Johne's disease, inflammatory bowel disease, and Mycobacterium paratuberculosis

Annual Review of Microbiology

Volumn 58, Issue , 2004, Pages 329-363

  Chacon, Ofelia ^a,b   Bermudez, Luiz E ^c   Barletta, Raúl G ^a  

^a UNIVERSITY OF NEBRASKA LINCOLN   (United States)

^b Unidad de Biología Celular y Molecular   (Colombia)

^c OREGON STATE UNIVERSITY   (United States)

Author keywords

Crohn's disease; Diarrhea; Granulomatous enteritis; Mycobacteria; Ruminants

Indexed keywords

CLARITHROMYCIN; ETHAMBUTOL; PLACEBO; RIFABUTIN;

ANIMAL DISEASE; BOVIDS; CATTLE; CHRONIC DIARRHEA; CROHN DISEASE; DISEASE ASSOCIATION; DISEASE TRANSMISSION; ENTERITIS; HUMAN; INFECTION; MILK; MYCOBACTERIUM AVIUM; MYCOBACTERIUM PARATUBERCULOSIS; NONHUMAN; PARATUBERCULOSIS; PASTEURIZATION; PATHOGENICITY; PRIORITY JOURNAL; REVIEW; RISK FACTOR; ULCERATIVE COLITIS;

ANIMALS; CATTLE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; INFLAMMATORY BOWEL DISEASES; MYCOBACTERIUM PARATUBERCULOSIS; PARATUBERCULOSIS; VIRULENCE;

ANIMALIA; BOS TAURUS; BOVIDAE; BOVINAE; CORYNEBACTERINEAE; MYCOBACTERIUM; MYCOBACTERIUM AVIUM SUBSP. PARATUBERCULOSIS; NEGIBACTERIA;

EID: 9244261648     PISSN: 00664227     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.micro.58.030603.123726     Document Type: Review

References (187)

