilly lecture 1980. Insulin resistance and insulin action. An in vitro and in vivo perspective
    • Olefsky, J.M. Lilly lecture 1980. Insulin resistance and insulin action. An in vitro and in vivo perspective [Review]. Diabetes 30:148-162, 1981.
    • (1981) Diabetes , vol.30 , pp. 148-162
    • Olefsky, J.M.1
  • 76
    • 0030299975 scopus 로고    scopus 로고
    • Acetylsalicylic acid and sodium salicylate inhibit LPS-induced NF-kappa B/c-Rel nuclear translocation, and synthesis of tissue factor (TF) and tumor necrosis factor alpha (TNF-alpha) in human monocytes
    • Osnes, L.T., B. Foss, G.B. Joo, C. Okkenhaug, A.B. Westvik, R. Ovstebo, and P. Kierulf. Acetylsalicylic acid and sodium salicylate inhibit LPS-induced NF-kappa B/c-Rel nuclear translocation, and synthesis of tissue factor (TF) and tumor necrosis factor alpha (TNF-alpha) in human monocytes. Thromb. Haemost. 76:970-976, 1996.
    • (1996) Thromb. Haemost. , vol.76 , pp. 970-976
    • Osnes, L.T.1    Foss, B.2    Joo, G.B.3    Okkenhaug, C.4    Westvik, A.B.5    Ovstebo, R.6    Kierulf, P.7
  • 77
    • 1842360052 scopus 로고
    • Selective inhibition of synthesis of enzymes for de novo fatty acid biosynthesis by an endotoxin-induced mediator from exudate cells
    • Pekala, P.H., Kawakami, C.W. Angus, M.D. Lane, and A. Cerami. Selective inhibition of synthesis of enzymes for de novo fatty acid biosynthesis by an endotoxin-induced mediator from exudate cells. Proc. Natl. Acad. Sci. USA 80:2743-2747, 1983.
    • (1983) Proc. Natl. Acad. Sci. USA , vol.80 , pp. 2743-2747
    • Pekala, P.H.1    Kawakami2    Angus, C.W.3    Lane, M.D.4    Cerami, A.5
  • 80
    • 0029933665 scopus 로고    scopus 로고
    • Tumor necrosis factor (TNF)-alpha inhibits insulin signaling through stimulation of the p55 TNF receptor and activation of sphingomyelinase
    • Peraldi, P., S. Hotamisligil, W.A. Buurman, M.F. White, and B.M. Spiegeman. Tumor necrosis factor (TNF)-alpha inhibits insulin signaling through stimulation of the p55 TNF receptor and activation of sphingomyelinase. J. Biol. Chem. 271:13018-13022, 1996.
    • (1996) J. Biol. Chem. , vol.271 , pp. 13018-13022
    • Peraldi, P.1    Hotamisligil, S.2    Buurman, W.A.3    White, M.F.4    Spiegeman, B.M.5
  • 83
    • 0024160877 scopus 로고
    • Role of insulin resistance in human disease
    • Reaven, G.M. Role of insulin resistance in human disease. Diabetes 37:1595-1607, 1988.
    • (1988) Diabetes , vol.37 , pp. 1595-1607
    • Reaven, G.M.1
  • 84
    • 0030956673 scopus 로고    scopus 로고
    • Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men
    • Ridker, P.M., Cushman, M.J. Stampfer, R.P. Tracy, and C.H. Hennekens. Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men. N. Engl. J. Med. 336:973-979, 1997.
    • (1997) N. Engl. J. Med. , vol.336 , pp. 973-979
    • Ridker, P.M.1    Cushman2    Stampfer, M.J.3    Tracy, R.P.4    Hennekens, C.H.5
  • 85
    • 0027942465 scopus 로고
    • In search of a satiety factor
    • Rink, T.J. Genetics. In search of a satiety factor. Nature 372:406-407, 1994.
    • (1994) Nature , vol.372 , pp. 406-407
    • Genetics, R.T.J.1
  • 87
    • 0027241856 scopus 로고
    • The pathogenesis of atherosclerosis: A perspective for the 1990s
    • Ross, R. The pathogenesis of atherosclerosis: A perspective for the 1990s. Nature 362:801-809, 1993.
