메뉴 건너뛰기




Volumn 21, Issue 2, 1998, Pages 239-246

High-throughput screening: Advances in assay technologies

Author keywords

[No Author keywords available]

Indexed keywords


EID: 0004558052     PISSN: 10811672     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (3)

References (72)
  • 7
    • 0031152073 scopus 로고    scopus 로고
    • 1997; 1:72-78. An excellent review of new technologies for high-throughput screening. The paper contains references on nonradioactive assay technologies, screening methods for combinatorial libraries, and issues associated with assay miniaturization.
    • 6.Burbaum JJ, Sigal NH: New technologies for high-throughput screening. Curr Opin Chem Biol 1997; 1:72-78. An excellent review of new technologies for high-throughput screening. The paper contains references on nonradioactive assay technologies, screening methods for combinatorial libraries, and issues associated with assay miniaturization.
    • Sigal NH: New Technologies for High-throughput Screening. Curr Opin Chem Biol
    • Burbaum, J.J.1
  • 8
    • 0001180917 scopus 로고    scopus 로고
    • 1997;2:159-169. This paper describes the concept of signal windows, which provides a degree of separation between measured signals. The size of the signal window is a critical performance parameter (in high-throughput screens) which impacts the identification of active compounds (hits) in the presence of varibility.
    • l: Sittampalam GS, Iversen PW, Boadt JA, Kahl SD, Bright S, Zock JM, Janzen WP, Lister MD: Design of signal windows in high throughput screening assays for drug discovery. J Biomol Screening 1997;2:159-169. This paper describes the concept of signal windows, which provides a degree of separation between measured signals. The size of the signal window is a critical performance parameter (in high-throughput screens) which impacts the identification of active compounds (hits) in the presence of varibility.
    • Iversen PW, Boadt JA, Kahl SD, Bright S, Zock JM, Janzen WP, Lister MD: Design of Signal Windows in High Throughput Screening Assays for Drug Discovery. J Biomol Screening
    • Sittampalam, G.S.1
  • 12
    • 0000885268 scopus 로고    scopus 로고
    • 1:287-294. A good account of the basic principles of the scintillation proximity assay and its specific applications in high-throughput screening, with 70 references cited.
    • 11.' Cook ND: Scintillation proximity assay: a versatile high throughput screening technology. Drug Discov Tech 1996,1:287-294. A good account of the basic principles of the scintillation proximity assay and its specific applications in high-throughput screening, with 70 references cited.
    • Scintillation Proximity Assay: A Versatile High Throughput Screening Technology. Drug Discov Tech 1996
    • Cook, N.D.1
  • 14
    • 33748073283 scopus 로고    scopus 로고
    • This paper describes the development of a scintillation proximity assay for receptor binding studies in high-throughput mode. Validation concepts and factors affecting robustness of the assays in highthroughput screening mode are addressed in detail.
    • Concepts, T.P.1    Detail, F.A.2
  • 27
    • 33748083848 scopus 로고    scopus 로고
    • 1997, 94:4-8. A good review of the fundamentals of fluorescence techniques for biological measurements. Detection techniques described are easily amenable to high-throughput screening assays. A section on recent advances describes developments in fluorescence resonance energy transfer (FRET) and fluorescence in situ hybridization (FISH) technologies, membrane potential measurements, and karyotyping human chromosomes. Over 40 references are cited on various applications.
    • 24.' Glazer AN : Recent advances in fluorescence labeling, detection and visualization. BioRadiations 1997, 94:4-8. A good review of the fundamentals of fluorescence techniques for biological measurements. Detection techniques described are easily amenable to high-throughput screening assays. A section on recent advances describes developments in fluorescence resonance energy transfer (FRET) and fluorescence in situ hybridization (FISH) technologies, membrane potential measurements, and karyotyping human chromosomes. Over 40 references are cited on various applications.
    • Recent Advances in Fluorescence Labeling, Detection and Visualization. BioRadiations
    • Glazer, A.N.1
  • 42
    • 0031016380 scopus 로고    scopus 로고
    • Method to Analyze Drug/target Interactions. J Recept Signal Transduct Res 1997; 17:511-520. This Paper Describes the Use of Fluorescence Correlation Spectroscopy to Measure Molecular Interactions in A Homogeneous Mode. It Has Been Developed to Accommodate Measurements in 96- and 384well Microtiter Plates, and Is A Good Candidate for High-throughput Screening Applications
    • 39.' S terrer S, Henco K: Fluorescence correlation spectroscopy (PCS)A highly sensitive method to analyze drug/target interactions. J Recept Signal Transduct Res 1997; 17:511-520. This paper describes the use of fluorescence correlation spectroscopy to measure molecular interactions in a homogeneous mode. It has been developed to accommodate measurements in 96- and 384well microtiter plates, and is a good candidate for high-throughput screening applications.
    • Fluorescence Correlation Spectroscopy (PCS)A Highly Sensitive
    • Sterrer, S.1    Henco, K.2
  • 55
    • 33748031267 scopus 로고    scopus 로고
    • 384-well plate: pros and cons. J Biomol Screening 1996;l:63-64.
    • Janzen B, Domanico P: The 384-well plate: pros and cons. J Biomol Screening 1996;l:63-64.
    • Domanico P: the
    • Janzen, B.1
  • 60
    • 0030072782 scopus 로고    scopus 로고
    • 1996; 3:113-120. A unique, membrane-based colorimetric system that detects molecular interactions is described. Gangliosides that specifically bind cholera toxin, Escherichia coli enterotoxin and botulism neurotoxin were incorporated into a polydiacetylene membrane. The polymer-ized membrane containing gangliosides is blue, and turns red when the toxin is added. The response is sensitive, specific and selective. An excellent technology for high-throughput screening applications.
    • 57. Charych D, Cheng Q, Reichert A, Kuziemko G, Stroh M, Nagy JO, Spevak W, Stevens RC: A 'litmus test' for molecular recognition using artificial membranes. Chem Biol 1996; 3:113-120. A unique, membrane-based colorimetric system that detects molecular interactions is described. Gangliosides that specifically bind cholera toxin, Escherichia coli enterotoxin and botulism neurotoxin were incorporated into a polydiacetylene membrane. The polymer-ized membrane containing gangliosides is blue, and turns red when the toxin is added. The response is sensitive, specific and selective. An excellent technology for high-throughput screening applications.
    • Cheng Q, Reichert A, Kuziemko G, Stroh M, Nagy JO, Spevak W, Stevens RC: A 'Litmus Test' for Molecular Recognition Using Artificial Membranes. Chem Biol
    • Charych, D.1
  • 67
    • 0029670262 scopus 로고    scopus 로고
    • TyagiS, Kramer FR: Molecular beacons: probes that fluoresce upon hybridization. Nat Biotechnol 1996; 14:303-308.
    • Tyagis Kramer, F.R.1    Beacons, M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.