In Vivo Antioxidant Treatment Suppresses Nuclear Factor-κB Activation and Neutrophilic Lung Inflammation

Journal of Immunology

Volumn 157, Issue 4, 1996, Pages 1630-1637

  Blackwell, Timothy S ^a   Blackwell, Thomas R ^b   Holden, Edsel P ^a,b   Christman, Brian W ^a   Christman, John W ^a,b  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

8 EPI PROSTAGLANDIN F2ALPHA; 8-EPI-PROSTAGLANDIN F2ALPHA; ACETYLCYSTEINE; ALPHA CHEMOKINE; ANTIOXIDANT; CHEMOTACTIC FACTOR; CYTOKINE INDUCED NEUTROPHIL CHEMOATTRACTANT, RAT; CYTOKINE-INDUCED NEUTROPHIL CHEMOATTRACTANT, RAT; DRUG DERIVATIVE; ENDOTOXIN; GLUTATHIONE; GROWTH PROMOTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; ISOPROSTANE DERIVATIVE; MESSENGER RNA; NONSTEROID ANTIINFLAMMATORY AGENT; PROSTAGLANDIN F2 ALPHA; SIGNAL PEPTIDE;

ADULT RESPIRATORY DISTRESS SYNDROME; ANIMAL; ARTICLE; BIOSYNTHESIS; CHEMICALLY INDUCED DISORDER; DISEASE MODEL; DRUG ANTAGONISM; DRUG EFFECT; DRUG SCREENING; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; INFLAMMATION; LEUKOCYTE COUNT; LUNG; LUNG DISEASE; MALE; METABOLISM; MOLECULAR GENETICS; NEUTROPHIL; NEUTROPHIL CHEMOTAXIS; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; RAT; SEPSIS; SPRAGUE DAWLEY RAT;

ACETYLCYSTEINE; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTIOXIDANTS; BASE SEQUENCE; CHEMOKINES, CXC; CHEMOTACTIC FACTORS; CHEMOTAXIS, LEUKOCYTE; DINOPROST; DISEASE MODELS, ANIMAL; DRUG EVALUATION, PRECLINICAL; ENDOTOXINS; F2-ISOPROSTANES; GENE EXPRESSION REGULATION; GLUTATHIONE; GROWTH SUBSTANCES; INFLAMMATION; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LEUKOCYTE COUNT; LUNG; LUNG DISEASES; MALE; MOLECULAR SEQUENCE DATA; NEUTROPHILS; NF-KAPPA B; RATS; RATS, SPRAGUE-DAWLEY; RESPIRATORY DISTRESS SYNDROME, ADULT; RNA, MESSENGER; SEPSIS;

