New insights into inhibitor design from the crystal structure and NMR studies of Escherichia coli GAR transformylase in complex with β-GAR and 10- formyl-5,8,10-trideazafolic acid

Biochemistry

Volumn 38, Issue 51, 1999, Pages 16783-16793

  Greasley, Samantha E ^a   Yamashita, Mason M ^a,b   Cai, Hui ^a   Benkovic, Stephen J ^c   Boger, Dale L ^a   Wilson, Ian A ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b CELGENE CORPORATION   (United States)

^c PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

10 FORMYL 5,8,10 TRIDEAZAFOLIC ACID; FOLIC ACID ANTAGONIST; FOLIC ACID DERIVATIVE; PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; COMPLEX FORMATION; CRYSTAL STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; ESCHERICHIA COLI; NONHUMAN; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; PURINE SYNTHESIS;

BINDING, COMPETITIVE; CARBON ISOTOPES; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; ESCHERICHIA COLI; GLUTAMATES; GLYCINE; HYDROXYMETHYL AND FORMYL TRANSFERASES; LIGANDS; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE; PROTEIN BINDING; QUINAZOLINES; RIBONUCLEOTIDES; SUBSTRATE SPECIFICITY;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; NEGIBACTERIA;

EID: 0033592939     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi991888a     Document Type: Article

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