    • (1993) Nature , vol.362 , pp. 801-809
    • Ross, R.1
  • 88
    • 0029829386 scopus 로고    scopus 로고
    • The effects of acute hyperglycemia and hyperinsulimmia on plasma leptin levels - Its relationships with body fat, visceral adiposity, and age in women
    • Ryan, A.S., and D. Elahi. The effects of acute hyperglycemia and hyperinsulimmia on plasma leptin levels - Its relationships with body fat, visceral adiposity, and age in women. J. Clin. Endocrin. Metab. 81:4433-4438, 1996.
    • (1996) J. Clin. Endocrin. Metab. , vol.81 , pp. 4433-4438
    • Ryan, A.S.1    Elahi, D.2
  • 89
    • 0029827134 scopus 로고    scopus 로고
    • Tissue distribution and regulation of plasminogen activator inhibitor-1 in obese mice
    • Samad, F., and D.J. Loskutoff. Tissue distribution and regulation of plasminogen activator inhibitor-1 in obese mice. Mol. Med. 2:568-582, 1996.
    • (1996) Mol. Med. , vol.2 , pp. 568-582
    • Samad, F.1    Loskutoff, D.J.2
  • 90
    • 0030805628 scopus 로고    scopus 로고
    • The fat mouse: A powerful genetic model to study elevated plasminogen activator inhibitor-1 in obesity/NIDDM
    • Samad, P., and D.J. Loskutoff. The fat mouse: A powerful genetic model to study elevated plasminogen activator inhibitor-1 in obesity/NIDDM [Review]. Thromb. Haemost. 78:652-655, 1997.
    • (1997) Thromb. Haemost. , vol.78 , pp. 652-655
    • Samad, P.1    Loskutoff, D.J.2
  • 91
    • 0030050952 scopus 로고    scopus 로고
    • Distribution and regulation of plasminogen activator inhibitor-1 in murine adipose tissue in vivo. Induction by tumor necrosis factor-a and lipopolysaccharide
    • Samad, F., Yamamoto, and D.J. Loskutoff. Distribution and regulation of plasminogen activator inhibitor-1 in murine adipose tissue in vivo. Induction by tumor necrosis factor-a and lipopolysaccharide. J. Clin. Invest. 97:37-46, 1996,
    • (1996) J. Clin. Invest. , vol.97 , pp. 37-46
    • Samad, F.1    Yamamoto2    Loskutoff, D.J.3
  • 93
    • 0025949379 scopus 로고
    • Regulation of murine type 1 plasminogen activator inhibitor gene expression in vivo. Tissue specificity and induction by lipopolysaccharide, tumor necrosis factor-alpha, and transforming growth factor-beta
    • Sawdey, M.S., and D.J. Loskutoff. Regulation of murine type 1 plasminogen activator inhibitor gene expression in vivo. Tissue specificity and induction by lipopolysaccharide, tumor necrosis factor-alpha, and transforming growth factor-beta. J. Clin. Invest. 88:1346-1353, 1991.
    • (1991) J. Clin. Invest. , vol.88 , pp. 1346-1353
    • Sawdey, M.S.1    Loskutoff, D.J.2
  • 94
    • 0030851109 scopus 로고    scopus 로고
    • Aspirin inhibits tumor necrosis factor-alpha gene expression in murine tissue macrophages
    • Shackelford, R.E., B. Alford, Y. Xue, S.F. Thai, D.O. Adams, and S. Pizzo. Aspirin inhibits tumor necrosis factor-alpha gene expression in murine tissue macrophages. Mol. Pharmacol. 52:421-429, 1997.
    • (1997) Mol. Pharmacol. , vol.52 , pp. 421-429
    • Shackelford, R.E.1    Alford, B.2    Xue, Y.3    Thai, S.F.4    Adams, D.O.5    Pizzo, S.6
  • 95
    • 0029565264 scopus 로고
    • Heavy exercise, nutrition and immune function - Is there a connection?
    • Shephard, R.J., and P.N. Shek. Heavy exercise, nutrition and immune function - Is there a connection? [Review]. Int. J. Sports Med. 16:491-497, 1995.
