메뉴 건너뛰기




Volumn 63, Issue SUPPL. 2, 2002, Pages 2-10

Radioprotectants: Current status and new directions

Author keywords

Amifostine; Cytoprotection; Mutagenesis; Radiation induced toxicity; Radiotherapy; Thiol compounds

Indexed keywords

2 (3 AMINOPROPYLAMINO)ETHANETHIOL; ACETYLCYSTEINE; AMIFOSTINE; ANTIOXIDANT; CAPTOPRIL; DRUG METABOLITE; MANGANESE SUPEROXIDE DISMUTASE; MESNA; MITOCHONDRIAL ENZYME; RADIOPROTECTIVE AGENT; RAZOXANE; RECOMBINANT ERYTHROPOIETIN; THIOL DERIVATIVE; WR 332728;

EID: 0036916372     PISSN: 00302414     EISSN: None     Source Type: Journal    
DOI: 10.1159/000067146     Document Type: Review
Times cited : (144)

References (26)
  • 1
    • 0031735316 scopus 로고    scopus 로고
    • Radiation-induced toxicities: The role of radioprotectants
    • Curran WJ: Radiation-induced toxicities: The role of radioprotectants. Semin Radiat Oncol 1998;8(4 suppl 1):2-4.
    • (1998) Semin Radiat Oncol , vol.8 , Issue.4 SUPPL. 1 , pp. 2-4
    • Curran, W.J.1
  • 2
    • 0031735185 scopus 로고    scopus 로고
    • Future directions in toxicity prevention
    • Brizel DM: Future directions in toxicity prevention. Semin Radiat Oncol 1998;8(4 suppl 1):17-20.
    • (1998) Semin Radiat Oncol , vol.8 , Issue.4 SUPPL. 1 , pp. 17-20
    • Brizel, D.M.1
  • 3
    • 0030756555 scopus 로고    scopus 로고
    • Current role of protective agents in cancer treatment
    • Schuchter LM: Current role of protective agents in cancer treatment. Oncology (Huntingt) 1997;11:505-512, 515-518.
    • (1997) Oncology (Huntingt) , vol.11 , pp. 505-512
    • Schuchter, L.M.1
  • 4
    • 0032973059 scopus 로고    scopus 로고
    • Clinical and preclinical modulation of chemotherapy-induced toxicity in patients with cancer
    • Hoekman K, van der Vijgh WJF, Vermorken JB: Clinical and preclinical modulation of chemotherapy-induced toxicity in patients with cancer. Drugs 1999;57:133-155.
    • (1999) Drugs , vol.57 , pp. 133-155
    • Hoekman, K.1    Van der Vijgh, W.J.F.2    Vermorken, J.B.3
  • 5
    • 0033014520 scopus 로고    scopus 로고
    • Chemoprotectants: A review of their clinical pharmacology and therapeutic efficacy
    • Links M, Lewis C: Chemoprotectants: A review of their clinical pharmacology and therapeutic efficacy. Drugs 1999;57:293-308.
    • (1999) Drugs , vol.57 , pp. 293-308
    • Links, M.1    Lewis, C.2
  • 6
    • 0034998360 scopus 로고    scopus 로고
    • Amifostine: An update on its clinical status as a cytoprotectant in patients with cancer receiving chemotherapy or radiotherapy and its potential therapeutic application in myelodysplastic syndrome
    • Culy CR, Spencer CM: Amifostine: An update on its clinical status as a cytoprotectant in patients with cancer receiving chemotherapy or radiotherapy and its potential therapeutic application in myelodysplastic syndrome. Drugs 2001;61:641-684.
    • (2001) Drugs , vol.61 , pp. 641-684
    • Culy, C.R.1    Spencer, C.M.2
  • 7
    • 0029779875 scopus 로고    scopus 로고
    • Guidelines for the administration of amifostine
    • Schuchter LM: Guidelines for the administration of amifostine. Semin Oncol 1996;23(4 suppl 8):40-43.
    • (1996) Semin Oncol , vol.23 , Issue.4 SUPPL. 8 , pp. 40-43
    • Schuchter, L.M.1
  • 9
    • 0031693006 scopus 로고    scopus 로고
    • Dexrazoxane: A review of its use as a cardioprotective agent in patients receiving anthracycline-based chemotherapy
