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Volumn 4, Issue 6, 2004, Pages 555-561

Toll-like receptor ligands: Hygiene, atopy and therapeutic implications

Author keywords

Allergy; Asthma; CpG motif; Hygiene hypothesis; Immunostimulatory sequence oligodeoxynucleotide; Lipopolysaccharide; Peptidoglycan; Toll like receptor

Indexed keywords

LIGAND; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 9;

EID: 9644287997     PISSN: 15284050     EISSN: None     Source Type: Journal    
DOI: 10.1097/00130832-200412000-00014     Document Type: Review
Times cited : (33)

References (63)
  • 1
    • 0032865289 scopus 로고    scopus 로고
    • Role of microbial burden in aetiology of allergy and asthma
    • Martinez FD, Holt PG. Role of microbial burden in aetiology of allergy and asthma. Lancet 1999; 354 (Suppl. 2):SII12-SII15.
    • (1999) Lancet , vol.354 , Issue.SUPPL. 2
    • Martinez, F.D.1    Holt, P.G.2
  • 2
    • 0024417450 scopus 로고
    • Hay fever, hygiene, and household size
    • Strachan DP. Hay fever, hygiene, and household size. BMJ 1989; 299:1259-1260.
    • (1989) BMJ , vol.299 , pp. 1259-1260
    • Strachan, D.P.1
  • 3
    • 0033709560 scopus 로고    scopus 로고
    • Does the use of antibiotics in early childhood increase the risk of asthma and allergic disease?
    • Droste JH, Wieringa MH, Weyler JJ, et al. Does the use of antibiotics in early childhood increase the risk of asthma and allergic disease? Clin Exp Allergy 2000; 30:1547-1553.
    • (2000) Clin Exp Allergy , vol.30 , pp. 1547-1553
    • Droste, J.H.1    Wieringa, M.H.2    Weyler, J.J.3
  • 4
    • 0035495857 scopus 로고    scopus 로고
    • The germless theory of allergic diseases: Revisiting the hygiene hypothesis
    • Wills-Karp M, Santeliz J, Karp CL. The germless theory of allergic diseases: revisiting the hygiene hypothesis. Nat Rev Immunol 2001; 1:69-75.
    • (2001) Nat Rev Immunol , vol.1 , pp. 69-75
    • Wills-Karp, M.1    Santeliz, J.2    Karp, C.L.3
  • 5
    • 0037134046 scopus 로고    scopus 로고
    • Allergy, parasites, and the hygiene hypothesis
    • Yazdanbakhsh M, Kremsner PG, van Ree R. Allergy, parasites, and the hygiene hypothesis. Science 2002; 296:490-494.
    • (2002) Science , vol.296 , pp. 490-494
    • Yazdanbakhsh, M.1    Kremsner, P.G.2    Van Ree, R.3
  • 6
    • 0036280496 scopus 로고    scopus 로고
    • Environmental factors influencing the development and progression of pediatric asthma
    • von Mutius E. Environmental factors influencing the development and progression of pediatric asthma. J Allergy Clin Immunol 2002; 109:S525-S532.
    • (2002) J Allergy Clin Immunol , vol.109
    • Von Mutius, E.1
  • 7
    • 0036738382 scopus 로고    scopus 로고
    • Hay fever and asthma in relation to markers of infection in the United States
    • Matricardi PM, Rosmini F, Panetta V, et al. Hay fever and asthma in relation to markers of infection in the United States. J Allergy Clin Immunol 2002; 110:381-387.
    • (2002) J Allergy Clin Immunol , vol.110 , pp. 381-387
    • Matricardi, P.M.1    Rosmini, F.2    Panetta, V.3
  • 8
    • 0033135612 scopus 로고    scopus 로고
    • Atopy in children of families with an anthroposophic lifestyle
    • Aim JS, Swartz J, Lilja G, et al. Atopy in children of families with an anthroposophic lifestyle. Lancet 1999; 353:1485-1488.
