Essential fatty acids, immune function, and exercise

Exercise Immunology Review

Volumn , Issue 3, 1997, Pages 1-31

  König, Daniel ^a   Berg, Aloys ^b   Weinstock, Christoph ^c   Keul, Joseph ^a   Northoff, Hinnak ^b  

^a Medizinische Klinik   (Germany)

^b UNIVERSITY OF FREIBURG   (Germany)

^c UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; ESSENTIAL FATTY ACID;

B LYMPHOCYTE; EXERCISE; FATTY ACID METABOLISM; HUMAN; IMMUNE RESPONSE; MUSCLE FATIGUE; REVIEW; STRESS; T LYMPHOCYTE;

ACUTE-PHASE REACTION; ANIMALS; CYTOKINES; DIETARY FATS; DINOPROSTONE; EICOSANOIDS; EXERTION; FATTY ACIDS, ESSENTIAL; FREE RADICALS; HUMANS; IMMUNE SYSTEM; IMMUNE TOLERANCE; INFLAMMATION; LIPID PEROXIDATION; MEMBRANE FLUIDITY; MEMBRANE LIPIDS; OXIDATIVE STRESS; SIGNAL TRANSDUCTION; STRESS, MECHANICAL;

EID: 0030918065     PISSN: 10775552     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (237)

1. Abeywardena, M.Y., P.L. Mclennan, and J.S. Charnock. Differences between in vivo and in vitro production of eicosanoids following long-term dietary fish oil supplementation in the rat. Prostaglandins Leukot. Essent. Fatty Acids. 42:159-165, 1991.
2. Adam, O. Immediate and long range effects of the uptake of increased amounts of arachidonic acid. Clin Investig. 70:721-727, 1992.
3. Alexander, J.W., and M.M. Gottschlich. Nutritional immunomodulation in burn patients. Crit. Care Med. 18:S149-S153, 1990.
4. Alexander, J.W., H. Saito, O. Trocki, and C.K. Ogle. The importance of lipid type in the diet after burn injury. Ann. Surg. 204:1-8, 1986.
5. Amelink, G.J., R.W. Koot, W.B. Erich, J. Van Gijn, and P.R. Bar. Sex-linked variation in creatine kinase release, and its dependence on oestradiol, can be demonstrated in an in-vitro rat skeletal muscle preparation. Acta Physiol. Scand. 138:115-124, 1990.
6. Andus, T., T. Geiger, T. Hirano, T. Kishimoto, and P.C. Heinrich. Action of recombinant interleukin 6, interleukin 1b and tumor necrosis factor a on the mRNA induction of acute phase proteins. Eur. J. Imnnmol. 18:739-746, 1988.
7. Armstrong, R.B. Muscle damage and endurance events. Sports Med. 3:370-381, 1986.
8. Armstrong, R.B. Initial events in exercise-induced muscular injury. Med. Sci. Sports Exerc. 22:429-435, 1990.
9. Ayala, A., and I. H. Chaudry. Dietary n-3 polyunsaturated fatty acid modulation of immune function before or after trauma. Nutrition 11:1-11, 1995.
10. Baldie, G., D. Kaimakamis, and D. Rotondo. Fatty acid modulation of cytokine release from human monocytic cells. Biochim. Biophys. Acta 1179:125-133, 1993.
11. Barton, R.G., C.L. Wells, A. Carlson, R. Singh, J.J. Sullivan, and F.B. Cerra. Dietary omega-3 fatty acids decrease mortality and Kupffer cell prostaglandin E2 production in a rat model of chronic sepsis. J. Trauma 31:768-73, 1991.
12. Bates, E.J. Eicossanoids fatty acids and neutrophily - Their relevance to the pathophysiology of disease. Prostaglandins Leukot. Essent. Fatty Acids 53:75-86, 1995.
13. Bauer, S., A. Berg, and J. Keul. Ernährungserhebung bei Ausdauersportlern: I. Energiezufuhr und Nährstoffrelation [Evaluation of nutritional intake in elite athletes: I. The relation between energy supply and nutrients]. Akt. Ernähr. Med. 18:14-20, 1993.
14. Bendich, A. Exercise and free radicals: Effects of antioxidant vitamins. In: Advances in Nutrition and Top Sport, F. Brouns (Ed.). Basel: Med Sport Sci., 1991, pp. 59-78.
15. Benediktsdottir, V.E., and S. Gudbjarnason. Modification of the fatty acid composition of rat heart sarcolemma with dietary cod liver oil, corn oil or butter. J. Mol. Cell Cardiol. 20:141-147, 1988.
16. Berg, A. Essentielle Fettsäuren - ein Geheimtip nicht nur für die Sporternährung [Essential fatty acids - A secret not only for sport nutrition]. TW Sport + Medizin 4:293-294, 1992.
17. Berg, A., M. Baumstark, L. Rokitzki, and J. Keul. Die essentiellen Fettsäuren (ω-3-und ω-6- Fettsäuren): Ihre Bedeutung für die Prävention und Rehabilitation von Herz-Kreislauf-Erkrankungen [Essential fatty acids ω-3 and ω-6 fatty acids): Their meaning for prevention and rehabilitation of cardiopulmonary disease]. Dtsch. Z. Sportmed. 38:488-496, 1987.
18. Berg, A., S. Fischer, and J. Keul. Haferkleie - ein Nährstofflieferant mit physiologischer und therapeutischer Bedeutung [Oat bran - A nutrient source with physiological and therapeutic importance]. Getreide, Mehl und Brot 46:116-119, 1992.
19. Berg, A., M. Halle, M.W. Baumstark, J. Keul, and H. Northoff. Spontaneously low LDL cholesterol and relation to exercise-induced stress. Lancet 347:405, 1996.
20. Berg, A., D. König, M. Baumstark, D. Grathwohl, J. Keul, and H. Northoff. The exercise induced systemic interleukin 6 (IL-6) response is strongly correlated with other muscular stress indicators. Eur. J. Appl. Physiol. 69(Suppl. 3):S25, 1994.
21. Berk, L.S., D.C. Nieman, W.S. Youngberg, K. Arabatzis, M. Simpson-Westerberg, J.W. Lee, S.A. Tan, and W.C. Eby. The effect of long endurance running on natural killer cells in marathoners. Med. Sci. Sports Exerc. 22:207-212, 1990.
22. Biagi, P.L., A. Bordoni, S. Hrelia, M. Celadon, and D.F. Horrobin. Gamma-Linolenic acid dietary supplementation can reverse the aging influence on rat liver microsome delta-6-desaturase activity. Biochim. Biophys. Acta 1083:187-192, 1991.
23. Billiar, T.R., P.E. Bankey, B.A. Svingen, R.D. Curran, M.A. West, R.T. Holman, R.L. Simmons, and F.B. Cerra. Fatty acid intake and Kupffer cell function: Fish oil alters eicosanoid and monokine production to endotoxin stimulation. Surgery 104:343-349, 1988.
