Recombinant microorganisms as tools for high throughput screening for nonantibiotic compounds

Journal of Biomolecular Screening

Volumn 2, Issue 1, 1997, Pages 41-49

  Klein, Ronald D ^a   Geary, Timothy G ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0002025886     PISSN: 10870571     EISSN: None     Source Type: Journal    
DOI: 10.1177/108705719700200108     Document Type: Article

References (12)

1. Ehrlich, P., Shiga, K. (1904). Farbentherapeutische Versuche bei Trypanosomenerkrankung. Berlin, klin. Wochschr. 41:329;
2. Ehrlich, P., Shiga, K. Farbentherapeutische Versuche bei Trypanosomenerkrankung. Berlin, klin. Wochschr. 41:362.
3. Venuti, M.C. (1995). The role of recombinant DNA technology in medicinal chemistry and drug discovery. In Burger's Medicinal Chemistry and Drug Discovery, vol. 1. M.E. Wolff (ed.), pp. 661-696. John Wiley & Sons, Inc., New York.
4. Fleming, I.D., Nisbet, L.J., Brewer, S.J. (1982). Target directed antimicrobial screens. In Bioactive Microbial Products: Search and Discovery. J.D. Bu'lock, L.J. Nisbet, D.J. Winstanley (eds.), pp. 107-130. Academic Press, New York.
5. Elion, G.B. (1989). The purine path to chemotherapy. Science 244:41.
6. Hitchings, G.H. (1991). The Third Paul Ehrlich Lecture: Basic research as forerunner of new medications. Med. Res. Rev. 11:1.
7. Omura, S. (1986). Philosophy of new drug discovery. Microbiol. Rev. 50:259.
8. Tomoda, H., Omura, S. (1990). New strategy for discovery of enzyme inhibitors: Screening with intact mammalian cells or intact microorganisms having special functions. J. Antibiot. (Tokyo) 63:1207.
9. Hara, M., Akasaka, K., Akinaga, S., Okabe, M., Nakano, H., Gomez, R., Wood, D., Uh, M., Tamanoi, F. (1993). Identification of Ras famesyltransferase inhibitors by microbial screening. Proc. Natl. Acad. Sci. U.S.A. 90:2281.
10. Thompson, D.P., Klein, R.D., Geary, T.G. (1996). Prospects for rational approaches to anthelmintic discovery. Parasitology 113: S217.
11. Klein, R.D., Geary, T.G. (1992). Method of identifying compounds useful as antiparasitic drugs. United States Patent Number 5,079,143.
12. Klein, R.D., Olson, E.R., Favreau, M.A., Winterrowd, C.A., Hatzenbuhler, N.T., Shea, M.H., Nulf, S.C., Geary, T.G. (1991). Cloning of a cDNA encoding phosphofructokinase from Haemonchus contortus. Mol. Biochem. Parasitol. 48:17.