메뉴 건너뛰기




Volumn 159, Issue 7, 1997, Pages 3133-3139

B Cells Genetically Deficient in the c-Rel Transactivation Domain Have Selective Defects in Germline CH Transcription and Ig Class Switching

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN A; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; IMMUNOGLOBULIN HEAVY CHAIN; LIPOPOLYSACCHARIDE; ONCOPROTEIN; RNA; TRANSCRIPTION FACTOR REL;

EID: 0031252287     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (75)

References (44)
  • 1
    • 0028985037 scopus 로고
    • NF-κB and Rel proteins in innate immunity
    • Kopp, E. B., and S. Ghosh. 1995. NF-κB and Rel proteins in innate immunity. Adv. Immunol. 58:1.
    • (1995) Adv. Immunol. , vol.58 , pp. 1
    • Kopp, E.B.1    Ghosh, S.2
  • 2
    • 0027232067 scopus 로고
    • NF-κB and Rel: Participants in a multiform transcriptional regulatory system
    • Grilli, M., J.-S. Chiu, and M. J. Lenardo. 1993. NF-κB and Rel: participants in a multiform transcriptional regulatory system. Int. Rev. Cytol. 143:1.
    • (1993) Int. Rev. Cytol. , vol.143 , pp. 1
    • Grilli, M.1    Chiu, J.-S.2    Lenardo, M.J.3
  • 3
    • 0028174061 scopus 로고
    • Function and activation of NF-κB in the immune system
    • Baeuerle, P. A., and T. Henkel. 1994. Function and activation of NF-κB in the immune system. Annu. Rev. Immunol. 12:141.
    • (1994) Annu. Rev. Immunol. , vol.12 , pp. 141
    • Baeuerle, P.A.1    Henkel, T.2
  • 4
    • 0029874138 scopus 로고    scopus 로고
    • The NF-κB and IκB proteins: New discoveries and insights
    • Baldwin, A. S., Jr. 1996. The NF-κB and IκB proteins: new discoveries and insights. Annu. Rev. Immunol. 14:649.
    • (1996) Annu. Rev. Immunol. , vol.14 , pp. 649
    • Baldwin Jr., A.S.1
  • 5
    • 0028971289 scopus 로고
    • Rel/NF-kappa B/I kappa B family: Intimate tales of association and dissociation
    • Verma, I. M., J. K. Stevenson, E. M. Schwarz, D. van Antwerp, and S. Miyamoto. 1995. Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation. Genes Dev. 9:2723.
    • (1995) Genes Dev. , vol.9 , pp. 2723
    • Verma, I.M.1    Stevenson, J.K.2    Schwarz, E.M.3    Van Antwerp, D.4    Miyamoto, S.5
  • 6
    • 0026012185 scopus 로고
    • Cross-linking of surface IgM activates NF-κB in B lymphocytes
    • Rooney, J. W., P. M. Dubois, and C. H. Sibley. 1991. Cross-linking of surface IgM activates NF-κB in B lymphocytes. Eur. J. Immunol. 21:2993.
    • (1991) Eur. J. Immunol. , vol.21 , pp. 2993
    • Rooney, J.W.1    Dubois, P.M.2    Sibley, C.H.3
  • 8
    • 0028152658 scopus 로고
    • Cross-linking CD40 on B cells rapidly activates nuclear factors-κB1
    • Berberich, I. G., L. Shu, and E. A. Clark. 1994. Cross-linking CD40 on B cells rapidly activates nuclear factors-κB1. J. Immunol. 153:4357.
    • (1994) J. Immunol. , vol.153 , pp. 4357
    • Berberich, I.G.1    Shu, L.2    Clark, E.A.3
  • 9
    • 0028169302 scopus 로고
    • Sequential induction of NF-κB/Rel family proteins during B-cell terminal differentiation
    • Liou, H.-C., W. C. Sha, M. L. Scott, and D. Baltimore. 1994. Sequential induction of NF-κB/Rel family proteins during B-cell terminal differentiation. Mol. Cell. Biol. 14:5349.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 5349
    • Liou, H.-C.1    Sha, W.C.2    Scott, M.L.3    Baltimore, D.4
  • 10
    • 0028154853 scopus 로고
    • The subunit composition of NF-κB complexes changes during B-cell development
    • Grumont, R. J., and S. Gerondakis. 1994. The subunit composition of NF-κB complexes changes during B-cell development. Cell Growth Differ. 5:1321.
