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Volumn 17, Issue 2, 2003, Pages 163-174

Oncogenic transformation induces tumor angiogenesis: A role for PAR1 activation

Author keywords

Invasion; Metastasis; Thrombin receptor; Vascular endothelial growth factor

Indexed keywords

MESSENGER RNA; NEUTRALIZING ANTIBODY; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN KINASE C INHIBITOR; PROTEIN TYROSINE KINASE INHIBITOR; PROTEINASE ACTIVATED RECEPTOR 1; TETRACYCLINE; VASCULOTROPIN; VASCULOTROPIN ANTIBODY;

EID: 0037308089     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.02-0316com     Document Type: Article
Times cited : (108)

References (67)
  • 1
    • 0032710319 scopus 로고    scopus 로고
    • Clinical application of angiogenic growth factor and their inhibitors
    • Ferrara, N., and Alitalo, K. (1999) Clinical application of angiogenic growth factor and their inhibitors. Nature Med. 5, 1359-1364
    • (1999) Nature Med. , vol.5 , pp. 1359-1364
    • Ferrara, N.1    Alitalo, K.2
  • 3
    • 0034648765 scopus 로고    scopus 로고
    • Angiogenesis in cancer and other diseases
    • Carmeliet, P., and Jain, R. K. (2000) Angiogenesis in cancer and other diseases. Nature (London) 407, 249-257
    • (2000) Nature (London) , vol.407 , pp. 249-257
    • Carmeliet, P.1    Jain, R.K.2
  • 4
    • 0000009898 scopus 로고
    • Tumor angiogenic therapoeitic implications
    • Folkman,J. (1971) Tumor angiogenic therapoeitic implications. N. Engl. J. Med. 285, 1182-1186
    • (1971) N. Engl. J. Med , vol.285 , pp. 1182-1186
    • Folkman, J.1
  • 5
    • 0030576517 scopus 로고    scopus 로고
    • Pattern and emerging mechanisms of angiogenic switch during tumorigenesis
    • Hanahan, D., and Folkman, J. (1996) Pattern and emerging mechanisms of angiogenic switch during tumorigenesis. Cell 86, 353-364
    • (1996) Cell , vol.86 , pp. 353-364
    • Hanahan, D.1    Folkman, J.2
  • 7
    • 0020961939 scopus 로고
    • Activation of blood coagulation in cancer: Trousseau's syndrome revisited
    • Rickles, F. R., and Edwards, R. L. (1983) Activation of blood coagulation in cancer: Trousseau's syndrome revisited. Blood 62, 14-31
    • (1983) Blood , vol.62 , pp. 14-31
    • Rickles, F.R.1    Edwards, R.L.2
  • 9
    • 0029041208 scopus 로고
    • Cellular localization of enzymatically active thrombin in intact human tissues by hirudin binding
    • Zacharski, L. R., Memoli, V. A., Morian, W. D., Schlaeppi, J. M., and Roussceu, S. M. (1995) Cellular localization of enzymatically active thrombin in intact human tissues by hirudin binding. Throm. Haemostasis 73, 793-797
    • (1995) Throm. Haemostasis , vol.73 , pp. 793-797
    • Zacharski, L.R.1    Memoli, V.A.2    Morian, W.D.3    Schlaeppi, J.M.4    Roussceu, S.M.5
  • 11
    • 0035815711 scopus 로고    scopus 로고
    • Tumor cell invasion is promoted by activation of protease activated receptor-1 in cooperation with αvβ5 integrin
    • Even-Ram, C. S., Maoz, M., Pokroy, E., Reich, R., Katz, B.-Z., Gutwein, P., Altevogt, P., and Bar-Shavit, R. (2001) Tumor cell invasion is promoted by activation of protease activated receptor-1 in cooperation with αvβ5 integrin. J Biol. Chem. 276, 10952-10962
    • (2001) J. Biol. Chem. , vol.276 , pp. 10952-10962