EID: 0030586689     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Siebenlist, U., G. Franzoso, and K. Brown. 1994. Structure, regulation and function of NF-κB. Annu. Rev. Cell Biol. 10:405.
2. Donald, R., D. W. Ballard, and J. Hawiger. 1995. Proteolytic processing of NF-κB/IκB in human monocytes. J. Biol. Chem. 271:9.
3. Watanabe, K., and H. Nakagawa. 1987. Production of a chemotactic factor for polymorphonuclear leukocytes by epithelioid cells from rat renal glomeruli in culture. Biochem. Biophys. Res. Commun. 149:989.
4. Watanabe, K., K. Konishi., M. Fujioka, S. Kinoshita, and H. Nakagawa. 1989. The neutrophil chemoattractant produced by the rat kidney epithelioid cell line NRK-52E is a protein related to the KC/gro protein. J. Biol. Chem. 264:19559.
5. Watanabe, K., S. Kinoshita, and H. Nakagawa. 1989. Purification and characterization of cycokine induced neutrophil chemoattractant produced by epithelioid cell line of normal rat kidney. Biochem. Biophys. Res. Commun. 161:1093.
6. Zagorski, J., and J. E. DeLarco. 1993. Rat CINC (cytokine-induced neutrophil chemoattractant) is the homolog of the human GRO proteins but is encoded by a single gene. Biochem. Biophys. Res. Commun. 190:104.
7. Iida, M., K. Watanabe, M. Tsurufuji, K. Takaishi, Y. Iizuka, and S. Tsurufuji. 1992. Level of neutrophil chemotactic factor CINC/gro, a member of the interleukin-8 family, associated with lipopolysaccharide-induced inflammation in rats. Infect. Immun. 60:1268.
8. Watanabe, K., and H. Nakagawa. 1990. Cytokines enhance the production of a chemotactic factor for polymorphonuclear leukocytes by rat renal glomerular epilhelioid cells. Nephron 54:169.
9. Huang, S., J. D. Paulauskis, J. J. Godleski, and L. Kobzik. 1992. Expression of macrophage inflammatory protein-2 and KC mRNA in pulmonary inflammation. Am. J. Pathol. 141:981.
10. Ulich, T. R., S. C. Howard, D. G. Remick., A. Wittwer, E. S. Yi, S. Yin, K. Gou, J. K. Welply, and J. H. Williams. 1995. Intratracheal administrations of endotoxin and cytokines. VI. Antiserum to CINC inhibits acute inflammation. Am. J. Physiol. 268:L245.
11. Blackwell, T. S., E. P. Holden, T. R. Blackwell, J. E. DeLarco, and J. W. Christman. 1994. Cytokine induced neutrophil chemoattractant mediates neutrophilic alveolitis in rats: association with nuclear factor κ B activation. Am. J. Respir. Cell Mol. Biol. 11:464.
12. Frevert, C. W., S. Huang, H. Danaee, J. D. Paulauskis, and L. Kobzik. 1995. Functional characterization of the rat chemokine KC and its importance in neutrophil recruitment in a rat model of pulmonary inflammation. J. Immunol. 154:335.
13. Konishi, K., Y. Takata, M. Yamamoto, K. Yomogida, K. Watanabe, S. Tsurufiji, and M. Fujioka. 1993. Structure of the gene encoding rat neutrophil chemoattractant Gro. Gene 126:285.
14. Rinaldo J. E., Dauber J. H., Christman J., and R. M. Rogers. 1984. Neutrophil alveolitis following endotoxemia: enhancement by previous exposure to hyperoxia. Am. Rev. Respir. Dis. 130:1065.
15. Berggren, M., J. Dawson, and P. Moldeus. 1984. Glutathione biosynthesis in the isolated perfused rat lung: utilization of extracellular glutathione. FEBS Lett. 176:189.
16. Aruoma, O. I., B. Halliwell, B. M. Hoey, and J. Butler. 1989. The antioxidant action of N-acetylcysteine: its reaction with hydrogen peroxide, hydroxyl radical, superoxide and hypochlorous acid. Free Rad. Biol. Med. 6:593.
17. Schreck, R., K. Alberman, and P. A. Baeuerle. 1992. Nuclear factor κB: an oxidative stress-responsive transcription factor of eukaryotic cells (a review). Free Rad. Res. Commun. 17:221.
18. Staal, F. J. T., M. Roederer, L. A. Herzenberg, and L. A. Herzenberg. 1990. Intracellular thiols regulate activation of nuclear factor κ B and transcription of human immunodeficiency virus. Proc. Natl. Acad. Sci. USA 87:9943.
