Activation of p21-CDC42/Rac-activated kinases by CD28 signaling: p21- activated kinase (PAK) and MEK kinase 1 (MEKK1) may mediate the interplay between CD3 and CD28 signals

Journal of Immunology

Volumn 160, Issue 9, 1998, Pages 4182-4189

  Kaga, Shuji ^a,b,c   Ragg, Scott ^a,b   Rogers, Kem A ^b   Ochi, Atsuo ^a,b  

^a ROBARTS RESEARCH INSTITUTE   (Canada)

^b UNIVERSITY OF WESTERN ONTARIO   (Canada)

^c SHOWA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CD28 ANTIGEN; CD3 ANTIGEN; CELL SURFACE RECEPTOR; CERAMIDE; GUANINE NUCLEOTIDE BINDING PROTEIN; INTERLEUKIN 2; PROTEIN P21; T LYMPHOCYTE RECEPTOR;

ARTICLE; AUTOPHOSPHORYLATION; CELL PROLIFERATION; CELL SURFACE; CYTOKINE PRODUCTION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION;

ANTIGENS, CD28; ANTIGENS, CD3; HUMANS; JURKAT CELLS; LYMPHOCYTE ACTIVATION; MAP KINASE KINASE KINASE 1; PROTEIN-SERINE-THREONINE KINASES; PROTEIN-TYROSINE KINASES; SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

EID: 0032080604     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (44)