    • (1999) Lancet , vol.353 , pp. 1485-1488
    • Aim, J.S.1    Swartz, J.2    Lilja, G.3
  • 9
    • 0029808031 scopus 로고    scopus 로고
    • Measles and atopy in Guinea-Bissau
    • Shaheen SO, Aaby P, Hall AJ, et al. Measles and atopy in Guinea-Bissau. Lancet 1996; 347:1792-1796.
    • (1996) Lancet , vol.347 , pp. 1792-1796
    • Shaheen, S.O.1    Aaby, P.2    Hall, A.J.3
  • 10
    • 0031014668 scopus 로고    scopus 로고
    • The inverse association between tuberculin responses and atopic disorder
    • Shirakawa T, Enomoto T, Shimazu S, Hopkin JM. The inverse association between tuberculin responses and atopic disorder. Science 1997; 275:77-79.
    • (1997) Science , vol.275 , pp. 77-79
    • Shirakawa, T.1    Enomoto, T.2    Shimazu, S.3    Hopkin, J.M.4
  • 11
    • 0034639769 scopus 로고    scopus 로고
    • Exposure to foodborne and orofecal microbes versus airborne viruses in relation to atopy and allergic asthma: Epidemiological study
    • Matricardi PM, Rosmini F, Riondino S, et al. Exposure to foodborne and orofecal microbes versus airborne viruses in relation to atopy and allergic asthma: epidemiological study. BMJ 2000; 320:412-417.
    • (2000) BMJ , vol.320 , pp. 412-417
    • Matricardi, P.M.1    Rosmini, F.2    Riondino, S.3
  • 12
    • 0030967169 scopus 로고    scopus 로고
    • Cross sectional retrospective study of prevalence of atopy among Italian military students with antibodies against hepatitis A virus
    • Matricardi PM, Rosmini F, Ferrigno L, et al. Cross sectional retrospective study of prevalence of atopy among Italian military students with antibodies against hepatitis A virus. BMJ 1997; 314:999-1003.
    • (1997) BMJ , vol.314 , pp. 999-1003
    • Matricardi, P.M.1    Rosmini, F.2    Ferrigno, L.3
  • 13
    • 0037328580 scopus 로고    scopus 로고
    • Respiratory syncytial virus bronchiolitis and the pathogenesis of childhood asthma
    • Martinez FD. Respiratory syncytial virus bronchiolitis and the pathogenesis of childhood asthma. Pediatr Infect Dis J 2003; 22 (2 Suppl.):S76-S82.
    • (2003) Pediatr Infect Dis J , vol.22 , Issue.2 SUPPL.
    • Martinez, F.D.1
  • 14
    • 0037324333 scopus 로고    scopus 로고
    • Viruses and asthma: Inception, exacerbation, and possible prevention
    • discussion S7-S8
    • Lemanske RF Jr. Viruses and asthma: inception, exacerbation, and possible prevention. J Pediatr 2003; 142 (2 Suppl.):S3-S7; discussion S7-S8.
    • (2003) J Pediatr , vol.142 , Issue.2 SUPPL.
    • Lemanske Jr., R.F.1
  • 15
    • 0028956591 scopus 로고
    • Asthma and immunoglobulin E antibodies after respiratory syncytial virus bronchiolitis: A prospective cohort study with matched controls
    • Sigurs N, Bjarnason R, Sigurbergsson F, et al. Asthma and immunoglobulin E antibodies after respiratory syncytial virus bronchiolitis: a prospective cohort study with matched controls. Pediatrics 1995; 95:500-505.
    • (1995) Pediatrics , vol.95 , pp. 500-505
    • Sigurs, N.1    Bjarnason, R.2    Sigurbergsson, F.3
  • 16
    • 0035211713 scopus 로고    scopus 로고
    • Pathophysiologic mechanisms in atopic dermatitis
    • Boguniewicz M, Leung DY. Pathophysiologic mechanisms in atopic dermatitis. Semin Cutan Med Surg 2001; 4:217-225.
    • (2001) Semin Cutan Med Surg , vol.4 , pp. 217-225
    • Boguniewicz, M.1    Leung, D.Y.2
  • 17
    • 0035999874 scopus 로고    scopus 로고
    • Lipoteichoic acid from Staphylococcus aureus induces Th2-prone dermatitis in mice sensitized percutaneously with an allergen
    • Matsui K, Nishikawa A. Lipoteichoic acid from Staphylococcus aureus induces Th2-prone dermatitis in mice sensitized percutaneously with an allergen. Clin Exp Allergy 2002; 32:783-788.
