Inhibition of nitric oxide synthase and prospects for therapy in inflammatory diseases

Current Pharmaceutical Design

Volumn 3, Issue 5, 1997, Pages 447-462

  Fretland, Donald J ^a,c   Connor, Jane R ^b   Pitzele, Barnett S ^a   Currie, Mark G ^b   Manning, Pamela T ^b  

^a Depts Discov Pharmacol Med Chem   (United States)

^b Searle R and D ^*  (United States)

^c Searle R and D   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID DERIVATIVE; AMINOGUANIDINE; ANTIINFLAMMATORY AGENT; BENEXATE; CETRAXATE; CYCLOSPORIN; GUANIDINE DERIVATIVE; HETEROCYCLIC COMPOUND; LEUKOTRIENE RECEPTOR BLOCKING AGENT; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; PROSTAGLANDIN DERIVATIVE;

ANTIINFLAMMATORY ACTIVITY; CELL MEDIATED CYTOTOXICITY; CHRONIC INFLAMMATION; CYTOTOXICITY; HUMAN; INFLAMMATION; NONHUMAN; PRIORITY JOURNAL; REVIEW; STRUCTURE ACTIVITY RELATION; VASCULAR ENDOTHELIUM;

EID: 0030708908     PISSN: 13816128     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (170)

1. Ignarro, L.J. Circ. Res., 1989, 65, 1.
2. Davies, M.G.; Fulton, G.J.; Hagen, P-O. Brit. J. Surgery, 1995, 82, 1598.
3. Palmer, R.; Ferrige, A.; Moncada, S Nature, 1987, 288,524.
4. Forstermann, U., Closs, E.; Pollock, J. Hypertension, 1994, 23, 1121.
5. Stuehr, D. Annu. Rev. Pharmacol. Toxicol. 1997, 37, 339.
6. Wang, Y.; Marsden. P Adv. Pharmacol. 1995, 34, 71.
7. Evans, C.H.; Stefanovic-Racic, M.; Lancaster, J. J. Clin.Orthoped. and Related Res. 1995, 312, 275.
8. Moncada, S.; Higgs, A.; Furchgott, R. Pharmacol Rev. 1997, 49, 137.
9. Czabo, C.; Thiemermann, C. Adv. Pharmacol. 1995, 34, 113.
10. Lyons, C. R. Adv. Immunol. 1995, 60, 323.
11. Thiemermann, C. Adv. Pharmacol. 1994, 28, 45.
12. Crow, J ; Beckman, J. Adv. Pharmacol. 1995, 34, 17.
13. DiRosa, M.; Ialenti, A.; Ianaro, A., Sautebin, L. Prostagland. Leukotri. and Ess. Fatty Acids 1996, 54, 229.
14. Appleton, I.; Tomlinson, A.; Willoughby, D. Adv. Pharmacol. 1996, 35, 27
15. Salvemini, D.; Misko, T.; Masferrer, J ; Seibert, K.; Currie, M.; Needleman, P. Proc. Natl. Acad. Sci. USA 1993, 90, 7240.
