A proinflammatory role of IL-18 in the development of spontaneous autoimmune disease

Journal of Immunology

Volumn 167, Issue 9, 2001, Pages 5338-5347

  Esfandiari, E ^a   McInnes, I B ^a   Lindop, G ^a   Huang, F P ^a   Field, M ^a   Komai Koma, M ^a   Wei, X Q ^a   Liew, F Y ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN; INTERLEUKIN 12; INTERLEUKIN 18;

ANIMAL CELL; APOPTOSIS; ARTICLE; AUTOIMMUNE DISEASE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG TARGETING; FEMALE; GLOMERULONEPHRITIS; INFLAMMATION; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEINURIA; RASH; SYSTEMIC LUPUS ERYTHEMATOSUS; TH2 CELL; VASCULITIS;

EID: 0035500546     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.167.9.5338     Document Type: Article

References (68)

1. Systemic lupus erythematosus
2. Spontaneous murine lupus-like syndromes: clinical and immunopathological manifestations in several strains
3. Lpr and gld: single gene models of systemic autoimmunity and lymphoproliferative disease
4. Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis
5. Genetic analysis of MRL-lpr mice: relationship of the Fas apoptosis gene to disease manifestations and renal disease-modifying loci
6. Effects of thymectomy or androgen administration upon the autoimmune disease of MRL/Mp-lpr/lpr mice
7. Induction of nonpathologic, humoral autoimmunity in lupus-prone mice by a class II-restricted, transgenic αβ T cell: Separation of autoantigen-specific and -nonspecific help
8. Evidence for multiple mechanisms of polyclonal T cell activation in murine lupus
9. Treatment of murine lupus with CTLA41g
10. Preferential dependence of autoantibody production in murine lupus on CD86 costimulatory molecule
11. CD40-CD40 ligand interaction in autoimmune disease
12. Long-term inhibition of murine lupus by brief simultaneous blockade of the B7/ CD28 and CD40/gp39 costimulation pathways
13. Enhanced lymphoproliferation and diminished autoimmunity in CD4-deficient MRL/lpr mice
14. 1 disease with anti-I-A monoclonal antibodies
15. + T cells to lymphoproliferation and autoantibody production in MRL-lpr/lpr mice
16. Increased activation and altered ratio of interferon-γ Interleukin-4 secreting cells in MRL-lpr/lpr mice
17. Roles of interferon-γ and interleukin-4 in murine lupus
18. Interleukin-4 protects against a genetically linked lupus-like autoimmune syndrome
19. 1 mice
20. Deficient γ-interferon production in patients with systemic lupus erythematosus
21. Imbalance towards Th1 predominance is associated with acceleration of lupus-like autoimmune syndrome in MRL mice
22. Interferon-γ: Is required for lupus-like disease and lymphoaccumulation in MRL-lpr mice
23. 1 mice
24. 1 lupus-like nephritis with monoclonal antibody to γ interferon
25. The role of nitric oxide in the pathogenesis of spontaneous murine autoimmune disease: increased nitric oxide production and nitric oxide synthase expression in MRL-lpr/lpr mice, and reduction of spontaneous glomerulonephritis and arthritis by orally administered NG-monomethyl-L-arginine
26. The role of interleukin 12 and nitric oxide in the development of spontaneous autoimmune disease in MRLMP-lpr/lpr mice
27. IFN-γ-inducing factor (IGIF) is a costimulatory factor on the activation of Th1 but not Th2 cells and exerts its effect independently of IL-12
28. Caspase-1 processes IFN-γ-inducing factor and regulates LPS-induced IFN-γ production
29. Purification and characterization of the human interleukin-18 receptor
30. Interleukin-18
31. Cloning of a new cytokine that induces IFN-γ production by T cells
32. Production of functional IL-18 by different subtypes of murine and human dendritic cells (DC): DC-derived IL-18 enhances IL-12-dependent Th1 development
33. Interleukin-18 (interferon-γ-inducing factor) is produced by osteoblasts and acts via granulocyte/macrophage colony-stimulating factor and not via interferon-γ to inhibit osteoclast formation
34. IL-18 is produced by articular chondrocytes and induces proinflammatory and catabolic responses
35. Cultures of astrocytes and microglia express interleukin 18
36. Selective expression and functions of interleukin 18 receptor on T helper (Th) type 1 but not Th2 cells
37. IGIF does not drive Th1 development but synergizes with IL-12 for interferon-γ Production and activates IRAK and NFkB
38. IFN-γ-inducing factor (IL-18) increases allergic sensitization, semm rum IgE Th2 cytokines, and airway eosinophilia in a mouse model of allergic asthma
39. IL-18 is a potent coinducer of IL-13 in NK and T cells: A new potential role for IL-18 in modulating the immune response
40. IL-18 induces the differentiation of Th1 or Th2 cells depending upon cytokine milieu and genetic background
41. A proinflammatory role for IL-18 in rheumatoid arthritis
42. Bioactive IL-18 expression is upregulated in Crohn's disease
43. IL-18, a novel immunoregulatory cytokine, is up-regulated in Crohn's disease: expression and localization in intestinal mucosal cells
44. The 1982 revised criteria for the classification of systemic lupus erythematosus
45. Derivation of the SLEDAI: a disease activity index for lupus patients
46. Combined effects of IL-12 and IL-18 on the induction of collagen-induced arthritis
47. Nitrite and nitrate determinations in plasma: a critical evaluation
48. 15N]nitrate in biological fluids
49. Elevation of plasma interleukin 18 concentration is correlated with disease activity in systemic lupus erythematosus
50. Levels of interleukin 18 and its binding inhibitors in the blood circulation of patients with adult-onset Still's disease
51. A novel role for interleukin 18 in human natural killer cell death: high serum levels and low natural killer cell number in patients with systemic autoimmune diseases
52. Selective expression of a stable cell surface molecule on type 2 but not type 1 helper T cells
53. IL-12 up-regulates IL-18 receptor expression on T cells
54. Interleukin-10
55. Defective NK cell activity and Th1 response in IL-18-deficient mice
56. Altered immune responses and susceptibility to Leishmania major and Staphylococcus aureus infection in IL18-deficient mice
57. Systemic production of interferon-γ inducing factor (IGIF) versus local IFN-γ expression involved in the development of Th1 insulitis in NOD mice
58. + T lymphocytes
59. Interleukin 15: a proinflammatory role in rheumatoid arthritis synovitis
60. Interleukin-15 mediates T cell-dependent regulation of tumor necrosis factor-α production in rheumatoid arthritis
61. IFN-γ-dependent and -independent mechanisms in adverse effects caused by concomitant administration of IL-18 and IL-12
62. Serological markers of disease activity in systemic lupus erythematosus
63. Cutting edge: mouse IgG1 antibodies comprise two functionally distinct types that are differentially regulated by IL-4 and IL-12
64. Lymphocytes from autoimmune MRL/lpr/lpr mice are hyperresponsive to IL-18 and overexpress the IL-18 receptor accessory chain
65. Skin-specific caspase-1-transgenic mice show cutaneous apoptosis and pre-endotoxin shock condition with a high serum level of IL-18
66. DNase and defective disposal of cellular debris
67. IL-18 directs autoreactive T cells and promotes autodestruction in the central nervous system via induction of IFN-γ by NK cells
68. T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-γ