Immunosuppressant FK506 induces interleukin-6 production through the activation of transcription factor nuclear factor (NF)-κB implications for FK506 nephropathy

Journal of Clinical Investigation

Volumn 97, Issue 11, 1996, Pages 2433-2439

  Muraoka, Kei Ichi ^a   Fujimoto, Koutaro ^a   Sun, Xiangao ^a   Yoshioka, Katsuji ^a   Shimizu, Kou Ichi ^a   Yagi, Masao ^a   Bose Jr , Henry ^b   Miyazaki, Itsuo ^a   Yamamoto, Ken Ichi ^a  

^a KANAZAWA UNIVERSITY   (Japan)

^b UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

FK506; IL 6; Immunosuppressant; Nephrotoxicity; NF B

Indexed keywords

CYCLOSPORIN A; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMMUNOSUPPRESSIVE AGENT; INTERLEUKIN 6; MESSENGER RNA; RAPAMYCIN; TACROLIMUS; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR AP 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG BLOOD LEVEL; ELECTROPHORETIC MOBILITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FIBROBLAST; GENETIC TRANSFECTION; HISTOLOGY; IMMUNOHISTOCHEMISTRY; INTRAMUSCULAR DRUG ADMINISTRATION; KIDNEY DISEASE; MALE; MESANGIUM CELL; MOUSE; NEPHROTOXICITY; NONHUMAN; NORTHERN BLOTTING; PLASMID; PRIORITY JOURNAL; PROTEIN SYNTHESIS; TRANSCRIPTION REGULATION;

ANIMALS; BASE SEQUENCE; DNA-BINDING PROTEINS; GENE EXPRESSION; GLOMERULAR MESANGIUM; HUMANS; I-KAPPA B PROTEINS; IMMUNOHISTOCHEMISTRY; IMMUNOSUPPRESSIVE AGENTS; INTERLEUKIN-6; KIDNEY; L CELLS (CELL LINE); MALE; MICE; MICE, INBRED STRAINS; MOLECULAR SEQUENCE DATA; NF-KAPPA B; OLIGONUCLEOTIDE PROBES; RECOMBINANT FUSION PROTEINS; TACROLIMUS;

EID: 0029902996     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI118690     Document Type: Article

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