    • Even-Ram, C.S.1    Maoz, M.2    Pokroy, E.3    Reich, R.4    Katz, B.-Z.5    Gutwein, P.6    Altevogt, P.7    Bar-Shavit, R.8
  • 12
    • 0026035523 scopus 로고
    • Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation
    • Vu, T.-K., Hung, D. T., Wheaton, V. I., and Coughlin, S. R. (1991) Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Cell 64, 1057-1068
    • (1991) Cell , vol.64 , pp. 1057-1068
    • Vu, T.-K.1    Hung, D.T.2    Wheaton, V.I.3    Coughlin, S.R.4
  • 14
    • 0035848718 scopus 로고    scopus 로고
    • The thrombin receptor. PAR-1 causes transformation by activation of Rhomediated signaling pathways
    • Martin, C. B., Mahon, G. M., Klinger, M. B., Kay, R. J., Symons, M., Der, C. J., and Whitehead, I. P. (2001) The thrombin receptor. PAR-1 causes transformation by activation of Rhomediated signaling pathways. Oncogene 20, 1953-1963
    • (2001) Oncogene , vol.20 , pp. 1953-1963
    • Martin, C.B.1    Mahon, G.M.2    Klinger, M.B.3    Kay, R.J.4    Symons, M.5    Der, C.J.6    Whitehead, I.P.7
  • 15
    • 0030008312 scopus 로고    scopus 로고
    • Role of the thrombin receptor in development and evidence for a second receptor
    • Connolly, A. J., Ishihara, H., Kahn, M. L., Fares, Jr., R. V., and Coughlin, S. R. (1996) Role of the thrombin receptor in development and evidence for a second receptor. Nature (London) 381, 516-519
    • (1996) Nature (London) , vol.381 , pp. 516-519
    • Connolly, A.J.1    Ishihara, H.2    Kahn, M.L.3    Fares R.V., Jr.4    Coughlin, S.R.5
  • 18
    • 0029794555 scopus 로고    scopus 로고
    • Targeted disruption of the murine tissue factor gene results in embryonic lethality
    • Toomey, J. R., Kratzer, K. E., Lasky, N. M., Stanton, J. J., and Broze, Jr., G.J. (1996) Targeted disruption of the murine tissue factor gene results in embryonic lethality. Blood 88, 1583-1587
    • (1996) Blood , vol.88 , pp. 1583-1587
    • Toomey, J.R.1    Kratzer, K.E.2    Lasky, N.M.3    Stanton, J.J.4    Broze G.J., Jr.5
  • 19
    • 0029854371 scopus 로고    scopus 로고
    • Fatal haemorrhage and incomplete block to embryogenesis in mice lacking coagulation factor V
    • Cui,J., O'Shea, K. S. M., Purkayastha, A., Saunders, T. L., and Ginsburg, D. (1996) Fatal haemorrhage and incomplete block to embryogenesis in mice lacking coagulation factor V. Nature (London) 384, 66-68
    • (1996) Nature (London) , vol.384 , pp. 66-68
    • Cui, J.1    O'Shea, K.S.M.2    Purkayastha, A.3    Saunders, T.L.4    Ginsburg, D.5
  • 22
    • 0035979691 scopus 로고    scopus 로고
    • A role for thrombin receptor signaling in endothelial cells during embryonic development
    • Griffin, C. T., Snirivasan, Y., Zheng, Y.-W., Haung, W., and Coughlin, S. R. (2001) A role for thrombin receptor signaling in endothelial cells during embryonic development. Science 293, 1666-1670
    • (2001) Science , vol.293 , pp. 1666-1670
    • Griffin, C.T.1    Snirivasan, Y.2    Zheng, Y.-W.3    Haung, W.4    Coughlin, S.R.5
  • 23
    • 0034102401 scopus 로고    scopus 로고
    • Vascular protease receptors: Integrating haemostasis and endothelial cell functions
    • Preissner, K. T., Nawroth, P. P., and Kanse, S. M. (2000) Vascular protease receptors: integrating haemostasis and endothelial cell functions. J. Pathol. 190, 360-372