    • Wiseman LR, Spencer CM: Dexrazoxane: A review of its use as a cardioprotective agent in patients receiving anthracycline-based chemotherapy. Drugs 1998;56:385-403.
    • (1998) Drugs , vol.56 , pp. 385-403
    • Wiseman, L.R.1    Spencer, C.M.2
  • 10
    • 0025237857 scopus 로고
    • The iron(III) and copper(II) complexes of adriamycin promote the hydrolysis of the cardioprotective agent ICRF-187 ((+)-1,2-bis(3,5-dioxopiperazinyl-1-yl)propane)
    • Hasinoff BB: The iron(III) and copper(II) complexes of adriamycin promote the hydrolysis of the cardioprotective agent ICRF-187 ((+)-1,2-bis(3,5-dioxopiperazinyl-1-yl)propane). Agents Actions 1990;29:374-381.
    • (1990) Agents Actions , vol.29 , pp. 374-381
    • Hasinoff, B.B.1
  • 13
    • 0023937127 scopus 로고
    • Radioprotection of DNA by thiols: Relationship between the net charge on a thiol and its ability to protect DNA
    • Zheng S, Newton GL, Gonick G, Fahey RC, Ward JF: Radioprotection of DNA by thiols: Relationship between the net charge on a thiol and its ability to protect DNA. Radiat Res 1988;114:11-27.
    • (1988) Radiat Res , vol.114 , pp. 11-27
    • Zheng, S.1    Newton, G.L.2    Gonick, G.3    Fahey, R.C.4    Ward, J.F.5
  • 14
    • 0026661425 scopus 로고
    • Aerobic radioprotection of pBR322 by thiols: Effect of thiol net charge upon scavenging of hydroxyl radicals and repair of DNA radicals
    • Zheng S, Newton GL, Ward JF, Fahey RC: Aerobic radioprotection of pBR322 by thiols: Effect of thiol net charge upon scavenging of hydroxyl radicals and repair of DNA radicals. Radiat Res 1992;130:183-193.
    • (1992) Radiat Res , vol.130 , pp. 183-193
    • Zheng, S.1    Newton, G.L.2    Ward, J.F.3    Fahey, R.C.4
  • 15
    • 0021796650 scopus 로고
    • The radioprotector WR1065 reduces radiation-induced mutations at the hypoxanthine-guanine phosphoribosyl transferase locus in V79 cells
    • Grdina DJ, Nagy B, Hill CK, Wells RL, Peraino C: The radioprotector WR1065 reduces radiation-induced mutations at the hypoxanthine-guanine phosphoribosyl transferase locus in V79 cells. Carcinogenesis 1985;6:929-931.
    • (1985) Carcinogenesis , vol.6 , pp. 929-931
    • Grdina, D.J.1    Nagy, B.2    Hill, C.K.3    Wells, R.L.4    Peraino, C.5
  • 16
    • 0028953642 scopus 로고
    • Thiol and disulfide metabolites of the radiation protector and potential chemopreventive agent WR-2721 are linked to both its anti-cytotoxic and anti-mutagenic mechanisms of action
    • Grdina DJ, Shigematsu N, Dale P, Newton GL, Aguilera JA, Fahey RC: Thiol and disulfide metabolites of the radiation protector and potential chemopreventive agent WR-2721 are linked to both its anti-cytotoxic and anti-mutagenic mechanisms of action. Carcinogenesis 1995;16:767-774.
    • (1995) Carcinogenesis , vol.16 , pp. 767-774
    • Grdina, D.J.1    Shigematsu, N.2    Dale, P.3    Newton, G.L.4    Aguilera, J.A.5    Fahey, R.C.6
  • 17
    • 0033029608 scopus 로고    scopus 로고
    • Pharmacokinetics of amifostine: Effects of dose and method of administration
    • Shaw LM, Bonner HS, Schuchter L, Schiller J, Lieberman R: Pharmacokinetics of amifostine: Effects of dose and method of administration. Semin Oncol 1999;26(2 suppl 7):34-36.
    • (1999) Semin Oncol , vol.26 , Issue.2 SUPPL. 7 , pp. 34-36