1. Davis, M. M., and P. J. Bjorkman. 1988. T cell antigen receptor genes and T cell recognition. Nature 334:395.
2. Cantrell, D. 1996. T cell antigen receptor signal transduction pathways. Annu. Rev. Immunol. 14:259.
3. Fraser, J. D., D. Straus, and A. Weiss. 1993. Signal transduction events leading to T-cell lymphokine gene expression. Immunol. Today 14:357.
4. Aruffo, A., and B. Seed. 1987. Molecular cloning of a CD28 cDNA by a high-efficiency COS cell expression system. Proc. Natl. Acad. Sci. USA 84:8573.
5. August, A., and B. Dupont. 1995. CD28 of T lymphocytes associates with phosphatidylinositol 3-kinase. Int. Immunol 6:769.
6. Truitt, K. E., C. M. Hicks, and J. B. Imboden. 1994. Stimulation of CD28 triggers an association between CD28 and phosphatidylinositol 3-kinase in Jurkat cells. J. Exp. Med. 179:1071.
7. Prasad, K. V. S., Y.-C. Cai, M. Raab, B. Duckworth, L. Cantley, S. E. Shoelson, and C. E. Rudd. 1994. T-cell antigen CD28 interacts with the lipid kinase phosphatidylinositol 3-kinase by a cytoplasmic Tyr(P)-Met-Xaa-Met motif. Proc. Natl. Acad. Sci. USA 91:2834.
8. Crooks, M. E., D. R. Littman, R. H. Carter, D. T. Fearon, A. Weiss, and P. E. Stein. 1995. CD28-mediated costimulation in the absence of phosphatidylinositol 3-kinase association and activation. Mol. Cell. Biol. 15:6820.
9. Lu, Y., C. A. Phillips, and J. M. Trevillyan. 1995. Phosphatidylinositol 3-kinase activity is not essential for CD28 costimulatory activity in Jurkat T cells: studies with a selective inhibitor, wortmannin. Eur. J. Immunol. 25:533.
10. Hutchcroft, J. E., D. P. Franklin, B. Tsai, D. Harrison-Findik, L. Varticovski, and B. E. Bierer. 1995. Phorbol ester treatment inhibits phosphatidylinositol 3-kinase activation by, and association with, CD28, a T-lymphocyte surface receptor. Proc. Natl. Acad. Sci. USA 92:8808.
11. Nunès, J. A., Y. Collette, A. Truneh, D. Olive, and D. A. Cantrell. 1994. The role of p21ras in CD28 signal transduction: triggering of CD28 with antibodies, but not the ligand B7-1, activates p21ras. J. Exp. Med. 180:1067.
12. Boucher, L.-M., K. Wiegmann, A. Fütterer, K. Pfeffer, T. Machleidt, S. Shütze, T. W. Mak, and M. Krönke. 1995. CD28 signals through acidic sphingomyelinase. J. Exp. Med. 181:2059.
13. Chan, G., and A. Ochi. 1995. Sphingomyelin-ceramide turnover in CD28 co-stimulatory signalling. Eur. J. Immunol. 25:1999.
14. Ballou, L. R., S. J. F. Laulederkind, E. F. Rosloniec, and R. Raghow. 1996. Ceramide signalling and the immune response. Biochim. Biophys. Acta 1301:273.
15. Mathias, S., A. Younes, C. Kan, I. Orlow, C. Joseph, and R. N. Kolesnick. 1993. Activation of the sphingomyelin signalling pathway in intact EL4 cells and in a cell-free system by IL-1β. Science 259:519.
16. Westwick, J. K., A. E. Bielawska, G. Dbaibo, Y. A. Hannun, and D. A. Brenner. 1995. Ceramide activates the stress-activated protein kinases. J. Biol. Chem. 270: 22689.
17. Verheij, M., R. Bose, X. H. Lin, B. Yao, W. D. Jarvis, S. Grant, M. J. Birrer, E. Szabo, L. I. Zon, J. M. Kyriakis, A. Haimovitz-Friedman, Z. Fuks, and R. N. Kolesnick. 1996. Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis. Nature 380:75.
18. Su, B., E. Jacinto, M. Hibi, T. Kallunki, M. Karin, and Y. Ben-Neriah. 1994. JNK is involved in signal integration during costimulation of T lymphocytes. Cell 77:727.
19. Brenner, B., U. Koppenhoefer, C. Weinstock, O. Linderkamp, F. Lang, and E. Gulbins. 1997. Fas-or ceramide-induced apoptosis is mediated by a Rac1-regulated activation of Jun N-terminal kinase/p38 kinases and GADD153. J. Biol. Chem. 272:22173.
20. Fanger, G. R., P. Gerwins, C. Widmann, M. B. Jarpe, and G. L. Johnson. 1997. MEKKs, GCKs, MLKs, PAKs, TAKs, and Tp1s: upstream regulators of the c-Jun amino-terminal kinases? Curr. Opin. Genet. Dev. 7:67.
21. Faris, M., N. Kokot, L. Lee, and A. E. Nel. 1996. Regulation of interleukin-2 transcription by inducible stable expression of dominant negative and dominant active mitogen-activated protein kinase kinase kinase in Jurkat T cells: evidence for the importance of Ras in a pathway that is controlled by dual receptor stimulation. J. Biol. Chem. 271:27366.
22. Nishina, H., M. Bachmann, A. J. Oliveira-dos-Santos, I. Kozieradzki, K. D. Fischer, B. Odermatt, A. Wakeham, A. Shahinian, H. Takimoto, A. Bernstein, T. W. Mak, J. R. Woodgett, P. S. Ohashi, and J. M. Penninger. 1997. Impaired CD28-mediated interleukin 2 production and proliferation in stress kinase SAPK/ERK1 kinase (SEK1)/mitogen-activated protein kinase kinase 4 (MKK4)-deficient T lymphocytes. J. Exp. Med. 186:941.
23. Ridley, A. J., and A. Hall. 1992. The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. Cell 70:389.
24. Kaga, S., S. Ragg, K. A. Rogers, and A. Ochi. 1998. Stimulation of CD28 with B7-2 promotes focal adhesion-like cell contacts where Rho family small G proteins accumulates in T cells. J. Immunol. 160:24.
25. Herskowitz, I. 1995. MAP kinase pathways in yeast: for mating and more. Cell 80:187.
26. Xu, S., D. J. Robbins, L. B. Christerson, J. M. English, C. A Vanderbilt, and M. H. Cobb. 1996. Cloning of rat MEK kinase 1 cDNA reveals an endogenous membrane-associated 195-kDa protein with a large regulatory domain. Proc. Natl. Acad. Sci. USA 93:5291.
27. Hannun, Y. A. 1994. The sphingomyelin cycle and the second messenger function of ceramide. J. Biol. Chem. 269:3125.
28. Hill, C. S., and R. Treisman. 1995. Transcriptional regulation by extracellular signals: mechanisms and specificity. Cell 80:199.
29. Chant, J., and L. Stower. 1995. GTPase cascades choreographing cellular behavior: movement, morphogenesis, and more. Cell 81:1.
30. Nobes, C. D., and A. Hall. 1995. Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. Cell 81:53.
31. Ridley, A. J., H. F. Paterson, C. L. Johnston, D. Diekman, and A. Hall. 1992. The small GTP-binding protein Rac regulates growth factor-induced membrane ruffling. Cell 70:401.
32. Qiu, R.-G., J. Chen, D. Kirn, F. MacCormick, and M. Symons. 1995. An essential role for Rac in Ras transformation. Nature 374:457.
33. rasGTP complex in Swiss mouse 3T3 cells. Proc. Natl. Acad. Sci. USA 87:5993.
34. Hawkins, P. T., A. Eguinoa, R.-G. Qiu., D. Stokoe, F. T. Cooke, R. Walters, S. Wennström, L. Claesson-Welsh, T. Evans, M. Symons, and L. Stephens. 1995. PDGF stimulates an increase in GTP-Rac via activation of phosphoinositide 3-kinase. Curr. Biol. 5:393.
35. ras upon T-cell activation. Nature 346:719.
36. Siow, Y. L., G. B. Kalmar, J. S. Sanghera, G. Tai, S. S. Oh, and S. L. Pelech. 1997. Identification of two essential phosphorylated threonine residues in the catalytic domain of Mekk1: indirect activation by Pak3 and protein kinase C. J. Biol. Chem. 272:7586.
37. Fanger, G. R., N. L. Johnson, and G. L. Johnson. 1997. MEK kinases are regulated by EGF and selectively interact with Rac/Cdc42. EMBO J. 16:4961.
38. Cardone, M. H., G. S. Salvesen, C. Widmann, G. Johnson, and S. M. Frisch. 1997. The regulation of anoikis: MEKK-1 activation requires cleavage by caspases. Cell 90:315.
39. Hannun, Y. A., and L. M. Obeid. 1995. Ceramide: an intracellular signal for apoptosis. Trends Biochem. Sci. 20:73.
40. Kolesnick, R., and Z. Fuks. 1995. Ceramide: a signal for apoptosis or mitogenesis? J. Exp. Med. 181:1949.
41. Xia, Z., M. Dickens, J. Raingeaud, R. J. Davis, and M. E. Greenberg. 1995. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 270: 1326.
42. Marshall, C. J. 1995. Specificity of receptor tyrosine kinase signalling: transient versus sustained extracellular signal-regulated kinase activation. Cell 80:179.
43. Rodriguez-Viciana, P., P. H. Warne, R. Dhand, B. Vanhaesebroeck, I. Gout, M. J. Fry, M. D. Waterfield, and J. Downward. 1994. Phosphatidylinositol-3-OH kinase as a direct target of Ras. Nature 370:527.
44. Chuang, T.-H., B. P. Bohl, and G. M. Bokoch. 1993. Biologically active lipids are regulators of Rac · GDI complexation. J. Biol. Chem. 268:26206.