16. Schehr, R. Nature Biotechnol. 1996, 14, 1549.
17. Feldmann, M., Brennan, F.; Maini, R. Annu. Rev. Immunol 1996, 14, 397.
18. Meijer, F ; Tak, C.; Van Haeringen, N., Kijlstra, A. Prostaglandins 1996, 52, 431.
19. Konturek, S.; Konturek, P. Digestion 1995, 56, 1.
20. Sirsjo, A ; Karlsson, M., Gidof, A ; Rollman, O.: Torma, H Brit J. Dermatol. 1996, 134, 643.
21. Waage, A , Brandtzaeg, P.; Halstensen, A ; Kierulf, P., Espevik, T. J Exp Med. 1989, 169, 333.
22. Dawson, V.; Dawson, T. Adv. Pharmacol. 1995, 34, 323
23. Schulz, R.; Panas, D ; Catena, R.; Moncada, S.; Olley, P.; Stanley, R ; Lopaschuk, G. Brit. J. Pharmacol 1995, 114, 27
24. Knowles, R ; Moncada, S. Biochem. J. 1994, 298, 249.
25. Groeneveld, P.; Kwappenberg, K.; Langermans, J.; Nibbering, P.; Curtis, L. Cytokine, 1997, 9, 138.
26. Lowenstein, C.; Dinerman, J.; Snyder, S. Ann Intern. Med. 1994, 120, 227.
27. Barton, B Exp. Opin. Ther Patents. 1995, 5, 13.
28. Parrillo, J New Engl. J. Med. 1993, 328, 1471.
29. Szabo, C.; Southan, G.; Thiemermann, C. Proc. Natl. Acad. Sci. USA 1994, 91, 12472.
30. Fretland, D.; Anglin, C ; Widomski, D.; Connor, J.; Wyatt, P.; Manning, P.; Currie, M. Inflamm Rres. 1997, 46, S17.
31. Herfath, H.; Mohanty, S., Rath, H.; Tonkonogy, S ; Sartor, R Gut 1996, 39, 836
32. Jilg, S.; Barsig, J.; Leist, M.; Kusters, S.; Volk, H-D.; Wendel, A. J. J. Pharmacol. Exp. Therapeu. 1996, 278, 421.
33. Fukatsu, K.; Saito, H.;, Lin, M.; Inoue, T ; Furukawa, S.; Muto, T. Inflam. Res. 1996, 45, 109.
34. Teale, D.; Atkinson, A. Eur. J. Pharmacol. 1994, 277, 87
35. Tracey, W.; Tse, J., Carter, G. J. Pharmacol. Exp Therapeu. 1995, 272, 1011.
36. Kilbourn, R.; Cromeens, D.; Chelly, F.; Griffith, O. Crit. Care Med. 1994, 22, 1835.
37. Kilbourn, R.; Schaub, L.; Cromeens, D.; Gross, S., Flaherty, M ; Santee, S ; Alak, A.; Griffith, O. J. Appl Physiol. 1994, 76, 1130.
38. Kilbourn, R.; Gross, S.; Jubran, A ; Griffith, O ; Levi, R., Lodato, R Proc. Natl. Acad. Sci. USA, 1990, 87, 3629
39. Tracey, R ; Nakane, M.; Kuk, J.; Budzik, G; Klinghofer, V.; Harris, R., Carter, G. J. Pharmaol. Exp Therap. 1995, 273, 1295
40. Salvemini, D.; Manning, P.; Zweifel, B.; Seibert, K ; Connor, J., Curne, M.; Needleman, P.; Masferrer, J. J. Clin. Invest. 1995, 96, 301.
41. Salvemini, D.; Wang, Z.; Wyatt, P.; Bourdon, D., Marino, M ; Manning, P.; Currie, M. Brit J. Pharmacol 1996, 118, 829.
42. Weichman, B. In Pharmacological Methods for the Control of Inflammation Chang, J ; Lewis, A., Ed Liss, New York, 1989, pp 363-380.
43. Ialenti, A.; Moncada, S., Di Rosa, M. Br J. Pharmacol 1993, 110, 701.
44. Stefanovic-Racic, M.; Meyers, K.; Meschter, C.; Coffey, J.; Hoffman, R.; Evans, C J. Rheumatol 1995, 22, 1922.
45. Moore, W., Webber, R.; Jerome, G.; Tjoeng, F.; Misko, T ; Currie, M J. Med. Chem. 1994, 37, 3886.
46. Connor, J.; Manning, P; Settle, S., Moore, W., Jerome, G.; Webber, R ; Tjoeng, R; Currie, M. Eur. J. Pharmacol 1995, 273, 15