1. Deleted in proof
2. Deleted in proof
3. Deleted in proof
4. Allen S, Sotos J, Sylte MJ, Czuprynski C. 2001. Use of Hoechst 33342 staining to detect apoptotic changes in bovine mononuclear phagocytes infected with Mycobacterium avium subsp. paratuberculosis. Clin. Diagn. Lab. Immunol. 8:460-64
5. Arulanantham K, Kramer MS, Gryboski JD. 1980. The association of inflammatory bowel disease and X chromosomal abnormality. Pediatrics 66:63-67
6. Bannantine JP, Baechler E, Zhang Q, Li L, Kapur V. 2002. Genome scale comparison of Mycobacterium avium subsp. paratuberculosis with Mycobacterium avium subsp. avium reveals potential diagnostic sequences. J. Clin. Microbiol. 40:1303-10
7. a. Bannantine JP, Barletta RG, Stabel JR, Paustian ML, Kapur V. 2004. Application of the genome sequence to address concerns that Mycobacterium avlum subspecies paratuberculosis is a foodborne pathogen. Foodborne Pathog. Dis. 1:3-15
8. Bannantine JP, Hansen JK, Paustian ML, Amonsin A, Li LL, et al. 2004. Expression and immunogenicity of proteins encoded by sequences specific to Mycobacterium avium subsp. paratuberculosis. J. Clin. Microbiol. 42:106-14
9. Bannantine JP, Huntley JF, Miltner E, Stabel JR, Bermudez LE. 2003. The Mycobacterium avium subsp. paratuberculosis 35 kDa protein plays a role in invasion of bovine epithelial cells. Microbiology 149:2061-69
10. Bannantine JP, Stabel JR. 2000. HspX is present within Mycobacterium paratuberculosis-infected macrophages and is recognized by sera from some infected cattle. Vet. Microbiol. 76:343-58
11. Bannantine JP, Zhang Q, Li LL, Kapur V. 2003. Genomic homogeneity between Mycobacterium avium subsp. avium and Mycobacterium avium subsp. paratuberculosis belies their divergent growth rates. BMC Microbiol. 3:10
12. Barthel R, Feng J, Piedrahita JA, McMurray DN, Templeton JW, Adams LG. 2001. Stable transfection of the bovine NRAMP1 gene into murine RAW264.7 cells: effect on Brucella abortus survival. Infect. Immun. 69:3110-19
13. Beard PM, Rhind SM, Buxton D, Daniels MJ, Henderson D, et al. 2001. Natural paratuberculosis infection in rabbits in Scotland. J. Comp. Pathol. 124:290-99
14. Beard PM, Stevenson K, Pirie A, Rudge K, Buxton D, et al. 2001. Experimental paratuberculosis in calves following inoculation with a rabbit isolate of Mycobacterium avium subsp. paratuberculosis. J. Clin. Microbiol. 39:3080-84
15. Bellamy R. 1999. The natural resistance-associated macrophage protein and susceptibility to intracellular pathogens. Microbes Infect. 1:23-27
16. Bene L, Fust G, Huszti Z, Hernadi Z, Fekete B, et al. 2002. Impaired humoral immune response against mycobacterial 65-kDa heat shock protein (HSP65) in patients with inflammatory bowel disease. Dig. Dis. Sci. 47:1432-37
17. Bernstein CN, Nayar G, Hamel A, Blanchard JF. 2003. Study of animal-borne infections in the mucosas of patients with inflammatory bowel disease and population-based controls. J. Clin. Microbiol. 41:4986-90
18. Bertalot G, Villanacci V, Gramegna M, Orvieto E, Negrini R, et al. 2001. Evidence of Epstein-Barr virus infection in ulcerative colitis. Dig. Liver Dis. 33:551-58
19. a. Board on Agriculture and Natural Resources. 2003. Diagnosis and Control of Johne's Disease. Washington, DC: Natl. Acad. Press
20. Brandwein SL, McCabe RP, Cong Y, Waites KB, Ridwan BU, et al. 1997. Spontaneously colitic C3H/HeJBir mice demonstrate selective antibody reactivity to antigens of the enteric bacterial flora. J. Immunol. 159:44-52
21. Braun C, Zahn R, Martin K, Albert E, Folwaczny C. 2001. Polymorphisms of the ICAM-1 gene are associated with inflammatory bowel disease, regardless of the p-ANCA status. Clin. Immunol. 101:357-60
22. Brooks BW, Young NM, Watson DC, Robertson RH, Sugden EA, et al. 1991. Mycobacterium paratuberculosis antigen D: characterization and evidence that it is a bacterioferritin. J. Clin. Microbiol. 29:1652-58
23. Buergelt CD, Hall C, McEntee K, Duncan JR. 1978. Pathological evaluation of paratuberculosis in naturally infected cattle. Vet. Pathol. 15:196-207
24. Bull TJ, Hermon-Taylor J, Pavlik I, El-Zaatari F, Tizard M. 2000. Characterization of IS900 loci in Mycobacterium avium subsp. paratuberculosis and development of multiplex PCR typing. Microbiology 146(Pt. 9):2185-97
25. Bull TJ, McMinn EJ, Sidi-Boumedine K, Skull A, Durkin D, et al. 2003. Detection and verification of Mycobacterium avium subsp. paratuberculosis in fresh ileocolonic mucosal biopsy specimens from individuals with and without Crohn's disease. J. Clin. Microbiol. 41:2915-23
26. Buza JJ, Mon Y, Bari AM, Hikono H, Aodon G, et al. 2003. Mycobacterium avium subsp. paratuberculosis infection causes suppression of RANTES, monocyte chemoattractant protein 1, and tumor necrosis factor alpha expression in peripheral blood of experimentally infected cattle. Infect. Immun. 71:7223-27
27. Cameron RM, Stevenson K, Inglis NF, Klausen J, Sharp JM. 1994. Identification and characterization of a putative serine protease expressed in vivo by Mycobacterium avium subsp. paratuberculosis. Microbiology 140(Pt. 8):1977-82