24. Bjerve, K.S., I.L. Mostad, and L. Thoresen. Alpha-linolenic acid deficiency in patients on long-term gastric-tube feeding: Estimation of linolenic acid and long-chain unsaturated n-3 fatty acid requirement in man. Am. J. Clin. Nutr. 45:66-77, 1987.
25. Boberg, M., B. Vessby, and I. Selinus. Effects of dietary supplementation with n-6 and n-3 long-chain polyunsaturated fatty acids on serum lipoproteins and platelet function in hypertriglyceridaemic patients. Acta Med. Scand. 220:153-160, 1986.
26. Bonta, I.L., and M.J. Parnham. Immunomodulatory-antiinflammatory functions of E-type prostaglandins: Minireview with emphasis on macrophage-mediated effects. Int. J. Immunopharmacol. 4:103-109, 1982.
27. Boveris, A., and B. Chance. The mitochondrial generation of hydrogen peroxide. Biochem. 134:707-718, 1973.
28. Brock-Utne, J.G., S.L. Gaffin, M.T. Wells, P. Gathiram, E. Sohar, M.F. James, D.F. Morrell, and R.J. Norman. Endotoxaemia in exhausted runners after a long-distance race. S. Afr. Med. J. 73:533-536, 1988.
29. Brouard, C., and M. Pascaud. Effects of moderate dietary supplementations with n-3 fatty acids on macrophage and lymphocyte phospholipids and macrophage eicosanoid synthesis in the rat. Biochim. Biophys. Acta 1047:19-28, 1990.
30. Calder, P.C. Fatty acids, dietary lipids and lymphocyte functions. Bioch. Soc. Trans. 23:302-309, 1995.
31. Calder, P.C., J.A. Bond, D.J. Harvey, S. Gordon, and E.A. Newsholme. Uptake and incorporation of saturated and unsaturated fatty acids into macrophage lipids and their effect upon macrophage adhesion and phagocytosis. Biochem. J. 269:807-814, 1990.
32. Calder, P.C., and E.A. Newsholme. Polyunsaturated fatty acids suppress human peripheral blood lymphocyte proliferation and interleukin-2 production. Clin. Sci. (Colch.) 82:695-700, 1992.
33. Cameron, N.B., M.A. Cotter, and S. Robertson. Essential fatty acid diet supplementation-Effect on peripheral nerve and skeletal muscle function and capillarization in streptozocin-induced diabetic rats. Diabetes 40:532-539, 1991.
34. Camus, G., G. Deby-Dupont, J. Duchateau, C. Deby, J. Pincemail, and M. Lamy. Are similar inflammatory factors involved in strenuous exercise and sepsis? Intensive Care Med. 20:602-610, 1994.
35. Cannon, J.G., S.N. Meydani, R.A. Fielding, M.A. Fiatarone, M. Meydani, M. Farhangmehr, S.F. Orencole, J.B. Blumberg, and W.J. Evans. Acute phase response in exercise: II. Associations between vitamin E, cytokines, and muscle proteolysis. Am. J. Physiol. 260:R1235-R1240, 1991.
36. Cannon, J.G., S.F. Orencole, R.A. Fielding, M. Meydani, S.N. Meydani, M.A. Fiatarone, J.B. Blumberg, and W.J. Evans. Acute phase response in exercise: Interaction of age and vitamin E on neutrophils and muscle enzyme release. Am. J. Physiol. 259:R1214-R1219, 1990.
37. Capdevila, J.H., J.R. Falck, and R.W. Estabrook. Cytochrome P450 and the arachidonate cascade. FASEB J. 6: 731-736, 1992.
38. Cathcart, E.S., W.A. Gonnerman, C.A. Leslie, and K.C. Hayes. Dietary n-3 fatty acids and arthritis. J. Intern. Med. Supplement. 225:217-223, 1989.
39. Caughey, G.E., E. Mantzioris, R.A. Gibson, L.G. Cleland, M.J. James. Flaxseed oil, alpha-linolenic acid, eicosapentaenoic acid, monocytes, tumor necrosis factor alpha, and 1. Interleukin: The effect on human tumor necrosis factor alpha and interleukin 1-beta production of diets enriched in n-3 fatty acids from vegetable oil or fish oil. Am. J. Clin. Nutr. 63:116-122, 1996.
40. Cerra, F.B., S. Lehmann, N. Konstantinides, J. Dzik, J. Fish, Konstantinides, F.J.J. LiCari, and R. T. Holman. Improvement in immune function in ICU patients by enteral nutrition supplemented with arginine, RNA, and menhaden oil is independent of nitrogen balance. Nutrition 7: 193-199, 1991.
41. Cerra, F.B., S. Lehman, N. Konstantinides, F. Konstantinides, E.P. Shronts, and R. Holman. Effect of enteral nutrient on in vitro tests of immune function in ICU patients: A preliminary report. Nutrition 6:84-87, 96-98, 1990.
42. Chapkin, R.S., and S. L. Carmichael. Effects of dietary n-3 and n-6 polyunsaturated fatty acids on macrophage phospholipid classes and subclasses. Lipids 25:827-834, 1990.
43. Chilton, F.H., M. Patel, A.N. Fonteh, W.C. Hubbard, and M. Triggiani. Dietary n-3 fatty acid effects on neutrophil lipid composition and mediator production: Influence of duration and dosage. J. Clin. Invest. 91:115-122, 1993.
44. Chow, S.C., L. Sisfontes, I. Bjorkhem, and M. Jondal. Suppression of growth in a leukemic T cell line by n-3 and n-6 polyunsaturated fatty acids. Lipids 24:700-704, 1989.
45. Christiansen, E.N., J.S. Lund, T. Rortveit, and A.C. Rustan. Effect of dietary n-3 and n-6 fatty acids on fatty acid desaturation in rat liver. Biochim. Biophys. Acta 1082:57-62, 1991.
46. Clarkson, P.M., W. Kroll, J. Graves, and W.A. Record. The relationship of serum creatine kinase, fiber type, and isometric exercise. Int. J. Sports Med. 3:145-148, 1982.
47. Coffey, R.G., E.M. Hadden, and J.W. Hadden. Evidence for cyclic GMP and calcium mediation of lymphocyte activation by mitogens. J. Immunol. 119:1387-1394, 1977.
48. Coffey, R.G., E.M. Hadden, C. Lopez, and J.W. Hadden. cGMP and calcium in the initiation of cellular proliferation. Adv. Cyclic. Nucleotide. Res. 9:661-676, 1978.
49. Cohen, F., and R. Heikkila. The generation of hydrogen peroxide, superoxide and hydroxyl radical by 6-hydroxydopamine dialuric acid and related cytotoxic agents. J. Biol. Chem. 249:2447-2450, 1974.
50. Conroy, D.M., C.D. Stubbs, J. Belin, C.L. Pryor, and A.D. Smith. The effects of dietary ω-3 fatty acid supplementation on lipid dynamics and composition in rat lymphocytes and liver microsomes. Biochim. Biophys. Acta 861:457-462, 1986.