    • (2000) J. Pathol. , vol.190 , pp. 360-372
    • Preissner, K.T.1    Nawroth, P.P.2    Kanse, S.M.3
  • 24
    • 0035979719 scopus 로고    scopus 로고
    • Clotting factors build blood vessels
    • Carmeliet, P. (2001) Clotting factors build blood vessels. Science 293, 1602-1604
    • (2001) Science , vol.293 , pp. 1602-1604
    • Carmeliet, P.1
  • 25
    • 0025259592 scopus 로고
    • Nucleotide sequence and expression of a novel human receptor-type tyrosine kinase gene (flt) closely related to the fms family
    • Shibuya, M., Yamaguchi, S., Yamane, A., Ikeda, T., Tojo, A., Matsushime, H., and Sato, M. (1990) Nucleotide sequence and expression of a novel human receptor-type tyrosine kinase gene (flt) closely related to the fms family. Oncogene 5, 519-524
    • (1990) Oncogene , vol.5 , pp. 519-524
    • Shibuya, M.1    Yamaguchi, S.2    Yamane, A.3    Ikeda, T.4    Tojo, A.5    Matsushime, H.6    Sato, M.7
  • 26
    • 0025739016 scopus 로고
    • Identification of a new endothelial cell growth factor receptor tyrosine kinase
    • Terman, B. I., Carrion, M. E., Kovacs, E., Rasmussen, B. A., Eddy, R. L., and Shows, T. B. (1991) Identification of a new endothelial cell growth factor receptor tyrosine kinase. Oncogene 6, 1677-1683
    • (1991) Oncogene , vol.6 , pp. 1677-1683
    • Terman, B.I.1    Carrion, M.E.2    Kovacs, E.3    Rasmussen, B.A.4    Eddy, R.L.5    Shows, T.B.6
  • 27
    • 0032907687 scopus 로고    scopus 로고
    • Vascular endothelial growth factor (VEGF) and its receptors
    • Neufeld, G., Cohen, T., Gengrinovitch, S., and Poltorak, Z. (1999) Vascular endothelial growth factor (VEGF) and its receptors. FASEB J. 13, 9-22
    • (1999) FASEB J. , vol.13 , pp. 9-22
    • Neufeld, G.1    Cohen, T.2    Gengrinovitch, S.3    Poltorak, Z.4
  • 28
    • 0027197245 scopus 로고
    • Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo
    • Kim, K. J., Li, B., Winer, J., Armanini, M., Gillett, N., Phillips, H. S., and Ferrara, N. (1993) Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo. Nature (London) 362, 841-844
    • (1993) Nature (London) , vol.362 , pp. 841-844
    • Kim, K.J.1    Li, B.2    Winer, J.3    Armanini, M.4    Gillett, N.5    Phillips, H.S.6    Ferrara, N.7
  • 29
    • 0028174337 scopus 로고
    • Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant
    • Millauer, B., Shawver, L. K., Plate, K. H., Risau, W., and Ullrich, A. (1994) Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant. Nature (London) 367, 576-579
    • (1994) Nature (London) , vol.367 , pp. 576-579
    • Millauer, B.1    Shawver, L.K.2    Plate, K.H.3    Risau, W.4    Ullrich, A.5
  • 32
    • 0029021660 scopus 로고
    • Role of Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium
    • Fong, G. H., Rossant, J., Gertsenstein, M., and Breitman, M. L. (1995) Role of Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium. Nature (London) 376, 66-70
    • (1995) Nature (London) , vol.376 , pp. 66-70
    • Fong, G.H.1    Rossant, J.2    Gertsenstein, M.3    Breitman, M.L.4
  • 33
    • 0026485002 scopus 로고
    • Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis
    • Shweiki, D., Itin, A., Soffer, D., and Keshet, E. (1992) Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature (London) 359, 843-845