    • (1994) Cell Growth Differ. , vol.5 , pp. 1321
    • Grumont, R.J.1    Gerondakis, S.2
  • 11
    • 0027984087 scopus 로고
    • Developmental expression of the mouse c-rel proto-oncogene in hematopoietic organs
    • Carrasco, D., F. Weih, and R. Bravo. 1994. Developmental expression of the mouse c-rel proto-oncogene in hematopoietic organs. Development 120:2991.
    • (1994) Development , vol.120 , pp. 2991
    • Carrasco, D.1    Weih, F.2    Bravo, R.3
  • 12
    • 0028804551 scopus 로고
    • Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses
    • Sha, W. C., H.-C. Liou, E. I. Tuomanen, and D. Baltimore. 1995. Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses. Cell 80:321.
    • (1995) Cell , vol.80 , pp. 321
    • Sha, W.C.1    Liou, H.-C.2    Tuomanen, E.I.3    Baltimore, D.4
  • 14
    • 0029150389 scopus 로고
    • Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression
    • Kontgen, F., R. J. Grumont, A. Strasser, D. Metcalf, R. Li, D. Tarlington, and S. Gerondakis. 1995. Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression. Genes Dev. 9:1965.
    • (1995) Genes Dev. , vol.9 , pp. 1965
    • Kontgen, F.1    Grumont, R.J.2    Strasser, A.3    Metcalf, D.4    Li, R.5    Tarlington, D.6    Gerondakis, S.7
  • 15
    • 0029903486 scopus 로고    scopus 로고
    • B cells lacking RelB are defective in proliferative responses, but undergo normal B cell maturation to Ig secretion and Ig class switching
    • Snapper, C. M., F. R. Rosas, P. Zelazowski, M. A. Moorman, M. R. Kehry, R. Bravo, and F. Weih. 1996. B cells lacking RelB are defective in proliferative responses, but undergo normal B cell maturation to Ig secretion and Ig class switching. J. Exp. Med. 184:1537.
    • (1996) J. Exp. Med. , vol.184 , pp. 1537
    • Snapper, C.M.1    Rosas, F.R.2    Zelazowski, P.3    Moorman, M.A.4    Kehry, M.R.5    Bravo, R.6    Weih, F.7
  • 16
    • 0028917885 scopus 로고
    • Characterization of an interleukin 4 (IL-4) responsive region in the immunoglobulin heavy chain germline ε promoter: Regulation by NF-IL-4, a C/EBP family member and NF-κB/p50
    • Delphin, S., and J. Stavnezer. 1995. Characterization of an interleukin 4 (IL-4) responsive region in the immunoglobulin heavy chain germline ε promoter: regulation by NF-IL-4, a C/EBP family member and NF-κB/p50. J. Exp. Med. 181: 181.
    • (1995) J. Exp. Med. , vol.181 , pp. 181
    • Delphin, S.1    Stavnezer, J.2
  • 17
    • 0025943189 scopus 로고
    • Structure and expression of mouse germline immunoglobulin γ3 heavy chain transcripts induced by the mitogen lipopolysaccharide
    • Gerondakis, S., C. Gaff, D. J. Goodman, and R. J. Gramont. 1991. Structure and expression of mouse germline immunoglobulin γ3 heavy chain transcripts induced by the mitogen lipopolysaccharide. Immunogenetics 34:392.