28. Camphausen RT, Jones RL, Brennan PJ. 1985. A glycolipid antigen specific to Mycobacterium paratuberculosis: structure and antigenicity. Proc. Natl. Acad. Sci. USA 82:3068-72
29. Capuano SV 3rd, Croix DA, Pawar S, Zinovik A, Myers A, et al. 2003. Experimental Mycobacterium tuberculosis infection of cynomolgus macaques closely resembles the various manifestations of human M. tuberculosis infection. Infect. Immun. 71:5831-44
30. Chan J, Xing Y, Magliozzo RS, Bloom BR. 1992. Killing of virulent Mycobacterium tuberculosis by reactive nitrogen intermediates produced by activated murine macrophages. J. Exp. Med. 175:1111-22
31. Chen L, Xie QW, Nathan C. 1998. Alkyl hydroperoxide reductase subunit C (ahpC) protects bacterial and human cells against reactive nitrogen intermediates. Mol. Cell 1:795-805
32. Chiodini RJ. 1989. Crohn's disease and the mycobacterioses: a review and comparison of two disease entities. Clin. Microbiol. Rev. 2:90-117
33. Chiodini RJ. 1993. The History of Paratuberculosis (Johne's Disease). A Review of the Literature 1895 to 1992. Providence, RI: Int. Assoc. Paratuberc.
34. Chiodini RJ, Van Kruiningen HJ, Merkal RS, Thayer WR Jr, Coutu JA. 1984. Characteristics of an unclassified Mycobacterium species isolated from patients with Crohn's disease. J. Clin. Microbiol. 20:966-71
35. Chiodini RJ, Van Kruiningen HJ, Thayer WR, Coutu JA. 1986. Spheroplastic phase of mycobacteria isolated from patients with Crohn's disease. J. Clin. Microbiol. 24:357-63
36. Chiodini RJ, Van Kruiningen HJ, Thayer WR, Merkal RS, Coutu JA. 1984. Possible role of mycobacteria in inflammatory bowel disease. I. An unclassified Mycobacterium species isolated from patients with Crohn's disease. Dig. Dis. Sci. 29:1073-79
37. Cho J. 2000. Update on inflammatory bowel disease genetics. Curr. Gastroenterol. Rep. 2:434-39
38. Cho JH. 2003. Significant role of genetics in IBD: the NOD2 gene. Rev. Gastroenterol. Disord. 3(Suppl. 1):S18-22
39. Cirillo JD, Falkow S, Tompkins LS, Bermudez LE. 1997. Interaction of Mycobacterium avium with environmental amoebae enhances virulence. Infect. Immun. 65:3759-67
40. Clarke CJ. 1994. Host responses to Mycobacterium paratuberculosis/M. avium infection. Proc. 4th Int. Colloq. Paratuberc., pp. 345-54. Cambridge, UK
41. Clemens DL, Horwitz MA. 1995. Characterization of the Mycobacterium tuberculosis phagosome and evidence that phagosomal maturation is inhibited. J. Exp. Med. 181:257-70
42. Cobb AJ, Frothingham R. 1999. The GroES antigens of Mycobacterium avium and Mycobacterium paratuberculosis. Vet. Microbiol. 67:31-35
43. Cohavy O, Harth G, Horwitz M, Eggena M, Landers C, et al. 1999. Identification of a novel mycobacterial histone H1 homologue (HupB) as an antigenic target of pANCA monoclonal antibody and serum immunoglobulin A from patients with Crohn's disease. Infect. Immun. 67:6510-17
44. Collins MT. 1996. Diagnosis of paratuberculosis. Vet. Clin. North Am. Food Anim. Pract. 12:357-71
45. Collins MT, Lisby G, Moser C, Chicks D, Christensen S, et al. 2000. Results of multiple diagnostic tests for Mycobacterium avium subsp. paratuberculosis in patients with inflammatory bowel disease and in controls. J. Clin. Microbiol. 38:4373-81
46. Cousins DV, Whittington R, Marsh I, Masters A, Evans RJ, Kluver P. 1999. Mycobacteria distinct from Mycobacterium avium subsp. paratuberculosis isolated from the faeces of ruminants possess IS900-like sequences detectable IS900 polymerase chain reaction: implications for diagnosis. Mol. Cell. Probes 13:431-42
47. Coussens PM, Colvin CJ, Rosa GJ, Perez Laspiur J, Elftman MD. 2003. Evidence for a novel gene expression program in peripheral blood mononuclear cells from Mycobacterium avium subsp. paratuberculosis-infected cattle. Infect. Immun. 71:6487-98
48. Coussens PM, Colvin CJ, Wiersma K, Abouzied A, Sipkovsky S. 2002. Gene expression profiling of peripheral blood mononuclear cells from cattle infected with Mycobacterium paratuberculosis. Infect. Immun. 70:5494-502
49. Crohn BB, Ginzburg K, Oppenheimer GD. 1932. Regional ileitis: a pathological and clinical entity. JAMA 99:1323-29
50. De Kesel M, Gilot P, Misonne MC, Coene M, Cocito C. 1993. Cloning and expression of portions of the 34-kilodalton-protein gene of Mycobacterium paratuberculosis: its application to serological analysis of Johne's disease. J. Clin. Microbiol. 31:947-54
51. Dheenadhayalan V, Shin KS, Chang CF, Chang CD, Wang SJ, et al. 2002. Cloning and characterization of the genes coding for antigen 85A, 85B and 85C of Mycobacterium avium subsp. paratuberculosis. DNA Seq. 13:287-94
52. Dohmann K, Strommenger B, Stevenson K, de Juan L, Stratmann J, et al. 2003. Characterization of genetic differences between Mycobacterium avium subsp. paratuberculosis type I and type II isolates. J. Clin. Microbiol. 41:5215-23
