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Volumn 26, Issue 6-7, 2004, Pages 283-293

Adjuvant guided polarization of the immune humoral response against a protective multicomponent antigenic protein (Q) from Leishmania infantum. A CpG + Q mix protects Balb/c mice from infection

Author keywords

Antigens; Leishmania; Q protein; Vaccine

Indexed keywords

BCG VACCINE; DOUBLE STRANDED DNA; EPITOPE; FREUND ADJUVANT; IMMUNOGLOBULIN; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A; IMMUNOGLOBULIN M; OLIGODEOXYNUCLEOTIDE; PARASITE ANTIGEN; Q PROTEIN; UNCLASSIFIED DRUG;

EID: 9644272761     PISSN: 01419838     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.0141-9838.2004.00711.x     Document Type: Article
Times cited : (30)

References (56)
  • 1
    • 0024325070 scopus 로고
    • Heterogeneity of cytokine secretion patterns and functions of helper T cells
    • Mosmann TR & Coffman RL. Heterogeneity of cytokine secretion patterns and functions of helper T cells. Adv Immunol 1989; 46: 111-147.
    • (1989) Adv Immunol , vol.46 , pp. 111-147
    • Mosmann, T.R.1    Coffman, R.L.2
  • 2
    • 0023818702 scopus 로고
    • The role of helper T cell products in mouse B cell differentiation and isotype regulation
    • Coffman RL, Seymour BW, Lebman DA, et al. The role of helper T cell products in mouse B cell differentiation and isotype regulation. Immunol Rev 1988; 102: 5-28.
    • (1988) Immunol Rev , vol.102 , pp. 5-28
    • Coffman, R.L.1    Seymour, B.W.2    Lebman, D.A.3
  • 3
    • 0025216937 scopus 로고
    • Lymphokine control of in vivo immunoglobulin isotype selection
    • Finkelman FD, Holmes J, Katona IM, et al. Lymphokine control of in vivo immunoglobulin isotype selection. Annu Rev Immunol 1990; 8: 303-333.
    • (1990) Annu Rev Immunol , vol.8 , pp. 303-333
    • Finkelman, F.D.1    Holmes, J.2    Katona, I.M.3
  • 4
    • 0031104797 scopus 로고    scopus 로고
    • Vaccine strategies: Selective elicitation of cellular or humoral immunity?
    • Shearer GM & Clerici M. Vaccine strategies: selective elicitation of cellular or humoral immunity? Trends Biotechnol 1997; 15: 106-109.
    • (1997) Trends Biotechnol , vol.15 , pp. 106-109
    • Shearer, G.M.1    Clerici, M.2
  • 5
    • 0022640843 scopus 로고
    • Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins
    • Mosmann TR, Cherwinski H, Bond MW, Giedlin MA & Coffman RL. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol 1986; 136: 2348-2357.
    • (1986) J Immunol , vol.136 , pp. 2348-2357
    • Mosmann, T.R.1    Cherwinski, H.2    Bond, M.W.3    Giedlin, M.A.4    Coffman, R.L.5
  • 6
    • 0023622458 scopus 로고
    • Two types of mouse helper T cell clone. III. Further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodies
    • Cherwinski HM, Schumacher JH, Brown KD & Mosmann TR. Two types of mouse helper T cell clone. III. Further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodies. J Exp Med 1987; 166: 1229-1244.
    • (1987) J Exp Med , vol.166 , pp. 1229-1244
    • Cherwinski, H.M.1    Schumacher, J.H.2    Brown, K.D.3    Mosmann, T.R.4
  • 8
    • 0025478438 scopus 로고
    • Regulation of isotype immunoglobulin and interleukin production by adjuvants in vitro
    • Karagouni EE & Hadjipetrou-Kourounakis L. Regulation of isotype immunoglobulin and interleukin production by adjuvants in vitro. J Clin Lab Immunol 1990; 33: 29-39.