51. Crinnion, J.N., S. Homer-Vanniasinkam, S.M. Parkin, and M.J. Gough. Neutrophils and the endothelium in post-ischemic alterations in skeletal muscle blood flow. Ann. N.Y. Acad. Sci. 723:442-443, 1994.
52. Cunnane, S.C., M.S. Manku, and D.F. Horrobin. Essential fatty acids in the liver and adipose tissue of genetically obese mice: Effect of supplemental linoleic and gammalinolenic acids. Br. J. Nutr. 53:441-448, 1985.
53. Davies, P. Lipoxygenase products in immunity: Immunological Investigations 16:623-647, 1987.
54. Deforge, L.E., D.T. Nguyen, S.L. Kunkel, and D.G. Remick. Regulation of the pathophysiology of tumor necrosis factor. J. Lab. Clin. Med. 116:429-438, 1990.
55. Deutsche Gesellschaft für Ernährung (DGE). Empfehlungen für die Nährstoffziifuhr [Recommendations for the nutrient supply]. Frankfurt: Umschau Verlag, 1991.
56. Dinarello, C.A. Biology of interleukin 1. FASEB J. 2:108-115, 1988.
57. Dinarello, C.A., S. Endres, S.N. Meydani, M. Meydani, and M.K. Hellerstein. Interleukin-1, anorexia, and dietary fatty acids. Ann. N. Y. Acad. Sci. 587:332-338, 1990.
58. Driss, F., E. Vericel, M. Lagarde, M. Dechavanne, and P. Darcet. Inhibition of platelet aggregation and thromboxane synthesis after intake of small amount of icosapentaenoic acid. Thromb. Res. 36:389-396, 1984.
59. Dudley, G.A., R.S. Staron, T.F. Murray, F.C. Hagerman, and A. Luginbuhl. Muscle fiber composition and blood ammonia levels after intenseexercise in humans. J. Appl. Physiol. 54:582-586, 1983.
60. Dufaux, B., U. Order, H. Geyer, and W. Hollmann. C-reactive protein serum concentrations in well-trained athletes. Int. J. Sports Med. 5:102-106, 1984.
61. Eaton, S.B. Humans, lipids and evolution. Lipids 27:814-820, 1992.
62. Endres, S. N-3 polyunsaturated fatty acids and human cytokine synthesis. Lipids 31:S239-S242, 1996.
63. Endres, S., R. Ghorbani, V. E. Kelley, K. Georgilis, G. van der Lonnemann, J.W. Meer, J.G. Cannon, T.S. Rogers, M.S. Klempner, P.C. Weber, E.J. Schaefer, S.M. Wolff, and C.A. Dinarello. The effect of dietary supplementation with n-3 polyunsaturated fatty acids on the synthesis of interleukin-1 and tumor necrosis factor by mononuclear cells. N. Engl. J. Med. 320: 265-271, 1989.
64. Endres, S., V.E. Kelley, and C.A. Dinarello. Effects of dietary omega-3 fatty acids on the in vitro production of human interleukin-1. Leukoc. Biol. 42:617, 1987.
65. Endres, S., S.N. Meydani, and C.A. Dinarello. Effects of omega 3 fatty acid supplements on ex vivo synthesis of cytokines in human volunteers: Comparison with oral aspirin and ibuprofen. World Rev. Nutr. Diet. 66:401-406, 1991.
66. Endres, S., S.N. Meydani, R. Ghorbani, R. Schindler, and C.A. Dinarello. Dietary supplementation with n-3 fatty acids suppresses interleukin-2 production and mononuclear cell proliferation. J. Leukoc. Biol. 54:599-603, 1993.
67. Endres, S., B. Sinha, and T. Eisenhut. Omega 3 fatty acids in the regulation of cytokine synthesis. World Rev. Nutr. Diet. 76:89-94, 1994.
68. Ernst, E. Changes in blood rheology produced by exercise. JAMA 253:2962-2963, 1985.
69. Ernst, E., T. Saradeth, and G. Achhammer. N-3 fatty acids and acute-phase proteins. Eur. J. Clin. Invest. 21:77-82, 1991.
70. Ertel, W., and E. Faist. Immunologic monitoring after severe trauma. Unfallchirurg 96: 200-212, 1993.
71. Ertel, W., J.P. Kremer, J. Kenney, U. Steckholzer, D. Jarrar, O. Trentz, and F.W. Schildberg. Downregulation of proinflammatory cytokine release in whole blood from septic patients. Blood 85:1341-1347, 1995.
72. Ertel, W., M.H. Morrison, A. Ayala, and I.H. Chaudry. Modulation of macrophage membrane phospholipids by n-3 polyunsaturated fatty acids increases interleukin 1 release and prevents suppression of cellular immunity following hemorrhagic shock. Arch. Surg. 128: 15-21, 1993.
73. Ertel, W., M.H. Morrison, D.R. Meldrum, A. Ayala, and I.H. Chaudry. Ibuprofen restores cellular immunity and decreases susceptibility to sepsis following hemorrhage. J. Surg. Res. 53:55-61, 1992.
74. Faist, E., T.S. Kupper, C.C. Baker, I.H. Chaudry, J. Dwyer, and A.E. Baue. Depression of cellular immunity after major injury: Its association with posttraumatic complications and its reversal with immunomodulation. Arch. Surg. 121:1000-1005, 1986.
75. Fernandes, G. Effect of dietary fish oil supplement on autoimmune disease: Changes in lymphoid cell subsets, oncogene mRNA expression and neuroendokrine hormones. In: Health Effects of Fish and Fish Oil, R.K. Chandra (Ed.). St. Johns, Nova Scottia, Canada: ARTS Biomedical, 1989, pp. 115-137.
76. Fiehn, W., J.B. Peter, J.F. Mead, and M. Gan-Elepano. Lipids and fatty acids of sarcolemma, sarcoplasmic reticulum, and mitochondria from rat skeletal muscle. J. Biol. Chem. 246:5617-5620, 1971.
77. Fielding, R.A., T. J. Manfredi, W. Ding, M.A. Fiatarone, W.J. Evans, and J.G. Cannon. Acute phase response in exercise: III. Neutrophil and IL-1 beta accumulation in skeletal muscle. Am. J. Physiol. 265: R166-R172, 1993.
78. Fischer, S., and P. C. Weber. Thromboxane A3 (TXA3) is formed in human platelets after dietary eicosapentaenoic acid. Biochem. Biophys. Res. Commun. 116:1091-1099, 1983.
79. Fitts, R.H., J.B. Courtright, D.H. Kim, and F.A. Witzmann. Muscle fatique with prolonged exercise: Contractile and bio-chemical alterations. Am. J. Physiol. 242:C65-C72, 1982.
80. Friden, J. Changes in human skeletal muscle induced by long-term eccentric exercise. Cell. Tissue Res. 236:365-372, 1984.
81. Friden, J., U. Kjörell, and L.E. Thomell. Delayed muscle soreness and cytoskeletal alterations: An immunocytological study in man. Int. J. Sports. Med. 5:15-18, 1984.