53. Doran T, Tizard M, Millar D, Ford J, Sumar N, et al. 1997. IS900 targets translation initiation signals in Mycobacterium avium subsp. paratuberculosis to facilitate expression of its hed gene. Microbiology 143(Pt. 2):547-52
54. Eckstein TM, Belisle JT, Inamine JM. 2003. Proposed pathway for the biosynthesis of serovar-specific glycopeptidolipids in Mycobacterium avium serovar 2. Microbiology 149:2797-807
55. Ellingson JL, Bolin CA, Stabel JR. 1998. Identification of a gene unique to Mycobacterium avium subspecies paratuberculosis and application to diagnosis of paratuberculosis. Mol. Cell. Probes 12:133-42
56. Elsaghier A, Prantera C, Moreno C, Ivanyi J. 1992. Antibodies to Mycobacterium paratuberculosis-specific protein antigens in Crohn's disease. Clin. Exp. Immunol. 90:503-8
57. El-Zaatari FA, Naser SA, Engstrand L, Burch PE, Hachem CY, et al. 1995. Nucleotide sequence analysis and seroreactivities of the 65K heat shock protein from Mycobacterium paratuberculosis. Clin. Diagn. Lab. Immunol. 2:657-64
58. El-Zaatari FA, Naser SA, Engstrand L, Hachem CY, Graham DY. 1994. Identification and characterization of Mycobacterium paratuberculosis recombinant proteins expressed in E. coli. Curr. Microbiol. 29:177-84
59. El-Zaatari FA, Naser SA, Graham DY. 1997. Characterization of a specific Mycobacterium paratuberculosis recombinant clone expressing 35,000-molecular- weight antigen and reactivity with sera from animals with clinical and subclinical Johne's disease. J. Clin. Microbiol. 35:1794-99
60. El-Zaatari FA, Naser SA, Hulten K, Burch P, Graham DY. 1999. Characterization of Mycobacterium paratuberculosis p36 antigen and its seroreactivities in Crohn's disease. Curr. Microbiol. 39:115-19
61. El-Zaatari FA, Naser SA, Markesich DC, Kalter DC, Engstand L, Graham DY. 1996. Identification of Mycobacterium avium complex in sarcoidosis. J. Clin. Microbiol. 34:2240-45
62. Englund S, Bolske G, Johansson KE. 2002. An IS900-like sequence found in a Mycobacterium sp. other than Mycobacterium avium subsp. paratuberculosis. FEMS Microbiol. Lett. 209:267-71
63. Evans AS. 1976. Causation and disease: the Henle-Koch postulates revisited. Yale J. Biol. Med. 49:175-95
64. Falkow S. 1988. Molecular Koch's postulates applied to microbial pathogenicity. Rev. Infect. Dis. 10(Suppl. 2):S274-76
65. Feola RP, Collins MT, Czuprynski CJ. 1999. Hormonal modulation of phagocytosis and intracellular growth of Mycobacterium avium subsp. paratuberculosis in bovine peripheral blood monocytes. Microb. Pathog. 26:1-11
66. Foley-Thomas EM, Whipple DL, Bermudez LE, Barletta RG. 1995. Phage infection, transfection and transformation of Mycobacterium avium complex and Mycobacterium paratuberculosis. Microbiology 141(Pt. 5):1173-81
67. Fredericks DN, Relman DA. 1996. Sequence-based identification of microbial pathogens: a reconsideration of Koch's postulates. Clin. Microbiol. Rev. 9:18-33
68. a. Friedman S, Blumberg RS. 1999. Inflammatory bowel disease. In Harrison's Principles of Internal Medicine, ed. E Braunwald, SA Fauci, DL Kasper, SL Hauser, DL Longo, et al., pp. 1679-91. New York: McGraw-Hill. 15th ed.
69. Fujimura Y, Owen RL. 1996. M cells as portals of infection: clinical and pathophysiological aspects. Infect. Agent. Dis. 5:144-56
70. a. Geijtenbeek TB, Van Vliet SJ, Koppel EA, Sanchez-Hernandez M, Vandenbroucke-Grauls CM, et al. 2003. Mycobacteria target DC-SIGN to suppress dendritic cell function. J. Exp. Med. 197:7-17
71. Goodgame RW, Kimball K, Akram S, Ike E, Ou CN, et al. 2001. Randomized controlled trial of clarithromycin and ethambutol in the treatment of Crohn's disease. Alim. Pharmacol. Ther. 15:1861-66
72. Govoni G, Gros P. 1998. Macrophage NRAMP1 and its role in resistance to microbial infections. Inflamm. Res. 47:277-84
73. Greig A, Stevenson K, Henderson D, Ferez V, Hughes V, et al. 1999. Epidemiological study of paratuberculosis in wild rabbits in Scotland. J. Clin. Microbiol. 37:1746-51
74. Hagan W, Zeissig A. 1933. Six years experience with a herd experimentally infected with Johne's disease. Cornell Vet. 23:1-15
75. Hamilton HL, Follett DM, Siegfried LM, Czuprynski CJ. 1989. Intestinal multiplication of Mycobacterium paratuberculosis in athymic nude gnotobiotic mice. Infect. Immun. 57:225-30
76. Harris NB, Barletta RG. 2001. Mycobacterium avium subsp. paratuberculosis in veterinary medicine. Clin. Microbiol. Rev. 14:489-512
77. Deleted in proof
78. Harris NB, Feng Z, Liu X, Cirillo SL, Cirillo JD, Barletta RG. 1999. Development of a transposon mutagenesis system for Mycobacterium avium subsp. paratuberculosis. FEMS Microbiol. Lett. 175:21-26
79. Harris NB, Zinniel DK, Hsieh MK, Cirillo JD, Barletta RG. 2002. Cell sorting of formalin-treated pathogenic Mycobacterium paratuberculosis expressing GFP. Biotechniques 32:522-24, 26-27
80. Hermon-Taylor J, Bull TJ, Sheridan JM, Cheng J, Stellakis ML, Sumar N. 2000. Causation of Crohn's disease by Mycobacterium avium subspecies paratuberculosis. Can. J. Gastroenterol. 14:521-39
81. Hill AB. 1965. The environment and disease: association or causation? Proc. R. Soc. Med. 58:295-300