    • (1990) J Clin Lab Immunol , vol.33 , pp. 29-39
    • Karagouni, E.E.1    Hadjipetrou-Kourounakis, L.2
  • 10
    • 0030963532 scopus 로고    scopus 로고
    • In vivo induction of type 1 and 2 immune responses against protein antigens
    • Comoy EE, Capron A & Thyphronitis G. In vivo induction of type 1 and 2 immune responses against protein antigens. Int Immunol 1997; 9: 523-531.
    • (1997) Int Immunol , vol.9 , pp. 523-531
    • Comoy, E.E.1    Capron, A.2    Thyphronitis, G.3
  • 11
    • 0032738026 scopus 로고    scopus 로고
    • Advances in vaccine adjuvants
    • Singh M & O'Hagan D. Advances in vaccine adjuvants. Nat Biotechnol 1999; 17: 1075-1081.
    • (1999) Nat Biotechnol , vol.17 , pp. 1075-1081
    • Singh, M.1    O'Hagan, D.2
  • 12
    • 0033953695 scopus 로고    scopus 로고
    • Subunit vaccination of mice against new world cutaneous leishmaniasis: Comparison of three proteins expressed in amastigotes and six adjuvants
    • Aebischer T, Wolfram M, Patzer SI, Ilg T, Wiese M & Overath P. Subunit vaccination of mice against new world cutaneous leishmaniasis: comparison of three proteins expressed in amastigotes and six adjuvants. Infect Immun 2000; 68: 1328-1336.
    • (2000) Infect Immun , vol.68 , pp. 1328-1336
    • Aebischer, T.1    Wolfram, M.2    Patzer, S.I.3    Ilg, T.4    Wiese, M.5    Overath, P.6
  • 13
    • 0036831673 scopus 로고    scopus 로고
    • The immunology of susceptibility and resistance to Leishmania major in mice
    • Sacks D & Noben-Trauth N. The immunology of susceptibility and resistance to Leishmania major in mice. Nat Rev Immunol 2002; 2: 845-858.
    • (2002) Nat Rev Immunol , vol.2 , pp. 845-858
    • Sacks, D.1    Noben-Trauth, N.2
  • 14
    • 0023818704 scopus 로고
    • Regulation of IgG1 and IgE production by interleukin 4
    • Snapper CM, Finkelman FD & Paul WE. Regulation of IgG1 and IgE production by interleukin 4. Immunol Rev 1988; 102: 51-75.
    • (1988) Immunol Rev , vol.102 , pp. 51-75
    • Snapper, C.M.1    Finkelman, F.D.2    Paul, W.E.3
  • 16
    • 0026574557 scopus 로고
    • Interleukin 5 (IL-5) provides a signal that is required in addition to IL-4 for isotype switching to immunoglobulin (Ig) G1 and IgE
    • Purkerson JM & Isakson PC. Interleukin 5 (IL-5) provides a signal that is required in addition to IL-4 for isotype switching to immunoglobulin (Ig) G1 and IgE. J Exp Med 1992; 175: 973-982.
    • (1992) J Exp Med , vol.175 , pp. 973-982
    • Purkerson, J.M.1    Isakson, P.C.2
  • 17
    • 0027305427 scopus 로고
    • IL-13 induces proliferation and differentiation of human B cells activated by the CD40 ligand
    • Cocks BG, de Waal Malefyt R, Galizzi JP, de Vries JE & Aversa G. IL-13 induces proliferation and differentiation of human B cells activated by the CD40 ligand. Int Immunol 1993; 5: 657-663.
    • (1993) Int Immunol , vol.5 , pp. 657-663
    • Cocks, B.G.1    De Waal Malefyt, R.2    Galizzi, J.P.3    De Vries, J.E.4    Aversa, G.5
  • 18
    • 0028787484 scopus 로고
    • Disruption of the murine interleukin-4 gene inhibits disease progression during Leishmania mexicana infection but does not increase control of Leishmania donovani infection
    • Satoskar A, Bluethmann H & Alexander J. Disruption of the murine interleukin-4 gene inhibits disease progression during Leishmania mexicana infection but does not increase control of Leishmania donovani infection. Infect Immun 1995; 63: 4894-4899.