47. Smith, R ; Sly, L. J. Pharmacol Exp. Therapeu. 1996, 277, 1801.
48. Cannon, G ; Openshaw, S.; Hibbs, J , Hoidal, J ; Huecksteadt, T.; Griffiths. M Arth. Rheum 1996, 39, 1677.
49. Vespucci de Mello, S ; Novaes, G , Laurindo, I ; Muscara, M , De Barros Maciel, F., Cossermelli, W. Inflamm. Res. 1997, 46, 72
50. Miesel, R.; Kurpisz, M.; Kroger, H. Free Rad. Biol. Med. 1996, 20, 75.
51. Hom, J; Cole, H.; Bendele, A Clin. Immunol. Immunopath 1990, 55, 109.
52. Weinberg, J., Granger, D.; Pisetsky, D.; Seldin, M.; Gilkeson, G J Exp Med. 1994, 179, 651.
53. McCartney-Francis, N.; Allen, J.; Mizel, D.; Albina, J.; Xie, Q., Nathan, C.; Wahl, S. J Exp. Med. 1993, 178, 749.
54. Rachmilewitz, D.; Stamler, J.; Bachwich, D.; Karmeli, F; Ackerman, Z ; Podolsky, D Gut 1995,36,718.
55. Boughton-Smith, N ; Evans, S.; Hawkey, C.; Cole, A.; Balsitis, M.; Whittle, B., Moncada, S. Lancet, 1993, 342, 338.
56. Dykhuizen, R ; Masson, J ; McKnight, G , Mowat, F.; Smith, C ; Smith, L.; Benjamin, N. Cut, 1996,39, 393.
57. Lundberg, J.; Hellstrom, P.; Lundberg, J.M ; Alving, K. Lancet, 1994, 344, 1673.
58. Kimura, H., Ishii, H. Dig. Dis. Sci 1997, 42, 1047.
59. Fretland, D.; Anglin, C., Widosmki, D.; Baron, D.; Maziasz, T ; Smith, P. Inflammation, 1995, 19, 503.
60. Wallace, J.; Keenan, K.; Gale, D.; Shoupe, T. Gastroenterology, 1992, 102, 18
61. Rachmilewitz, D.; Stamler, J.; Karmeli, F; Mullins, M.; Singel, D.; Loscalzo, J.; Xavier, R.; Podolsky, D. Gastroenterology, 1993, 105, 1681
62. Okayasu, I.; Hatakeyama, S.; Yamada, M., Ohkusa, T.; Inagaki, Y.; Nakaya, R. Gastroenterology 1990, 98, 694.
63. Grisham, M. Cur Opin. Gastroenterol. 1993, 9, 524.
64. Kaiali, T. Biopharmaceu. Drug Disposition 1995, 16, 351.
65. Warren, B.; Watkins, P. J Pathol 1994, 172, 313.
66. Clapp, N., Henke, M. In A Primate Model for the Study of Colitis and Colonie Carcinoma. Clapp, N.K , Ed., CRC Press, Boca Raton, 1993: pp 171-85.
67. Fretland, D.; Sanderson, T.; Smith, P.; Adams, L; Carson, R.; Fuhr, J.; Tanner, J ; Clapp, N. Gut, 1995, 37, 702.
68. Ribbons, K., Zhang, X., Thompson, J.; Greenberg, S.; Moore, W ; Kommeier, C.; Currie, M.; Lerche, N.; Blanchard, J.; Clark, D.; Miller, M Gastroenterology 1995, 108, 705
69. Qiu, B , Blennerhassett, P ; Colins, S Gasterenterology 1997, 112, A1065.
70. Orchard, J , Blair, D.; Follette, D ; Kerchner, L.; Billiar, T. Gastroenterology, 1997, 112, A1057.
71. Ribbons, K.; Currie, M ; Connor, J.; Manning, P.; Allen, P., Didier, P ; Ratterree, M.; Clark, D ; Miller, M. J. Pharmacol. Exp. Therapeut 1997, 280, 1008.