82. Gabriel, H., L. Schwarz, G. Steffens, and W. Kindermann. Immunoregulatory hormones, circulating leucocyte and lymphocyte subpopulations before and after endurance exercise of different intensities. Int. J. Sports Med. 13:359-366, 1992.
83. Cannon, G.A., P.N. Shek, and R.J. Shephard. Natural killer cells: Modulation by intensity and duration of exercise. Exerc. Immunol. Rev. 1:26-48, 1995.
84. Garg, M.L., A.B.R. Thomson, and M.T. Clandinin. Interactions of saturated, n-6 and n-3 polyunsaturated fatty acids to modulate arachidonic acid metabolism. J. Lipid Res. 31:271-277, 1990.
85. Gasser, J.A., and D.J. Betteridge. Lipids and thrombosis. Bailliere. Clin. Endocrinol. Met. 4:923-938, 1990.
86. Gmunder, F.K., G. Lorenzi, B. Bechler, P. Joller, J. Muller, W.H. Ziegler, and A. Cogoli. Effect of long-term physical exercise on lymphocyte reactivity: Similarity to spaceflight reactions. Aviat. Space. Environ. Med. 59:146-151, 1988.
87. Goodwin, J.S., and D.R. Webb. Regulation of the immune response by prostaglandins. Clin. Immunol. Immunopathol. 15:106-122, 1980.
88. Gronn, M., C. Gorbitz, E. Christensen, A. Levorsen, L. Ose, T. A. Hagve, and B.O. Christophersen. Dietary n-6 fatty acids inhibit the incorporation of dietary n-3 fatty acids in thrombocyte and serum phospholipids in humans: a controlled dietetic study. Scand. J Clin. Lab. Invest. 51:255-263, 1991.
89. Hadden, J.W., E.M. Madden, and R.G. Coffey. Interleukin II increases cyclic GMP levels in immature thymocytes and mitogen-primed T-lymphocytes. Int. J. Immunopharmacol. 9:851-857, 1987.
90. Hagenfeldt, L., J. Wahren, B. Pernow, and L. Räf. Uptake of individual free fatty acids by skeletal muscle and liver in man. J. Clin. Invest. 51:2324-2330, 1972.
91. Hagve, T.A., O. Lie, and M. Gronn. The effect of dietary N-3 fatty acids on osmotic fragility and membrane fluidity of human erythrocytes. Scan. J. Clin. Lab. Invest. Suppl. 215:75-84, 1993.
92. Hamazaki, T. Intravenous infusion of n-3 polyunsaturated fatty acids. Proc. Soc. Exp. Biol. Med. 200:171-173, 1992.
93. Harris, W.S. Fish oils and plasma lipid and lipoprotein metabolism in humans: A critical review. J. Lipid Res. 30: 785-807, 1989.
94. Hawthorne, A.B., B. Filipowixz, T. Edwards, et al. High dose purified eicosapentaenoic acid (EPA): Effects on leukotriene synthesis and plasma lipids. Br. J. Pharmacol. 97:431, 1989.
95. Heagerty, A., M.J. Ollerenshaw, D.I. Robertson, R.F. Bing, and J.D. Swales. Influence of dietary linolenic acid on leucocyte sodium transport and blood pressure. Br. Med. J. 293:295-297, 1986.
96. Hoffmann-Goetz, L., and B.K. Pedersen. Exercise and the immune system: A model of the stress response? Immunol. Today 15:382-387, 1994.
97. Horrobin, D.E. The regulation of prostaglandin biosynthesis by the manipulation of essential fatty acid metabolism. Rev. Pure Appl. Pharmacol. Sci. 4:339-383, 1983.
98. Horrobin, D.F. Interactions between n-3 and n-6 essential fatty acids (EFAs) in the regulation of cardiovascular disorders and infammation. Prost. Leukot. Essent. Fatty Acids 44:127-131, 1991.
99. Horrobin, D.F. Fatty acid metabolism in health and disease: The role of delta-6-desaturase. Am. J. Clin. Nutr. 57: 732S-736S, 1993.
100. Horrobin, D.F, and M.S. Manku. Clinical biochemistry of essential fatty acids. In: Omega-6-Essential Fatty Acids: Pathophysiology and Roles in Clinical Medicine,D.F. Horrobin (Ed.). New York: Liss, 1990, pp. 21-53.
101. Horrobin, D.F., M.S. Manku, and Y.S. Huang. Effects of essential fatty acids on prostaglandin biosynthesis. Biomed. Biochim. Acta 43:114-120, 1984.
102. Huang, Y.S. Modification of liver fatty acid metabolism in mice by n-3 and n-6 delta-6-desaturase substrates and products. Biochim. Biophys. Acta 1082:319-327, 1991.
103. Huang, Y.S., and B.A. Nassar. Modulation of tissue fatty acid composition, prostaglandin production and cholesterol levels by dietary manipulations of n-3 and n-6 essential fatty acid metabolites. In: Omega-6-Essential Fatty Acids: Pathophysiology and Roles in Clinical Medicine, D.F. Horrobin (Ed.). New York: Liss, 1990, pp. 127-144.
104. Hwang, D. Essential fatty acids and immune response. FASEB J. 3:2052-2061, 1989.
105. Israel, D.H., and R. Gorlin. Fish oils in the prevention of atherosclerosis. J. Am. Coll. Cardiol. 19:174-185, 1992.
106. Iversen, L., K. Fogh, and K. Kragballe. Effect of dihomo-gamma-linolenic acid and its 15-lipoxygenase metabolite on eicosanoid metabolism by human mononuclear leukocytes in vitro - Selective inhibition of the 5-lipoxygenase ptahway. Arch. Dermatol. Res. 284:222-226, 1992.
107. Janniger, C.K., and S.P. Racis. The arachidonic acid cascade: An immunologically based review. J. Med. 18:69-80, 1987.
108. Jenkins, R.R. Free radical chemistry. Sports Med. 5:156-170, 1988.
109. Jenkins, R.R. Exercise, oxidative stress, and antioxidants: A review. Int. J. Sport. Nutr. 3:356-375, 1993.
110. Ji, L.L., F.W. Stratman, and H.A. Lardy. Antioxidant enzyme systems in rat liver and skeletal muscle: Influences of selenium deficiency, chronic training, and acute exercise. Arch. Biochem. Biophys. 263:150-160, 1988.
111. Kageyama, K., T. Nagasawa, S. Kimura, T. Kobayashi, and Y. Kinoshita. Cytotoxic activity of unsaturated fatty acids to lymphocytes. Can. J. Biochem. 58:504-508, 1980.
112. Kamada, T., S. Tokuda, S.I. Aozaki, and S. Otsuj. Higher levels of erythrocyte membrane fluidity in sprinters and long-distance runners. J. Appl. Physiol. 74:354-358, 1993.
113. Kamada, T., T. Yamashita, Y. Baba, Y. Kai, S. Setoyama, Y. Chuman, and S. Otsuji. Dietary sardine oil increases erythrocyte membrane fluidity in diabetic patients. Diabetes 35:604-611, 1986.
