Role of interleukin-18 in host defense against disseminated Candida albicans infection

Infection and Immunity

Volumn 70, Issue 6, 2002, Pages 3284-3286

  Stuyt, Rogier J L ^a   Netea, Mihai G ^a   Verschueren, Ineke ^a   Fantuzzi, Giamila ^a   Dinarello, Charles A ^a   Van der Meer, Jos W M ^a   Kullberg, Bart Jan ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE ANTIBODY; GAMMA INTERFERON; INTERLEUKIN 18; INTERLEUKIN 18 ANTIBODY; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY BURDEN; CANDIDA ALBICANS; CANDIDIASIS; CELL PROTECTION; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; HOST RESISTANCE; KIDNEY INFECTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN DEFICIENCY;

ANIMALS; CANDIDA ALBICANS; CANDIDIASIS; DISEASE MODELS, ANIMAL; FEMALE; INTERFERON TYPE II; INTERLEUKIN-1; INTERLEUKIN-18; INTERLEUKIN-6; KIDNEY; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, INBRED CBA; MICE, KNOCKOUT; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0036259915     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.70.6.3284-3286.2002     Document Type: Article

References (16)

1. Candidiasis in interferon-gamma knock-out (IFN-gamma-/-) mice
2. Leptin-deficient (ob/ob) mice are protected from T-cell mediated hepatotoxicity: Role of tumor necrosis factor alpha and IL-18
3. IL-12-induced IFN-gamma is dependent on caspase-1 processing of the IL-18 precursor
4. An IFN-gamma-independent proinflammatory role of IL-18 in murine streptococcal cell wall arthritis
5. Reduced host resistance and Th1 response to Cryptococcus neoformans in interleukin-18 deficient mice
6. IL-18 protects mice against pulmonary and disseminated infection with Cryptococcus neoformans by inducing IFN-gamma production
7. Recombinant murine granulocyte colony-stimulating factor protects against acute disseminated Candida albicans infection in non-neutropenic mice
8. Recombinant interferon-γ enhances resistance to acute disseminated Candida albicans infection in mice
9. Interleukin 18 contributes to host resistance and gamma interferon production in mice infected with virulent Salmonella typhimurium
10. Interleukin 18 restores defective Th1 immunity to Candida albicans in caspase 1-deficient mice
11. Low-density-lipoprotein receptor deficient mice are protected against lethal endotoxinemia and severe Gram-negative infections
12. Neutralization of interleukin-18 reduces neutrophil tissue accumulation and protects mice against lethal Escherichia coli and Salmonella typhimurium endotoxemia
13. Potentiality of interleukin-18 as a useful reagent for treatment and prevention of Leishmania major infection
14. A novel costimulatory factor for gamma interferon induction found in the livers of mice causes endotoxic shock
15. Interleukin-18 (IFNγ inducing factor) induces IL-8 and IL-1β via TNFα production from non-CD14+ human mononuclear cells
16. Role of interleukin-18 (IL-18) in mycobacterial infection in IL-18-gene-disrupted mice