Enhanced release of interleukin-10 and soluble tumor necrosis factor receptors as novel principles of methylxanthine action in murine models of endotoxic shock

Journal of Pharmacology and Experimental Therapeutics

Volumn 278, Issue 1, 1996, Pages 421-431

  Jilg, Sabine ^a   Barsig, Johannes ^a   Leist, Marcel ^a   Küsters, Sabine ^a   Volk, Hans Dieter ^b   Wendel, Albrecht ^a  

^a UNIVERSITY OF KONSTANZ   (Germany)

^b HUMBOLDT UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

A 802715; BACTERIUM LIPOPOLYSACCHARIDE; GALACTOSAMINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 6; METHYLXANTHINE DERIVATIVE; PENTOXIFYLLINE; RECOMBINANT TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; FEMALE; IMMUNOMODULATION; INTRAPERITONEAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; LIVER FAILURE; LIVER INJURY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SEPTIC SHOCK;

ANIMALS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; INTERLEUKIN-10; MALE; MICE; MICE, INBRED BALB C; RECEPTORS, TUMOR NECROSIS FACTOR; SHOCK, SEPTIC; TUMOR NECROSIS FACTOR-ALPHA; XANTHINES;

EID: 0030434274     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (75)

1. ALEGRE, M.-L., GASTALEDELLO, K., ABRAMOWICZ, D., KINNAERT, P., VEREER-STRAETEN, P., PAUW, L. D., VANDENABEELE, P., MOSER, M., OBERDAN, L. AND GOLDMAN, M.: Evidence that pentoxifylline reduces anti-CD3 monoclonal antibody-induced cytokine release syndrome. Transplantation 52: 674-679, 1991.
2. ARAI, T., HIROMATSU, K., KOBAYASHI, N., TAKANO, M., ISHIDA, H., NIMURA, Y. AND YOSHIKAI, Y.: IL-10 is involved in the protective effect of dibutyryl cyclic adenosine monophosphate on endotoxin-induced inflammatory liver injury. J. Immunol. 155: 5743-5749, 1995.
3. BARSIG, J., KüSTERS, S., VOGT, K., VOLK, H.-D., TIEGS, G. AND WENDEL, A.: Lipopolysaccharide-induced interleukin-10 in mice: Role of endogenous tumor necrosis factor-á. Eur. J. Immunol. 25: 2888-2893, 1995.
4. BAUMANN, H. AND GAULDIE, J.: The acute phase response. Immunol. Today. 15: 74-80, 1994.
5. γ. J. Immunol. 151: 5554-5562, 1993.
6. BERG, D. J., KÜHN, R., RAJEVSKY, K., MÜLLER, W., MENON, S., DAVIDSON, N., GRÜNIG, G. AND RENNICK, D.: Interleukin-10 is a central regulator of the response to LPS in murine models of endotoxic shock and the Shwartzman reaction but not endotoxin tolerance. J. Clin. Invest. 96: 2339-2347, 1995.
7. BERGMEYER, H. U.: Methods in Enzymatic Analysis, 3rd ed., Verlag Chemie, Weinheim, 1984.
8. BEUTLER, B., MILSARK, I. W. AND CERAMI, A.: Passive immunization against cachectin/tumor necrosis factor protects mice from lethal effect of endotoxin. Science 229: 869-871, 1985.
9. BJORNBERG, F., LANTZ, M., OLSSON, I. AND GULLBERG, U.: Mechanisms involved in the processing of the p55 and p75 tumor necrosis factor (TNF) receptors to soluble receptor forms. Lymphokine Cytokine Res. 13: 203-211, 1994.
10. BOHLINGER, I., LEIST, M., BARSIG, J., UHLIG, S., TIEGS, G. AND WENDEL, A.: Interleukin-1 and nitric oxide protect against tumor necrosis factor α-induced liver injury through distinct pathways. Hepatology 22: 1829-1837, 1995.
11. BONE, R. C.: The pathogenesis of sepsis. Ann. Intern. Med. 115; 457-469, 1991.