    • (1995) Infect Immun , vol.63 , pp. 4894-4899
    • Satoskar, A.1    Bluethmann, H.2    Alexander, J.3
  • 19
    • 0033788429 scopus 로고    scopus 로고
    • Endogenous IL-4 is necessary for effective drug therapy against visceral leishmaniasis
    • Alexander J, Carter KC, Al-Fasi N, Satoskar A & Brombacher F. Endogenous IL-4 is necessary for effective drug therapy against visceral leishmaniasis. Eur J Immunol 2000; 30: 2935-2943.
    • (2000) Eur J Immunol , vol.30 , pp. 2935-2943
    • Alexander, J.1    Carter, K.C.2    Al-Fasi, N.3    Satoskar, A.4    Brombacher, F.5
  • 21
    • 0042745627 scopus 로고    scopus 로고
    • Both interleukin-4 (IL-4) and IL-4 receptor alpha signaling contribute to the development of hepatic granulomas with optimal antileishmanial activity
    • Stager S, Alexander J, Carter KC, Brombacher F & Kaye PM. Both interleukin-4 (IL-4) and IL-4 receptor alpha signaling contribute to the development of hepatic granulomas with optimal antileishmanial activity. Infect Immun 2003; 71: 4804-4807.
    • (2003) Infect Immun , vol.71 , pp. 4804-4807
    • Stager, S.1    Alexander, J.2    Carter, K.C.3    Brombacher, F.4    Kaye, P.M.5
  • 22
    • 0025168823 scopus 로고
    • + T cells. IL 5 is essential for induction of antigen-specific antibody responses by TH2 but not TH1 clones
    • + T cells. IL 5 is essential for induction of antigen-specific antibody responses by TH2 but not TH1 clones. Eur J Immunol 1990; 20: 2219-2227.
    • (1990) Eur J Immunol , vol.20 , pp. 2219-2227
    • De Kruyff, R.H.1    Mosmann, R.R.2    Umetsu, D.T.3
  • 23
    • 8944253295 scopus 로고    scopus 로고
    • Immunostimulatory DNA sequences necessary for effective intradermal gene immunization
    • Sato Y, Roman M, Tighe H, et al. Immunostimulatory DNA sequences necessary for effective intradermal gene immunization. Science 1996; 273 (5273): 352-354.
    • (1996) Science , vol.273 , Issue.5273 , pp. 352-354
    • Sato, Y.1    Roman, M.2    Tighe, H.3
  • 24
    • 0031569601 scopus 로고    scopus 로고
    • Contribution of CpG motifs to the immunogenicity of DNA vaccines
    • Klinman DM, Yamshchikov G & Ishigatsubo Y. Contribution of CpG motifs to the immunogenicity of DNA vaccines. J Immunol 1997; 158: 3635-3639.
    • (1997) J Immunol , vol.158 , pp. 3635-3639
    • Klinman, D.M.1    Yamshchikov, G.2    Ishigatsubo, Y.3
  • 25
    • 0030764558 scopus 로고    scopus 로고
    • Immunostimulatory DNA sequences function as T helper-1-promoting adjuvants
    • Roman M, Martin-Orozco E, Goodman JS, et al. Immunostimulatory DNA sequences function as T helper-1-promoting adjuvants. Nat Med 1997; 3: 849-854.
    • (1997) Nat Med , vol.3 , pp. 849-854
    • Roman, M.1    Martin-Orozco, E.2    Goodman, J.S.3
  • 26
    • 0032720361 scopus 로고    scopus 로고
    • Mechanisms and application of immune stimulatory CpG oligodeoxynucleotides
    • Krieg AM. Mechanisms and application of immune stimulatory CpG oligodeoxynucleotides. Biochim Biophys Acta 1999; 1489: 107-116.
    • (1999) Biochim Biophys Acta , vol.1489 , pp. 107-116
    • Krieg, A.M.1
  • 27
    • 0032758720 scopus 로고    scopus 로고
    • Immunostimulatory DNA and applications to allergic diseases
    • Van Uden J & Raz E. Immunostimulatory DNA and applications to allergic diseases. J Allergy Clin. Immunol 1999; 104: 902-910.
