Transcription factors in immune-mediated disease

Current Opinion in Biotechnology

Volumn 8, Issue 4, 1997, Pages 467-473

  Peltz, Gary ^a  

^a ROCHE BIOSCIENCE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; CD4 ANTIGEN; CYTOKINE; GLUCOCORTICOID; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMMUNOSUPPRESSIVE AGENT; INTERLEUKIN 4; TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; CELL SUBPOPULATION; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE THERAPY; HELPER CELL; HUMAN; HUMAN CELL; IMMUNE RESPONSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN PROTEIN INTERACTION; REVIEW; SIGNAL TRANSDUCTION; T LYMPHOCYTE; TRANSCRIPTION REGULATION; TRANSGENIC MOUSE;

ANIMALIA; MUS MUSCULUS;

EID: 0030835648     PISSN: 09581669     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0958-1669(97)80070-5     Document Type: Article

References (60)

1. McCaffrey PG, Perrino BA, Soderling TR, Rao A: NF-ATp, a T lymphocyte DNA-binding protein that is a target of calcineurin and immunosuppressive drugs. J Biol Chem 1993, 268:3747-3752.
2. Baldwin AS: The NF-κB and IκB proteins: new discoveries and insights. Annu Rev Immunol 1996, 14:649-681.
3. Baeuerle PA, Baltimore D: NF-κB: ten years after. Cell 1996, 87:13-20.
4. Scherer DC, Brockman JA, Chen Z, Maniatis T, Ballard DW: Signal-induced degradation of IκB-α requires site-specific ubiquitination. Proc Natl Acad Sci USA 1995, 92:11259-11263.
5. Chen ZJ, Parent L, Maniatis T: Site-specific phosphorylation of IκB-α by a novel ubiquitination-dependent protein kinase activity. Cell 1996, 84:853-862. Characterization of a multisubunit protein complex that phosphorylates IκB-α, and requires ubiquitination for kinase activity.
6. Hochstrasser M: Protein degradation or regulation: Ub the judge. Cell 1996, 84:813-815.
7. Suyang H, Phillips R, Douglas I, Ghosh S: Role of unphosphorylated, newly synthesized IκB-β in persistent activation of NF-κB. Mol Cell Biol 1996, 16:5444-5449. A novel mechanism regulating NF-κB activation by IκB-β is proposed. Unlike IkB-α, IkB-β must be phosphorylated in order for it to inhibit NF-κB activation.
8. Imbert V, Rupec RA, Livolsi A, Pahl HL, Traechner EB-M, Mueller-Dieckmann C, Farahifar D, Rossi B, Auberger P, Baeuerle PA, Peyron J-F: Tyrosine phosphorylation of IκB-α activates NF-κB without proteolytic degradation of IκB-α. Cell 1996, 86:787-798. Demonstrates that IκB-α can be phosphorylated on Tyr42, and this leads to its release from NF-κB.
9. Perkins ND, Felzien LK, Betts JC, Leung K, Beach DH, Nabel GJ: Regulation of NF-κB by cyclin-dependent kinases associated with the p300 coactivator. Science 1997, 275:523-527. This paper demonstrates that NF-κB associates with the p300 coactivator, and that transcriptional activation by NF-κB is regulated by the activity of cyclin-dependent kinases.
10. Hsu H, Shu H, Baichwal V, Goeddel DV: TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signalling complex. Immunity 1996, 4:387-396. Characterization of RIP, a serine kinase that becomes part of the membrane proximal protein complex associated with the type 1 TNF receptor. RIP is required for TNF-α-induced NF-κB activation and apoptosis induction.
11. Malinin NL, Boldin MP, Kovalenko AV, Wallach D: MAP3K-related kinase involved in NF-κB induction by TNF, CD95, and IL-1, Nature 1997, 385:540-544.
12. Lee FS, Hagler J, Chen ZJ, Maniatis T: Activation of the IκB-α kinase complex by MEKK1, a kinase of the JNK pathway. Cell 1997, 88:213-222.
13. Hirano H, Osada S, Aoki T, Hirai S, Hosaka M, Inoue J, Ohno S: MEK kinase is involved in tumor necrosis factor-α induced NF-κB activation and degradation of IκB-α. J Biol Chem 1996, 271:13234-13238.
14. Bodmer J, Burns K, Schneider V, Thome M, Bomand T, Hahne M, Schroter M, Becker K, Wilson A, French L et al.: TRAMP, a novel apoptosis-mediating receptor with sequence homology to tumor necrosis factor receptor 1 and Fas (Apo-1/CD95). Immunity 1997, 6:79-88.
15. Feldmann M, Brennan FM, Maini RN: Role of cytokines in rheumatoid arthritis. Annu Rev Immunol 1996, 14:397-440.
16. Klement JF, Rice NR, Car BD, Abbondanzo SJ, Powers GD, Bhatt H, Chen C, Rosen CA, Stewart CL: IιB-α deficiency results in a sustained NF-κB response and severe widespread dermatitis in mice. Mol Cell Biol 1996, 16:2341-2349.