12. BONE, R. C., BALK, R. A., CERRA, F. B., DELLINGER, R. P., FEIN, A. M., KNAUS, W. A., SCHEIN, R. H. AND SIBBALD, W. J.: Accp/sccm consensus conference. Definitions for sepsis and organ failure and guidlines for the use of innovative therapies in sepsis. Chest. 101: 1644-1655, 1992.
13. BOURRIE, B., BOUABOULA, M., BENOIT, J.-M., DEROCQ, J.-M., ESCLANGON, M. LE FUR, G. CASELLAS, P.: Enhancement of endotoxin-induced interleukin-10 production by SR 31747A, a sigma ligand. Eur. J. Immunol. 25: 2882-2887, 1995.
14. CERAMI, A. AND BEUTLER, B.: The role of cachectin/TNF in endotoxic shock and cachexia. Immunol. Today. 9: 28-31, 1988.
15. CHOMCZYNSKI, P. AND SACCHI, N.: Single-step method of RNA isolation by acid guanidine thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162: 156-159, 1987.
16. DAVIS, J.: Setbacks in the war against sepsis. Scrip Mag. 50-52, 1994.
17. DENDORFER, U., OETTGEN, P. AND LIBERMANN, T. A.: Multiple regulatory elements in the interleukin-6 gene mediate induction by prostaglandins, cyclic AMP, and lipopolysaccharide. Mol. Cell. Biol. 14: 4443-4454, 1994.
18. DERKX, B., TAMINIAU, J., RADEMA, S., STRONKHORST, A., WORTEL, C., TYTGAT, G. AND VAN DEVENTER, S.: Tumour-necrosis-factor antibody treatment in Crohn's disease. Lancet 342: 173-174, 1993.
19. DEZUBE, B. J., SHERMAN, M. L., FRIDOVICH-KEIL, J. L., ALLEN-RYAN, J. AND PARDEE, A. B.: Down-regulation of tumor necrosis factor expression by pentoxifylline in cancer patients: A pilot study. Cancer Immunol. Immunother. 36: 57-60, 1993.
20. DINARELLO, C. A.: The proinflammatory cytokines Interleukin-1 and Tumor Necrosis Factor and treatment of the septic shock syndrome. J. Infect. Dis. 163: 1177-1184, 1991.
21. DUREZ, P., ABRAMOWICZ, D., GERARD, C., VAN MECHELEN, M., AMEAOUI, Z., DUBOIS, C., LEO, O., VELU, T. AND GOLDMAN, M.: In vivo induction of interleukin 10 by anti-CD3 monoclonal antibody or bacterial lipopolysaccharide: Differential modulation by cyclosporin A. J. Exp. Med. 177: 551-555, 1993.
22. ELLIOTT, M. J., MAINI, R. N., FELDMANN, M., LONG-FOX, A., CHARLES, P., BIJL, H. AND WOODY, J. N.: Repeated therapy with monoclonal antibody to tumour necrosis factor alpha (cA2) in patients with rheumatoid arthritis. Lancet 344: 1125-1127, 1894.
23. FIORENTINO, D. F., ZLOTNIK, A., MOSMANN, T. R., ZOWAKD, M. AND O'GARRA, A.: IL-10 inhibits cytokine production by activated macrophages. J. Immunol. 147; 3815-3822, 1991.
24. FISCHER, W., SCHUDT, CH. AND WENDEL, A.: Protection by phosphodiesterase inhibitors against endotoxin-induced liver injury in galactosamine-sensitized mice. Biochem. Pharmacol. 45: 2399-2404, 1993.
25. GANTNER, F., LEIST, M., LOHSE, A. W., GERMANN, P. G. AND TIEGS, G.: Concanavalin A-induced T-cell-mediated hepatic injury in mice: The role of tumor necrosis factor. Hepatology 21: 190-198, 1995.
26. GERARD, C., BRUYNS, C., MARCHANT, A., ABRAMOWICZ, D., VANDENABEELE, P., DELVAUX, A., FIERS, W. AND GOLDMAN, M. VELU, T.: Interleukin 10 reduces the release of tumor necrosis factor and prevents lethality in experimental endotoxemia. J. Exp. Med. 177: 547-550, 1993.
27. GÓMEZ-HIMÉNEZ, J., MARTIN, M. C., SAURI, R., SEGURA, R. M., ESTEBAN, F., RUIZ, J. C., NUVIALS, X., BÓVEDA, J. L., PERACAULA, R. AND SALGADO, A.: Interleukin-10 and the monocyte/macrophage-induced inflammatory response in septic shock. J. Infect. Dis. 171; 472-475, 1995.
28. HARAGUCHI, S., GOOD, R. A. AND DAY, N. K.: Immunosuppressive retroviral peptides: cAMP and cytokine patterns. Immunol. Today 16: 595-603, 1995.