    • (2002) Clin Exp Allergy , vol.32 , pp. 783-788
    • Matsui, K.1    Nishikawa, A.2
  • 18
    • 0037533022 scopus 로고    scopus 로고
    • Lipoteichoic acid from Staphylococcus aureus enhances allergen-specific immunoglobulin E production in mice
    • Matsui K, Nishikawa A. Lipoteichoic acid from Staphylococcus aureus enhances allergen-specific immunoglobulin E production in mice. Clin Exp Allergy 2003; 33:842-848. This paper and ref. 17 provide direct evidence that cutaneous exposure to a S. aureus-derived TLR2 ligand primes mice for IgE production and experimental eczema.
    • (2003) Clin Exp Allergy , vol.33 , pp. 842-848
    • Matsui, K.1    Nishikawa, A.2
  • 19
    • 0016808137 scopus 로고
    • Asthma and IgE levels in rural and urban communities of The Gambia
    • Godfrey RC. Asthma and IgE levels in rural and urban communities of The Gambia. Clin Allergy 1975; 5:201-207.
    • (1975) Clin Allergy , vol.5 , pp. 201-207
    • Godfrey, R.C.1
  • 20
    • 0027842863 scopus 로고
    • Effect of anthelmintic treatment on the allergic reactivity of children in a tropical slum
    • Lynch NR, Hagel I, Perez M, et al. Effect of anthelmintic treatment on the allergic reactivity of children in a tropical slum. J Allergy Clin Immunol 1993; 92:404-411.
    • (1993) J Allergy Clin Immunol , vol.92 , pp. 404-411
    • Lynch, N.R.1    Hagel, I.2    Perez, M.3
  • 21
    • 0034641540 scopus 로고    scopus 로고
    • Influence of maternal age at delivery and birth order on risk of type 1 diabetes in childhood: Prospective population based family study
    • Bart's Oxford Family Study Group
    • Bingley PJ, Douek IF, Rogers CA, Gale EA. Influence of maternal age at delivery and birth order on risk of type 1 diabetes in childhood: prospective population based family study. Bart's Oxford Family Study Group. BMJ 2000; 321:420-424.
    • (2000) BMJ , vol.321 , pp. 420-424
    • Bingley, P.J.1    Douek, I.F.2    Rogers, C.A.3    Gale, E.A.4
  • 22
    • 0035941762 scopus 로고    scopus 로고
    • Relation between occurrence of type 1 diabetes and asthma
    • Stene LC, Nafstad P. Relation between occurrence of type 1 diabetes and asthma. Lancet 2001; 357:607-608.
    • (2001) Lancet , vol.357 , pp. 607-608
    • Stene, L.C.1    Nafstad, P.2
  • 23
    • 0034307339 scopus 로고    scopus 로고
    • The Toll receptor family and microbial recognition
    • Medzhitov R, Janeway C Jr. The Toll receptor family and microbial recognition. Trends Microbiol 2000; 8:452-456.
    • (2000) Trends Microbiol , vol.8 , pp. 452-456
    • Medzhitov, R.1    Janeway Jr., C.2
  • 24
    • 3142724031 scopus 로고    scopus 로고
    • Toll-like receptor signaling
    • Akira S, Takeda K. Toll-like receptor signaling. Nat Rev Immunol 2004; 4:499-511. This review provides an up-to-date and comprehensive summary of our current knowledge of TLRs and their associated signaling pathways.
    • (2004) Nat Rev Immunol , vol.4 , pp. 499-511
    • Akira, S.1    Takeda, K.2
  • 25
    • 3142654210 scopus 로고    scopus 로고
    • Inferences, questions and possibilities in Toll-like receptor signaling
    • Beutler B. Inferences, questions and possibilities in Toll-like receptor signaling. Nature 2004; 430:257-263.