    • (1995) Int. J. Sports Med. , vol.16 , pp. 491-497
    • Shephard, R.J.1    Shek, P.N.2
  • 96
    • 0030297919 scopus 로고    scopus 로고
    • Adipogenesis and obesity: Rounding out the big picture
    • Spiegelman, B.M., and J.S. Flier. Adipogenesis and obesity: Rounding out the big picture [Review]. Cell 87:377-389, 1996.
    • (1996) Cell , vol.87 , pp. 377-389
    • Spiegelman, B.M.1    Flier, J.S.2
  • 97
    • 0027324558 scopus 로고
    • Through thick and thin: Wasting, obesity, and TNF alpha
    • Spiegelman, B.M., and G.S. Hotamisligil. Through thick and thin: Wasting, obesity, and TNF alpha [Review]. Cell 73:625-627, 1993.
    • (1993) Cell , vol.73 , pp. 625-627
    • Spiegelman, B.M.1    Hotamisligil, G.S.2
  • 98
    • 0023130521 scopus 로고
    • Plasminogen activator inhibitors
    • Sprengers, E.D., and C. Kluft. Plasminogen activator inhibitors [Review]. Blood 69: 381-387, 1987.
    • (1987) Blood , vol.69 , pp. 381-387
    • Sprengers, E.D.1    Kluft, C.2
  • 99
    • 0031022434 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha-induced insulin resistance in 3T3-L1 adipocytes is accompanied by a loss of insulin receptor substrate-1 and GLUT4 expression without a loss of insulin receptor-mediated signal transduction
    • Stephens, J.M., Lee, and P.F. Pilch. Tumor necrosis factor-alpha-induced insulin resistance in 3T3-L1 adipocytes is accompanied by a loss of insulin receptor substrate-1 and GLUT4 expression without a loss of insulin receptor-mediated signal transduction. J. Biol. Chem. 272:971-976, 1997.
    • (1997) J. Biol. Chem. , vol.272 , pp. 971-976
    • Stephens, J.M.1    Lee2    Pilch, P.F.3
  • 100
    • 0025837140 scopus 로고
    • Transcriptional repression of the GLUT4 and C/EBP genes in 3T3-L1 adipocytes by tumor necrosis factor-alpha
    • Stephens, J.M., and P.H. Pekala. Transcriptional repression of the GLUT4 and C/EBP genes in 3T3-L1 adipocytes by tumor necrosis factor-alpha. J. Biol. Chem. 266:21839-21845, 1991.
    • (1991) J. Biol. Chem. , vol.266 , pp. 21839-21845
    • Stephens, J.M.1    Pekala, P.H.2
  • 103
    • 0027308663 scopus 로고
    • Tumor necrosis factor's cytotoxic activity is signaled by the p55 TNF receptor
    • Tartaglia, L.A., Rothe, Y.F. Hu, and D.V. Goeddel. Tumor necrosis factor's cytotoxic activity is signaled by the p55 TNF receptor [Review]. Cell 73:213-216, 1993.
    • (1993) Cell , vol.73 , pp. 213-216
    • Tartaglia, L.A.1    Hu, R.Y.F.2    Goeddel, D.V.3
  • 104
    • 0022385114 scopus 로고
    • A macrophage factor inhibits adipocyte gene expression: An in vitro model of cachexia
    • Torti, F.M., Dieckmann, B. Beutler, A. Cerami, and G.M. Ringold. A macrophage factor inhibits adipocyte gene expression: An in vitro model of cachexia. Science 229:867-869, 1985.
    • (1985) Science , vol.229 , pp. 867-869
    • Torti, F.M.1    Dieckmann2    Beutler, B.3    Cerami, A.4    Ringold, G.M.5
  • 105
    • 0030756346 scopus 로고    scopus 로고
    • Protection from obesity-induced insulin resistance in mice lacking TNF-a function
    • Uysal, K.T., M. Wiesbrock, M.W. Marino, and G.S. Hotamisligil. Protection from obesity-induced insulin resistance in mice lacking TNF-a function. Nature 389:610-614, 1997.