17. Neurath MF, Petersson S, Buschenfelde K-HMZ, Strober W: Local administration of antisense phosphorothiate oligonucleotides to the p65 subunit of NF-κB abrogates established experimental colitis in mice. Nat Med 1996, 2:998-1004. Administration of an antisense oligonucleotide targeting the p65 subunit of NF-κB inhibits the severity of experimentally induced colitis in mice.
18. Scherer DC, Brockman JA, Bendall HH, Zhang GM, Ballard DW, Oltz EM: Corepression of ReIA and c-Rel inhibits immunoglobulin kappa gene transcription and rearrangement in precursor B lymphocytes. Immunity 1996, 5:563-574.
19. Kopp E, Ghosh S: Inhibition of NF-κB by sodium salicylate and aspirin. Science 1994, 265:956-959.
20. Ray A, Prefontane KE: Physical association and functional antagonism between the p65 subunit of transcription factor NF-κB and the glucocorticoid receptor. Proc Natl Acad Sci USA 1994, 91:752-756.
21. Mukaida N, Morita M, Ishikawa Y, Rice N, Okamoto S, Kasahara T, Matsushima K: Novel mechanism of glucocorticoid-mediated gene repression. NF-κB is target for glucocorticoid-mediated interleukin 8 gene repression. J Biol Chem 1994, 269:13289-13295.
22. 2 and antioxidants have opposite effects on activation of NF-κB and AP-1 in intact cells: AP-1 as secondary antioxidant-responsive factor. EMBO J 1993, 12:2005-2015.
23. Blackwell TS, Blackwell TR, Holden EP, Christman BW, Christman JW: In vivo antioxidant treatment suppresses nuclear factor κB activation and neutrophilic lung inflammation. J Immunol 1996, 157:1630-1637.
24. Romano MF, Lamberti A, Petrella A, Bisogni R, Tassone P, Formisano S, Venuta S, Turco MC: IL-10 inhibits nuclear factor-κB/Rel nuclear activity in CD3-stimulated human peripheral T lymphocytes. J Immunol 1996, 156:2119-2123.
25. Auphan N, Didonato JA, Rosette C, Helmberg A, Karin M: Immunosuppression by glucocorticoids: inhibition of NF-κB activity through induction of IκB synthesis. Science 1995, 270:286-290.
26. Scheinman RI, Cogswell PC, Lofquist AK, Baldwin AS: Role of transcriptional activation of IκB-α in mediation of immunosuppression by glucocorticoids. Science 1995, 270:283-286.
27. Brosjan C, Csizmadia V, Stroka D, Soares M, Bach FH, Winkler H: Glucocorticoid-mediated repression of NFκB activity in endothelial cells does not involve induction of IκBα synthesis. J Biol Chem 1996, 271:19612-19616.
28. Van der Saag PT, Caldenhoven E, van de Velde A: Molecular mechanisms of steroid action: a novel type of cross talk between glucocorticoids and NF-κB transcription factors. Eur Respir J 1996, 9:146-153.
29. Adcock IM, Brown CR, Barnes PJ: Tumor necrosis factor α causes retention of activated glucocorticoid receptor within the cytoplasm of A549 cells. Biochem Biophys Res Commun 1996, 225:545-550.
30. Adcock IM, Lane SJ, Brown CR, Lee TH, Barnes PJ: Abnormal glucocorticoid receptor-activator protein 1 interaction in steroid resistant asthma. J Exp Med 1995, 182:1951-1958.
31. Weih F, Carrasco D, Durham SK, Barton DS, Rizzo CA, Ryseck R, Lira SA, Bravo R: Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of ReIB, a member of the NF-κB family. Cell 1995, 80:331-340.
32. •].
33. •] describes a truncated mutant of IκB-α which inhibits NF-κB activation, promotes cell death in response to TNF-α, radiation or chemotherapeutic agents.
34. Song HY, Rothe M, Goeddel DV: The tumor necrosis factor-inducible zinc finger protein A20 interacts with TRAF1/TRAF2 and inhibits NF-κB activation. Proc Natl Acad Sci USA 1996, 93:6721-6725.
35. Muraoka K, Fujimoto K, Sun X, Yoshioka K, Shimizu K, Yagi M, Bose H, Miyazaki I, Yamamoto K: Immunosuppressant FK506 induces interleukin 6 production through the activation of transcription factor nuclear factor (NF)-κB. J Clin Invest 1996, 97:2433-2439.
36. Peltz G: A role for CD4 T cell subsets producing a selective pattern of lymphokines in the pathogenesis of human chronic inflammatory and allergic diseases. Immunol Rev 1991, 123:23-35.
37. Romagnani S: Lymphokine production by human T cells in disease states. Annu Rev Immunol 1994, 12:227-257.
38. Abbas AK, Murphy KM, Sher A: Functional diversity of helper T lymphocytes. Nature 1996, 383:787-793.
39. •].
40. •] demonstrates that the β2 subunit of the IL-12 receptor is differentially expressed on Th1 and Th2 cells. Th1 cells retain expression of this receptor subunit, but Th2 cells do not.