114. Kanter, M.M. Free radicals, exercise, and antioxidant supplemenation. Int. J. Sport. Nutr. 4:205-220, 1994.
115. Kim, D.N., A. Eastman, J.E. Baker, A. Mastrangelo, S. Sethi, J.S. Ross, J. Schmee, and W.A. Thomas. Fish oil, atherogenesis, and thrombogenesis. Ann. N.Y.Acad. Sci. 748:474-480, 1995.
116. Kirtland, S.J. Prostaglandin E1 : A review. Prostaglandins Leukot. Essent. Fatty Acids. 32: 165-174, 1988.
117. Knapp, H.R., and M.A. Melly. Bactericidal effects of polyunsaturated fatty acids. J. Infect. Dis. 154:84-94, 1986.
118. Koot, R.W., G.J. Amelink, M.A. Blankenstein, and P.R. Bar. Tamoxifen and oestrogen both protect the rat muscle against physiological damage. J. Steroid Biochem. Mol. Biol. 40:689-695, 1991.
119. König, D., M.W. Baumstark, J. Keul, and A. Berg. Influence of supplementation with fishoil on the exercise-induced peripheral stress reaction. In: Proceedings From the Scientific Conference on Omega-3 Fatty Acids in Nutrition, Vascular Biology, and Medicine, H.J. Pownall, A.A. Spector, and Council on Arteriosclerosis (Eds.). Dallas, TX: American Heart Association, 1994, p. 260
120. König, D., A. Berg, M.W. Baumstark, D. Grathwohl, M. Halle, and J. Keul. Correlation between plasma fatty acids and the immunologie response to exercise in endurance trained athletes. Med. Sci. Sports Exerc. 28(Suppl.):30, 1996.
121. Kramer, T.R., N. Schoene, L.W. Douglass, J.T. Judd, R. Ballard-Barbash, P.R. Taylor, H.N. Bhagavan, and P.P. Nair. Increased vitamin E intake restores fish-oil-induced suppressed blastogenesis of mitogen-stimulated T lymphocytes. Am. J. Clin. Nittr. 54:896-902, 1991.
122. Kuehl, F.A., Jr. and R.W. Egan. Prostaglandins, arachidonic acid, and inflammation. Science 210:978-984, 1980.
123. Kunkel, S.L., and S.W. Chensue. Arachidonic acid metabolites regulate interleukin-1 production. Biochem. Biophys. Res. Commun. 128:892-897, 1985.
124. Kunkel, S.L., D.G. Remick, R.M. Stricter, and J.W. Larrick. Mechanisms that regulate the production and effects of tumor necrosis factor-alpha. Crit. Rev. Immunol. 9:93-117, 1989.
125. Kunkel, S.L., R.C. Wiggins, S.W. Chensue, and J. Larrick. Regulation of macrophage tumor necrosis factor production by prostaglandin E2. Biochem. Biophys. Res. Commun. 137:404-410, 1986.
126. Lagarde, M. Metabolism of fatty acids by platelets and the functions of various metabolites in mediating platelet function. Prog. Lipid Res. 27:135-152, 1988.
127. Lagarde, M., E. Vericel, M. Croset, C. Calzada, J.C. Bordet, and M. Guichardant. Interactions between arachidonic and eicosapentaenoic acids during their dioxygenase-dependent peroxidation. Prostaglandins Leukot. Essent. Fatty Acids 48:23-25, 1993.
128. Lee, T.H., J.P. Arm, C.E. Horton, A.E. Crea, J.M. Mencia-Huerta, and B.W. Spur. Effects of dietary fish oil lipids on allergic and inflammatory diseases. Allergy Proc. 12:299-303, 1991.
129. Lee, T.H., R.L. Hoover, J.D. Williams, R.I. Sperling, and J. Ravalese. Effect of dietary enrichment with eicosapentaenoic and docosahexaenoic acids on in vitro neutrophil and monocyte leukotriene generation and neutrophil funktion. New. Engl. J. Med. 312:1217-1224, 1985.
130. Lefkowith, J.B. Essential fatty acid deficiency inhibits the in vivo generation of leukotriene B4 and suppresses levels of resident and elicited leukocytes in acute inflammation. J. Immunol. 140:228-233, 1988.
131. Lefkowith, J.B. Essential fatty acid deficiency: Probing the role of arachidonate in biology. Adv. Prostaglandin. Thromboxane. Leukot. Res. 20:224-231, 1990.
132. Lefkowith, J.B., A.S. Evers, W.J. Elliott, and P. Needleman. Essential fatty acid deficiency: A new look at an old problem. Prostaglandins Leukot. Med. 23:123-127, 1986.
133. Lefkowith, J.B., M. Rogers, M.R. Lennartz, and E.J. Brown. Essential fatty acid deficiency impairs macrophage spreading and adherence: Role of arachidonate in cell adhesion. J. Biol. Cliem. 266:1071-1076, 1991.
134. Leger, C. L. Physicochemical approach of the function of the fatty acid incorporation in biological membranes. Prostaglandins Leukot. Essent. Fatty Acids 48:17-21, 1993.
135. Lew, H., and A. Quintanilha. Effects of endurance training and exercise on tissue antioxidative capacity and acetaminophen detoxification. Eur. J. Drug Metab. Phannacokinet. 16:59-68, 1991.
136. Lieberman, M.D., J. Shou, A.S. Torres, F. Weintraub, J. Goldfine, R. Sigal, and J.M. Daly. Effects of nutrient substrates on immune function. Nutrition 6:88-91, 96-98, 1990.
137. Lowe, D.A., G.L. Warren, D.A. Hayes, M.A. Farmer, and R.B. Armstrong. Eccentric contraction-induced injury of mouse soleus muscle: Effect of varying [Ca2+]. J. Appl. Physiol. 76:1445-1453, 1994.
138. Mackinnon, L.T. Exercise and immunology. Champaign, IL: Human Kinetics, 1992.
139. Magrum, L.J., and P.V. Johnston. Modulation of prostaglandin synthesis in rat peritoneal macrophages with omega-3 fatty acids. Lipids 18:514-521, 1983.
140. Mahoney, E.M., A.L. Hamill, W.A. Scott, and Z.A. Cohn. Response of endocytosis to altered fatty acyl composition of macrophage phospholipids. Proc. Natl. Acad. Sci. U.S.A. 74:4895-4899, 1977.
141. Manku, M.S., D.F. Horrobin, Y.S. Huang, and N. Morse. Fatty acids in plasma and red cell membranes in normal humans. Lipids 18:906-908, 1983.
142. Marangoni, F., C. Mosconi, G. Galella, and C. Galli. Increments of dietary linoleate raise liver arachidonate, but markedly reduce heart n-6 and n-3 fatty acids in the rat. Lipids 27:624-628, 1992.
143. Marshall, L.A., and P.V. Johnston. Modulation of tissue prostaglandin synthesizing capacity by increased ratios of dietary alpha-linolenic acid to linoleic acid. Lipids 17:905-913, 1982.