72. Murthy, S.; Hui-Qi, Q.; Sakai, T., Depace, D.; Fondacaro, J. Inflammation, 1997, 21, 173.
73. Pr, F ; Hotter, G.; Closa, D.; Prats, N ; Cruz, L.; Badosa, F.; Gelpi, E ; Catafau, J Dig. Dis. Sci 1997, 42, 962.
74. Dijkstra, C.; De groot, C ; Huitinga, I. J. Neuroimmunol. 1992, 40, 183.
75. Hartung, H , Jung, S , Stoll. G.: Zielasek. J ; Schmidt, B.; Archelos, J, J Neuroimmunol. 1992, 40, 197.
76. Brosnan, C., Battistini, L , Lees, S., Dev. Neurosci 1994, 10, 152
77. Bo, L , Dawson, T , Wessellingh S.; Choi, S , Mindi, M. ; Kong, P , Ann Neurol. 1994 36,778
78. Okuda, Y.; Nakatasuji Y.; Fujimura, H.; Esumi, H., Ogura, T.; Sakoda, S. J. Neuroimmunol 1995, 62, 103.
79. Borel J.; Baumann, G ; Chapman, I.; Donatsch, P.; Fahr, A.; Mueller E.; Vigouret, J. Adv. Pharmacol. 1996, 35, 115.
80. Reder, A.; Thapar, M., Sapugay, A.; Jensen, M. J. Neuroimmunol. 1994, 54, 117.
81. Misko, T ; Trotter, J.; Cross, A J Neuroimmunol. 1995, 61, 195.
82. Scott, G.; Williams, K , Bolton, C. Inflamm. Res. 1996, 45, 524.
83. Misko, T.; Moore, W.; Kasten, T ; Nickols, G.; Corbett, J.; Tilton, R.; McDaniel, M ; Williamson, J ; Currie, M. Eur. J. Pharmacol. 1993, 233, 119
84. Cross, A.; Misko, T.; Rin, R , Hicket, W.; Trotter, J., Tilton, R J. Clin. Invest. 1994, 93, 2684.
85. Iadecola, C.; Zhang, F ; Xu, X. Am. J. Physiol. 1995, 37, R286.
86. Zhang, F.; Casey, R.; Ross, M ; Iadecola, C. Stroke 1996, 27, 1.
87. Yoshida, T.; Waeber, C.; Huang, Z , Moskowitz, M. Neurosci Letters 1995, 194, 214.
88. Hamada, Y.; Ikata, T ; Katon, S.; Tsuchiya, K.; Niwa, M.; Tsutsumishita, Y.; Fukuzawa, K. Free Rad. Biol Med 1996, 20, 1.
89. Stuehr, D.J ; Griffith, O.W.; In: Advances in Enzymology and Related Areas of Molecular Biology. 1992, 65, 287-346, Meister A (Ed.), John Wiley & Sons, New York.
90. Kerwin, J F.; Lancaster, Jr., J.R.; Feldman, P.L. J. Med. Chem. 1995, 38, 4343.
91. Southan, G.J.; Szabo, C. Biochem Pharmacol 1996, 51, 383.
92. Pitzele, B.S. Expert Opinion on Therapeutic Patents, 1997, 7, 717-727.
93. Faraci, F.M.; Brian, Jr., J E ; Heistad, D.D Am. J. Physiol. 1995, 269 (Heart Circ. Physiol. 38), H1522.
94. Liaudet, L.; Feihl, F., Rosselet, A.; Markeret, M.; Hurni, J.-M.; Perret, C. Clin. Sci. 1996, 90, 369
95. Narayanan, K.; Griffith, O.W. J Med. Chem., 1994, 37, 885.
96. Hallinan, E.A., Tsymbalov, S., Moore, W.M., Currie, M G , Pitzele, R.S. Endothelium 1995, 3: (Suppl.) S35.
97. Abbott Laboratories WO9528377 (1995).
98. Galea, E ; Regunathan, S.; Eliopoulos. V.; Feinstein, D.L.; Reis, D J ; Biochem J. 1996, 316, 247-9.
99. Arimoto, T.; Yoshikawa, T.; Komon, Y; Kumagai, Y. Life Sci., 1996, 59, 953-959.
100. Southan, G J.; Szabo, C.; O'Connor, M.P.; Salzman, A.L.; Thiemermann, C. Eur. J. Pharmacol., 1995, 311-318
101. Garvey, E.P.; Oplinger, J A ; Furfine, E.S.; Kiff, R J ; Laszlo, F.; Whittle, B.J R.; Knowles, R.G. J Biol. Chem. 1997, 272, 4959-4963.