    • (2004) Nature , vol.430 , pp. 257-263
    • Beutler, B.1
  • 26
    • 1542377424 scopus 로고    scopus 로고
    • A toll-like receptor that prevents infection by uropathogenic bacteria
    • Zhang D, Zhang G, Hayden MS, et al. A toll-like receptor that prevents infection by uropathogenic bacteria. Science 2004; 303:1481-1482. These investigators have recently identified TLR11, when previously it was thought that only 10 TLRs were encoded in mammalian genomes. One important implication of these studies is that still other TLRs await discovery.
    • (2004) Science , vol.303 , pp. 1481-1482
    • Zhang, D.1    Zhang, G.2    Hayden, M.S.3
  • 27
    • 0031571230 scopus 로고    scopus 로고
    • The requirement of intestinal bacterial flora for the development of an IgE production system fully susceptible to oral tolerance induction
    • Sudo N, Sawamura S, Tanaka K, et al. The requirement of intestinal bacterial flora for the development of an IgE production system fully susceptible to oral tolerance induction. J Immunol 1997; 159:1739-1745.
    • (1997) J Immunol , vol.159 , pp. 1739-1745
    • Sudo, N.1    Sawamura, S.2    Tanaka, K.3
  • 28
    • 0034775153 scopus 로고    scopus 로고
    • Toll-like receptors control activation of adaptive immune responses
    • Schnare M, Barton GM, Holt AC, et al. Toll-like receptors control activation of adaptive immune responses. Nat Immunol 2001; 2:947-950.
    • (2001) Nat Immunol , vol.2 , pp. 947-950
    • Schnare, M.1    Barton, G.M.2    Holt, A.C.3
  • 29
    • 0036312668 scopus 로고    scopus 로고
    • Endotoxin can induce MyD88-deficient dendritic cells to support T(h)2 cell differentiation
    • Kaisho T, Hoshino K, Iwabe T, et al. Endotoxin can induce MyD88-deficient dendritic cells to support T(h)2 cell differentiation. Int Immunol 2002; 14:695-700.
    • (2002) Int Immunol , vol.14 , pp. 695-700
    • Kaisho, T.1    Hoshino, K.2    Iwabe, T.3
  • 30
    • 0037471003 scopus 로고    scopus 로고
    • Pyogenic bacterial infections in humans with IRAK-4 deficiency
    • Picard C, Puel A, Bonnet M, et al. Pyogenic bacterial infections in humans with IRAK-4 deficiency. Science 2003; 299:2076-2079.
    • (2003) Science , vol.299 , pp. 2076-2079
    • Picard, C.1    Puel, A.2    Bonnet, M.3
  • 31
    • 0036775463 scopus 로고    scopus 로고
    • IRAK-4 as the central TIR signaling mediator in innate immunity
    • Suzuki N, Suzuki S, Yeh WC. IRAK-4 as the central TIR signaling mediator in innate immunity. Trends Immunol 2002; 23:503-506.
    • (2002) Trends Immunol , vol.23 , pp. 503-506
    • Suzuki, N.1    Suzuki, S.2    Yeh, W.C.3
  • 32
    • 0034643729 scopus 로고    scopus 로고
    • Relation between house-dust endotoxin exposure, type 1 T-cell development, and allergen sensitisation in infants at high risk of asthma
    • Gereda JE, Leung DY, Thatayatikom A, et al. Relation between house-dust endotoxin exposure, type 1 T-cell development, and allergen sensitisation in infants at high risk of asthma. Lancet 2000; 355:1680-1683.
    • (2000) Lancet , vol.355 , pp. 1680-1683
    • Gereda, J.E.1    Leung, D.Y.2    Thatayatikom, A.3
  • 33
    • 0033129061 scopus 로고    scopus 로고
    • A polymorphism in the 5′ flanking region of the CD14 gene is associated with circulating soluble CD14 levels and with total serum immunoglobulin E
    • Baldini M, Lohman IC, Halonen M, et al. A polymorphism in the 5′ flanking region of the CD14 gene is associated with circulating soluble CD14 levels and with total serum immunoglobulin E. Am J Respir Cell Mol Biol 1999; 20:976-983.
