Adenosine A2 receptor function in rat ventricular myocytes

Cardiovascular Research

Volumn 34, Issue 2, 1997, Pages 337-347

  Dobson Jr , James G ^a   Fenton, Richard A ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

Adenosine; Adenosine receptor; Adenosine receptor antagonists; Adenylyl cyclase; Adrenergic receptors; c AMP; Contractility; Isoproterenol; Rat; ventricular myocytes

Indexed keywords

2 [4 (2 CARBOXYETHYL)PHENETHYLAMINO]ADENOSINE 5' (N ETHYLCARBOXAMIDE); 8 CYCLOPENTYL 1,3 DIPROPYLXANTHINE; 9 CHLORO 2 (2 FURYL) 5,6 DIHYDRO 5 IMINO 1,2,4 TRIAZOLO[2,3 C]QUINAZOLINE; ADENOSINE; ADENOSINE 5' (N ETHYLCARBOXAMIDE); ADENOSINE A1 RECEPTOR; ADENOSINE A2 RECEPTOR; ADENYLATE CYCLASE; BETA ADRENERGIC RECEPTOR; CYCLIC AMP; ISOPRENALINE; PHENYLISOPROPYLADENOSINE; ADENOSINE RECEPTOR; ANTIHYPERTENSIVE AGENT; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; DRUG DERIVATIVE; PHENETHYLAMINE DERIVATIVE; PURINE P2 RECEPTOR; VASODILATOR AGENT;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; HEART MUSCLE CELL; HEART MUSCLE CONTRACTILITY; HEART VENTRICLE; INOTROPISM; NONHUMAN; PRIORITY JOURNAL; RAT; ANIMAL; CELL CULTURE; DRUG EFFECT; DRUG POTENTIATION; HEART CONTRACTION; HEART MUSCLE; METABOLISM; SPRAGUE DAWLEY RAT; STIMULATION;

ADENOSINE; ADENOSINE-5'-(N-ETHYLCARBOXAMIDE); ADENYLATE CYCLASE; ADRENERGIC BETA-AGONISTS; ANIMALS; ANTIHYPERTENSIVE AGENTS; CELLS, CULTURED; CYCLIC AMP; HEART VENTRICLES; ISOPROTERENOL; MYOCARDIAL CONTRACTION; MYOCARDIUM; PHENETHYLAMINES; PHENYLISOPROPYLADENOSINE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, PURINERGIC P1; RECEPTORS, PURINERGIC P2; STIMULATION, CHEMICAL; VASODILATOR AGENTS;

EID: 0030612311     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0008-6363(97)00023-0     Document Type: Article

References (36)