102. Baer, H. P.; Schmidt, K.; Mayer, B.: Kukovetz, W. R Life Sci. 1995, 57, 1973-1980.
103. G.D. Searle & Co. WO9511231 (1995).
104. Merck & Co., Inc. WO9614842 (1996).
105. Merck & Co, Inc WO9614844 (1996)
106. Hoechst AG, EP-713704-A (1996)
107. Japan Tobacco, Inc EP-717040-A (1996).
108. G D. Searle & Co WO9633175 (1996)
109. G D. Searle & Co WO9635677 (1996)
110. Moore, W. M.; Webber, R. K.; Fok, K. F.; Jerome, G. M.; Connor, J. R.; Manning, P.T., Wyatt, P.S.; Misko, T. P.; Tjoeng, F S.; Currie, M.G. J Med Chem. 1996, 39, 669.
111. Hansen Jr., D.W.; Peterson, K. B., Trivedi, M.; Webber, R. K., Tjoeng, F. S ; Moore, W. M.; Currie, M. G.; Manning, P.T.; Connor, J. R ; Pitzele, B. S. Endothelium 1995, 3: (Suppl ) S80.
112. Green, B. G.; Chabin, R., Grant, S.K. Biochem. Biophys. Res. Comm. 1996, 621
113. Nakane, M.; Klinghofer, V ; Kuk, J. E.; Donnelly, J. L.; Budzik, G. P.; Pollock, J S.; Basha, F.; Carter, G. W. Mol. Pharmacol. 1995, 47, 831.
114. Jang, D ; Szabo, C., Murreil, G.A.C. Eur. J. Pharmacol. 1996, 312, 341.
115. Stratman, N. C ; Fici, G J.; Sethy, V. H. Life Sci. 1996, 59, 945.
116. Shearer, B. G , Lee, S.; Oplinger, J. A ; Frick, L. W.; Garvey, E. P.; Furfine, E. S. J. Med Chem. 1997, 40, 1901.
117. Handy, R. L. C.; Harb, H. L.; Wallace, P.; Gaffen, Z.; Whitehead, K. J., Moore, P. K. Br. J. Pharmacol. 1996, 119, 423.
118. Handy, R. L. C.; Wallace, P.; Gaffen, Z.; Whitehead, K. J., Moore, P. K. Br. J. Pharmacol 1995, 116, 2349.
119. th Ann. Mtg. Soc. Neurosci., Washington, DC, 1996, 1162 (Abstr 458.7).
120. Renodon, A.; Boucher, J -L.; Sari, M -A.; Delaforge, M.; Ouazzani, J.; Mansuy, D. FEBS Lett. 1997, 33.
121. Davda, R, K.; Stepniakowski, K. T.; Lu, G.; Ullian, M. E.; Goodfriend, T. L ; Egan, B. M. Hypertension 1995, 26, 764.
122. Chen, Q.-M ; LaBella, F. S. Eur. J. Pharmacol. 1997, 321, 355.
123. Jaffrey, S. R.: Snyder, S. H. Science 1996, 274, 774
124. Barthlen, W.; Stadler, J, Lehn, N. L.; Miethke, T.; Bartels, H ; Stewert. J.R. Shock 1994, 2, 398.
125. Petros, A.; Bennert, D.; Vallance, P. Lancet 1991, 338, 1557
126. Kilbourn , R.; Szabo, C.; Traber, D. Shock 1997, 7, 235.
127. Script World Pharm News 1997, 2231, 26.
128. Maas, R., Dullens, H.; Den Otter, W. Cancer Immunol. Immunother. 1993, 36, 141.
129. Rosenberg, S.; Yang, J.; Topalian, S.; Schwartzentruber, D.; Weber, J.; Parkinson, D , Seipp, C.; Einhorn, J.; White, D. JAMA 1994, 27, 907.
