Endogenous nitric oxide is decreased in asthmatic patients by an inhibitor of inducible nitric oxide synthase

American Journal of Respiratory and Critical Care Medicine

Volumn 154, Issue 1, 1996, Pages 247-250

  Yates, Deborah H ^a   Kharitonov, Sergei A ^a   Thomas, Paul S ^a   Barnes, Peter J ^a  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOGUANIDINE; GLUCOCORTICOID; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR;

ADULT; ARTICLE; ASTHMA; BRONCHUS MUSCLE; CLINICAL ARTICLE; ENZYME ACTIVATION; ENZYME INHIBITION; FEMALE; FORCED EXPIRATORY VOLUME; HUMAN; INHALATIONAL DRUG ADMINISTRATION; LUNG FUNCTION; MALE; NEBULIZER; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; REGULATORY MECHANISM;

EID: 0030017086     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/ajrccm.154.1.8680689     Document Type: Article

References (18)

1. Barnes, P. J. 1995. Nitric oxide and airway disease. Ann. Med. 27: 389-393.
2. Leone, A. M., L. E. Gustafsson, P. L. Francis, M. G. Persson, N. P. Wiklund, and S. Moncada. 1994. Nitric oxide in exhaled breath in humans: direct GC-MS confirmation. Biochem. Biophys. Res. Commun. 201:883-887.
3. Kharitonov, S. A., D. Yates, R. A. Robbins, R. Logan-Sinclair, E. Shine-bourne, and P. J. Barnes. 1994. Increased nitric oxide in exhaled air of asthmatic patients. Lancet 343:133-135.
4. Persson, M. G., O. Zetterstrom, V. Argenius, E. Ihre, and L . E. Gustafsson. 1994. Single-breath oxide measurements in asthmatic patients and smokers. Lancet 343:146-147.
5. Kharitonov, S. A., A. U. Wells, B. J. O'Connor, D. M. Hansell, P. J. Cole, and P. J. Barnes. 1995. Elevated levels of exhaled nitric oxide in bronchiectasis. Am. J. Respir. Crit. Care Med. 152:609-612.
6. Gerlach, H., R. Rossaint, D. Pappert, M. Knorr, and K. J. Falke. 1994. Autoinhalation of nitric oxide after endogenous synthesis in nasopharynx. Lancet 343:518-519.
7. Nathan, C., and Q.-W. Xie. 1994. Regulation of biosynthesis of nitric oxide. J. Biol. Chem. 269:13725-13728.
8. Kobzik, L., D. S. Bredt, C. J. Lowenstein, J. Drazen, B. Gaston, D. Sugarbaker, and J, S. Stamler. 1993. Nitric oxide synthase in human and rat lung: immunoeytochemical and histochemical localization. Am. J. Respir. Cell Mol Biol. 9:371-377.
9. Robbins, R. A., P. J. Barnes, D. R. Springall, J. B. Warren, O. J. Kwon, L. D. K. Buttery, A. J. Wilson, D. A. Geller and J. M. Polak. 1994. Expression of inducible nitric oxide synthase in human bronchial epithelial cells. Biochem. Biophys. Res. Commun. 203:209-218.
10. Hamid, Q., D. R. Springall, V. Riveros-Morena, P. Chanez, P. Howarth, A. Redington, J. Bousquet, P. Godard, S. Holgate, and J. Polak. 1993. Induction of nitric oxide synthase in asthma. Lancet 342: 1510-1513.
11. Schilling, J., M. Cakmakci, U. Battig, and G. Geroulanos. 1993. A new approach to the treatment of hypotension in septic shock by NG-monomethyl-L-arginine, an inhibitor of nitric oxide synthase. Intensive Care Med. 19:221-231.
12. Peters, A., G. Lamb, A. Leone, S. Moncada, D. Bennett, and P. Vallance. 1994. Effects of a nitric oxide synthase inhibitor in humans with septic shock. Cardiovasc. Res. 28:34-39.
13. Misko, T. P., W. M. Moore, T. P. Kasten, G. A. Nickols, J. A. Corbett, R. G. Tilton, M. L. McDaniel, J. R. Williamson, and M. G. Currie. 1993. Selective inhibition of inducible nitric oxide synthase by aminoguanidine. Eur. J. Pharmacol. 233:119-125.
14. Hasan, K., B. J. Heesen, J. A. Corbett, M. L. McDaniel, K. Chang, W. Allison, B. H. Wolffenbuttel, J. R. Williamson, and B. G. Tilton. 1993. Inhibition of nitric oxide formation by guanidines. Eur. J. Pharmacol. 249:101-106.
15. Stamler, J. S., E. Loh, M.-A. Roddy, X. E. Currie, and M. A. Creager. 1994. Nitric oxide regulates broad systemic and pulmonary vascular resistance in normal humans. Circulation 89:2035-2040.
16. Yates, D. H., S. A. Kharitonov, R. A. Robbins, P. S. Thomas, and P. J. Barnes. 1995. Effect of a nitric oxide synthase inhibitor and a glucocorticosteroid on exhaled nitric oxide. Am. J. Respir. Crit. Care Med. 152:892-896.
17. Nijkamp, F. P ., H. J. van der Linde, and G. Folkerts. 1993. Nitric oxide synthesis inhalations induce airway hyperresponsiveness in guinea pig in vivo and in vitro. Am. Rev. Respir. Dis. 148:727-734.
18. Gaston, B., J. Reilly, J. M. Drazen, J. Fackler, P. Ramden, D. Arnelle, M. E. Mullins, D. J. Sugarbaker, C. Chee, D. J. Singel, J. Loscalzo, and J. S. Stamler. 1993. Endogenous nitrogen oxides and bronchodilator S-nitrosolthiols in human airways. Proc. Natl. Acad. Sci. U.S.A. 90:10957-10961.