    • (1999) J Allergy Clin Immunol , vol.104 , pp. 902-910
    • Van Uden, J.1    Raz, E.2
  • 28
    • 0032995849 scopus 로고    scopus 로고
    • Bacterial CpG DNA activates immune cells to signal infectious danger
    • Wagner H. Bacterial CpG DNA activates immune cells to signal infectious danger. Adv Immunol 1999; 73: 329-368.
    • (1999) Adv Immunol , vol.73 , pp. 329-368
    • Wagner, H.1
  • 29
    • 0028785237 scopus 로고
    • Involvement of natural killer cells in nitric oxide production by spleen cells after stimulation with Mycobacterium bovis BCG. Study of the mechanism of the different abilities of viable and killed BCG
    • Yang J, Kawamura I, Zhu H & Mitsuyama M. Involvement of natural killer cells in nitric oxide production by spleen cells after stimulation with Mycobacterium bovis BCG. Study of the mechanism of the different abilities of viable and killed BCG. J Immunol 1995; 155: 5728-5735.
    • (1995) J Immunol , vol.155 , pp. 5728-5735
    • Yang, J.1    Kawamura, I.2    Zhu, H.3    Mitsuyama, M.4
  • 30
    • 0029934138 scopus 로고    scopus 로고
    • Nitric oxide production by peritoneal macrophages of Mycobacterium bovis BCG-infected or non-infected mice: Regulatory role of T lymphocytes and cytokines
    • Saito S & Nakano M. Nitric oxide production by peritoneal macrophages of Mycobacterium bovis BCG-infected or non-infected mice: regulatory role of T lymphocytes and cytokines. J Leukoc Biol 1996; 59: 908-915.
    • (1996) J Leukoc Biol , vol.59 , pp. 908-915
    • Saito, S.1    Nakano, M.2
  • 31
    • 0037456693 scopus 로고    scopus 로고
    • A Leishmania infantum multi-component antigenic protein mixed with live BCG confers protection to dogs experimentally infected with L. infantum
    • Molano I, Alonso MG, Miron C, et al. A Leishmania infantum multi-component antigenic protein mixed with live BCG confers protection to dogs experimentally infected with L. infantum. Vet Immunol Immunopathol 2003; 92: 1-13.
    • (2003) Vet Immunol Immunopathol , vol.92 , pp. 1-13
    • Molano, I.1    Alonso, M.G.2    Miron, C.3
  • 32
    • 0036293726 scopus 로고    scopus 로고
    • An innate sense of danger
    • Matzinger P. An innate sense of danger. Ann N Y Acad Sci 2002; 961: 341-342.
    • (2002) Ann N Y Acad Sci , vol.961 , pp. 341-342
    • Matzinger, P.1
  • 33
    • 0034125081 scopus 로고    scopus 로고
    • Immunological concepts of vaccine adjuvant activity
    • Schijns V. Immunological concepts of vaccine adjuvant activity. Current Opin Immunol 2000; 12: 456-463.
    • (2000) Current Opin Immunol , vol.12 , pp. 456-463
    • Schijns, V.1
  • 35
    • 0033382112 scopus 로고    scopus 로고
    • Immunostimulatory properties of the Leishmania infantum heat shock proteins HSP70 and HSP83
    • Rico AI, Angel SO, Alonso C & Requena JM. Immunostimulatory properties of the Leishmania infantum heat shock proteins HSP70 and HSP83. Mol Immunol 1999; 36: 1131-1139.
    • (1999) Mol Immunol , vol.36 , pp. 1131-1139
    • Rico, A.I.1    Angel, S.O.2    Alonso, C.3    Requena, J.M.4
  • 36
    • 0034113617 scopus 로고    scopus 로고
    • HSP70 stimulates cytokine production through a CD14-dependant pathway, demonstrating its dual role as a chaperone and cytokine
    • Asea A, Kraeft SK, Kurt-Jones EA, et al. HSP70 stimulates cytokine production through a CD14-dependant pathway, demonstrating its dual role as a chaperone and cytokine. Nat Med 2000; 6: 435-442.