29. HARBRECHT, B. G., BILLIAR, T. R., STADLER, J., DEMETRIS, A. J., OCHOA, J. B. AND CURRAN, R. D: Simmons, R. L.: Nitric oxide synthesis serves to prevent hepatic damage during acute murine endotoxemia. Crit. Care Med. 20: 1568-1574, 1992.
30. HARTUNG, T., DOECKE, W.-D., GANTNER, F., KRIEGER, G., SAUER, A., STEVENS, P., VOLK, H.-D. AND WENDEL, A.: Effect of granulocyte colony-stimulating factor treatment on ex vivo blood cytokine response in human volunteers. Blood 85: 2482-2489, 1995.
31. γ in the pathology of experimental endotoxemia. J. Immunol. 145: 2920-2924, 1990.
32. HOPKINS, S. J. AND HUMPHREYS, M.: Simple, sensitive and specific bioassay of interleukin-1. J. Immunol. Methods 120: 271-276, 1989.
33. HOWARD, M., MUCHAMUEL, T., ANDRADE, S. AND MENON, S.: Interleukin 10 protects mice from lethal endotoxemia. J. Exp. Med. 177: 1205-1208, 1993.
34. ISHIDA, H., HASTINGS, R., THOMPSON-SNIPES, L. AND HOWARD, M.: Modified immunological status of anti-IL-10 treated mice. Cell Immunol. 148: 371-384, 1993.
35. JOYCE, D. A., GIBBONS, D. P., GREEN, P., STEER, J. H., FELDMANN, M. AND BRENNAN, F. M.: Two inhibitors of pro-inflammatory cytokine release, interleukin-10 and interleukin-4, have contrasting effects on release of soluble p75 tumor necrosis factor receptor by cultured monocytes. Eur. J. Immunol. 24: 2699-2705, 1994.
36. KEPPLER, D. O. R., PAUSCH, J. AND DECKER, K.: Selective uridine triphosphate deficiency induced by D-galactosamine in liver and reversed by pyrimidine nucleotide precursors. J. Biol. Chem. 249: 211-216, 1974.
37. KIM, J. M., BRANNAN, C. I., COPELAND, N. G., JENKINS, N. A., KHAN, T. A. AND MOORE, K. W.: Structure of the mouse IL-10 gene and chromosomal localization of the mouse and human genes. J. Immunol. 148: 3618-3623, 1992.
38. KLAUNIG, J. E., GOLDBLATT, P. J., HINTON, D. E., LIPSKY, M. M., CHACKO, J. AND TRUMP, B. F.: Mouse liver cell culture. I. Hepatocyte isolation. In Vitro. 17: 913-925, 1981.
39. KÜHN, R., LOEHLER, J., RENNICK, D., RAJEWSKY, K. AND MÜLLER, W.: Interleukin-10-deficient mice develop chronic enterocolitis. Cell 75: 263-274, 1993.
40. LEIST, M., AUER-BARTH, S. AND WENDEL, A.: Tumor necrosis factor production in the perfused mouse liver and its pharmacological modulation by methylxanthines. J. Pharmacol. Exp. Ther. 276: 968-976, 1996.
41. LEIST, M., GANTNER, F., BOHLINGER, I., GERMANN, P. G., TIEGS, G. AND WENDEL, A.: Murine hepatocyte apoptosis induced in vitro and in vivo by TNF-α requires transcriptional arrest. J. Immunol. 153: 1778-1788, 1994.
42. LEIST, M., GANTNER, F., BOHLINGER, I., TIEGS, G., GERMANN, P. G. AND WENDEL, A.: Tumor necrosis factor-induced hepatocyte apoptosis precedes liver failure in experimental murine shock models. Am. J. Pathol. 146: 1220-1234, 1995a.
43. LEIST, M., GANTNER, F., JILG, S. AND WENDEL, A.: Activation of the 55 kDaTNF receptor is necessary and sufficient for TNF-induced liver failure, hepatocyte apoptosis, and nitrite release. J. Immunol. 154: 1307-1316, 1995b.
44. LESSLAUER, W., TABUCHI, H., GENTZ, R., BROCKHAUS, M., SCHLAEGER, E. J., GRAU, G., PIGUET, P. F., POINTAIRE, P., VASSALLI, P. AND LOETSCHER, H.: Recombinant soluble tumor necrosis factor receptor proteins protect mice from lipopolysaccharide-induced lethality. Eur. J. Immunol. 21: 2883-2886, 1991.
