Inhibition of nitric oxide synthase by 1-(2-trifluoromethylphenyl) imidazole (TRIM) in vitro: Antinociceptive and cardiovascular effects

British Journal of Pharmacology

Volumn 119, Issue 2, 1996, Pages 423-431

  Handy, Rachel L C ^a   Harb, H L ^a   Wallace, P ^a   Gaffen, Z ^a   Whitehead, K J ^a   Moore, P K ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Antinociception; Blood pressure; Chlorophenyl imidazole; Endothelium dependent vasodilatation; Nitric oxide; Nitric oxide synthase; Phenylimidazole; Trifluoromethylphenyl imidazole

Indexed keywords

1 (2 TRIFLUOROMETHYLPHENYL)IMIDAZOLE; 1 (2,3,5,6 TETRAFLUOROPHENYL)IMIDAZOLE; 1 CHLOROPHENYLIMIDAZOLE; 1 PHENYLIMIDAZOLE; ACETIC ACID; ARGININE; CARBACHOL; ENDOTOXIN; IMIDAZOLE; IMIDAZOLE DERIVATIVE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRITE; PHENYLEPHRINE; UNCLASSIFIED DRUG;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTINOCICEPTION; AORTA; ARTERY CONSTRICTION; ARTICLE; ATAXIA; CARDIOVASCULAR RESPONSE; CATTLE; CEREBELLUM; CHEMOLUMINESCENCE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG POTENCY; ENZYME ACTIVITY; ENZYME INHIBITION; INTRAPERITONEAL DRUG ADMINISTRATION; LUNG; MALE; MEAN ARTERIAL PRESSURE; MESENTERY; MOUSE; NONHUMAN; PRIORITY JOURNAL; RABBIT; RAT; SEDATION; VASCULAR ENDOTHELIUM; VASODILATATION;

EID: 0029793223     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1476-5381.1996.tb16003.x     Document Type: Article

References (32)