82. Hines ME 2nd, Styer EL. 2003. Preliminary characterization of chemically generated Mycobacterium avium subsp. paratuberculosis cell wall deficient forms (spheroplasts). Vet. Microbiol. 95:247-58
83. Hines SA, Buergelt CD, Wilson JH, Bliss EL. 1987. Disseminated Mycobacterium paratuberculosis infection in a cow. J. Am. Vet. Med. Assoc. 190:681-83
84. Hodgson HJ, Potter BJ, Jewell DP. 1977. Immune complexes in ulcerative colitis and Crohn's disease. Clin. Exp. Immunol. 29:187-96
85. Hosteller JM, Steadham EM, Haynes JS, Bailey TB, Cheville NF. 2002. Cytokine effects on maturation of the phagosomes containing Mycobacterium avium subspecies paratuberculosis in J774 cells. FEMS Immunol. Med. Microbiol. 34:127-34
86. Hugot JP, Chamaillard M, Zouali H, Lesage S, Cezard JP, et al. 2001. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature 411:599-603
87. Hugot JP, Laurent-Puig P, Gower-Rousseau C, Olson JM, Lee JC, et al. 1996. Mapping of a susceptibility locus for Crohn's disease on chromosome 16. Nature 379:821-23
88. Hulten K, El-Zimaity HM, Karttunen TJ, Almashhrawi A, Schwartz MR, et al. 2001. Detection of Mycobacterium avium subspecies paratuberculosis in Crohn's diseased tissues by in situ hybridization. Am. J. Gastroenterol. 96:1529-35
89. Hulten K, Karttunen TJ, El-Zimaity HM, Naser SA, Almashhrawi A, et al. 2000. In situ hybridization method for studies of cell wall deficient M. paratuberculosis in tissue samples. Vet. Microbiol. 77:513-18
90. Hulten K, Karttunen TJ, El-Zimaity HM, Naser SA, Collins MT, et al. 2000. Identification of cell wall deficient forms of M. avium subsp. paratuberculosis in paraffin embedded tissues from animals with Johne's disease by in situ hybridization. J. Microbiol. Methods 42:185-95
91. Iizuka M, Itou H, Sato M, Yukawa M, Shirasaka T, et al. 2001. Crohn's disease associated with selective immunoglobulin A deficiency. J. Gastroenterol. Hepatol. 16:951-52
92. Inderlied CB, Kemper CA, Bermudez LE. 1993. The Mycobacterium avium complex. Clin. Microbiol. Rev. 6:266-310
93. Johnson-Ifearulundu Y, Kaneene JB, Lloyd JW. 1999. Herd-level economic analysis of the impact of paratuberculosis on dairy herds. J. Am. Vet. Med. Assoc. 214:822-25
94. a. Katz JA, Fiocchi C. 1996. Causes and mechanisms of Crohn's disease. In Crohn's Disease, ed. C Prantera, BI Korelitz, pp. 9-56. New York: Marcel Dekker
95. Kaufmann SHE. 1993. Immunity to intracellular bacteria. Annu. Rev. Immunol. 11:129-63
96. Kawahito Y, Cannon GW, Gulko PS, Remmers EF, Longman RE, et al. 1998. Localization of quantitative trait loci regulating adjuvant-induced arthritis in rats: evidence for genetic factors common to multiple autoimmune diseases. J. Immunol. 161:4411-19
97. Kim J, Nietfeldt J, Benson AK. 1999. Octamer-based genome scanning distinguishes a unique subpopulation of Escherichia coli O157:H7 strains in cattle. Proc. Natl. Acad. Sci. USA 96:13288-93
98. Kim JH, Lee SY, Lee SH, Sin C, Shim JJ, et al. 2003. NRAMP1 genetic polymorphisms as a risk factor of tuberculous pleurisy. Int. J. Tuberc. Lung Dis. 7:370-75
99. Kluge JP, Merkal RS, Monlux WS, Larsen AB, Kopecky KE, et al. 1968. Experimental paratuberculosis in sheep after oral, intratracheal, or intravenous inoculation lesions and demonstration of etiologic agent. Am. J. Vet. Res. 29:953-62
100. Koch R. 1932. The Aetiology of Tuberculosis. New York: Natl. Tuberc. Assoc. 48 pp.
101. Kreuzpaintner G, Das PK, Stronkhorst A, Slob AW, Strohmeyer G. 1995. Effect of intestinal resection on serum antibodies to the mycobacterial 45/48 kilodalton doublet antigen in Crohn's disease. Gut 37:361-66
102. Kucharzik T, Lugering N, Weigelt H, Adolf M, Domschke W, Stoll R. 1996. Immunoregulatory properties of IL-13 in patients with inflammatory bowel disease; comparison with IL-4 and IL-10. Clin. Exp. Immunol. 104:483-90
103. Kuehnel MP, Goethe R, Habermann A, Mueller E, Rohde M, et al. 2001. Characterization of the intracellular survival of Mycobacterium avium subsp. paratuberculosis: phagosomal pH and fusogenicity on J774 macrophages compared with other mycobacteria. Cell. Microbiol. 3:551-66
104. Lambrecht RS, Carriere JF, Collins MT. 1988. A model for analyzing growth kinetics of a slowly growing Mycobacterium sp. Appl. Environ. Microbiol. 54:910-16
105. Lambrecht RS, Collins MT. 1992. Mycobacterium paratuberculosis. Factors that influence mycobactin dependence. Diagn. Microbiol. Infect. Dis. 15:239-46
106. Liu X, Feng Z, Harris NB, Cirillo JD, Bercovier H, Barletta RG. 2001. Identification of a secreted superoxide dismutase in Mycobacterium avium subsp. paratuberculosis. FEMS Microbiol. Lett. 202:233-38
107. Lombardi ML, Pirozzi G, Luongo V, Mercuro O, Pace E, et al. 2001. Crohn disease: susceptibility and disease heterogeneity revealed by HLA genotyping. Hum. Immunol. 62:701-4
108. Lugton IW. 1999. Mucosa-associated lymphoid tissues as sites for uptake, carriage and excretion of tubercle bacilli and other pathogenic mycobacteria. Immunol. Cell Biol. 77:364-72
