Sequence-selective peptide binding with a peptido-A,B-trans-steroidal receptor selected from an encoded combinatorial receptor library

Journal of the American Chemical Society

Volumn 118, Issue 7, 1996, Pages 1813-1814

  Cheng, Yuan ^a   Suenaga, Toshiro ^a   Still, W Clark ^a  

^a Columbia University ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

STEROID RECEPTOR;

ARTICLE; MOLECULAR DYNAMICS; PROTEIN FOLDING; RECEPTOR BINDING; STRUCTURE ACTIVITY RELATION;

EID: 0029925955     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja952976v     Document Type: Article

References (8)

1. Boyce, R.; Li, G.; Nestler, H. P.; Suenaga, T.; Still, W. C. J. Am. Chem. Soc. 1994, 116, 7955.
2. Ohlmeyer, M. H. J.; Swanson, R. N.; Dillard, L. W ; Reader, J. C.; Asouline, G.; Kobayashi, R.; Wieler, M.; Still, W. C. Proc. Natl. Acad. Sci U.S.A. 1993, 90, 10922.
3. Under the same conditions, no members of library 1 were observed to bind the dye (Disperse Red 1) to a significant extent
4. Nomenclature defined by standard single letter code for amino acids (AA1-AA4).
5. 1H NMR) that could be monitored over a sufficiently large concentration range during a titration of 1NnfS methyl ester with P1.
6. free corresponds to the concentration of P in the supernatant solution over the beads at equilibrium.
7. tree. Data was collected at three such points, and K's were calculated for each of the three pairs of points. The binding experiment was repeated. The resulting six K's were averaged, and error limits were computed from the different K's as l standard deviation. Related methodology: Smith, P. W.; Chang. G.; Still, W C. J. Org. Chem, 1988, 53, 1587.
8. 4. we used (L)Ala to simplify the search