130. Kilbourn, R.G ; Fonseca, G.A; Griffith, W.W.; Ewer, M., Price, K ; Striegel, A.; Jones, E.; Logothetis, C J. Crit. Care Med 1995, 23, 1018.
131. Mier, J.; Vachino, G.; Klempner, M.; Aronson, R.; Noring, R.; Smith, S.; Brandon, E.; Laird, W.; Atkins, M. Blood 1990, 76, 1933.
132. Ochoa, J.; Curti, B ; Peitzman, A.; Simmons, R.; Billiar, T; Hoffman, R ; Rault, R.; Longo, D , Urba, W., Ochoa, A. J Natl Cancer Instit. 1992, 84, 864.
133. Radomski, M.; Palmer, R ; Moncada, S. Proc. Natl. Acad. Sci. USA 1990, 87, 10043.
134. Winlaw, D.S.; Smythe, G.A.; Keogh, A. M , Schynevs. C G.; Spratt, P. M.; Macdonald, P.S. Lancet 1994, 344, 373
135. Haywood, G.A ; Tsao, P.S , von der Leyen, H. E., Mann, M J.; Keeling, P J : Trindade, P T., Lewis, N P.; Byrne, C D. Rickenbacher, P R , Bishopric, N. H ; Cooke, J P , McKenna, W. J ; Fowler, M B Circ 1996, 93, 1087
136. De Belder, A. J.; Rdomski, M. W.; Why, H. J ; Richardson, P. J.; Martin, J. F. Br. Heart J. 1995, 74, 426.
137. Thoenes, M.; Forstermann, U.; Tracey, W. R., Bleese, N M.; Nussler, A. K.; Scholz, H.; Stein, B. J. Mol. Cell Cardiol. 1996, 28, 165.
138. Habib, F. M.; Springall, D. R., Davies, G. J.; Oakley, C. M.; Yacoub, M. H.; Polak, J. M. Lancet 1996, 347, 1151
139. Hare, J. M.; Loh, E.; Creager, M. A.; Colucci, W.S. Circ. 1995, 92, 2198.
140. Palmer, R ; Hickery, M.; Charles, I.; Moncada, S.; Bayliss, M. Biochem. Biophys. Res. Comm. 1993, 193, 398.
141. Charles, I.; Palmer, R.; Hickery, M.; Bayliss, M.; Chubb, A.; Hall, V.; Moss, D.; Moncada, S Proc. Natl. Acad. Sci USA 1993, 90, 11419.
142. McInnes, I.; Leung, B ; Field, M.; Wei, X ; Huang, F-P.; Stimpel R ; Kinninmonth, A ; Weidner, J.; Mumford, R.; Liew, F J Exp. Med. 1996, 184, 1519.
143. Sakurai, H ; Kohsaka, H.; Liu, M-F.; Higashiyama, H.; Hirata, Y.; Kanno, K.; Sito, I ; Miyasaka, N. J. Clin. Invest. 1995, 96, 2357.
144. Murrell, G.: Jang, D.; Williams, R. Biochem. Biaphys. Res. Comm. 1995, 206, 15.
145. Farrell, A.J.; Blake, D.R ; Palmer, M.J.; Moncada, S Ann. Rheum Dis. 1992, 51, 1219.
146. Stichtenoth, D O.; Fauler, J.; Zeidler, H.; Frolich, J.C. Ann. Rheum. Dis 1995, 54, 820.
147. Kaur, H.; Halliwell, B. FEBS Letters 1994, 350, 9.
148. Amin, A ; Di Caesare, P.; Vyas, P.; Attur, M ; Tzeng, E.; Billiar, T.; Stuchin, S ; Abramson, S. J. Exp. Med. 1995, 182, 2097.