41. Szabo SJ, Jacobson NG, Dighe AS, Gubler U, Murphy KM: Developmental commitment to the Th2 lineage by extinction of IL-12 signaling. Immunity 1995, 2:665-675.
42. Jacobson NG, Szabo SJ, Weber-Nordt RM, Zhong Z, Schreiber RD, Darnell JE Jr, Murphy KM: Interleukin 12 signaling in T helper Type 1 (Th1) cells involves tyrosine phosphyorylation of signal transducer and activator of transcription (Stat)3 and Stat4. J Exp Med 1995, 181:1755-1762.
43. Wenner CA, Szabo SJ, Murphy KM: Identification of IL-4 promoter elements conferring Th2-restricted expression during T helper cell subset development J Immunol 1997, 158:765-773. Analysis of reporter gene expression in transgenic mice demonstrates that the proximal promoter region of IL-4 directs Th2-specific expression. Their data, however, also indicate that there are elements outside the proximal promoter region which make substantial contributions to Th2-specific IL-4 gene expression.
44. Todd MD, Grusby MJ, Lederer JA, Lacy E, Lichtman AH, Glimcher LH: Transcription of interleukin 4 gene is regulated by multiple promoter elements. J Exp Med 1993, 177:1663-1674.
45. Ho I, Hodge MR, Rooney JW, Glimcher LH: The proto-oncogene c-maf is responsible for tissue-specific expression of Interleukin-4. Cell 1996, 85:973-983. Identifies c-Maf as an NF-AT interacting protein which regulates tissue-specific expression of IL-4.
46. Hodge MR, Rooney JW, Glimcher LH: The proximal promoter of the IL-4 gene is composed of multiple essential regulatory sites that bind at least two distinct factors. J Immunol 1995, 154:6397-6405.
47. Rooney JW, Hodge MR, McCaffrey PG, Rao A, Glimcher LH: A common factor regulates both Th and Th2 specific cytokine gene expression. EMBO J 1994, 13:625-633.
48. Szabo SJ, Gold JS, Murphy TL, Murphy KM: Identification of cis-acting regulatory elements controlling interleukin-4 gene expression in T cells: roles for NF-Y and NF-ATc. Mol Cell Biol 1993, 13:4793-4805.
49. Bruhn KW, Nelms K, Boulay J, Paul WE, Lenardo MJ: Molecular dissection of the mouse interleukin-4 promoter. Proc Natl Acad Sci USA 1993, 90:9707-9711.
50. Nolan GP: NF-AT-AP-1 and Rel-bZIP: hybrid vigor and binding under the influence. Cell 1994, 77:795-798.
51. Rao A: NF-ATp: a transcription factor required for the coordinate induction of several cytokine genes. Immunol Today 1994, 15:274-281.
52. Hodge MR, Chun HJ, Rengarajan J, Alt A, Lieberson R, Glimcher LH: NF-AT-driven interleukin-4 transcription potentiated by NIP45. Science 1996, 274:1903-1905. Identifies NIP45 as an NF-AT interacting protein which promotes expression of IL-4.
53. Xanthoudakis S, Viola JPB, Shaw KTY, Luo C, Wallace JD, Bozza PT, Curran T, Rao A: An enhanced immune response in mice lacking the transcription factor NFAT1. Science 1996, 272:892-895.
54. Hodge MR, Ranger AM, Charles De La Brousse F, Hoey T, Grusby MJ, Glimcher LH: Hyperproliferation and dysregulation of IL-4 expression in NF-Atp deficient mice. Immunity 1996, 4:397-405.
55. Henkel G, Brown MA: PU.1 and GATA: components of a mast cell-specific interleukin-4 intronic enhancer. Proc Natl Acad Sci USA 1994, 91:7737-7741.
56. h1 cell development Science 1996, 271:984-987.
57. + T cells purified from Balb/c and B10.D2 mice differ in the profile of cytokines produced after antigen stimulation. Analysis of experimental intercrosses of Balb/c and B10.D2 mice demonstrates that a genetic locus on murine chromosome 11 determines whether CD4 T cells have a Th1 or Th2 profile of cytokine production.
58. Postma DS, Bleecker ER, Amelung PJ, Holroyd KJ, Xu J, Panhuysen CIM, Meyers DA, Levitt RC: Genetic susceptibility to asthma - bronchial hyperresponsiveness coinherited with a major gene for atopy. New Engl J Med 1995, 333:874-900.
59. Marsh DG, Neely JD, Breazeale DR, Ghosh B, Freidhoff LR, Ehrlich-Kautzky E, Schou C, Krishnaswamy G, Beaty TH: Linkage analysis of IL4 and other chromosome 5q31.1 markers and total serum immunoglobulin E concentrations. Science 1994, 264:1152-1156.
60. Xu J, Levitt RC, Panhuysen CIM, Postma DS, Taylor EW, Amelung PJ, Holroyd KJ, Bleecker ER, Meyers DA: Evidence for two unlinked loci regulating total serum IgE levels. Am J Hum Genet 1995, 57:425-430.