144. Marshall, L.A., and P.V. Johnston. The effect of dietary alpha-linolenic acid in the rat on fatty acid profiles of immunocompetent cell populations. Lipids 18:737-742, 1983.
145. McCord, J.M. Superoxide and superoxide dismutase in oxygen toxicity. In: Oxygen and Physiological Function, F.F. Jobsis (Ed.). Dallas: Professional Information Library, 1977, pp. 379-387.
146. McEwen, B.S., and E. Stellar. Stress and the individual: Mechanisms leading to disease. Arch. Intern. Med. 153:2093-2101, 1993.
147. Meydani, S.N. Dietary modulation of cytokine production and biologic functions. Nutr. Rev. 48:361-369, 1990.
148. Meydani, S.N., S. Endres, M.M. Woods, B.R. Goldin, C. Soo, A. Morrill-Labrode, C.A. Dinarello, and S.L. Gorbach. Effect of oral n-3 fatty acid supplementation on the immune response of young and older women. Adv. Prostaglandin. Thromboxane. Leukot. Res. 21A: 245-248, 1991.
149. Meydani, S.N., S. Endres, M.M. Woods, B.R. Goldin, C. Soo, A. Morrill-Labrode, C.A. Dinarello, and S.L. Gorbach. Oral (n-3) fatty acid supplementation suppresses cytokine production and lymphocyte proliferation: comparison between young and older women. J. Nutr. 121:547-555, 1991.
150. 2 synthesis in young and old mice. J. Nutr. 118:1245-1252, 1988.
151. Miller-Graziano, C.L., M. Fink, J.Y. Wu, G. Szabo, and K. Kodys. Mechanisms of altered monocyte prostaglandin E2 production in severely injured patients. Arch. Surg. 123:293-299, 1988.
152. Moncada, S., and J.A. Salmon. Leukocytes and tissue injury: The use of eicosapentaenoic acid in the control of white cell activation. Prog. Lipid. Res. 25:563-566, 1986.
153. Moriguchi, S., H. Miwa, and Y. Kishino. Glutamine supplementation prevents the decrease of mitogen response after a treadmill exercise in rats. J. Nutr. Sci. Vitaminol. (Tokyo) 41:115-125, 1995.
154. Nassar, B.A., Y.S. Huang, M.S. Manku, U.N. Das, and D.F. Horrobin. The influence of dietary manipulations with n-3 and n-6 fatty acids on liver and plasma phospolidid fatty acids in rats. Lipids 216:652-656, 1986.
155. Needleman, P., A. Raz, M.S. Minkes, J.A. Ferrendelli, and H. Sprecher. Triene prostaglandins: prostacyclin and thromboxane biosynthesis and unique biological properties. Proc. Natl. Acad. Sci. 176:944-948, 1979.
156. Newsholme, E.A. Biochemical mechanisms to explain immunosuppression in welltrained and overtrained athletes. Int. J. Sports Med. 15(Suppl. 3):S142-S147, 1994.
157. Newsholme, E.A., P. Calder, and P. Yaqoob. The regulatory, informational, and immunomodulatory roles of fat fuels. Am. J. Clin. Nutr. 57:738S-750S, 1993.
158. Nieman, D.C. Exercise, infection, and immunity. Int. J. Sports Med. 15(Suppl 3):S131-S141, 1994.
159. Nieman, D.C., L.S. Berk, M. Simpson-Westerberg, K. Arabatzis, S. Youngberg, S.A. Tan, J.W. Lee, and W.C. Eby. Effects of long-endurance running on immune system parameters and lymphocyte function in experienced marathoners. Int. J. Sports Med. 10:317-323, 1989.
160. Nieman, D.C., D.A. Henson, C.S. Sampson, J.L. Herring, J. Suttles, M. Conley, M.H. Stone, D.E. Butterworth, J.M. Davis. Weight training, immune system, lymphocyte, natural killer cell, activity, lymphocyte proliferative response, cortisol, and epinephrine: The acute immune response to exhaustive resistance exercise. Int. J. Sports Med. 16:322-328, 1995.
161. Nieman, D.C, and S.L. Nehlsen-Cannarella. The effects of acute and chronic exercise of immunoglobulins. Sports Med. 11:183-201, 1991.
162. Nieman, D.C., S.A. Tan, J.W. Lee, and L.S. Berk. Complement and immunoglobulin levels in athletes and sedentary controls. Int. J. Sports Med. 10:124-128, 1989.
163. Ninnemann, J.L., and A.E. Stockland. Participation of prostaglandin E in immunosuppression following thermal injury. J. Trauma 24:201-207,1984.
164. (Retracted by J.L. Ninnemann in J. Trauma 37:685, 1994)
165. Northoff, H., and A. Berg. Immunologie mediators as parameters of the reaction to strenous exercise. Int. J. Spans Med. 14:S9-S15, 1991.
166. Northoff, H., S. Enkel, and C. Weinstock. Exercise, injury, and immune function. Exerc. Immunol. Rev. 1:1-25, 1995.
167. Northoff, H., W.A. Flegel, D.N. Männel, M.W. Baumstark, and A. Berg. Increased levels of interleukin-6 (IL-6) and/or IL-7 in sera of long-distance runners. In: The physiological and Pathological Effects of Cytokines, M. Powanda, J.J. Oppenheim, M. Kluger, and C.A. Dinarello (Eds.). New York: Wiley-Liss, 1990, pp. 75-79.
168. Northoff, H., C. Weinstock, and A. Berg. The cytokine response to strenuous exercise. Int. J. Sports Med. 15:S167-S171, 1994.
169. Nunez, E.A. Free fatty acids as modulators of the steroid hormone message. Prostaglandins Leukot. Essent. Fatty Acids 48:63-70, 1993.
170. Nunez, E.A. Preface: Fatty acids and cell signalling. Prostaglandins Leukot. Essent. Fatty Acids 48:1-4, 1993.
171. Ogle, C.K., J.Z. Wu, S. Wood, J.D. Ogle, J.W. Alexander, and G.D. Warden. The increased release of prostaglandin E2 by Kupffer cells from burned guinea pigs. J. Burn Care Rehabil. 11:287-294, 1990.
172. Onega Rincon, E. Physiology and biochemistry: Influence of exercise on phagocytosis. Int. J. Sports Med. 15(Suppl. 3):S172-S178, 1994.
173. Parker, C.W. Leukotrienes and prostaglandins in the immune system. Adv. Prostaglandin Thromboxane Leukot. Res. 16: 113-134, 1986.
174. Parker, C.W. Lipid mediators produced through the lipoxygenase pathway. Ann. Rev. Immunol. 5:65-84, 1987.
175. Parnham, M.J. Eicosanoide und Entzündung: Mechanismen und Perspektiven fur die Therapie [Eicosanoids and inflammation: Mechanisms and perspectives for therapy]. Pharmazie heute 3: 211-219, 1986.
176. Patton, G.M., S.J. Robins, J.M. Fasulo, and S.B. Clark. Influence of lecithin acyl chain composition on the kinetics of exchange between chylomicrons and high density lipoproteins.y. Lipid Res. 26:1285-1293, 1985.