45. LIBERT, C., BROUCKAERT, P. AND FIERS, W.: Protection by al-acid glycoprotein against tumor necrosis factor-induced lethality. J. Exp. Med. 180: 1571-1575, 1994.
46. MAKSYMOWYCH, W. P., AVINA-ZUBIETA, A., LUONG, M. H. AND RUSSELL, A. S.: An open study of pentoxifylline in the treatment of severe refractory rheumatoid arthritis. J. Rheumatol. 22: 625-629, 1995.
47. MARCHANT, A., BRUYNS, C., VANDENABEELE, P., DUCARME, M., GERARD, C., DELVAUX, A., DE GROOTE, D., ABRAMOWICZ, C., VELU, T. AND GOLDMAN, M.: Interleukin-10 controls interferon-γ and tumor necrosis factor production during experimental endotoxemia. Eur J Immunol. 24:1167-1171, 1994a.
48. MARCHANT, A., DEVIERE, J., BYL, B., DE GROOTE, D., VINCENT, J.-L. AND GOLDMAN, M.: Interleukin-10 as a protective cytokine produced during human septicemia. Crit. Care Med. 20: suppl. 1, S68, 1994b.
49. MARCHANT, A., DEVIERE, J., BYL, B., DE GROOTE, D., VINCENT, J. L. AND GOLDMAN, M.: Interleukin-10 production during septicaemia. Lancet 343: 707-708, 1994c.
50. MEEK, D. W. AND STREET, A. J.: Nuclear protein phosphorylation and growth control. Biochem. J. 287: 1-15, 1992.
51. MOSMANN, T.: Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods 65: 55-63, 1983.
52. MURRAY, K. J.: Cyclic AMP and mechanisms of vasodilation. Pharmacol. Ther. 47: 329-345, 1990.
53. NEUNER, P., KLOSNER, G., SCHAUER, E., POURMOJIB, M., MACHEINER, W., GRÜNWALD, C., KNOBLER, R., SCHWARZ, A., LUGER, T. A. AND SCHWARZ, T.: Pentoxifylline in vivo down-regulates the release of IL-1 beta, IL-6, IL-8 and tumor necrosis factor-alpha by human peripheral blood mononuclear cells. Immunology 83: 262-267, 1994.
54. NIEHOERSTER, M., SCHOENHARTING, M. AND WENDEL, A.: A novel xanthine derivative counteracting in vivo tumor necrosis factor α toxicity in mice. Circ. Shock 37: 270-273, 1992.
55. OHLSSON, K., BJOERK, P., BEHGENFELDT, M., HAGEMAN, R. AND THOMPSON, R. C.: Interleukin-1 receptor antagonist reduces mortality from endotoxin shock. Nature 348: 550-552, 1990.
56. PLATZER, C., MEISEL, CH., VOGT, K., PLATZER, M. AND VOLK, H.-D.: Up-regulation of monocytic IL-10 by tumor necrosis factor-α and cAMP elevating drugs. Int. Immunol. 7: 517-523, 1995.
57. POBER, J. S., SLOWIK, M. R., DE LUCA, L. G. AND RITCHIE, A. J.: Elevated cyclic AMP inhibits endothelial cell synthesis and expression of TNF-induced endothelial leukocyte adhesion molecule-1, and vascular cell adhesion molecule-1, but not intercellular adhesion molecule-1. J. Immunol. 150: 5114-5123, 1993.
58. REDL, H., BAHRAMI, S., SCHLAG, G. AND TRABER, D. L.: Clinical detection of LPS and animal models of endotoxemia. Immunobiology 187: 330-345, 1993.
59. ROGY, M. A., AUFFENBERG, T., ESPAT, N. J., PHILIP, R., REMICK, D., WOLLENBERG, G. K., COPELAND, I. AND MOLDAWER, L. L.: Human tumor necrosis factor receptor (p55) and interleukin 10 gene transfer in the mouse reduces mortality to lethal endotoxemia and also attenuates local inflammatory responses. J. Exp. Med. 181: 2289-2293, 1995.
60. SCHADE, U. F.: Pentoxifylline increases survival in murine endotoxin shock and decreases formation of tumor necrosis factor. Circ. Shock 31: 171-181, 1990.
61. SCHANDENÉ, L., VANDENBUSSCHE, P., CRUSIAUX, A., ALÉGRE, M.-L., ABRAMOWICZ, D., DUPONT, E., CONTENT, J. AND GOLDMAN, M.: Differential effects of pentoxifylline on the production of tumour necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6) by monocytes and T cells. Immunology 76: 30-34, 1992.
