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Pasqualini R, Ruoslahti E: Organ targeting in vivo using phage display peptide libraries. Nature 1996, 380:364-366. This paper describes a new approach to studying organ-selective targeting is based on in vivo screening of random peptide libraries. This approach is demonstrated by the identification of peptides capable of mediating selective localization of phage to brain and kidney vessels with significant selectivity over other organs.
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Smith GP, Yu J: In search of dark horses: affinity maturation of phage-displayed ligands. Mol Divers 1996, 2:2-4. Introduces a new strategy for securing all possible clones. In this strategy, clones are selected from the initial library by some criterion of 'fitness,' such as affinity for a particular receptor. The selected clones are then mutagenized to generate a mutant library, which serves as input to the next round of selection.
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Wrighton NC, Farrell FX, Chang R, Kashyap AK, Barbone FP, Mulcahy LS, Johnson DL, Barrett RW, Jolliffe LK, Dower WJ: Small peptides as potent mimetics of the protein hormone erythropoietin. Science 1996, 273:458-463. A good example of the application of a random phage display library and affinity selection methods to identify small peptide ligands. Here a small 14-residue cyclic peptide mimic of erythropoietin has been isolated which shares no sequence or structural homology to erythropoietin (EPO), but binds to and activates the EPO receptor.
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Wrighton, N.C.1
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Identification of D-peptide ligands through mirror-image phage display
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Schumacher TNM, Mayr LM, Minor DL Jr, Milhollen MA, Burgess MW, Kim PS: Identification of D-peptide ligands through mirror-image phage display. Science 1996, 271:1854-1857. This new strategy led to the successful identification of cyclic D-peptide ligands for the Src homology 3 domain of c-Src. In this approach, a D-protein was synthesized to select peptide ligands from a random L-amino-acid phage display library. For reasons of symmetry, the mirror images of these phage-displayed peptides interact with the target protein of the natural handedness.
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(1996)
Science
, vol.271
, pp. 1854-1857
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Tnm, S.1
Mayr, L.M.2
Jr, M.D.L.3
Ma, M.4
Burgess, M.W.5
Kim, P.S.6
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49
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0011958990
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High affinity type I interleukin I receptor antagonists discovered by screening recombinant peptide libraries
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Yanofsky SD, Baldwin DN, Butler JH, Holden FR, Jacobs JW, Balasubramanian P, Chinn JP, Cwirla SE, Peters-Bhatt E, Whitehorn EA et al.: High affinity type I interleukin I receptor antagonists discovered by screening recombinant peptide libraries. Proc Natl Acad Sci USA 1996, 93:7381-7386.
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(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 7381-7386
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Yanofsky, S.D.1
Baldwin, D.N.2
Butler, J.H.3
Holden, F.R.4
Jacobs, J.W.5
Balasubramanian, P.6
Chinn, J.P.7
Cwirla, S.E.8
Peters-Bhatt, E.9
Whitehorn, E.A.10
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50
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0030210311
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Chicken monoclonal antibody isolated by a phage display system
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Yamanaka HI, Inoue T, Ikeda-Tanaka O: Chicken monoclonal antibody isolated by a phage display system. J Immunol 1996, 157:1156-1162.
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(1996)
J Immunol
, vol.157
, pp. 1156-1162
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Yamanaka, H.I.1
Inoue, T.2
Ikeda-Tanaka, O.3
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51
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0030595361
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Use of a conformationally restricted secondary structural element to display peptide libraries: A two-stranded α-helical coiled-coil stabilized by lactam bridges
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Houston ME Jr, Wallace A, Bianchi E, Pessi A, Hodges RS: Use of a conformationally restricted secondary structural element to display peptide libraries: a two-stranded α-helical coiled-coil stabilized by lactam bridges. J Mol Biol 1996, 262:270-282.
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(1996)
J Mol Biol
, vol.262
, pp. 270-282
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Jr, H.M.E.1
Wallace, A.2
Bianchi, E.3
Pessi, A.4
Hodges, R.S.5
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52
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0029741201
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Development of the first potent and selective inhibitor of the zinc endopeptidase neurolysin using a systematic approach based on combinatorial chemistry of phosphinic peptides
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Jiráček J, Yiotakis A, Vincent B, Checler F, Dive V: Development of the first potent and selective inhibitor of the zinc endopeptidase neurolysin using a systematic approach based on combinatorial chemistry of phosphinic peptides. J Biol Chem 1996, 271:19606-19611.