109. Manca C, Paul S, Barry CE 3rd, Freedman VH, Kaplan G. 1999. Mycobacterium tuberculosis catalase and peroxidase activities and resistance to oxidative killing in human monocytes in vitro. Infect. Immun. 67:74-79
110. a. McQuaid KR. 1999. Alimentary tract. In Current Medical Diagnosis and Treatment, ed. LM Tierney, SJ McPhee, MA Papadakis, pp. 538-637. Stanford, CT: Appleton & Lange
111. Mishina D, Katsel P, Brown ST, Gilberts EC, Greenstein RJ. 1996. On the etiology of Crohn disease. Proc. Natl. Acad. Sci. USA 93:9816-20
112. Mokresh AH, Czuprynski CJ, Butler DG. 1989. A rabbit model for study of Mycobacterium paratuberculosis infection. Infect. Immun. 57:3798-807
113. Momotani E, Whipple DL, Thiermann AB, Cheville NF. 1988. Role of M cells and macrophages in the entrance of Mycobacterium paratuberculosis into domes of ileal Peyer's patches in calves. Vet. Pathol. 25:131-37
114. Motiwala AS, Strother M, Amonsin A, Byrum B, Naser SA, et al. 2003. Molecular epidemiology of Mycobacterium avium subsp. paratuberculosis: evidence for limited strain diversity, strain sharing, and identification of unique targets for diagnosis. J. Clin. Microbiol. 41:2015-26
115. Mullerad J, Hovav AH, Fishman Y, Barletta RG, Bercovier H. 2002. Antigenicity of Mycobacterium paratuberculosis superoxide dismutase in mice. FEMS Immunol. Med. Microbiol. 34:81-88
116. Mullerad J, Hovav AH, Nahary R, Fishman Y, Bercovier H. 2003. Immunogenicity of a 16.7 kDa Mycobacterium paratuberculosis antigen. Microb. Pathog. 34:81-90
117. Mullerad J, Michal I, Fishman Y, Hovav AH, Barletta RG, Bercovier H. 2002. The immunogenicity of Mycobacterium paratuberculosis 85B antigen. Med. Microbiol. Immunol. (Berlin) 190:179-87
118. Mutharia LM, Moreno W, Raymond M. 1997. Analysis of culture filtrate and cell wall-associated antigens of Mycobacterium paratuberculosis with monoclonal antibodies. Infect. Immun. 65:387-94
119. Mutwiri GK, Butler DG, Rosendal S, Yager J. 1992. Experimental infection of severe combined immunodeficient beige mice with Mycobacterium paratuberculosis of bovine origin. Infect. Immun. 60:4074-79
120. NAHMS (National Animal Health Monitoring System). 1997. Johne's disease on U.S. dairy operations. Rep. N245.1087., USDA:APHIS:VS, CEAH, Fort Collins, CO
121. Naser SA, Felix J, Liping H, Romero C, Naser N, et al. 1999. Occurrence of the IS900 gene in Mycobacterium avium complex derived from HIV patients. Mol. Cell. Probes 13:367-72
122. Naser SA, Hulten K, Shafran I, Graham DY, El-Zaatari FA. 2000. Specific seroreactivity of Crohn's disease patients against p35 and p36 antigens of M. avium subsp. paratuberculosis. Vet. Microbiol. 77:497-504
123. Naser SA, Schwartz D, Shafran I. 2000. Isolation of Mycobacterium avium subsp. paratuberculosis from breast milk of Crohn's disease patients. Am. J. Gastroenterol. 95:1094-95
124. Naser SA, Shafran I, Schwartz D, El-Zaatari F, Biggerstaff J. 2002. In situ identification of mycobacteria in Crohn's disease patient tissue using confocal scanning laser microscopy. Mol. Cell. Probes 16:41-48
125. Ogura Y, Bonen DK, Inohara N, Nicolae DL, Chen FF, et al. 2001. A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature 411:603-6
126. Ogura Y, Lala S, Xin W, Smith E, Dowds TA, et al. 2003. Expression of NOD2 in Paneth cells: a possible link to Crohn's ileitis. Gut 52:1591-97
127. Oh YK, Straubinger RM. 1996. Intracellular fate of Mycobacterium avium: use of dual-label spectrofluorometry to investigate the influence of bacterial viability and opsonization on phagosomal pH and phagosome-lysosome interaction. Infect. Immun. 64:319-25
128. Ohene-Gyan KA, Haagsma J, Davies MJ, Hounsell EF. 1995. Novel glycolipids of Mycobacterium avium and related M. paratuberculosis strains of relevance to AIDS and Crohn's disease. Comp. Immunol. Microbiol. Infect. Dis. 18:161-70
129. Okazawa A, Kanai T, Watanabe M, Yamazaki M, Inoue N, et al. 2002. Th1-mediated intestinal inflammation in Crohn's disease may be induced by activation of lamina propria lymphocytes through synergistic stimulation of interleukin-12 and interleukin-18 without T cell receptor engagement. Am. J. Gastroenterol. 97:3108-17
130. Olsen I, Reitan LJ, Holstad G, Wiker HG. 2000. Alkyl hydroperoxide reductases C and D are major antigens constitutively expressed by Mycobacterium avium subsp. paratuberculosis. Infect. Immun. 68:801-8
131. Olsen I, Wiker HG, Johnson E, Langeggen H, Reitan LJ. 2001. Elevated antibody responses in patients with Crohn's disease against a 14-kDa secreted protein purified from Mycobacterium avium subsp. paratuberculosis. Scand. J. Immunol. 53:198-203
132. Oshitani N, Hato F, Jinno Y, Sawa Y, Nakamura S, et al. 2001. IgG subclasses of anti Saccharomyces cerevisiae antibody in inflammatory bowel disease. Eur. J. Clin. Invest. 31:221-25
133. Ostrowski M, Mundo SL, Harris NB, Barletta RG, Lopez OJ. 2003. B-cell epitopes in the immunodominant p34 antigen of Mycobacterium avium subsp. paratuberculosis recognized by antibodies from infected cattle. Scand. J. Immunol. 58:511-21