1. Schrader J, Baumann G, Gerlach E. Adenosine as inhibitor of myocardial effects of catecholamines. Pflügers Arch 1977;372:29-35.
2. Dobson JG, Jr. Mechanism of adenosine inhibition of catecholamine-induced elicited responses in heart. Circ Res 1983;52:151-160.
3. Belardinelli L, Linden J, Berne RM. The cardiac effects of adenosine. Prog Cardiovasc Dis 1989;32:73-97.
4. Romano FD, Macdonald SG, Dobson JG, Jr. Adenosine receptor coupling to adenylate cyclase of rat ventricular myocyte membranes. Am J Physiol 1989;257:H1088-H1095.
5. 2+ transients of isoproterenol-stimulated rat ventricular myocytes. Am J Physiol 1991;261:C1107-C1114.
6. Dobson JG, Jr, Fenton RA. Antiadrenergic effects of adenosine in the heart. In: Berne RM, Rall TW, Rubio R, eds. Regulatory Function of Adenosine. Boston: Nijhoff, 1983:363-376.
7. Fenton RA, Dobson JG, Jr. Adenosine and calcium alter adrenergic-induced intact heart protein phosphorylation. Am J Physiol 1984;246:H559-H565.
8. George EE, Romano FD, Dobson JG, Jr. Adenosine and acetyl-choline reduce isoproterenol-induced protein phosphorylation of rat myocytes. J Mol Cell Cardiol 1991;23:749-764.
9. Dobson JG, Jr. Adenosine reduces catecholamine contractile responses in oxygenated and hypoxic atria. Am J Physiol 1983;245:H468-H474.
10. Dobson JG, Jr. Interaction between adenosine and inotropic interventions in guinea pig atria. Am J Physiol 1983;245:H475-H480.
11. Berne RM. The role of adenosine in the regulation of coronary blood flow. Circ Res 1980;47:807-813.
12. Xu D, Kong H, Liang BT. Expression and pharmacological characterization of a stimulatory subtype of adenosine receptor in fetal chick ventricular myocytes. Circ Res 1992;70:56-65.
13. 2a receptor in adult rat ventricular myocyte. Am J Physiol 1996;270:H1655-H1661.
14. 2-adenosine receptors on ventricular cardiomyocytes. J Mol Cell Cardiol 1993;25:655-659.
15. 2-adenosine receptors in guinea pig ventricular myocytes. J Mol Cell Cardiol 1994;26:403-414.
16. 2 adenosine receptors on guinea pig ventricular myocytes. Eur J Physiol 1992;192:161-163.
17. 2-adenosine receptor agonists do not alter action potential duration, twitch shortening, or cyclic AMP accumulation in guinea pig, rat, or rabbit isolated ventricular myocytes. Circ Res 1993;72:194-205.
18. Chiba S, Himori N. Different inotropic responses to adenosine on the atrial and ventricular muscle of the dog heart. Jpn J Pharmacol 1975;25:489-491.
19. Bruckner R, Fenner A, Meyer W, Nobis T-M, Schmitz W, Scholz H. Cardiac effects of adenosine and adenosine analogs in guinea-pig atrial and ventricular preparations: evidence against a role of cyclic AMP and cyclic GMP. J Pharmacol Exp Ther 1985;234:766-774.
20. Legssyer A, Poggioli J, Renard D, Vassort G. ATP and other adenine compounds increase mechanical activity and inositol trisphosphate production in rat heart. J Physiol 1988;401:185-199.
21. Burnstock G, Meghji P. The effect of adenyl compounds in the rat heart. Br J Pharmacol 1983;79:211-218.
22. Gruver EJ, Toupin D, Smith TW, Marsh JD. Acadesine improves tolerance to ischemic injury in rat cardiac myocytes. J Mol Cell Cardiol 1994;26:1187-1195.
23. Salomon Y. Adenylate cyclase assay. Adv Cyclic Nucleotide Res 1979;10:35-55.
24. 2 receptors in rat brain. J Pharmacol Exp Ther 1989;251:888-893.
25. 1 adenosine receptor antagonist Life Sci 1987;40:555-561.
26. Ghai G, Francis JE, Williams M, et al. Pharmacological characterization of CGS15943A: A novel nonxanthine adenosine antagonist. J Pharmacol Exp Ther 1987;242:784-790.
27. 2-adenosine antagonist in vitro and in vivo. FEBS Lett 1993;323:141-144.
28. 2b receptors in cultured fetal chick heart cells. High- and low-affinity coupling to stimulation of myocyte contractility and cAMP accumulation. Circ Res 1995;76:242-251.
29. 2 receptor agonists alter cardiac functions and prostacyclin release in the isolated guinea-pig heart. Eur J Pharmacol 1994;263:261-268.
30. Sonnenblick EH. Force-velocity relations in mammalian heart muscle. Am J Physiol 1962;202:931-939.
31. Rockoff JB, Dobson JG, Jr. Inhibition by adenosine of catecholamine-induced increase in rat atrial contractility. Am J Physiol 1980;239:H365-H370.
32. Murray JJ, Dobson JG, Jr., Reed PW. Effects of divalent cation ionophore A23187 on cardiac contractile parameters. Am J Physiol 1985;249:H1195-H1203.
33. 2 adenosine receptors. Life Sci 1986;39:743-750.
34. 2a receptor in the intact cardiac cell. J Biol Chem 1996;271:18678-18685.
35. Dobson JG, Jr. Adenosine and adrenergic mediated effects in the heart. In: Abd-Elfattah AS, Wechsler AS, eds. Purines and Myocardial Protection. Norwell, MA: Kluwer, 1996:359-372.
36. Fenton RA, Dobson JG, Jr. Hypoxia enhances isoproterenol-induced increase in heart interstitial adenosine depressing β-adrenergic contractile responses. Circ Res 1993;72:571-578.