19. Ivanov, V., M. Merkenschlager, and R. Ceredig. 1993. Antioxidant treatment of thymic organ cultures decreases NF-κB and TCF1(α) transcription factor activities and inhibits αβ T cell development. J. Immunol. 151:4694.
20. Schreck, R., and P. A. Baeuerle. 1991. A role for oxygen radicals as second messengers. Trends Cell Biol. 1:39.
21. Repine, J. E., and P. E. Parsons. 1994. Oxidant-antioxidant balance in endotoxin-induced oxidative injury and tolerance to oxidative injury. In Endotoxin and the Lungs. K. L. Brigham, ed. Marcel Dekker, Inc., New York, p. 207.
22. Adamson, G. M., and R. E. Billings. 1992. Tumor necrosis factor induced oxidative stress in isolated mouse hepatocytes. Arch. Biochem. Biophys. 294:223.
23. Chirgwin, J. M., A. E. Przybyla, R. J. MacDonald, and W. J. Rutter. 1979. Isolation of biologically-active ribonucleic acid from sources enriched in ribonuclease. Biochemistry 18:5294.
24. Deryckere, F., and F. Gannon. 1994. A one-hour minipreparation technique for extraction of DNA-binding proteins from animal tissues. Biotechniques 16:405.
25. Bradford, M. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Ann. Biochem. 72:248.
26. Morrow, J. D., T. M. Harris, and L. L. Roberts II. 1990. Noncyclooxygenase oxidative formation of a series of novel prostaglandins: analytical ramifications for measurement of eicosanoids. Anal. Biochem. 184:1.
27. Tietze, F. 1969. Enzymatic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues. Ann. Biochem. 27:502.
28. Hill, K. E., M. A. Taylor, and R. F. Burk. 1987. Influence of selenium deficiency on glutathione disulfide metabolism in isolated perfused rat heart. Biochim. Biophys. Acta 923:431.
29. 2-isoprostanes) are formed in situ on phospholipids. Proc. Natl. Acad. Sci. USA 89:10721.
30. 2-isoprostanes) in carbon tetrachloride hepatotoxicity. J. Clin. Invest. 90:2502.
31. Henderson, A., and P. Hayes. 1994. Acetylcysteine as a cytoprotective antioxidant in patients with severe sepsis: Potential new use for an old drug. Ann. Pharmacother. 28:1086.
32. Jepsen, S., P. Herlevsen, P. Knudsen, M. I. Bud, and N. Klausen. 1992. Antioxidant treatment with N-acetylcysteine during adult respiratory distress syndrome: a prospective, randomized, placebo-controlled study. Crit. Care Med. 20:918.
33. Suter, P. M., G. Domenighetti, M. Schaller, M. Laverriere, R. Ritz, and C. Perret. 1994. N-acetylcysteine enhances recovery from acute lung injury in man. Chest 105:190.
34. Bernard, G. R., W. D. Lucht, M. E. Niedermeyer, J. R. Snapper, M. L. Ogletree, and K. L. Brigham. 1984. Effect of N-acetylcysteine on the pulmonary response to endotoxin in the awake sheep and upon in vitro granulocyte function. J. Clin. Invest. 73:1772.
35. Sciuto, A. M., P. T. Strickland, T. P. Kennedy, and G. H. Gurtner. 1995. Protective effects of N-acetylcysteine treatment after phosgene exposure in rabbits. Am. J. Respir. Crit. Care Med. 151:768.
36. Hoffer, E., I. Avidor, O. Benjaminov, L. Shenker, A. Tabak, A. Tamir, D. Merzbach, and U. Taitelman. 1993. N-acetylcysteine delays the infiltration of inflammatory cells into the lungs of paraquat-intoxicated rats. Toxicol. Appl. Pharmacol. 120:8.
37. Leff, J. A., C. P. Wilke, B. M. Hybertson, P. F. Shanley, C. J. Beehler, and J. E. Repine. 1993. Postinsult treatment with N-acetyl-L-cysteine decreases IL-1-induced neutrophil influx and lung leak in rats. Am. J. Physiol. 265:L501.
38. Christman, J. W., E. P. Holden, and T. S. Blackwell. 1995. Strategies for blocking the systemic effects of cytokines in the sepsis syndrome. Crit. Care Med. 23:955.
39. Kuhns, D. B., G. Alvord, and J. I. Gallin. 1995. Increased circulating cytokines, cytokine antagonists, and E-selectin after intravenous administration of endotoxin in humans. J. Infect. Dis. 171:145.
40. Van Zee, K. J., L. E. DeForge, R. Fischer, M. A. Marano, J. S. Kenney, D. G. Remick, S. F. Lowry, and L. L. Moldawer. 1991. IL-8 in septic shock, endotoxemia, and after IL-1 administration. J. Immunol. 146:3478.