    • (2000) Nat Med , vol.6 , pp. 435-442
    • Asea, A.1    Kraeft, S.K.2    Kurt-Jones, E.A.3
  • 37
    • 0031964187 scopus 로고    scopus 로고
    • Multicomponent chimeric antigen for serodiagnosis of canine visceral leishmaniasis
    • Soto M, Requena JM, Quijada L & Alonso C. Multicomponent chimeric antigen for serodiagnosis of canine visceral leishmaniasis. J Clin Microbiol 1998; 36: 58-63.
    • (1998) J Clin Microbiol , vol.36 , pp. 58-63
    • Soto, M.1    Requena, J.M.2    Quijada, L.3    Alonso, C.4
  • 38
    • 0031964659 scopus 로고    scopus 로고
    • Characterization of the immunostimulatory properties of Leishmania infantum HSP70 by fusion to the Escherichia coli maltose-binding protein in normal and nu/nu BALB/c mice
    • Rico AI, Del Real G, Soto M, et al. Characterization of the immunostimulatory properties of Leishmania infantum HSP70 by fusion to the Escherichia coli maltose-binding protein in normal and nu/nu BALB/c mice. Infect Immun 1998; 66: 347-352.
    • (1998) Infect Immun , vol.66 , pp. 347-352
    • Rico, A.I.1    Del Real, G.2    Soto, M.3
  • 39
    • 0023265277 scopus 로고
    • Vaccination against cutaneous leishmaniasis in a murine model. II. Immunologic properties of protective and nonprotective subfractions of soluble promastigote extract
    • Scott P, Pearce E, Natovitz P & Sher A. Vaccination against cutaneous leishmaniasis in a murine model. II. Immunologic properties of protective and nonprotective subfractions of soluble promastigote extract. J Immunol 1987; 139: 3118-3125.
    • (1987) J Immunol , vol.139 , pp. 3118-3125
    • Scott, P.1    Pearce, E.2    Natovitz, P.3    Sher, A.4
  • 40
    • 0031985666 scopus 로고    scopus 로고
    • Regional differences in the cellular immune response to experimental cutaneous or visceral infection with Leishmania donovani
    • Melby PC, Yang YZ, Cheng J & Zhao W. Regional differences in the cellular immune response to experimental cutaneous or visceral infection with Leishmania donovani. Infect Immun 1998; 66: 18-27.
    • (1998) Infect Immun , vol.66 , pp. 18-27
    • Melby, P.C.1    Yang, Y.Z.2    Cheng, J.3    Zhao, W.4
  • 41
    • 0037055963 scopus 로고    scopus 로고
    • Protective efficacy of a tandemly linked, multi-subunit recombinant leishmanial vaccine (Leish-111f) formulated in MPL adjuvant
    • Skeiky YA, Coler RN, Brannon M, et al. Protective efficacy of a tandemly linked, multi-subunit recombinant leishmanial vaccine (Leish-111f) formulated in MPL adjuvant. Vaccine 2002; 20: 3292-3303.
    • (2002) Vaccine , vol.20 , pp. 3292-3303
    • Skeiky, Y.A.1    Coler, R.N.2    Brannon, M.3
  • 42
    • 0033178828 scopus 로고    scopus 로고
    • The role of dendritic cells in the induction and regulation of immunity to microbial infection
    • Reis e Sousa C, Sher A & Kaye P. The role of dendritic cells in the induction and regulation of immunity to microbial infection. Curr Opin Immunol 1999; 11: 392-399.