    • (1992) Nature (London) , vol.359 , pp. 843-845
    • Shweiki, D.1    Itin, A.2    Soffer, D.3    Keshet, E.4
  • 34
    • 0026446102 scopus 로고
    • Vascular endothelial growth factor is a potent tumor angiogenesis factor in human gliomas in vivo
    • Plate, K. H., Breier, G., Weich, H. A., and Risau, W. (1992) Vascular endothelial growth factor is a potent tumor angiogenesis factor in human gliomas in vivo. Nature (London) 359, 845-848
    • (1992) Nature (London) , vol.359 , pp. 845-848
    • Plate, K.H.1    Breier, G.2    Weich, H.A.3    Risau, W.4
  • 35
    • 0024818355 scopus 로고
    • Vascular endothelial growth factor is a secreted angiogenic mitogen
    • Leung, D. W., Cachianes, G., Kuang, W. J., Goddel, D. V., and Ferrara, N. (1989) Vascular endothelial growth factor is a secreted angiogenic mitogen. Science 246, 1306-1309
    • (1989) Science , vol.246 , pp. 1306-1309
    • Leung, D.W.1    Cachianes, G.2    Kuang, W.J.3    Goddel, D.V.4    Ferrara, N.5
  • 37
    • 0032952010 scopus 로고    scopus 로고
    • Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal
    • Benjamin, L. E., Golijanin, D., Itin, A., Pode, D., and Keshet, E. (1999) Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal. J. Clin. Invest. 103, 159-165
    • (1999) J. Clin. Invest. , vol.103 , pp. 159-165
    • Benjamin, L.E.1    Golijanin, D.2    Itin, A.3    Pode, D.4    Keshet, E.5
  • 38
    • 0024801035 scopus 로고
    • Vascular permeability factor, an endothelial cell mitogen related to PDGF
    • Keck, P. J., Hauser, S. D., Krivi, G., Sanzo, K., Warren, T., Feder, J., and Connolly, D. T. (1989) Vascular permeability factor, an endothelial cell mitogen related to PDGF. Science 246, 1309-1312
    • (1989) Science , vol.246 , pp. 1309-1312
    • Keck, P.J.1    Hauser, S.D.2    Krivi, G.3    Sanzo, K.4    Warren, T.5    Feder, J.6    Connolly, D.T.7
  • 39
    • 0026395163 scopus 로고
    • The vascular endothelial growth factor family-identification of a fourth molecular species and characterization of a alternative splicing RNA
    • Houck, K. A., Ferrara, N., Winer, J., Cachiaes, G., Li, B., and Leung, D. W. (1991) The vascular endothelial growth factor family-identification of a fourth molecular species and characterization of a alternative splicing RNA. Mol. Endocrinol. 5, 1806-1814
    • (1991) Mol. Endocrinol. , vol.5 , pp. 1806-1814
    • Houck, K.A.1    Ferrara, N.2    Winer, J.3    Cachiaes, G.4    Li, B.5    Leung, D.W.6
  • 40
    • 0028990151 scopus 로고
    • VEGF121, a vascular endothelial growth factor isoform lacking heparin binding ability, requires cell surface heparan sulfates for efficient binding to the VEGF receptors of human melanoma cells
    • Cohen, T., Gitay-Goren, H., Sharon, R., Shibuya, M., Halaban, R., Levi, B., and Neufeld, G. (1995) VEGF121, a vascular endothelial growth factor isoform lacking heparin binding ability, requires cell surface heparan sulfates for efficient binding to the VEGF receptors of human melanoma cells. J. Biol. Chem. 270, 11322-11326
    • (1995) J. Biol. Chem. , vol.270 , pp. 11322-11326
    • Cohen, T.1    Gitay-Goren, H.2    Sharon, R.3    Shibuya, M.4    Halaban, R.5    Levi, B.6    Neufeld, G.7
  • 41
    • 0027751890 scopus 로고