177. Peck, M., Z.M. Li, and L. Mantelle. The effect of fatty acids on lymphocyte membrane organisation and blastogenesis. FASEB J. 6:A1370, 1992.
178. Peck, M.D. Interactions of lipids with immune function II: Experimental and clinical studies of lipids and immunity. J. Nutr. Biochem. 5:514-521, 1994.
179. Peck, M.D. Interactions of lipids with immune function I: Biochemical effects of dietary fatty lipids on plasma membranes. J. Nutr. Biochem. 5:466-478, 1994.
180. Pedersen, B.K. Influence of physical activity on the cellular immune system: Mechanisms of action. Int. J. Sports Med. 12:S23-S29, 1991.
181. Pedersen, B.K., N. Tvede, F.R. Hansen, V. Andersen, T. Bendix, G. Bendixen, K. Bendtzen, H. Galbo, P.M. Haahr, K. Klarlund, J. Sylvest, B.S. Thomsen, and J. Halkjaer-Kristensen. Modulation of natural killer cell activity in peripheral blood by physical exercise. Scand. J. Immunol. 27:673-678, 1988.
182. Pedersen, B.K., and H. Ullum. NK cell response to physical activity: Possible mechanisms of action. Med. Sci. Sports Exerc. 26:140-146, 1994.
183. Pereira, B., L.F. Costa Rosa, D.A. Safi, M.H. Medeiros, R. Curi, and E.J. Bechara. Superoxide dismutase, catalase, and glutathione peroxidase activities in muscle and lymphoid organs of sedentary and exercise-trained rats. Physiol. Behav. 56:1095-1099, 1994.
184. Pereira, B., L.F. Rosa, D.A. Safi, A.R. Guimaraes, E.J. Bechara, and R. Curi. Antioxidant enzyme activities in the lymphoid organs and muscles of rats fed fatty acids-rich diets subjected to prolonged physical exercise-training. Physiol. Behav. 56:1049-1055, 1994.
185. Petrou, S., R.W. Ordway, M.T. Kirber, A.M. Dopico, J.A. Hamilton, J.V. Walsh, Jr., and J.J. Singer. Direct effects of fatty acids and other charged lipids on ion channel activity in smooth muscle cells. Prostaglandins Leiikot. Essent. Fatty Acids 52:173-178, 1995.
186. Plaut, M. The role of cyclic AMP in modulating cytotoxic T lymphocytes: I. In-vivo-generated cytotoxic lymphocytes, but not in vitro-generated cytotoxic lymphocytes, are inhibited by cyclic AMP-active agents. J. Immunol. 123:692-701, 1979.
187. Rhind, G.S., P.N. Shek, and R.J. Shephard. The impact of exercise on cytokines and receptor expression. Exerc. Immunol. Rev. 1:97-148.
188. Rivest, S., and N. Laflamme. Neuronal activity and neuropeptide gene transcription in the brains of immune-challenged rats. J. Neuroendocrinol. 7:501-525, 1995.
189. Robertson, J.D., R.J. Maughan, G.G. Duthie, and P.C. Morrice. Increased blood antioxidant systems of runners in response to training load. Clin. Sci. (Colch.) 80:611-618, 1991.
190. Robinson, D.R., M. Urakaze, R.Y. Huang, H. Taki, E. Sugiyama, C.T. Knoell, L.L. Xu, E.T.H. Yeh, and P.E. Auron. Dietary marine lipids suppress continuous expression of interleukin-1-beta gene transcription. Lipids 31:S23-S31, 1996.
191. Rubin, D., and M. Laposata. Cellular interactions between n-6 and n-3 fatty acids - A mass analysis of fatty acid elongation/desaturation, distribution among complex lipids, and conversion to eicosanoids. J. Lipid Res. 33:1431-1440, 1992.
192. Salo, D.C., C.M. Donovan, and K.J.A. Davies. HSP70 and other possible heat shock oroxidative stress proteins are induced in skeletal muscle, heart and liver during exercise. Free Radic. Biol. Med. 11:239-246, 1991.
193. Samuelsson, B. Leukotrienes: Mediators of immediate hypersensitivity reactions and inflammation. Science 220:568-575, 1983.
194. Samuelsson, B., S.E. Dahlen, J.A. Lindgren, C.A. Rouzer, and C.N. Serhan. Leukotrienes and lipoxins: Structures, biosynthesis, and biological effects. Science 237:1171-1176, 1987.
195. Samuelsson, B., J.Z. Haeggstrom, and A. Wetterholm. Leukotriene biosynthesis. Ann. N.Y. Acacl. Sci. 629:89-99, 1991.
196. Sanders, T.A., and F. Roshanai. The influence of different types of omega 3 polyunsaturated fatty acids on blood lipids and platelet function in healthy volunteers. Clin. Sci. (Colch.) 64:91-99, 1983.
197. Sanders, T.A.B. Effects on blood lipids and haemostasis of a supplement of cod-liver oil rich on eicosapentaenoic and docosahexaenoic acids in healthy young man. Clin. Sci. 61:317, 1981.
198. Sanders, T.A.B., and M.C. Hochland. A comparison of the influence on plasma lipids and platelet function of supplements of ω-3 and ω-6 polyunsaturated fatty acids. Br. J. Nutr. 50:521-529, 1983.
199. Sanders, T.A.B., and F. Roshani. The influence of different types of polyunsaturated fatty acidson blood lipids and platelet function in healthy volunteers. Clin. Sci. 64:91-99, 1983.
200. Santoli, D., and R.B. Zurier. Prostaglandin E precursor fatty acids inhibit human IL-2 production by a prostaglandin E-independent mechanism. J. Immunol. 143:1303-1309, 1989.
201. Schacky, C. von. Neue Aspekte in der diätetischen Prophylaxe der Atherosklerose [New aspects in dietary prevention of atherosclerosis]. Akt. Ernähr. 12:158-159, 1987.
202. Schreit, A.J., and R. Gallily. Macrophage fatty acid composition and phagocytosis: Effect of unsaturation on cellular phagocytic activity. Immunology 36:199-205, 1979.
203. Schroit, A.J., S. Rottem, and R. Gallily. Motion of spin-labeled fatty acids in murine macrophages: Relation to cellular phagocytic activity. Biochim. Biophys. Acta 426:499-512, 1976.
204. Schultz, R.M. The role of macrophage-derived arachidonic acid oxygenation products in the modulation of macrophage and lymphocyte function. In: The Reticuloendothelial System, J.W. Hadden and A. Szentivanyi (Eds.). New York: Plenum, 1985, p. 129.
205. Shephard, R.J., and P.N. Shek. Amino acids, dieting, glycogen, muscle injury, overtraining, reactive, and species: Heavy exercise, nutrition and immune function. Is there a connection. Int. J. Sports Med. 16:491-497, 1995.
206. Simoneau, J.A., G. Lortie, M.R. Boulay, M. Marcotte, M.C. Thibault, and C. Bouchard. Inheritance of human skeletal muscle and anaerobic capacity adaptation to high-intensity intermittent training. Int. J. Sports Med. 7:167-171, 1986.