    • (1997) Nature , vol.389 , pp. 610-614
    • Uysal, K.T.1    Wiesbrock, M.2    Marino, M.W.3    Hotamisligil, G.S.4
  • 106
    • 0024451095 scopus 로고
    • Fat distribution and plasminogen activator inhibitor activity in nondiabetic obese women
    • Vague, P., Juhan-Vague, V. Chabert, M.C. Alessi, and C. Atlan. Fat distribution and plasminogen activator inhibitor activity in nondiabetic obese women. Metabolism 38:913-915, 1989.
    • (1989) Metabolism , vol.38 , pp. 913-915
    • Vague, P.1    Juhan-Vague2    Chabert, V.3    Alessi, M.C.4    Atlan, C.5
  • 108
    • 0027953316 scopus 로고
    • Differential effects of anti-tumor necrosis factor monoclonal antibodies on systemic inflammatory responses in experimental endotoxemia in chimpanzees
    • Van der Poll, T., Levi, S.J. van Deventer, H. Ten Cate, B.L. Haagmans, B.J. Biemond, H.R. Buller, C.E. Hack, and J.W. Ten Cate. Differential effects of anti-tumor necrosis factor monoclonal antibodies on systemic inflammatory responses in experimental endotoxemia in chimpanzees. Blood 83:446-451, 1994.
    • (1994) Blood , vol.83 , pp. 446-451
    • Van Der Poll, T.1    Levi2    Van Deventer, S.J.3    Ten Cate, H.4    Haagmans, B.L.5    Biemond, B.J.6    Buller, H.R.7    Hack, C.E.8    Ten Cate, J.W.9
  • 109
    • 0026053146 scopus 로고
    • The plasminogen activator/plasmin system
    • Vassalli, J.D., P. Sappino, and D. Belin. The plasminogen activator/plasmin system [Review]. J. Clin. Invest. 88:1067-1072, 1991.
    • (1991) J. Clin. Invest. , vol.88 , pp. 1067-1072
    • Vassalli, J.D.1    Sappino, P.2    Belin, D.3
  • 110
    • 0025779160 scopus 로고
    • Tumor necrosis factor. New insights into the molecular mechanisms of its multiple actions
    • Vilcek, J., and T.H. Lee. Tumor necrosis factor. New insights into the molecular mechanisms of its multiple actions [Review], J. Biol. Chem. 266:7313-7316, 1991.
    • (1991) J. Biol. Chem. , vol.266 , pp. 7313-7316
    • Vilcek, J.1    Lee, T.H.2
  • 111
    • 0029919298 scopus 로고    scopus 로고
    • White blood cell count and the risk of coronary heart disease and all-cause mortality in elderly men
    • Weijenberg, M.P., J. Feskens, and D. Kromhout. White blood cell count and the risk of coronary heart disease and all-cause mortality in elderly men. Arterioscler. Thromb. Vasc. Biol. 16:499-503, 1996.
    • (1996) Arterioscler. Thromb. Vasc. Biol. , vol.16 , pp. 499-503
    • Weijenberg, M.P.1    Feskens, J.2    Kromhout, D.3
  • 113
    • 0027529374 scopus 로고
    • Association between plasma fibrinogen concentration and five socioeconomic indices in the Kuopio Ischemic Heart Disease Risk Factor Study
    • Wilson, T.W., A. Kaplan, J. Kauhanen, R.D. Cohen, M. Wu, R. Salonen, and J.T. Salonen. Association between plasma fibrinogen concentration and five socioeconomic indices in the Kuopio Ischemic Heart Disease Risk Factor Study. Am. J. Epidemiol. 137:292-300, 1993,
    • (1993) Am. J. Epidemiol. , vol.137 , pp. 292-300
    • Wilson, T.W.1    Kaplan, A.2    Kauhanen, J.3    Cohen, R.D.4    Wu, M.5    Salonen, R.6    Salonen, J.T.7
  • 114
    • 0028139089 scopus 로고
    • Positional cloning of the mouse obese gene and its human homologue
    • Zhang, Y., Proenca, M. Maffei, M. Barone, L. Leopold, and J.M. Friedman. Positional cloning of the mouse obese gene and its human homologue. Nature 372:425-432, 1994.
    • (1994) Nature , vol.372 , pp. 425-432
    • Zhang, Y.1    Proenca2    Maffei, M.3    Barone, M.4    Leopold, L.5    Friedman, J.M.6


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