134. Ott SL, Wells SJ, Wagner BA. 1999. Herd-level economic losses associated with Johne's disease on US dairy operations. Prev. Vet. Med. 40:179-92
135. Pauleau AL, Murray PJ. 2003. Role of Nod2 in the response of macrophages to toll-like receptor agonists. Mol. Cell. Biol. 23:7531-39
136. Pavlik I, Bejckova L, Pavlas M, Rozsypalova Z, Koskova S. 1995. Characterization by restriction endonuclease analysis and DNA hybridization using IS900 of bovine, ovine, caprine and human dependent strains of Mycobacterium paratuberculosis isolated in various localities. Vet. Microbiol. 45:311-18
137. Pearce CB, Duncan HD, Timmis L, Green JR. 2000. Assessment of the prevalence of infection with Helicobacter pylori in patients with inflammatory bowel disease. Eur. J. Gastroenterol. Hepatol. 12:439-43
138. Peeters M, Joossens S, Vermeire S, Vlietinck R, Bossuyt X, Rutgeerts P. 2001. Diagnostic value of anti-Saccharomyces cerevisiae and antineutrophil cytoplasmic autoantibodies in inflammatory bowel disease. Am. J. Gastroenterol. 96:730-34
139. Deleted in proof
140. Richter E, Wessling J, Lugering N, Domschke W, Rusch-Gerdes S. 2002. Mycobacterium avium subsp. paratuberculosis infection in a patient with HIV, Germany. Emerg. Infect. Dis. 8:729-31
141. Rioux JD, Daly MJ, Silverberg MS, Lindblad K, Steinhart H, et al. 2001. Genetic variation in the 5q31 cytokine gene cluster confers susceptibility to Crohn disease. Nat. Genet. 29:223-28
142. Sanderson IR, Bisset WM, Milla PJ, Leonard JV. 1991. Chronic inflammatory bowel disease in glycogen storage disease type 1B. J. Inherit. Metab. Dis. 14:771-76
143. Schinella RA, Greco MA, Cobert BL, Denmark LW, Cox RP. 1980. Hermansky-Pudlak syndrome with granulomatous colitis. Ann. Intern. Med. 92:20-23
144. Schwartz D, Shafran I, Romero C, Piromalli C, Biggerstaff J, et al. 2000. Use of short-term culture for identification of Mycobacterium avium subsp. paratuberculosis in tissue from Crohn's disease patients. Clin. Microbiol. Infect. 6:303-7
145. a. Sechi LA, Mura M, Tanda F, Lissia A, Solinas A, et al. 2001. Identification of Mycobacterium avium subsp. paratuberculosis in biopsy specimens from patients with Crohn's disease identified by in situ hybridization. J. Clin. Microbiol. 39:4514-17
146. Secott TE, Lin TL, Wu CC. 2001. Fibronectin attachment protein homologue mediates fibronectin binding by Mycobacterium avium subsp. paratuberculosis. Infect. Immun. 69:2075-82
147. Deleted in proof
148. Secott TE, Lin TL, Wu CC. 2002. Fibronectin attachment protein is necessary for efficient attachment and invasion of epithelial cells by Mycobacterium avium subsp. paratuberculosis. Infect. Immun. 70:2670-75
149. Shafran I, Kugler L, El-Zaatari FA, Naser SA, Sandoval J. 2002. Open clinical trial of rifabutin and clarithromycin therapy in Crohn's disease. Dig. Liver. Dis. 34:22-28
150. Shafran I, Piromalli C, Decker JW, Sandoval J, Naser SA, El-Zaatari FA. 2002. Seroreactivities against Saccharomyces cerevisiae and Mycobacterium avium subsp. paratuberculosis p35 and p36 antigens in Crohn's disease patients. Dig. Dis. Sci. 47:2079-81
151. Sheridan JM, Bull TJ, Hermon-Taylor J. 2003. Use of bioinformatics to predict a function for the GS element in Mycobacterium avium subspecies paratuberculosis. J. Mol. Microbiol. Biotechnol. 5:57-66
152. Sogawa M, Matsumoto T, Yamagami H, Yamada T, Ozeki Y, et al. 2003. A murine model of granulomatous colitis with mesenteric lymphadenitis induced by mycobacterial cord factor. Virchows. Arch. 442:151-58
153. Stabel JR. 1995. Temporal effects of tumor necrosis factor-α on intracellular survival of Mycobacterium paratuberculosis. Vet. Immunol. Immunopathol. 45:321-32
154. Stabel JR. 1998. Johne's disease: a hidden threat. J. Dairy. Sci. 81:283-88
155. Stabel JR, Goff JP, Ackermann MR. 1998. Dietary calcium modulates Mycobacterium paratuberculosis infection in beige mice. Vet. Immunol. Immunopathol. 66:377-90
156. 3 infusion modulate immune responses during Mycobacterium paratuberculosis infection in beige mice. Vet. Immunol. Immunopathol. 50:127-43
157. Stainsby KJ, Lowes JR, Allan RN, Ibbotson JP. 1993. Antibodies to Mycobacterium paratuberculosis and nine species of environmental mycobacteria in Crohn's disease and control subjects. Gut 34:371-74
158. Stenson WF. 2000. Inflammatory bowel disease. In Cecil Textbook of Medicine, ed. L Goldman, JC Bennett, pp. 722-29. Philadelphia: Saunders
159. Stevens TR, Winrow VR, Blake DR, Rampton DS. 1992. Circulating antibodies to heat-shock protein 60 in Crohn's disease and ulcerative colitis. Clin. Exp. Immunol. 90:271-74
160. Stevenson K, Hughes VM, de Juan L, Inglis NF, Wright F, Sharp JM. 2002. Molecular characterization of pigmented and nonpigmented isolates of Mycobacterium avium subsp. paratuberculosis. J. Clin. Microbiol. 40:1798-804
161. Deleted in proof