149. Singer, I.; Kawka, D ; Scott, S.; Weidner, J.; Mumford, R.; Riehl, T.; Stenson, W. Gastroenterology 1996, 111, 1996.
150. Lundberg, J.; Hellstrom, P ; Lundberg, J., Alving, K. Lancet 1994, 344, 1673.
151. Reynolds, P.; Middleton, S ; Hansford, G.; Hunter. J. Eur. J. Gastoenterol. Hepatol. 1997, 9, 463.
152. Bradley, B.; Azzawi, M.; Jacobson, M.; Assoufi, B.; Collins, J ; Irani, A.; Schwartz, L ; Durham, S.; Jeffery, P.; Kay, A. J. Allergy Clin. Immunol 1991, 88, 661.
153. Kharitonov, S.A.; Rajakulasingam, K.; O'Connor, B ; Durham, S. R.; Barnes, P.J. J. Allergy Clin. Immunol. 1996, 99, 58.
154. Nelson, B.V.; Sears, S ; Woods, J.; Ling, C.Y.; Hunt, J.; Clapper, L.M.; Gaston, B. J Pediatr. 1997, 130, 423.
155. KaKanazawa, H.; Shoji, S.; Yamada, M.; Fujii, T.; Kawaguchi, T ; Kudoh, S.; Hirata, K.; Yoshikawa, J. J. Allergy Clin. Immunol. 1997, 99, 624.
156. Hamid, Q.; Springall, D.R.; Riveros-Moreno, V.; Chanez, P; Howarth, P.; Redington, A ; Bousquet, J.; Godard, P ; Holgate, S ; Polak, J M. Lancet 1993, 342, 1510.
157. Yates, D.; Kharitonov, S.; Robbins, R.; Thomas, P.; Barnes, P. Am J. Respir. Crit. Care Med 1995, 152, 292.
158. Yates, D.H , Kharitonov, S.A.; Thomas, P.S., Barnes, P.J. Am J. Respir Crit Care Med 1996, 154, 241.
159. Olesen, J ; Thomsen, L ; Iversen, H Trends Pharamcol. Sci. 1994, 15, 149.
160. Olesen, J ; Thomsen, L.; Lassen, L.; Olesen, I. Cephalalgia 1995, 15, 94.
161. Olesen, J., Iverson, H.; Thomsen, L. NeuroReport 1993, 4, 1027.
162. Lassen, L.; Thomsen, H., Kruuse, C.; Iversen, H.; Olesen, J. Eur. J. Clin. Pharmacol 1996, 49, 335.
163. Lassen, L H.; Ashina, M.; Christiansen, I.; Ulrich, V.; Olesen, J. Lancet 1997, 349, 401
164. Smith, M.; Perry, G.; Richey, P.; Sayre, L.; Anderson, V.; Beal, M.; Kowall, N. Nature 1996, 382, 120.
165. Dorheim, M.A.; Tracey, W.R.; Pollock, J.S.; Grammas, P. BBRC 1994, 205, 659
166. Vodovotz, Y ; Lucia, M..; Flanders, K ; Chester, L.; Xie, Q.; Smith, T , Weidner, J , Mumford, R.; Webber, R.; Nathan, C.; Roberts, A..; Lippa, C.; Sporn, M. 1996, 184, 1425.
167. Beckman, J.; Koppenol. Am. J. Physiol. 1996, 271, C1424.
168. Good, P ; Werner, P , Hsu, A.; Olanow, C.; Perl, D. Am. J. Pathol. 1996, 149, 21.
169. Smith, M ; Harris, P.; Sayre, L.; Beckman, J.; Perry, G. J. Neurosci 1997, 17, 2653.
170. Moore, P.; Handy, R Trends in Pharmacol. Sci. 1997, 18, 204.