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(1996)
J Biol Chem
, vol.271
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Jiráček, J.1
Yiotakis, A.2
Vincent, B.3
Checler, F.4
Dive, V.5
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53
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0342318652
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Rapid identification of phosphopeptide ligands for SH2 domains
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Müller K, Gombert FO, Manning U, Grossmüller F, Graff P, Zaegel H, Zuber JF, Freuler F, Tschopp C, Baumann G: Rapid identification of phosphopeptide ligands for SH2 domains. J Biol Chem 1996, 271:16500-16505. This paper describes a method for the identification of high-affinity ligands to SH2 domains by fluorescence-activated bead sorting.
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(1996)
J Biol Chem
, vol.271
, pp. 16500-16505
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Müller, K.1
Gombert, F.O.2
Manning, U.3
Grossmüller, F.4
Graff, P.5
Zaegel, H.6
Zuber, J.F.7
Freuler, F.8
Tschopp, C.9
Baumann, G.10
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54
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0343010435
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The synthesis of peptidomimetic combinatorial libraries through successive amide alkylations
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Dörner B, Husar GM, Ostresh JM, Houghton RA: The synthesis of peptidomimetic combinatorial libraries through successive amide alkylations. Bioorg Med Chem 1996, 4:709-715.
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(1996)
Bioorg Med Chem
, vol.4
, pp. 709-715
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Dörner, B.1
Husar, G.M.2
Ostresh, J.M.3
Houghton, R.A.4
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55
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0029855561
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Complementarity of combinatorial chemistry and structure-based ligand design: Application to the discovery of novel inhibitors of matrix metalloproteinases
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Rockwell A, Melden M, Copeland RA, Decicco CP, Degrado WF: Complementarity of combinatorial chemistry and structure-based ligand design: application to the discovery of novel inhibitors of matrix metalloproteinases. J Am Chem Soc 1996, 118:10337-10338.
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(1996)
J am Chem Soc
, vol.118
, pp. 10337-10338
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Rockwell, A.1
Melden, M.2
Copeland, R.A.3
Decicco, C.P.4
Degrado, W.F.5
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56
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0029925955
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Sequence-selective peptide binding with a peptido-A,B-trans-steroidal receptor selected from an encoded combinatorial receptor library
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Cheng Y, Suenaga T, Still WC: Sequence-selective peptide binding with a peptido-A,B-trans-steroidal receptor selected from an encoded combinatorial receptor library. J Am Chem Soc 1996, 118:1813-1814.
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(1996)
J am Chem Soc
, vol.118
, pp. 1813-1814
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Cheng, Y.1
Suenaga, T.2
Still, W.C.3
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57
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33748220036
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Solid-phase, parallel syntheses by Ugi multicomponent condensation
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Tempest PA, Brown SD Armstrong RW: Solid-phase, parallel syntheses by Ugi multicomponent condensation. Angew Chem Int Ed 1996, 35:640-642. This novel approach has all the advantages of solid-phase synthesis, and at the same time, the diversity of the libraries is controlled by the number of components and their availability.
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(1996)
Angew Chem int Ed
, vol.35
, pp. 640-642
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Tempest, P.A.1
Brown, S.D.2
Armstrong, R.W.3
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58
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0030252581
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Design considerations and computer modeling related to the development of molecular scaffolds and peptide mimetics for combinatorial chemistry
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Hruby VJ, Shenderovich M, Lam K, Lebl M: Design considerations and computer modeling related to the development of molecular scaffolds and peptide mimetics for combinatorial chemistry. Mol Divers 1996, 2:46-56. This paper describes the use of computational chemistry to evaluate topographical similarities and differences of scaffolds and mimetics.
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(1996)
Mol Divers
, vol.2
, pp. 46-56
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Hruby, V.J.1
Shenderovich, M.2
Lam, K.3
Lebl, M.4
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59
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0029987185
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Generalized dipeptidomimetic template: Solution phase parallel synthesis of combinatorial libraries
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Boger DL, Tarby CM, Myers PL, Caporale LH: Generalized dipeptidomimetic template: solution phase parallel synthesis of combinatorial libraries. J Am Chem Soc 1996, 118:2109-2110.
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(1996)
J am Chem Soc
, vol.118
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Boger, D.L.1
Tarby, C.M.2
Myers, P.L.3
Caporale, L.H.4
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60
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0029926720
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Novel solution phase strategy for the synthesis of chemical libraries containing small organic molecules
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Cheng S, Comer DC, Williams JP, Myers PL, Boger DL: Novel solution phase strategy for the synthesis of chemical libraries containing small organic molecules. J Am Chem Soc 1996, 118:2567-2573.
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(1996)
J am Chem Soc
, vol.118
, pp. 2567-2573
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Cheng, S.1
Comer, D.C.2
Williams, J.P.3
Myers, P.L.4
Boger, D.L.5
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