    • (1991) Immunogenetics , vol.34 , pp. 392
    • Gerondakis, S.1    Gaff, C.2    Goodman, D.J.3    Gramont, R.J.4
  • 18
    • 0029664798 scopus 로고    scopus 로고
    • Activation of NF-κB/Rel by CD40 engagement induces the mouse germ line immunoglobulin Cγ1 promoter
    • Lin, S.-C., and J. Stavnezer. 1996. Activation of NF-κB/Rel by CD40 engagement induces the mouse germ line immunoglobulin Cγ1 promoter. Mol. Cell. Biol. 16:4591.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 4591
    • Lin, S.-C.1    Stavnezer, J.2
  • 19
    • 0030584725 scopus 로고    scopus 로고
    • Regulation of 3′ IgH enhancers by a common set of factors, including κB-binding proteins
    • Michaelson, J. S., M. Singh, C. M. Snapper, W. C. Sha, D. Baltimore, and B. K. Birshtein. 1996. Regulation of 3′ IgH enhancers by a common set of factors, including κB-binding proteins. J. Immunol. 156:2828.
    • (1996) J. Immunol. , vol.156 , pp. 2828
    • Michaelson, J.S.1    Singh, M.2    Snapper, C.M.3    Sha, W.C.4    Baltimore, D.5    Birshtein, B.K.6
  • 20
    • 0027519483 scopus 로고
    • Switch recombination breakpoints occur at nonrandom positions in the Sγ tandem repeat
    • Kenter, A. L., R. Wuerffel, R. Sen, C. E. Jamieson, and G. V. Merkulov. 1993. Switch recombination breakpoints occur at nonrandom positions in the Sγ tandem repeat. J. Immunol. 151:4718.
    • (1993) J. Immunol. , vol.151 , pp. 4718
    • Kenter, A.L.1    Wuerffel, R.2    Sen, R.3    Jamieson, C.E.4    Merkulov, G.V.5
  • 21
    • 0026770992 scopus 로고
    • Switch recombination breakpoints are strictly correlated with DNA recognition motifs for immunoglobulin Sγ3 DNA-binding proteins
    • Wuerffel, R., C. E. Jamieson, L. Morgan, G. V. Merkulov, R. Sen, and A. L. Kenter. 1992. Switch recombination breakpoints are strictly correlated with DNA recognition motifs for immunoglobulin Sγ3 DNA-binding proteins. J. Exp. Med. 176:339.
    • (1992) J. Exp. Med. , vol.176 , pp. 339
    • Wuerffel, R.1    Jamieson, C.E.2    Morgan, L.3    Merkulov, G.V.4    Sen, R.5    Kenter, A.L.6
  • 22
    • 0025215091 scopus 로고
    • Detection of an immunoglobulin switch region-specific DNA-binding protein in mitogen-stimulated mouse splenic B cells
    • Wuerffel, R. A., A. T. Nathan, and A. L. Kenter. 1990. Detection of an immunoglobulin switch region-specific DNA-binding protein in mitogen-stimulated mouse splenic B cells. Mol. Cell. Biol. 10:1714.
    • (1990) Mol. Cell. Biol. , vol.10 , pp. 1714
    • Wuerffel, R.A.1    Nathan, A.T.2    Kenter, A.L.3
  • 23
    • 0023887424 scopus 로고
    • Picogram quantities of anti-Ig antibodies coupled to dextran induce B cell proliferation
    • Brunswick, M., F. D. Finkelman, P. F. Highet, J. K. Inman, H. M. Dintzis, and J. J. Mond. 1988. Picogram quantities of anti-Ig antibodies coupled to dextran induce B cell proliferation. J. Immunol. 140:3364.
    • (1988) J. Immunol. , vol.140 , pp. 3364
    • Brunswick, M.1    Finkelman, F.D.2    Highet, P.F.3    Inman, J.K.4    Dintzis, H.M.5    Mond, J.J.6
  • 24
    • 0023787454 scopus 로고
    • Anti-IgE monoclonal antibodies directed at the Fcε receptor binding site
    • Baniyash, M., M. Kehry, and Z. Eshhar. 1988. Anti-IgE monoclonal antibodies directed at the Fcε receptor binding site. Mol. Immunol. 25:705.
    • (1988) Mol. Immunol. , vol.25 , pp. 705
    • Baniyash, M.1    Kehry, M.2    Eshhar, Z.3
  • 26
    • 0028177788 scopus 로고
    • IFN-γ represses ε germline transcription and subsequently down-regulales switch recombination to ε
    • Xu, L., and P. Rothman. 1994. IFN-γ represses ε germline transcription and subsequently down-regulales switch recombination to ε. Int. Immunol. 6:515.