    • (1999) Am J Respir Cell Mol Biol , vol.20 , pp. 976-983
    • Baldini, M.1    Lohman, I.C.2    Halonen, M.3
  • 34
    • 2342561724 scopus 로고    scopus 로고
    • Microbial exposure of rural school children, as assessed by levels of N-acetyl-muramic acid in mattress dust, and its association with respiratory health
    • van Strien RT, Engel R, Holst O, et al. Microbial exposure of rural school children, as assessed by levels of N-acetyl-muramic acid in mattress dust, and its association with respiratory health. J Allergy Clin Immunol 2004; 113:860-867. These investigators have recently found that the endotoxin content of dust samples correlates with their content of N-acetyl-muramic acid, a breakdown product of the TLR2 ligand, peptidoglycan.
    • (2004) J Allergy Clin Immunol , vol.113 , pp. 860-867
    • Van Strien, R.T.1    Engel, R.2    Holst, O.3
  • 35
    • 0042235227 scopus 로고    scopus 로고
    • Bacterial DNA in house and farm barn dust
    • Roy SR, Schlitz AM, Marrotta A, et al. Bacterial DNA in house and farm barn dust. J Allergy Clin Immunol 2003; 112:571-578. In these studies, dust samples from environments with higher endotoxin levels were also found to have increased levels of bacterial DNA, a TLR9 ligand.
    • (2003) J Allergy Clin Immunol , vol.112 , pp. 571-578
    • Roy, S.R.1    Schlitz, A.M.2    Marrotta, A.3
  • 36
    • 0028291593 scopus 로고
    • Independent regulation of DNA recombination and immunoglobulin (Ig) secretion during isotype switching to IgG1 and IgE
    • Purkerson JM, Isakson PC. Independent regulation of DNA recombination and immunoglobulin (Ig) secretion during isotype switching to IgG1 and IgE. J Exp Med 1994; 179:1877-1883.
    • (1994) J Exp Med , vol.179 , pp. 1877-1883
    • Purkerson, J.M.1    Isakson, P.C.2
  • 37
    • 0034069884 scopus 로고    scopus 로고
    • Modification of the inflammatory response to allergen challenge after exposure to bacterial lipopolysaccharide
    • Tulic MK, Wale JL, Holt PG, Sly PD. Modification of the inflammatory response to allergen challenge after exposure to bacterial lipopolysaccharide. Am J Respir Cell Mol Biol 2000; 22:604-612.
    • (2000) Am J Respir Cell Mol Biol , vol.22 , pp. 604-612
    • Tulic, M.K.1    Wale, J.L.2    Holt, P.G.3    Sly, P.D.4
  • 38
    • 0037121946 scopus 로고    scopus 로고
    • Lipopolysaccharide-enhanced, toll-like receptor 4-dependent T helper cell type 2 responses to inhaled antigen
    • Eisenbarth SC, Piggott DA, Huleatt JW, et al. Lipopolysaccharide- enhanced, toll-like receptor 4-dependent T helper cell type 2 responses to inhaled antigen. J Exp Med 2002; 196:1645-1651.
    • (2002) J Exp Med , vol.196 , pp. 1645-1651
    • Eisenbarth, S.C.1    Piggott, D.A.2    Huleatt, J.W.3
  • 39
    • 0032758720 scopus 로고    scopus 로고
    • Immunostimulatory DNA and applications to allergic disease
    • Van Uden J, Raz E. Immunostimulatory DNA and applications to allergic disease. J Allergy Clin Immunol 1999; 104:902-910.
    • (1999) J Allergy Clin Immunol , vol.104 , pp. 902-910
    • Van Uden, J.1    Raz, E.2
  • 40
    • 0036858610 scopus 로고    scopus 로고
    • Immunostimulatory sequence oligodeoxynucleotide-based vaccination and immunomodulation: Two unique but complementary strategies for the treatment of allergic diseases
    • Horner AA, Raz E. Immunostimulatory sequence oligodeoxynucleotide-based vaccination and immunomodulation: two unique but complementary strategies for the treatment of allergic diseases. J Allergy Clin Immunol 2002; 110:706-712.