62. SCHUDT, C., WINDER, S., FORDERKUNZ, S., HATZELMANN, A. AND ULLRICH, V.: Influence of selective phophodiesterase inhibitors on human neutrophil functions and levels of cAMP and Ca. Naunyn-Schmiedeberg's Arch. Pharmacol. 344: 682-690, 1991.
63. SEGLEN, P. O.: Preparation of rat liver cells: Enzymatic requirements for tissue dispersion. Exp. Cell Res. 82: 391-398, 1973.
64. SEMMLER, J., GEBERT, U., EISENHUT, T., MOELLER, J., SCHÖNHARTING, M. M., ALLËRA, A. AND ENDRES, S.: Xanthine derivatives: comparison between suppression of tumour necrosis factor-α production and inhibition of cAMP phosphodiesterase activity. Immunology 78: 520-525, 1993.
65. SHIRAFUJI, M., ASANO, S., MATSUDA, S., WATARI, K., TAKAKU, F. AND NAGATA, S.: A new bioassay for human granulocyte colony-stimulating factor (hG-CSF) using murine myeloblastic NFS-60 cells as targets and estimation of its levels in sera from normal healthy persons and patients with infectious and hematological disorders. Exp. Hematol. 17: 116-119, 1989.
66. SIEGLING, A., LEHMANN, M., PLATZER, C., EMMRICH, F. AND VOLK, H.-D.: A novel multispecific competitor fragment for quantitative PCR analysis of cytokine gene expression in rats. J. Immunol. Methods 177: 23-28, 1994.
67. SINHA, B., SEMMLER, J., EISENHUT, T., EIGLER, A. AND ENDRES, S.: Enhanced tumor necrosis factor suppression and cyclic adenosine monophosphate accumulation by combination of phosphodiesterase inhibitors and prostanoids. Eur. J. Immunol. 25: 147-153, 1995.
68. STANDIFORD, T. J., STRIETER, R. M., LUKACS, N. W. AND KUNKEL, S. L.: Neutralization of IL-10 increases lethality in endotoxemia. Cooperative effects of macrophage inflammatory protein-2 and tumor necrosis factor. J. Immunol. 155: 2222-2229, 1995.
69. 2. J. Exp. Med. 180: 2365-2370, 1994.
70. TARAZONA, R., GONZÁLEZ-GARCÍA, A., ZAMZAMI, N., MARCHETTI, P., FRECHIN, N., GONZALO, J. A., RUIZ-GAYO, M., VAN ROOIJEN, N., MARTÍNEZ-A., C. AND KROEMER, G.: Chlorpromazine amplifies macrophage-dependent IL-10 production in vivo. J. Immunol. 154: 861-870, 1995.
71. TIEGS, G., WOLTER, M. AND WENDEL, A.: Tumor necrosis factor is a terminal mediator in galactosamine/endotoxin-induced hepatitis in mice. Biochem. Pharmacol. 38: 627-631, 1989.
72. VAN ZEE, K. J., KOHNO, T., FISCHER, E., ROCK, C. S., MOLDAWER, L. L. AND LOWRY, S. F.: Tumor necrosis factor soluble receptors circulate during experimental and clinical inflammation and can protect against excessive tumor necrosis factor α in vitro and in vivo. Proc. Natl. Acad. Sci. U.S.A. 89: 4845-4849, 1992.
73. WENDEL, A.: Biochemical pharmacology of inflammatory liver injury in mice. Methods Enzymol. 186: 675-680, 1990.
74. WHERRY, J., WENZEL, R., WUNDERLINK, R., SILVERMAN, H., PERL, T. AND NASRAWAY, S.: Monoclonal antibody to human tumor necrosis factor (TNF mAb): Multicenter efficacy and safety in patients with the sepsis syndrome. Presented at the 33rd Interscience Conference on Antimicrobial Agents and Chemotherapy, American Society for Microbiology, New Orleans, Louisiana (Abstract). 696: 246, 1993.
75. ZABEL, P., WOLTER, D. T., SCHÖNHARTING, M. M. AND SCHADE, U. F.: Oxpentifylline in endotoxemia. Lancet II: 1474-1477, 1989.