    • (1994) Int. Immunol. , vol.6 , pp. 515
    • Xu, L.1    Rothman, P.2
  • 27
    • 0023889066 scopus 로고
    • Mitogen-and IL-4-regulated expression of germ-line Ig γ2b transcripts: Evidence for directed heavy chain class switching
    • Lutzker, S., P. Rothman, R. Pollock, R. Coffman, and F. W. Alt. 1988. Mitogen-and IL-4-regulated expression of germ-line Ig γ2b transcripts: evidence for directed heavy chain class switching. Cell 53:177.
    • (1988) Cell , vol.53 , pp. 177
    • Lutzker, S.1    Rothman, P.2    Pollock, R.3    Coffman, R.4    Alt, F.W.5
  • 28
    • 0027240518 scopus 로고
    • Germline transcripts of the murine immunoglobulin γ2a gene: Structure and induction by IFN-γ
    • Collins, J. T., and W. A. Dunnick. 1993. Germline transcripts of the murine immunoglobulin γ2a gene: structure and induction by IFN-γ. Int. Immunol. 5: 885.
    • (1993) Int. Immunol. , vol.5 , pp. 885
    • Collins, J.T.1    Dunnick, W.A.2
  • 29
    • 0017187483 scopus 로고
    • B lymphocyte differentiation induced by lipopolysaccharide. III. Suppression of B cell maturation by antimouse immunoglobulin antibodies
    • Kearney, J. F., M. D. Cooper, and A. Lawton. 1976. B lymphocyte differentiation induced by lipopolysaccharide. III. Suppression of B cell maturation by antimouse immunoglobulin antibodies. J. Immunol. 116:1664.
    • (1976) J. Immunol. , vol.116 , pp. 1664
    • Kearney, J.F.1    Cooper, M.D.2    Lawton, A.3
  • 30
    • 0020031839 scopus 로고
    • T cell-derived B cell differentiation factor(s): Effect on the isotype switch of murine B cells
    • Isakson, P. C., E. Pure, E. S. Vitetta, and P. H. Krammer. 1982. T cell-derived B cell differentiation factor(s): effect on the isotype switch of murine B cells. J. Exp. Med. 155:734.
    • (1982) J. Exp. Med. , vol.155 , pp. 734
    • Isakson, P.C.1    Pure, E.2    Vitetta, E.S.3    Krammer, P.H.4
  • 31
    • 0022625666 scopus 로고
    • A T cell activity that enhances polyclonal IgE production and its inhibition by interferon-γ
    • Coffman, R. L., and J. Carty. 1986. A T cell activity that enhances polyclonal IgE production and its inhibition by interferon-γ. J. Immunol. 136:949.
    • (1986) J. Immunol. , vol.136 , pp. 949
    • Coffman, R.L.1    Carty, J.2
  • 32
    • 0024446350 scopus 로고
    • Transforming growth factor β specifically enhances IgA production by lipopolysaccharide-stimulated murine B lymphocytes
    • Coffman, R. L., D. A. Lebman, and B. Shrader. 1989. Transforming growth factor β specifically enhances IgA production by lipopolysaccharide-stimulated murine B lymphocytes. J. Exp. Med. 170:1039.
    • (1989) J. Exp. Med. , vol.170 , pp. 1039
    • Coffman, R.L.1    Lebman, D.A.2    Shrader, B.3
  • 33
    • 0028916191 scopus 로고
    • Novel in vitro model for high-rate IgA class switching
    • McIntyre, T. M., M. R. Kehry, and C. M. Snapper. 1995. Novel in vitro model for high-rate IgA class switching. J. Immunol. 154:3156.