    • (2002) J Allergy Clin Immunol , vol.110 , pp. 706-712
    • Horner, A.A.1    Raz, E.2
  • 41
    • 0036438889 scopus 로고    scopus 로고
    • CpG motifs as possible adjuvants for the treatment of allergic diseases
    • Bohle B. CpG motifs as possible adjuvants for the treatment of allergic diseases. Int Arch Allergy Immunol 2002; 129:198-203.
    • (2002) Int Arch Allergy Immunol , vol.129 , pp. 198-203
    • Bohle, B.1
  • 42
    • 0035005506 scopus 로고    scopus 로고
    • CpG oligonucleotide modulation of allergic inflammation
    • Wild JS, Sur S. CpG oligonucleotide modulation of allergic inflammation. Allergy 2001; 56:365-376.
    • (2001) Allergy , vol.56 , pp. 365-376
    • Wild, J.S.1    Sur, S.2
  • 43
    • 0033938275 scopus 로고    scopus 로고
    • Systemic or mucosal administration of immunostimulatory DNA inhibits early and late phases of murine allergic conjunctivitis
    • Magone MT, Chan CC, Beck L, et al. Systemic or mucosal administration of immunostimulatory DNA inhibits early and late phases of murine allergic conjunctivitis. Eur J Immunol 2000; 30:1841-1850.
    • (2000) Eur J Immunol , vol.30 , pp. 1841-1850
    • Magone, M.T.1    Chan, C.C.2    Beck, L.3
  • 44
    • 0035101984 scopus 로고    scopus 로고
    • DNA-based immunotherapeutics for the treatment of allergic disease
    • Horner AA, Van Uden JH, Zubeldia JM, et al. DNA-based immunotherapeutics for the treatment of allergic disease. Immunol Rev 2001; 179:102-118.
    • (2001) Immunol Rev , vol.179 , pp. 102-118
    • Horner, A.A.1    Van Uden, J.H.2    Zubeldia, J.M.3
  • 45
    • 0035423454 scopus 로고    scopus 로고
    • Immunostimulatory DNA-based vaccines elicit multifaceted immune responses against HIV at systemic and mucosal sites
    • Horner AA, Datta SK, Takabayashi K, et al. Immunostimulatory DNA-based vaccines elicit multifaceted immune responses against HIV at systemic and mucosal sites. J Immunol 2001; 167:1584-1591.
    • (2001) J Immunol , vol.167 , pp. 1584-1591
    • Horner, A.A.1    Datta, S.K.2    Takabayashi, K.3
  • 47
    • 0036738405 scopus 로고    scopus 로고
    • Optimized conjugation ratios lead to allergen immunostimulatory oligodeoxynucleotide conjugates with retained immunogenicity and minimal anaphylactogenicity
    • Horner AA, Takabayashi K, Beck L, et al. Optimized conjugation ratios lead to allergen immunostimulatory oligodeoxynucleotide conjugates with retained immunogenicity and minimal anaphylactogenicity. J Allergy Clin Immunol 2002; 110:413-420.
    • (2002) J Allergy Clin Immunol , vol.110 , pp. 413-420
    • Horner, A.A.1    Takabayashi, K.2    Beck, L.3
  • 48
    • 0036126748 scopus 로고    scopus 로고
    • Amb a 1-linked CpG oligodeoxynucleotides reverse established airway hyperresponsiveness in a murine model of asthma
    • Santeliz JV, Van Nest G, Traquina P, et al. Amb a 1-linked CpG oligodeoxynucleotides reverse established airway hyperresponsiveness in a murine model of asthma. J Allergy Clin Immunol 2002; 109:455-462.
    • (2002) J Allergy Clin Immunol , vol.109 , pp. 455-462
    • Santeliz, J.V.1    Van Nest, G.2    Traquina, P.3
  • 49
    • 0037379515 scopus 로고    scopus 로고
    • Intranasal immunotherapy is more effective than intradermal immunotherapy for the induction of airway allergen tolerance in th2-sensrtized mice
    • Takabayashi K, Libet L, Chisholm D, et al. Intranasal immunotherapy is more effective than intradermal immunotherapy for the induction of airway allergen tolerance in th2-sensrtized mice. J Immunol 2003; 170:3898-3905.
