Preclinical study of the systemic toxicity and pharmacokinetics of 5-iodo-2-deoxypyrimidinone-2' -deoxyribose as a radiosensitizing prodrug in two, non-rodent animal species: Implications for Phase I study design

Clinical Cancer Research

Volumn 6, Issue 9, 2000, Pages 3670-3679

  Kinsella, T J ^a   Schupp, J E ^a   Davis, T W ^a   Berry, S E ^a   Hwang, H S ^a   Warren, K ^a   Balis, F ^a   Barnett, J ^a   Sands, H ^a  

^a UNIVERSITY HOSPITALS OF CLEVELAND   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 IODO 2 DEOXYPYRIMIDINONE 2' DEOXYRIBOSE; IDOXURIDINE; RADIOSENSITIZING AGENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COMPARTMENT MODEL; CONTROLLED STUDY; DIARRHEA; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG ELIMINATION; DRUG METABOLISM; DRUG TOLERABILITY; FEMALE; FERRET; LIVER WEIGHT; MALE; MOTOR DYSFUNCTION; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; RHESUS MONKEY; VOMITING; WEIGHT REDUCTION; XENOGRAFT;

ALDEHYDE OXIDOREDUCTASES; ANIMALS; BONE MARROW; DNA; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; FEMALE; FERRETS; HEMATOLOGIC TESTS; IDOXURIDINE; LIVER; MACACA MULATTA; MALE; PRODRUGS; PYRIMIDINE NUCLEOSIDES; RADIATION-SENSITIZING AGENTS; STOMACH; URINE;

EID: 0033813259     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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