Crystal structure of avian aminoimidazole-4-carboxamide ribonucleotide transformylase in complex with a novel non-folate inhibitor identified by virtual ligand screening

Journal of Biological Chemistry

Volumn 279, Issue 48, 2004, Pages 50555-50565

  Xu, Lan ^a   Li, Chenglong ^a   Olson, Arthur J ^a   Wilson, Ian A ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHESIS; CHEMOTHERAPY; CRYSTAL STRUCTURE; NEGATIVE IONS; SCAFFOLDS; TOXICITY;

ANTIFOLATES; METHOTREXATE; OXYANION HOLE; VIRTUAL LIGAND SCREENING;

ENZYME IMMOBILIZATION;

10 FORMYL TETRAHYDROFOLATE; 2 [5 HYDROXY 3 METHYL 1 (2 METHYL 4 SULFOPHENYL) 1H PYRAZOL 4 YLAZO] 4 SULFOBENZOIC ACID; AMINO ACID DERIVATIVE; ANION; ANTINEOPLASTIC AGENT; FOLIC ACID ANTAGONIST; LIGAND; LYSINE; NATURAL PRODUCT; OXYGEN; PHENYL GROUP; PHOSPHORIBOSYLAMINOIMIDAZOLECARBOXAMIDE FORMYLTRANSFERASE; SULFONIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ALPHA HELIX; AROMATIZATION; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG FORMULATION; DRUG POTENCY; DRUG SCREENING; DRUG TARGETING; MOLECULAR INTERACTION; NONHUMAN; POLARIZATION; PRIORITY JOURNAL; STRUCTURE ANALYSIS;

ANIMALS; AZO COMPOUNDS; BENZENESULFONATES; BIRDS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; FOLIC ACID; HUMANS; HYDROXYMETHYL AND FORMYL TRANSFERASES; KINETICS; LIGANDS; PHOSPHORIBOSYLAMINOIMIDAZOLECARBOXAMIDE FORMYLTRANSFERASE; PROTEIN STRUCTURE, TERTIARY;

AVES;

EID: 9644290872     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M406801200     Document Type: Article

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