Systemic or mucosal administration of immunostimulatory DNA inhibits early and late phases of murine allergic conjunctivitis

European Journal of Immunology

Volumn 30, Issue 7, 2000, Pages 1841-1850

  Magone, M Teresa ^a   Chan, Chi Chao ^a   Beck, Lucinda ^b   Whitcup, Scott M ^a   Raz, Eyal ^b  

^a NATIONAL EYE INSTITUTE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Allergic conjunctivitis; Corticosteroids; IL 12; Immunostimulatory DNA; Th1 Th2

Indexed keywords

ALLERGEN; CYTOKINE; DEXAMETHASONE; DNA; IMMUNOGLOBULIN E; IMMUNOSTIMULATING AGENT; OLIGONUCLEOTIDE; RAGWEED ANTIGEN;

ALLERGIC CONJUNCTIVITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL INFILTRATION; CONTROLLED STUDY; CPG ISLAND; DNA SEQUENCE; IMMEDIATE TYPE HYPERSENSITIVITY; IMMUNIZATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAGWEED; SEASONAL VARIATION; SENSITIZATION; TH2 CELL; TITRIMETRY;

ADMINISTRATION, TOPICAL; ALLERGENS; ANIMALS; CONJUNCTIVITIS, ALLERGIC; DISEASE MODELS, ANIMAL; DNA; DOWN-REGULATION; HYPERSENSITIVITY, DELAYED; HYPERSENSITIVITY, IMMEDIATE; IMMUNOGLOBULIN E; INJECTIONS, INTRAPERITONEAL; MICE; MUCOUS MEMBRANE; OLIGODEOXYRIBONUCLEOTIDES; POACEAE; POLLEN; TH1 CELLS; TIME FACTORS;

EID: 0033938275     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(200007)30:7<1841::AID-IMMU1841>3.0.CO;2-E     Document Type: Article

References (33)