162. a. Sudre P, ten Dam G, Kochi A. 1992. Tuberculosis: a global overview of the situation today. Bull. World Health Org. 70:149-59
163. Sugden EA, Samagh BS, Bundle DR, Duncan JR. 1987. Lipoarabinomannan and lipid-free arabinomannan antigens of Mycobacterium paratuberculosis. Infect. Immun. 55:762-70
164. Sweeney RW. 1996. Transmission of paratuberculosis. Vet. Clin. North Am. Food Anim. Pract. 12:305-12
165. Tamura K, Fukuda Y, Sashio H, Takeda N, Bamba H, et al. 2002. IL18 polymorphism is associated with an increased risk of Crohn's disease. J. Gastroenterol. 37(Suppl. 14):111-16
166. Targan SR. 1999. The utility of ANCA and ASCA in inflammatory bowel disease. Inflamm. Bowel Dis. 5:61-63; discussion 66-67
167. - dendritic cell populations in the colonic mucosa of patients with Crohn's disease. Eur. J. Immunol. 33:143-51
168. Thomsen BV, Steadham EM, Gallup JM, Ackermann MR, Brees DJ, Cheville NF. 2001. T cell-dependent inducible nitric oxide synthase production and ultrastructural morphology in BALB/c mice infected with Mycobacterium avium subspecies paratuberculosis. J. Comp. Pathol. 125:137-44
169. Thorel MF, Krichevsky M, Levy-Frebault W. 1990. Numerical taxonomy of mycobactin-dependent mycobacteria, emended description of Mycobacterium avium, and description of Mycobacterium avium subsp. avium subsp. nov., Mycobacterium avium subsp. paratuberculosis subsp. nov., and Mycobacterium avium subsp. silvaticum subsp. nov. Int. J. Syst. Bacteriol. 40:254-60
170. Tooker BC, Burton JL, Coussens PM. 2002. Survival tactics of M. paratuberculosis in bovine macrophage cells. Vet. Immunol. Immunopathol. 87:429-37
171. Twort C. 1914. The experimental production of Johne's disease in some laboratory animals. Vet. News 11:79-81
172. Twort F, Ingram GLY. 1912. A method for isolating and cultivating the Mycobacterium enteritidis chronicae pseudotuberculosis bovis, Johne, and some experiments on the preparation of a diagnostic vaccine for pseudotuberculosis enteritis of bovines. Proc. R. Soc. Ser. B 84:517-42
173. Tysk C, Lindberg E, Jarnerot G, Floderus-Myrhed B. 1988. Ulcerative colitis and Crohn's disease in an unselected population of monozygotic and dizygotic twins. A study of heritability and the influence of smoking. Gut
174. Van Den Bogaerde J, Cahill J, Emmanuel AV, Vaizey CJ, Talbot IC, et al. 2002. Gut mucosal response to food antigens in Crohn's disease. Aliment. Pharmacol. Ther. 16:1903-15
175. Van Deventer SJ. 2000. Immunotherapy of Crohn's disease. Scand. J. Immunol. 51:18-22
176. Wall S, Kunze ZM, Saboor S, Soufleri I, Seechurn P, et al. 1993. Identification of spheroplast-like agents isolated from tissues of patients with Crohn's disease and control tissues by polymerase chain reaction. J. Clin. Microbiol. 31:1241-45
177. Walmsley RS, Ibbotson JP, Chahal H, Allan RN. 1996. Antibodies against Mycobacterium paratuberculosis in Crohn's disease. QJM 89:217-21
178. Weiss DJ, Evanson OA, Moritz A, Deng MQ, Abrahamsen MS. 2002. Differential responses of bovine macrophages to Mycobacterium avium subsp. paratuberculosis and Mycobacterium avium subsp. avium. Infect. Immun. 70:5556-61
179. White WB, Whipple DL, Stabel JR, Bolin CA. 1994. Comparison of cellular and extracellular proteins expressed by various isolates of Mycobacterium paratuberculosis and other mycobacterial species. Am. J. Vet. Res. 55:1399-405
180. Whitlock RH, Buergelt C. 1996. Preclinical and clinical manifestations of paratuberculosis (including pathology). Vet. Clin. North Am. Food Anim. Pract. 12:345-56
181. Whittington RJ, Hope AF, Marshall DJ, Taragel CA, Marsh I. 2000. Molecular epidemiology of Mycobacterium avium subsp. paratuberculosis: IS900 restriction fragment length polymorphism and IS1311 polymorphism analyses of isolates from animals and a human in Australia. J. Clin. Microbiol. 38:3240-48
182. Whittington RJ, Marsh I, McAllister S, Turner MJ, Marshall DJ, Fraser CA. 1999. Evaluation of modified BACTEC 12B radiometric medium and solid media for culture of Mycobacterium avium subsp. paratuberculosis from sheep. J. Clin. Microbiol. 37:1077-83
183. Williams SL, Harris NB, Barletta RG. 1999. Development of a firefly luciferase-based assay for determining antimicrobial susceptibility of Mycobacterium avium subsp. paratuberculosis. J. Clin. Microbiol. 37:304-9
184. Witkin SS, Gerber S, Ledger WJ. 2002. Influence of interleukin-1 receptor antagonist gene polymorphism on disease. Clin. Infect. Dis. 34:204-9
185. Zhao B, Collins MT, Czuprynski CJ. 1997. Effects of γ-interferon and nitric oxide on the interaction of Mycobacterium avium subsp. paratuberculosis with bovine monocytes. Infect. Immun. 65:1761-66
186. Zhao BY, Czuprynski CJ, Collins MT. 1999. Intracellular fate of Mycobacterium avium subspecies paratuberculosis in monocytes from normal and infected, interferon-responsive cows as determined by a radiometric method. Can. J. Vet. Res. 63:56-61
187. Targan SR, Shanahan F, Karp LC. 2003. Inflammatory Bowel Disease: From Bench to Bedside. Boston: Kluwer