207. Simopoulos, A.P. Omega-3 fatty acids in health and disease and in growth and development. Am. J. Clin. Nutr. 54:438-463, 1991.
208. Solito, E., and L. Parente. Modulation of phospholipase A2 activity in human fibroblasts. Br. J. Phannacol. 96:656-660, 1989.
209. Somjen, D., Y. Weisman, A. Harell, E. Berger, and A. M. Kaye. Direct and sex-specific stimulation by sex steroids of creatine kinase activity and DNA synthesis in rat bone. Proc. Natl. Acad. Seci. U.S.A. 86:3361-3365, 1989.
210. Spengler, R.N., M.L. Spengler, P. Lincoln, D.G. Remick, R.M. Stricter, and S.L. Kunkel. Dynamics of dibutyryl cyclic AMP- and prostaglandin E2-mediated suppression of lipopolysaccharide-induced tumor necrosis factor alpha gene expression. Infect. Immun. 57:2837-2841, 1989.
211. Spurney, R.F., P. Ruiz, C.R. Albrightson, D.S. Pisetsky, and T.M. Coffman. Fish oil feeding modulates leukotriene production in murine lupus nephritis. Prostaglandins 48:331-348, 1994.
212. Stamler, J. Assessing diets to improve world health: Nutritional research on disease causation in populations. Am. J. Clin. Nutr. 59(Suppl.):146S-156S, 1994.
213. Stephan, R.N., P.J. Conrad, M. Saizawa, R.E. Dean, and I.H. Chaudry. Prostaglandin E2 depresses antigen-presenting cell function of peritoneal macrophages. J. Surg. Res. 44:733-739, 1988.
214. Sternberg, E.M., G.P. Chrousos, R.L. Wilder, and P.W. Gold. The stress response and the regulation of inflammatory disease. Ann. Int. Med. 117:854-866, 1992.
215. Strasser, T., S. Fischer, and P.C. Weber. Leukotriene B5 is formed in human neutrophils after dietary supplementation with icosapentaenoic acid. Proc. Natl. Acad. Sci. U.S.A. 82:1540-1543, 1985.
216. Stubbs, C.D. Membrane fluidity: structure and dynamics of membrane lipids. Essays Biochem. 19:1-39, 1983.
217. Stubbs, C.D., and A.D. Smith. The modification of mammalian membrane polyunsaturated fatty acid composition in relation to membrane-fluidity and function. Biochim. Biophys. Acta 779:89-137, 1984.
218. Stubbs, C.D., and A.D. Smith. Essential fatty acids in membrane: Physical properties and function. Biochem. Soc. Trans. 18:779-781, 1990.
219. Sumida, C., R. Graber, and E. Nunez. Role of fatty acids in signal transduction: Modulators and messengers. Pmstaglandins Leukot. Essent. Fatty Acids 48:117-122, 1993.
220. Tappia, P. S., W. J. Man, and R. F. Grimble. Influence of unsaturated fatty acids on the production of tumour necrosis factor and interleukin-6 by rat peritoneal macrophages. Mol. Cell Biochem. 143:89-98, 1995.
221. Terblanche, S., T.D. Noakes, S.C. Dennis, D. Marais, and M. Eckert. Failure of magnesium supplementation to influence marathon running performance or recovery in magnesium-replete subjects. Int. J. Span. Nutr. 2:154-164, 1992.
222. Thomas, T.R., B.R. Londeree, K.O. Gerhardt, and C.W. Gehrke. Fatty acid profile and cholesterol in skeletal muscle of trained and untrained men. J. Appl. Phys.: Resp. Environ. Exerc. Physiol. 43:709-713, 1977.
223. Tomasi, T.B., F.B. Trudeau, D. Czerwinski, and S. Erredge. Immune parameters in athletes before and after strenuous exercise. J. Clin. Immunol. 2:173-178, 1982.
224. Traill, K.N., K. Ratheiser, R. Pfeilschifter, and G. Wick. Lymphocyte membrane lipid composition and mitogen responsiveness in chickens: Role of membrane "fluidity." Eur. J. Immunol. 16:75-82, 1986.
225. Turini, M.E., W.S. Powell, S.R. Behr, and B.J. Holub. Effects of a fish-oil and vegetable-oil formula on aggregation and ethanolamine-containing lysophospholipid generation in activated human platelets and on leukotriene production in stimulated neutrophils. Am. J. Clin. Nutr. 60:717-724, 1994.
226. Tvede, N., C. Heilmann, J. Halkjaer-Kristensen, and B.K. Pedersen. Mechanisms of B-lymphocyte suppression induced by acute physical exercise. J. Clin. Lab. Immunol. 30:169-173, 1989.
227. Tvede, N., B.K. Pedersen, FR. Hansen, T. Bendix, L.D. Christensen, H. Galbo, and J. Halkjaer-Kristensen. Effect of physical exercise on blood mononuclear cell subpopulations and in vitro proliferative responses. Scand. J Immunol. 29:383-389, 1989.
228. Ward, P.A., J.S. Warren, and K.J. Johnson. Oxygen radicals, inflammation, and tissue injury. Free Radic. Biol. Med. 5:403-408, 1988.
229. Watanabe, T., A. Morimoto, Y. Sakata, N.C. Long, and N. Murakami. Prostaglandin E2 is involved in adrenocorticotrophic hormone release during swimming exercise in rats. J. Physiol. (Lond.) 433:719-725, 1991.
230. Waymack, J.P., L.L. Moldawer, S.F. Lowry, R.F. Guzman, C.V. Okerberg, A.D. Mason, Jr., and B.A. Pruitt, Jr. Effect of prostaglandin E in multiple experimental models: IV. Effect on resistance to endotoxin and tumor necrosis factor shock. J. Surg. Res. 49:328-332, 1990.
231. Weber, P.C., and A. Sellmayer. Modification of the eicosanoid system and cell signalling by precursor fatty acids. Prostaglandins Related Comp. 21:217-224, 1991.
232. Weicker, H., and E. Werle. Interaction between hormones and the immune system. Int. J. Sports Med. 12:S30-S37, 1991.
233. Weinstock, C., D. König, R. Harnischmacher, J. Keul, A. Berg, and H. Northoff. The effect of exhaustive exercise stress on the cytokine response. Med Sci. Sports Exerc. in press.
234. Wilson, J.R., and S.C. Kapoor. Contribution of prostaglandins to exercise-induced vasodilation in humans. Am. J. Physiol. 265:H171-H175, 1993.
235. Wolfram, G. Bedeutung der n-3 Fettsäuren in der Ernährung der Menschen [The importance of n-3 fatty acids in human nutrition]. Emähmngs-Umschau. 36:319-330, 1989.
236. Zierler, K. Fatty acids as substrates for heart and skeletal muscle. Circul. Res. 38:459-463, 1967.
237. Zurier, R.B. Fatty acids, inflammation and immune responses. Prostaglandins Leukot. Essent. Fatty Acids 48:57-62, 1993.