    • Shaw, L.M.1    Bonner, H.S.2    Schuchter, L.3    Schiller, J.4    Lieberman, R.5
  • 19
    • 0035144389 scopus 로고    scopus 로고
    • Modulation of radiation-induced cytokine elevation associated with esophagitis and esophageal stricture by manganese superoxide dismutase-plasmid/liposome (SOD2-PL) gene therapy
    • Epperly MW, Gretton JA, DeFilippi SJ, Greenberger JS, Sikora CA, Liggitt D, Koe G: Modulation of radiation-induced cytokine elevation associated with esophagitis and esophageal stricture by manganese superoxide dismutase-plasmid/liposome (SOD2-PL) gene therapy. Radiat Res 2001;155:2-14.
    • (2001) Radiat Res , vol.155 , pp. 2-14
    • Epperly, M.W.1    Gretton, J.A.2    DeFilippi, S.J.3    Greenberger, J.S.4    Sikora, C.A.5    Liggitt, D.6    Koe, G.7
  • 20
    • 0035921188 scopus 로고    scopus 로고
    • Manganese superoxide dismutase-plasmid/liposome (MnSOD-PL) administration protects mice from esophagitis associated with fractionated radiation
    • Epperly MW, Kagan VE, Sikora CA, Gretton JE, Defilippi SJ, Bar-Sagi D, Greenberger JS: Manganese superoxide dismutase-plasmid/liposome (MnSOD-PL) administration protects mice from esophagitis associated with fractionated radiation. Int J Cancer 2001;96:221-231.
    • (2001) Int J Cancer , vol.96 , pp. 221-231
    • Epperly, M.W.1    Kagan, V.E.2    Sikora, C.A.3    Gretton, J.E.4    Defilippi, S.J.5    Bar-Sagi, D.6    Greenberger, J.S.7
  • 21
    • 0035874637 scopus 로고    scopus 로고
    • Activation of NFkappaB and MnSOD gene expression by free radical scavengers in human microvascular endothelial cells
    • Murley JS, Kataoka Y, Hallahan DE, Roberts JC, Grdina DJ: Activation of NFkappaB and MnSOD gene expression by free radical scavengers in human microvascular endothelial cells. Free Radic Biol Med 2001;30:1426-1439.
    • (2001) Free Radic Biol Med , vol.30 , pp. 1426-1439
    • Murley, J.S.1    Kataoka, Y.2    Hallahan, D.E.3    Roberts, J.C.4    Grdina, D.J.5
  • 22
    • 0028829574 scopus 로고
    • Activation of NF-kappa B elevation of MnSOD gene expression by thiol-reducing agents in lung adenocarcinoma (A549) cells
    • Das KC, Lewis-Molock Y, White CW: Activation of NF-kappa B and elevation of MnSOD gene expression by thiol-reducing agents in lung adenocarcinoma (A549) cells. Am J Physiol 1995;269(5 Pt 1):L588-L602.
    • (1995) Am J Physiol , vol.269 , Issue.5 PART 1
    • Das, K.C.1    Lewis-Molock, Y.2    White, C.W.3
  • 24
    • 0032994129 scopus 로고    scopus 로고
    • Use of amifostine in hematologic malignancies, myelodysplastic syndrome, and acute leukemia
    • List AF: Use of amifostine in hematologic malignancies, myelodysplastic syndrome, and acute leukemia. Semin Oncol 1999;26(2 suppl 7):61-65.
    • (1999) Semin Oncol , vol.26 , Issue.2 SUPPL. 7 , pp. 61-65
    • List, A.F.1
  • 25
    • 0029093948 scopus 로고
    • Interaction of inflammatory cytokines and erythropoietin in iron metabolism and erythropoiesis in anaemia of chronic disease
    • Jongen-Lavrencic M, Peeters HR, Vreugdenhil G, Swaak AJ: Interaction of inflammatory cytokines and erythropoietin in iron metabolism and erythropoiesis in anaemia of chronic disease. Clin Rheumatol 1995;14:519-525.
    • (1995) Clin Rheumatol , vol.14 , pp. 519-525
    • Jongen-Lavrencic, M.1    Peeters, H.R.2    Vreugdenhil, G.3    Swaak, A.J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.