1. G methyl arginine, an inhibitor of endothelium-derived nitric oxide synthesis, is a potent pressor agent in the guinea pig; does nitric oxide regulate blood pressure in vivo? Biochem. Biophys. Res. Commun., 160, 881-886.
2. ANGGARD, E. (1994). Nitric oxide: mediator, murderer, and medicine. Lancet, 343, 1199-1206.
3. BABBEDGE, R.C. (1993). Nitric Oxide Synthase Inhibitors: Biochemical and Pharmacological Evaluation of Their Antinociceptive and Cardiovascular Activity in The Mouse. PhD thesis, University of London.
4. BABBEDGE, R.C., BLAND-WARD, P.A., HART, S.L. & MOORE, P.K. (1993). Inhibition of rat cerebellar nitric oxide synthase by 7-nitro indazole and related substituted indazoles. Br. J. Pharmacol., 110, 225-228.
5. BHARDWAJ, R. & MOORE, P.K. (1988). Endothelium-derived relaxing factor and the effect of acetylcholine and histamine on resistance blood vessels. Br. J. Pharmacol., 95, 835-843.
6. DALKARA, T. & MOSKOWITZ, M.A. (1994). The complex role of nitric oxide in focal cerebral ischemia. Brain Pathol., 4, 49-57.
7. DAVIES, J.K. & WALLACE, P. (1976). The box maze test. Br. J. Pharmacol., 57, 474P.
8. GARTHWAITE, J. & BOULTON, C.L. (1993). Nitric oxide signaling in the central nervous system. Ann. Rev. Physiol., 57, 683-706.
9. HANDY, R.L.C., WALLACE, P., GAFFEN, Z.A., WHITEHEAD, K.J. & MOORE, P.K. (1995). 1-(2-Trifluoromethylphenyl)imidazole (TRIM): a potent inhibitor of neuronal nitric oxide synthase in vitro is antinociceptive in the mouse. Br. J. Pharmacol., 116, 2349-2350.
10. HANDY, R.L.C., WHITEHEAD, K.J. & MOORE, P.K. (1996). Inhibition of nitric oxide synthase by 1-(2-trifluoromethylphenyl) imidazole (TRIM) and related imidazoles. Br. J. Pharmacol., 117, 208P.
11. HARB, H.L., HANDY, R.L.C., WHITEHEAD, K.J. & MOORE, P.K. (1996). Lack of effect of 1-(2-trifluoromethylphenyl) imidazole (TRIM) on endothelium dependent vasodilatation in rabbit aorta and perfused rat mesentery. Br. J. Pharmacol., 117, 280P.
12. KAPAS, L., FANG, J. & KRUEGER, J.M. (1994). Inhibition of nitric oxide synthesis inhibits rat sleep. Brain Res., 664, 189-196.
13. KELLY, P.A.T., RITCHIE, I.M. & ARBUTHNOTT, W.W. (1995). Inhibition of neuronal nitric oxide synthase by 7-nitroindazole: Effects upon local cerebral blood flow and glucose use in the rat. J. Cereb. Blood Flow Metab., 15, 766-773.
14. KLATT, P., SCHMID, M., LEOPOLD, E., SCHMIDT, K., WERNER, E.R. & MAYER, B. (1994). The pteridine binding site of brain nitric oxide synthase: tetrahydrobiopterin binding kinetics, specificity and allosteric interaction with substrate domain. J. Biol. Chem., 269, 13861-13866.
15. KNOWLES, R.G., PALACIOS, M., PALMER, R.M.J. & MONCADA, S. (1989). Formation of nitric oxide from L-arginine in the central nervous system: a transduction mechanism for stimulation of the soluble guanylate cyclase. Proc. Natl. Acad. Sci. U.S.A., 86, 5159-5162.
16. LOWRY, O.J., ROSEBROUGH, N.J., FARR, A.L. & RANDALL, R.J. (1951). Protein measurement with Folin-phenol reagent. J. Biol. Chem., 193, 265-269.
17. MALMBERG, A. & YAKSH, T.L. (1993). Spinal nitric oxide synthesis inhibition blocks NMDA-induced thermal hyperalgesia and produces antinociception in the formalin test in rats. Pain, 54, 291-300.
18. MAYER, B., KLATT, P., WERNER, R. & SCHMIDT, K. (1994). Molecular mechanisms of inhibition of porcine brain nitric oxide synthase by the antinociceptive drug 7-nitro indazole. Neuropharmacology, 33, 1253-1259.
19. MCMILLAN, K. & MASTERS, B.S.S. (1993). Optical difference spectrophotometry as a probe of rat brain nitric oxide synthase heme-substrate interaction. Biochemistry, 32, 9875-9880.
20. MELLER, S.T. & GEBHART, G.F. (1993). Nitric oxide (NO) and nociceptive processing in the spinal cord. Pain, 52, 127-136.
21. G nitro arginine (L-NOARG), a novel, L-arginine-reversible inhibitor of endothelium-dependent vasodilatation in vitro. Br. J. Pharmacol., 99, 408-412.
22. G nitroarginine methyl ester exhibits antinociceptive activity in the mouse. Br. J. Pharmacol., 102, 198-202.
23. MOORE, P.K., WALLACE, P., GAFFEN, Z.A., HART, S.L. & BABBEDGE, R.C. (1993a). 7-Nitro indazole, an inhibitor of nitric oxide synthase, exhibits anti-nociceptive activity in the mouse without increasing blood pressure. Br. J. Pharmacol., 108, 296-297.
24. MOORE, P.K., WALLACE, P., GAFFEN, Z., HART, S.L. & BABBEDGE, R.C. (1993b). Characterisation of the novel nitric oxide synthase inhibitor 7-nitro indazole and related indazoles: antinociceptive and cardiovascular effects. Br. J. Pharmacol., 110, 219-224.
25. G nitro arginine methyl ester (L-NAME) and flurbiprofen in the mouse. Br. J. Pharmacol., 106, 493-497.
26. OGDEN, J.E. & MOORE, P.K. (1995). Inhibition of nitric oxide synthase - potential for a novel class of therapeutic agent? Trends Biotechnol., 13, 70-78.
27. PETROS, A., BENNETT, D. & VALLANCE, P. (1991). Effect of nitric oxide synthase inhibitors on hypotension in patients with septic shock. Lancet, 338, 1557-1558.
28. REES, D.D., PALMER, R.M.J. & MONCADA, S (1989). Role of endothelium-derived nitric oxide in the regulation of blood pressure. Proc. Natl. Acad. Sci. U.S.A., 86, 3375-3378.
29. SCHMIDT, H.H.H.W., POLLOCK, J.S., NAKANE, M., GORSKY, L.D., FORSTERMAN, U. & MURAD, F. (1991). Purification of a soluble isoform of guanylyl cyclase-activating factor synthase. Proc. Natl. Acad. Sci. U.S.A., 88, 10480-10484.
30. WANG, Q., PELLIGRINO, D.A., BAUGHMAN, V.L., KOENIG, H.M. & ALBRECHT, R.F. (1995). The role of neuronal nitric oxide synthase regulation of cerebral blood flow in normocapnia and hypercapnia in rat. J. Cereb. Blood Flow Metab., 15, 774-778.
31. WOLFF, D.J., DATTO, G.A., SAMATOVICZ, R.A. & TEMPSICK, R.A. (1993). Calmodulin-dependent nitric oxide synthase: mechanism of inhibition by imidazole and phenylimidazoles. Proc. Natl. Acad. Sci. U.S.A., 268, 9425-9429.
32. WOLFF, D.J. & GRIBIN, B.J. (1994). The inhibition of the constitutive and inducible nitric oxide synthase isoforms by indazole agents. Arch. Biochem. Biophys., 311, 300-306.