    • (1995) J. Immunol. , vol.154 , pp. 3156
    • McIntyre, T.M.1    Kehry, M.R.2    Snapper, C.M.3
  • 34
    • 0026636784 scopus 로고
    • Quantitation of immunoglobulin μ-μ1 heavy chain switch region recombination by a digestion-circularization polymerase chain reaction method
    • Chu, C. C., W. E. Paul, and E. E. Max. 1992. Quantitation of immunoglobulin μ-μ1 heavy chain switch region recombination by a digestion-circularization polymerase chain reaction method. Proc. Natl. Acad. Sci. USA 89:6978.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 6978
    • Chu, C.C.1    Paul, W.E.2    Max, E.E.3
  • 35
    • 0022599997 scopus 로고
    • Specificity of immunoglobulin heavy chain switch correlates with activity of germline heavy chain genes prior to switching
    • Stavnezer-Nordgren, I., and S. Sirlin. 1986. Specificity of immunoglobulin heavy chain switch correlates with activity of germline heavy chain genes prior to switching. EMBO J. 5:95.
    • (1986) EMBO J. , vol.5 , pp. 95
    • Stavnezer-Nordgren, I.1    Sirlin, S.2
  • 37
    • 0030933777 scopus 로고    scopus 로고
    • The Ig class switch: Beyond "accessibility."
    • Snapper, C. M., K. B. Marcu, and P. Zelazowski. 1997. The Ig class switch: beyond "accessibility." Immunity 6:217.
    • (1997) Immunity , vol.6 , pp. 217
    • Snapper, C.M.1    Marcu, K.B.2    Zelazowski, P.3
  • 38
    • 0025315540 scopus 로고
    • Structure and expression of germline immunoglobulin γ3 heavy chain gene transcripts: Implications for mitogen and lymphokine directed class-switching
    • Rothman, P., S. Lutzker, B. Gorham, V. Stewart, R. Coffman, and F. W. Alt. 1990. Structure and expression of germline immunoglobulin γ3 heavy chain gene transcripts: implications for mitogen and lymphokine directed class-switching. Int. Immunol. 2:621.
    • (1990) Int. Immunol. , vol.2 , pp. 621
    • Rothman, P.1    Lutzker, S.2    Gorham, B.3    Stewart, V.4    Coffman, R.5    Alt, F.W.6
  • 40
    • 0024231914 scopus 로고
    • Mitogen plus interleukin 4 induction of Cε transcripts in B lymphoid cells
    • Rothman, P., S. Lutzker, W. Cook, R. Coffman, and F. W. Alt. 1988. Mitogen plus interleukin 4 induction of Cε transcripts in B lymphoid cells. J. Exp. Med. 168:2385.
    • (1988) J. Exp. Med. , vol.168 , pp. 2385
    • Rothman, P.1    Lutzker, S.2    Cook, W.3    Coffman, R.4    Alt, F.W.5
  • 41
    • 0025329369 scopus 로고
    • Molecular characterization of germ-line immunoglobulin A transcripts produced during transforming growth factor type β-induced isotype switching
    • Lebman, D. A., D. Y. Nomura, R. L. Coffman, and F. D. Lee. 1990. Molecular characterization of germ-line immunoglobulin A transcripts produced during transforming growth factor type β-induced isotype switching. Proc. Natl. Acad. Sci. USA 87:3962.
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 3962
    • Lebman, D.A.1    Nomura, D.Y.2    Coffman, R.L.3    Lee, F.D.4
  • 42
    • 0000268309 scopus 로고
    • Immunoglobulin class switching
    • W. E. Paul, ed. Raven Press, New York
    • Snapper, C. M., and F. D. Finkelman. 1993. Immunoglobulin class switching. In Fundamental Immunology, 3rd Ed. W. E. Paul, ed. Raven Press, New York, pp. 837-863.
    • (1993) Fundamental Immunology, 3rd Ed. , pp. 837-863
    • Snapper, C.M.1    Finkelman, F.D.2
  • 43
    • 0027969316 scopus 로고
    • Identification of a locus control region in the immunoglobulin heavy-chain locus that deregulates c-myc expression in plasmacytoma and Burkitt's lymphoma cells
    • Madisen, L., and M. Groudine. 1994. Identification of a locus control region in the immunoglobulin heavy-chain locus that deregulates c-myc expression in plasmacytoma and Burkitt's lymphoma cells. Genes Dev. 8:2212.
    • (1994) Genes Dev. , vol.8 , pp. 2212
    • Madisen, L.1    Groudine, M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.