    • (1999) Curr Opin Immunol , vol.11 , pp. 392-399
    • Reis E Sousa, C.1    Sher, A.2    Kaye, P.3
  • 43
    • 0032531036 scopus 로고    scopus 로고
    • Activation of cutaneous dendritic cells by CpG-containing oligodeoxynucleotides: A role for dendritic cells in the augmentation of Th1 responses by immunostimulatory DNA
    • Jakob T, Walker PS, Krieg AM, Udey MC & Vogel JC. Activation of cutaneous dendritic cells by CpG-containing oligodeoxynucleotides: a role for dendritic cells in the augmentation of Th1 responses by immunostimulatory DNA. J Immunol 1998; 161: 3042-3049.
    • (1998) J Immunol , vol.161 , pp. 3042-3049
    • Jakob, T.1    Walker, P.S.2    Krieg, A.M.3    Udey, M.C.4    Vogel, J.C.5
  • 44
    • 0034254201 scopus 로고    scopus 로고
    • CpG-DNA-mediated transient lymphadenopathy is associated with a state of Th1 predisposition to antigen-driven responses
    • Lipford GB, Sparwasser T, Zimmermann S, Heeg K & Wagner H. CpG-DNA-mediated transient lymphadenopathy is associated with a state of Th1 predisposition to antigen-driven responses. J Immunol 2000; 165: 1228-1235.
    • (2000) J Immunol , vol.165 , pp. 1228-1235
    • Lipford, G.B.1    Sparwasser, T.2    Zimmermann, S.3    Heeg, K.4    Wagner, H.5
  • 45
    • 0043163724 scopus 로고    scopus 로고
    • Dendritic cells are responsible for the capacity of CpG oligodeoxynucleotides to act as an adjuvant for protective vaccine immunity against Leishmania major in mice
    • Shah JA, Darrah PA, Ambrozak DR, et al. Dendritic cells are responsible for the capacity of CpG oligodeoxynucleotides to act as an adjuvant for protective vaccine immunity against Leishmania major in mice. J Exp Med 2003; 198: 281-291.
    • (2003) J Exp Med , vol.198 , pp. 281-291
    • Shah, J.A.1    Darrah, P.A.2    Ambrozak, D.R.3
  • 46
    • 0038740849 scopus 로고    scopus 로고
    • IgG1/IgG2 antibody dichotomy in sera of vaccinated or naturally infected dogs with visceral leishmaniasis
    • de Oliveira Mendes C, Paraguai de Souza E, Borja-Cabrera GP, et al. IgG1/IgG2 antibody dichotomy in sera of vaccinated or naturally infected dogs with visceral leishmaniasis. Vaccine 2003; 21: 2589-2597.
    • (2003) Vaccine , vol.21 , pp. 2589-2597
    • De Oliveira Mendes, C.1    Paraguai De Souza, E.2    Borja-Cabrera, G.P.3
  • 47
    • 0033382112 scopus 로고    scopus 로고
    • Immuno-stimulatory properties of the Leishmania infantum heat shock proteins HSP70 and HSP83
    • Rico AI, Angel SO & Alonso C & Requena JM. Immuno-stimulatory properties of the Leishmania infantum heat shock proteins HSP70 and HSP83. Mol Immunol 1999; 36: 1131-1139.
    • (1999) Mol Immunol , vol.36 , pp. 1131-1139
    • Rico, A.I.1    Angel, S.O.2    Alonso, C.3    Requena, J.M.4
  • 48
    • 0033821991 scopus 로고    scopus 로고
    • A two-phase model of B-cell activation
    • Baumgarth N. A two-phase model of B-cell activation. Immunol Rev 2000; 176: 171-180.
    • (2000) Immunol Rev , vol.176 , pp. 171-180
    • Baumgarth, N.1
  • 49
    • 0029680476 scopus 로고    scopus 로고
    • Heat shock proteins as immunological carriers and vaccines
    • Suzue K & Young RA. Heat shock proteins as immunological carriers and vaccines. EXS 1996; 77: 451-465.