    • (2003) J Immunol , vol.170 , pp. 3898-3905
    • Takabayashi, K.1    Libet, L.2    Chisholm, D.3
  • 50
    • 1142273128 scopus 로고    scopus 로고
    • Amb a 1-immunostimulatory oligodeoxynucleotide conjugate immunotherapy decreases the nasal inflammatory response
    • Tulic MK, Fiset PO, Christodoulopoulos P, et al. Amb a 1-immunostimulatory oligodeoxynucleotide conjugate immunotherapy decreases the nasal inflammatory response. J Allergy Clin Immunol 2004; 113:235-241. Results from this clinical trial suggest that ISS oligodeoxynucleotide-conjugated allergens may prove to be safe and effective for the treatment of allergic diseases.
    • (2004) J Allergy Clin Immunol , vol.113 , pp. 235-241
    • Tulic, M.K.1    Fiset, P.O.2    Christodoulopoulos, P.3
  • 51
    • 3042718066 scopus 로고    scopus 로고
    • Selective immune redirection in humans with ragweed allergy by injecting Amb a 1 linked to immunostimulatory DNA
    • Simons FE, Shikishima Y, Van Nest G, et al. Selective immune redirection in humans with ragweed allergy by injecting Amb a 1 linked to immunostimulatory DNA. J Allergy Clin Immunol 2004; 113:1144-1151. This series of investigations demonstrates that injections of ISS oligodeoxynucleotide-conjugated Amb a 1 can redirect allergen-specific immunity in sensitized patients.
    • (2004) J Allergy Clin Immunol , vol.113 , pp. 1144-1151
    • Simons, F.E.1    Shikishima, Y.2    Van Nest, G.3
  • 52
    • 0035500862 scopus 로고    scopus 로고
    • Lipopolysaccharides from distinct pathogens induce different classes of immune responses in vivo
    • Pulendran B, Kumar P, Cutler CW, et al. Lipopolysaccharides from distinct pathogens induce different classes of immune responses in vivo. J Immunol 2001; 167:5067-5076.
    • (2001) J Immunol , vol.167 , pp. 5067-5076
    • Pulendran, B.1    Kumar, P.2    Cutler, C.W.3
  • 53
    • 0037442003 scopus 로고    scopus 로고
    • Cutting edge: Distinct toll-like receptor 2 activators selectively induce different classes of mediator production from human mast cells
    • McCurdy JD, Olynych TJ, Maher LH, Marshall JS. Cutting edge: distinct toll-like receptor 2 activators selectively induce different classes of mediator production from human mast cells. J Immunol 2003; 170:1625-1629.
    • (2003) J Immunol , vol.170 , pp. 1625-1629
    • McCurdy, J.D.1    Olynych, T.J.2    Maher, L.H.3    Marshall, J.S.4
  • 54
    • 0036105543 scopus 로고    scopus 로고
    • Differential responses of mast cell Toll-like receptors 2 and 4 in allergy and innate immunity
    • Supajatura V, Ushio H, Nakao A, et al. Differential responses of mast cell Toll-like receptors 2 and 4 in allergy and innate immunity. J Clin Invest 2002; 109:1351-1359.
    • (2002) J Clin Invest , vol.109 , pp. 1351-1359
    • Supajatura, V.1    Ushio, H.2    Nakao, A.3
  • 55
    • 0035813157 scopus 로고    scopus 로고
    • Toll-like receptor 2 (TLR2) and TLR4 differentially activate human dendritic cells
    • Re F, Strominger JL. Toll-like receptor 2 (TLR2) and TLR4 differentially activate human dendritic cells. J Biol Chem 2001; 276:37692-37699.
    • (2001) J Biol Chem , vol.276 , pp. 37692-37699
    • Re, F.1    Strominger, J.L.2
  • 56
    • 1342324768 scopus 로고    scopus 로고
    • Cutting edge: Activation of Toll-like receptor 2 induces a Th2 immune response and promotes experimental asthma
    • Redecke V, Hacker H, Datta SK, et al. Cutting edge: activation of Toll-like receptor 2 induces a Th2 immune response and promotes experimental asthma. J Immunol 2004; 172:2739-2743.