    • Vascular endothelial growth factor (VEGF) isoforms-differential deposition into the subepithelial eextracellular matrix and bioactivity of extracellular matrix-bound VEGF
    • Park, J. E., Keller, G. A., and Ferrara, N. (1993) Vascular endothelial growth factor (VEGF) isoforms-differential deposition into the subepithelial eextracellular matrix and bioactivity of extracellular matrix-bound VEGF. Mol. Biol. Cell 4, 1317-1326
    • (1993) Mol. Biol. Cell , vol.4 , pp. 1317-1326
    • Park, J.E.1    Keller, G.A.2    Ferrara, N.3
  • 43
    • 0030933923 scopus 로고    scopus 로고
    • Vascular endothelial growth factor, a possible paracrine growth factor in human acute myeloid leukemia
    • Fiedler, W., Graeven, U., Ergun, S., Verago, S., Kilic, N., Stockschlader, M., and Hossfeld, D. K. (1997) Vascular endothelial growth factor, a possible paracrine growth factor in human acute myeloid leukemia. Blood, 89, 1870-1875
    • (1997) Blood , vol.89 , pp. 1870-1875
    • Fiedler, W.1    Graeven, U.2    Ergun, S.3    Verago, S.4    Kilic, N.5    Stockschlader, M.6    Hossfeld, D.K.7
  • 45
    • 0026495179 scopus 로고
    • A simple, quantitative method for assessing angiogenesis and antiangiogenic agents using reconstituted basement membrane, heparin, and fibroblast growth factor
    • Passaniti, A., Taylor, R. M., Pili, R., Guo, Y., Long, P. V., Haney, J. A., Pauly, R. R., Grants, D. S., and Martin, G. R. (1992) A simple, quantitative method for assessing angiogenesis and antiangiogenic agents using reconstituted basement membrane, heparin, and fibroblast growth factor. Lab. Invest. 67, 519-528
    • (1992) Lab. Invest. , vol.67 , pp. 519-528
    • Passaniti, A.1    Taylor, R.M.2    Pili, R.3    Guo, Y.4    Long, P.V.5    Haney, J.A.6    Pauly, R.R.7    Grants, D.S.8    Martin, G.R.9
  • 46
    • 0032031861 scopus 로고    scopus 로고
    • Reduced angiogenesis and tumor progression in gelatinase A-deficient mice
    • Itoh, T., Tanioka, M., Yoshida, H., Yoshioka, T., Nishimoto, H., and Itohara, S. (1998) Reduced angiogenesis and tumor progression in gelatinase A-deficient mice. Cancer Res. 58, 1048-1051
    • (1998) Cancer Res. , vol.58 , pp. 1048-1051
    • Itoh, T.1    Tanioka, M.2    Yoshida, H.3    Yoshioka, T.4    Nishimoto, H.5    Itohara, S.6
  • 47
    • 0033674846 scopus 로고    scopus 로고
    • Neuropilin-1 expression by tumor cells promotes tumor angiogenesis and progression
    • Miao, H.-Q., Lee, P., Lin, H., Soker, S., and Klagsbrun, M. (2000) Neuropilin-1 expression by tumor cells promotes tumor angiogenesis and progression. FASEB J. 14, 2532-2539
    • (2000) FASEB J. , vol.14 , pp. 2532-2539
    • Miao, H.-Q.1    Lee, P.2    Lin, H.3    Soker, S.4    Klagsbrun, M.5
  • 48
    • 0027999621 scopus 로고
    • Activation of Src family kinase activity by the G protein-coupled thrombin receptor in growth-responsive fibroblasts
    • Chen, Y.-H., Pouyssegur, J., Coutridge, S. A., and Van Obberghen-Schilling, E. (1994) Activation of Src family kinase activity by the G protein-coupled thrombin receptor in growth-responsive fibroblasts. J. Biol. Chem. 269, 27372-27377
    • (1994) J. Biol. Chem. , vol.269 , pp. 27372-27377
    • Chen, Y.-H.1    Pouyssegur, J.2    Coutridge, S.A.3    Van Obberghen-Schilling, E.4
  • 49
    • 0031036735 scopus 로고    scopus 로고