    • (1996) EXS , vol.77 , pp. 451-465
    • Suzue, K.1    Young, R.A.2
  • 50
    • 0033750826 scopus 로고    scopus 로고
    • The Leishmania infantum acidic ribosomal protein LiP2a induces a prominent humoral response in vivo and stimulates cell proliferation in vitro and interferon-gamma (IFN-gamma) production by murine splenocytes
    • Soto M, Alonso C & Requena JM. The Leishmania infantum acidic ribosomal protein LiP2a induces a prominent humoral response in vivo and stimulates cell proliferation in vitro and interferon-gamma (IFN-gamma) production by murine splenocytes. Clin Exp Immunol 2000; 122: 212-218.
    • (2000) Clin Exp Immunol , vol.122 , pp. 212-218
    • Soto, M.1    Alonso, C.2    Requena, J.M.3
  • 51
    • 0032768534 scopus 로고    scopus 로고
    • Immunostimulatory DNA as an adjuvant in vaccination against Leishmania major
    • Stacey KJ & Blackwell JM. Immunostimulatory DNA as an adjuvant in vaccination against Leishmania major. Infect Immun 1999; 67: 3719-3726.
    • (1999) Infect Immun , vol.67 , pp. 3719-3726
    • Stacey, K.J.1    Blackwell, J.M.2
  • 52
    • 0037124332 scopus 로고    scopus 로고
    • + T cell responses and protection against Leishmania major infection
    • + T cell responses and protection against Leishmania major infection. J Exp Med 2002; 195: 1565-1573.
    • (2002) J Exp Med , vol.195 , pp. 1565-1573
    • Rhee, E.G.1    Mendez, S.2    Shah, J.A.3
  • 53
    • 0032920816 scopus 로고    scopus 로고
    • Leishmania donovani infection initiates T cell-independent chemokine responses, which are subsequently amplified in a T cell-dependent manner
    • Cotterell SE, Engwerda CR & Kaye PM. Leishmania donovani infection initiates T cell-independent chemokine responses, which are subsequently amplified in a T cell-dependent manner. Eur J Immunol 1999; 29: 203-214.
    • (1999) Eur J Immunol , vol.29 , pp. 203-214
    • Cotterell, S.E.1    Engwerda, C.R.2    Kaye, P.M.3
  • 54
    • 0033974189 scopus 로고    scopus 로고
    • The capacity to produce IFN-gamma rather than the presence of interleukin-4 determines the resistance and the degree of susceptibility to Leishmania donovani infection in mice
    • Lehmann J, Enssle KH, Lehmann I, Emmendorfer A & Lohmann-Matthes ML. The capacity to produce IFN-gamma rather than the presence of interleukin-4 determines the resistance and the degree of susceptibility to Leishmania donovani infection in mice. J Interferon Cytokine Res 2000; 20: 63-77.
    • (2000) J Interferon Cytokine Res , vol.20 , pp. 63-77
    • Lehmann, J.1    Enssle, K.H.2    Lehmann, I.3    Emmendorfer, A.4    Lohmann-Matthes, M.L.5
  • 55
    • 0035199675 scopus 로고    scopus 로고
    • Leishmania donovani. Evolution and architecture of the splenic cellular immune response related to control of infection
    • Melby PC, Tabares A, Restrepo BI, Cardona AE, McGuff HS & Teale JM. Leishmania donovani. evolution and architecture of the splenic cellular immune response related to control of infection. Exp Parasitol 2001; 99: 17-25.
    • (2001) Exp Parasitol , vol.99 , pp. 17-25
    • Melby, P.C.1    Tabares, A.2    Restrepo, B.I.3    Cardona, A.E.4    McGuff, H.S.5    Teale, J.M.6
  • 56
    • 0242349620 scopus 로고    scopus 로고
    • The Leishmania infantum acidic ribosomal protein PO administered as a DNA vaccine confers protective immunity to Leishmania major infection in BALB/c mice
    • Iborra S, Soto M, Carrion J, et al. The Leishmania infantum acidic ribosomal protein PO administered as a DNA vaccine confers protective immunity to Leishmania major infection in BALB/c mice. Infect Immun 2003; 71: 6562-6572.
    • (2003) Infect Immun , vol.71 , pp. 6562-6572
    • Iborra, S.1    Soto, M.2    Carrion, J.3


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