Effects of three inhibitors of nitric oxide synthase on host resistance to bacterial infection

Inflammation Research

Volumn 45, Issue 3, 1996, Pages 109-112

  Fukatsu, K ^a   Saito, H ^a   Fukushima, R ^a   Lin, M T ^a   Inoue, T ^a   Inaba, T ^a   Furukawa, S ^a   Han, I ^a   Muto, T ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

N(G) monomethyl L arginine (L NMMA); N(G) nitro L arginine methyl ester (L NAME); N iminoethyl L ornithine (L NIO); Septic shock; Survival

Indexed keywords

ARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; ORNITHINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL INFECTION; CONTROLLED STUDY; ESCHERICHIA COLI; FEMALE; HOST RESISTANCE; INTRAPERITONEAL DRUG ADMINISTRATION; MOUSE; NONHUMAN; PERITONEAL CAVITY; SEPSIS; SURVIVAL;

ANIMALS; ARGININE; DISEASE MODELS, ANIMAL; ENZYME INHIBITORS; ESCHERICHIA COLI INFECTIONS; FEMALE; MICE; MICE, INBRED BALB C; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; OMEGA-N-METHYLARGININE; ORNITHINE; PROSPECTIVE STUDIES; RANDOM ALLOCATION;

EID: 0029932556     PISSN: 10233830     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02265161     Document Type: Article

References (17)

1. Moncada S, Palmer RMJ, Higgs EA. Nitric oxide: physiology, pathophysiology and pharmacology. Pharm Rev 1991; 43: 109-42.
2. Hibbs JB Jr, Vavrin Z, Taintor RR. L-arginine is required for expression of the activated macrophage effector mechanism causing selective metabolic inhibition in target cells. J Immunol 1987;138:550-65.
3. Hibbs JB Jr, Taintor RR, Vavrin Z, et al. Nitric oxide: A cytotoxic activated macrophage effector molecule. Biochem Biophys Res Commun 1988;157:87-94.
4. McCall T, Boughton-Smith NK, Palmer RMJ, et al. Synthesis of nitric oxide from L-arginine by neutrophils. Biochem J 1989;261:293-6.
5. Rimele TJ, Sturm RJ, Adams LM, et al. Interaction of neutrophils with vascular smooth muscle. J Pharmacol Exp Ther 1988;245:102-11.
6. Green SJ, Nancy CA, Meltger MS. Cytokine induced synthesis of nitrogen oxides in macrophages. J Leukocyte Biol 1991;50:93-103.
7. Liew FY, Millot S, Parkinson C, Palmer RMJ, Monchada S. Macrophage killing of Lieshmania parasite in vivo is mediated by nitric oxide from L-arginine. J Immunol 1990;144:4794-7.
8. Ochoa JB, Udekwu AO, Billiar TR, et al. Nitrogen Oxide levels in patients after trauma and during sepsis. Ann Surg 1991;214:621-6.
9. Nava E, Palmer RMJ, Moncada S. Inhibition of nitric oxide synthesis in septic shock: how much is beneficial? Lancet 1991; 338:1557-7.
10. Petros A, Bennett D, Vallance P. Effect of nitric oxide synthase inhibitors on hypotension in patients with septic shock. Lancet 1991;338:1557-8.
11. G-methyl-L-arginine, an inhibitor of nitric oxide synthesis. Biochem Biophys Res Commun 1990;172:1132-8.
12. Rees DD, Palmer RMJ, Schulz R, et al. Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo. Br J Pharmacol 1990;101:746-52.
13. McCall TB, Feelisch M, Palmer RMJ, Moncada S. Identification of N-iminoethyl-L-ornithine as an irreversible inhibitor of nitric oxide synthase in phagocytic cells. Br J Pharmacol 1991;102:234-8.
14. Fukatsu K, Saito H, Fukushima R, et al. Detrimental effects of nitric oxide synthase inhibitor (Nω-nitro-L-arginine-ester) in a murine sepsis model. Arch Surg 1995;130:410-4.
15. Evans T, Carpenter A, Silva A, Cohen J. Inhibition of nitric oxide synthase in experimental gram-negative sepsis. J Infec Dis 1994;169:343-9.
16. Robertson FM, Offner PJ, Ciceri DP, et al. Detrimental hemodynamic effects of nitric oxide synthase inhibition in septic shock. Arch Surg 1994;129:149-56.
17. Minnard EA, Shou J, Naam H, et al. Inhibition of nitric oxide synthesis is detrimental during endotoxemia. Arch Surg 1994; 129:142-8.