1. Meltzer, E. O., Evaluating rhinitis: clinical rhinomanometric, and cytological assessment. J. Allergy Clin. Immunol. 1988. 82: 900-908.
2. King, T. P., Chemical and biological properties of some atopic allergens. Adv. Immunol. 1976. 23: 77-105.
3. Friedlaender, M. H., Current concepts in ocular allergy. Ann. Allergy 1991. 67:5-14.
4. Reiss, J., Abelson, M. B., George, M. A. and Wedner, H. J., Allergic conjunctivitis. In Pepose, J. S., Holland, G. N. and Wilhelmus, K. R. (Eds). Ocular infection and immunity, Mosby, St Louis 1996, pp 345-358.
5. Foster, C. S., The pathophysiology of ocular allergy: current thinking. Allergy 1995. 50: 6-9; discussion 34-38
6. Anderson, D. F., MacLeod, J. D., Baddeley, S. M., Bacon, A. S., McGill, J. I., Holgate, S. T. and Roche, W. R., Seasonal allergic conjunctivitis is accompanied by increased mast cell numbers in the absence of leucocyte infiltration. Clin. Exp. Allergy 1997. 27: 1060-1066.
7. Galli, S. J. and Lantz, C. S., Allergy. In Paul, W. E. (Ed.). Fundamental Immunology 4th Edn. Lippincott-Raven, Philadelphia 1998, Chapter 35.
8. + cells in the pathogenesis of allergic diseases. Proc. Soc. Exp. Biol. Med. 1997. 215: 11-19.
9. + T cell subsets producing a selective pattern of lymphokines in the pathogenesis of human chronic inflammatory and allergic diseases. Immunol. Rev. 1991. 123: 23-35.
10. Physician's desk reference, 53 Edn., Medical Economics Company, Montvale, NJ 1999.
11. Kline, J. N., Waldschmidt, T. J., Businga, T. R., Lemish, J. E., Weinstock, J. V., Thorne, P. S. and Krieg, A. M., Modulation of airway inflammation by CpG oligodeoxynucleotides in a murine model of asthma. J. Immunol. 1998. 160: 2555-2559.
12. Broide, D., Schwarze, J., Tighe, H., Gifford, T., Nguyen, M. D., Malek, S., Van Uden, J., Martin-Orozco, E., Gelfand, E. W. and Raz, E., Immunostimulatory DNA sequences inhibit IL-5, eosinophilic inflammation, and airway hyperresponsiveness in mice. J. Immunol. 1998. 161: 7054-7062.
13. Sur, S., Wild, J. S., Choudhury, B. K., Sur, N., Alam, R. and Klinman, D. M., Long-term prevention of allergic lung inflammation in a mouse model of asthma by CpG oligonucleotides. J. Immunol. 1999. 162: 6284-6293.
14. Shi, H., Zhong, X., Long, X. and Chen, Y., Effect of interferon-gamma on antigen-induced eosinophil infiltration into the mouse airway. Chin. Med. J. 1996. 109: 215-218.
15. Lack, G., Bradley, K. L., Hamelmann, E., Renz, H., Loader, J., Leung, D. Y. M., Larsen, G. and Gelfand, E. W., Nebulized IFN-γ inhibits the development of secondary allergic responses in mice. J. Immunol. 1996. 157: 1432-1439.
16. Brusselle, G. G., Kips, J. C., Peleman, R. A., Joos, G. F., Devos, R. R., Tavernier, J. H. and Pauwels, R. A., Role of IFN-gamma in the inhibition of the allergic airway inflammation caused by IL-12. Am. J. Respir. Cell. Mol. Biol. 1997. 17: 767-771.
17. Magone, M. T., Chan, C. C., Rizzo, L. V., Kozhich, A. T. and Whitcup, S. M., A novel murine model of allergic conjunctivitis. Clin. Immunol. Immunopathol. 1998. 87: 75-84.
18. Abelson, M. B., Udell, I. J. and Weston, J. H., Conjunctival eosinophils in compound 48/80 rabbit model. Arch. Opthalmol. 1983. 101: 631-633.
19. Bonini, S., Vecchione, A., Naim, D. M., Allansmith, M. R. and Balsano, F., Inflammatory changes in conjunctival scrapings after allergen provocation in humans. J. Allergy Clin. Immunol. 1988. 82: 462-469.
20. Li, Q., Luyo, D., Hikita, N., Whitcup, S. M. and Chan, C. C., Compound 48/80-induced conjunctivitis in the mouse: kinetics, susceptibility, and mechanism. Int. Arch. Allergy Immunol. 1996. 109: 277-285.
21. Bauer, M., Heeg, K., Wagner, H. and Lipford, G. B., DNA activates human immune cells through a CpG sequence-dependent manner. Immunology 1999. 97: 699-705.
22. Roman, M., Martin-Orozco, E., Goodman, J. S., Nguyen, M. D., Sato, Y., Ronaghy, A., Kornbluth, R. S., Richman, D. D., Carson, D. A. and Raz, E., Immunostimulatory DNA sequences function as T helper-1-promoting adjuvants. Nat. Med. 1997. 3: 849-854.
23. Stacey, K. J., Sweet, M. J. and Hume, D. A., Macrophages ingest and are activated by bacterial DNA. J. Immunol. 1996. 157: 2116-2122.
24. Halpern, M. D., Kurlander, R. J. and Pisetsky, D. S., Bacterial DNA induces murine interferon-gamma production by stimulation of interleukin-12 and tumor necrosis factor-alpha. Cell. Immunol. 1996. 167: 72-78.
25. Ruede, E., Schmitt, E. and Germann, T., Interleukin-12 and its receptor. In Delves, P. J. and Roitt, I. M., (Eds.) Encyclopedia of immunology. Academic Press, San Diego 1998, pp 1483-1488.
26. Magone, M. T., Whitecup, S. M., Fukushima, A., Chan, C. C., Silver, P. B. and Rizzo, L. V., IL-12 is essential for the development of the late phase cellular infiltration in a model of allergic conjunctivitis. Invest. Ophthalmol. Vis. Sci. 1999. 40: S770.
27. Sparwasser, T., Koch, E. S., Vabulas, R. M., Heeg, K., Lipford, G. B., Ellwart, J. W. and Wagner, H., Bacterial DNA and immunostimulatory CpG oligonucleotides trigger maturation and activation of murine dendritic cells. Eur. J. Immunol. 1998. 28: 2045-2054.
28. Jakob, T., Walker, P. S., Krieg, A. M., von Stebut, E., Udey, M. C. and Vogel, J. C., Bacterial DNA and CpG-containing oligodeoxynucleotides activate cutaneous dendritic cells and induce IL-12 production: implications for the augmentation of Th1 responses. Int. Arch. Allergy Immunol. 1999. 118: 457-461.
29. Martin-Orozco, E., Kobayashi, H., Van Uden, J., Nguyen, M. D., Kornbluth, R. S. and Raz, E., Enhancement of antigen-presenting cell surface molecules involved in cognate interactions by immunostimulatory DNA sequences. Int. Immunol. 1999. 11: 1111-1118.
30. Kobayashi, H., Horner, A. A., Takabayashi, K., Nguyen, M. D., Huang, E., Cinman, N. and Raz, E., Immunostimulatory DNA pre-priming: a novel approach for prolonged Th1-biased immunity. Cell. Immunol. 1999. 198: 69-75.
31. Broide, D. and Raz, E., DNA-based immunization for asthma. Int. Arch. Allergy Immunol. 1999. 118: 453-456.
32. Van Uden, J. and Raz, E., Immunostimulatory DNA and applications to allergic disease. J. Allergy Clin. Immunol. 1999. 104: 902-910.
33. Motulsky, H., Intuitive biostatistics. Oxford University Press. New York 1995.