    • (2004) J Immunol , vol.172 , pp. 2739-2743
    • Redecke, V.1    Hacker, H.2    Datta, S.K.3
  • 57
    • 1542407034 scopus 로고    scopus 로고
    • Airway peptidoglycan and immunostimulatory DNA exposures have divergent effects on the development of airway allergen hypersensitivities
    • Chisholm D, Libel L, Hayashi T, Horner AA. Airway peptidoglycan and immunostimulatory DNA exposures have divergent effects on the development of airway allergen hypersensitivities. J Allergy Clin Immunol 2004; 113:448-454.
    • (2004) J Allergy Clin Immunol , vol.113 , pp. 448-454
    • Chisholm, D.1    Libel, L.2    Hayashi, T.3    Horner, A.A.4
  • 58
    • 0036801463 scopus 로고    scopus 로고
    • Noncoding RNA danger motifs bridge innate and adaptive immunity and are potent adjuvants for vaccination
    • Wang L, Smith D, Bot S, et al. Noncoding RNA danger motifs bridge innate and adaptive immunity and are potent adjuvants for vaccination. J Clin Invest 2002; 110:1175-1184.
    • (2002) J Clin Invest , vol.110 , pp. 1175-1184
    • Wang, L.1    Smith, D.2    Bot, S.3
  • 59
    • 0242580118 scopus 로고    scopus 로고
    • Cutting edge: Different Toll-like receptor agonists instruct dendritic cells to induce distinct Th responses via differential modulation of extracellular signal-regulated kinase-mitogen-activated protein kinase and c-Fos
    • Agrawal S, Agrawal A, Doughty B, et al. Cutting edge: different Toll-like receptor agonists instruct dendritic cells to induce distinct Th responses via differential modulation of extracellular signal-regulated kinase-mitogen- activated protein kinase and c-Fos. J Immunol 2003; 171:4984-4989.
    • (2003) J Immunol , vol.171 , pp. 4984-4989
    • Agrawal, S.1    Agrawal, A.2    Doughty, B.3
  • 60
    • 2442652766 scopus 로고    scopus 로고
    • Flagellin promotes myeloid differentiation factor 88-dependent development of Th2-type response
    • Didierlaurent A, Ferrero I, Otten LA, et al. Flagellin promotes myeloid differentiation factor 88-dependent development of Th2-type response. J Immunol 2004; 172:6922-6930.
    • (2004) J Immunol , vol.172 , pp. 6922-6930
    • Didierlaurent, A.1    Ferrero, I.2    Otten, L.A.3
  • 61
    • 0033775777 scopus 로고    scopus 로고
    • Adjuvant activities of immune response modifier R-848: Comparison with CpG ODN
    • Vasilakos JP, Smith RM, Gibson SJ, et al. Adjuvant activities of immune response modifier R-848: comparison with CpG ODN. Cell Immunol 2000; 204:64-74.
    • (2000) Cell Immunol , vol.204 , pp. 64-74
    • Vasilakos, J.P.1    Smith, R.M.2    Gibson, S.J.3
  • 62
    • 0033540341 scopus 로고    scopus 로고
    • Modulation of TH1 and TH2 cytokine production with the immune response modifiers, R-848 and imiquimod
    • Wagner TL, Ahonen CL, Couture AM, et al. Modulation of TH1 and TH2 cytokine production with the immune response modifiers, R-848 and imiquimod. Cell Immunol 1999; 191:10-19.
    • (1999) Cell Immunol , vol.191 , pp. 10-19
    • Wagner, T.L.1    Ahonen, C.L.2    Couture, A.M.3
  • 63
    • 0037323845 scopus 로고    scopus 로고
    • The novel synthetic immune response modifier R-848 (Resiquimod) shifts human allergen-specific CD4+ TH2 lymphocytes into IFN-gamma-producing cells
    • Brugnolo F, Sampognaro S, Liotta F, et al. The novel synthetic immune response modifier R-848 (Resiquimod) shifts human allergen-specific CD4+ TH2 lymphocytes into IFN-gamma-producing cells. J Allergy Clin Immunol 2003; 111:380-388.
    • (2003) J Allergy Clin Immunol , vol.111 , pp. 380-388
    • Brugnolo, F.1    Sampognaro, S.2    Liotta, F.3


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