    • Ras activation in platelets after stimulation of the thrombin receptor, thromboxane A2 receptor or prote
    • Shock, D. D., He, K., Wencel-Drake, J. D., and Parise, L. V. (1997) Ras activation in platelets after stimulation of the thrombin receptor, thromboxane A2 receptor or prote. Biochem. J. 321, 525-530
    • (1997) Biochem. J. , vol.321 , pp. 525-530
    • Shock, D.D.1    He, K.2    Wencel-Drake, J.D.3    Parise, L.V.4
  • 50
    • 0033532076 scopus 로고    scopus 로고
    • Thrombin induces proteinase-activated receptor-1 gene expression in endothelialcells via activation of Gi-linked Ras/mitogen-activated protein kinase pathway
    • Ellis, C. A., Malik, A. B., Gilchrist, A., Hamm, H., Sandoval, R., Voyno-Yasenetskaya, T., and Tiruppathi, C. (1999) Thrombin induces proteinase-activated receptor-1 gene expression in endothelialcells via activation of Gi-linked Ras/mitogen-activated protein kinase pathway. J. Biol. Chem. 274, 13718-13727
    • (1999) J. Biol. Chem. , vol.274 , pp. 13718-13727
    • Ellis, C.A.1    Malik, A.B.2    Gilchrist, A.3    Hamm, H.4    Sandoval, R.5    Voyno-Yasenetskaya, T.6    Tiruppathi, C.7
  • 51
    • 0029960771 scopus 로고    scopus 로고
    • Thrombin receptor activation and integrin engagement stimulate tyrosine phosphorylation of the proto-oncogene product, p95vav, in platelets
    • Cichowski, K., Brugge, J. S., and Brass, L. F. (1996) Thrombin receptor activation and integrin engagement stimulate tyrosine phosphorylation of the proto-oncogene product, p95vav, in platelets. J. Biol. Chem. 271, 7544-7550
    • (1996) J. Biol. Chem. , vol.271 , pp. 7544-7550
    • Cichowski, K.1    Brugge, J.S.2    Brass, L.F.3
  • 52
    • 0036164574 scopus 로고    scopus 로고
    • Signalling pathways induced by protease-activated receptors and integrins in T cells
    • Bar-Shavit, R., Maoz, M., Yongjun, Y., Groysman, M., Dekel, I., and Katzav, S. (2002) Signalling pathways induced by protease-activated receptors and integrins in T cells. Immunology 105, 35-46
    • (2002) Immunology , vol.105 , pp. 35-46
    • Bar-Shavit, R.1    Maoz, M.2    Yongjun, Y.3    Groysman, M.4    Dekel, I.5    Katzav, S.6
  • 53
    • 0033588371 scopus 로고    scopus 로고
    • On the mechanism of thrombin-induced angiogenesis
    • Tsopanoglou, N. E., and Maragoudakis, M. E. (1999) On the mechanism of thrombin-induced angiogenesis. J. Biol. Chem. 274, 23969-23976
    • (1999) J. Biol. Chem. , vol.274 , pp. 23969-23976
    • Tsopanoglou, N.E.1    Maragoudakis, M.E.2
  • 54
    • 0035952713 scopus 로고    scopus 로고
    • Angiogenesis and G-protein coupled receptors: Signals and bridge the gap
    • Richard, D. E., Vouret-Craviari, V., and Pouyssegur, J. (2001) Angiogenesis and G-protein coupled receptors: signals and bridge the gap. Oncogene 20, 1556-1562
    • (2001) Oncogene , vol.20 , pp. 1556-1562
    • Richard, D.E.1    Vouret-Craviari, V.2    Pouyssegur, J.3
  • 55
    • 0034763273 scopus 로고    scopus 로고
    • Thrombin induces increased expression and secretion of VEGF from human FS4 fibroblasts. DU 145 prostate cells and CHRF megakaryocytes
    • Huang, Y.-Q., Li, J.-J., Hu, L., Lee, M., and Karpatkin, S. (2001) Thrombin induces increased expression and secretion of VEGF from human FS4 fibroblasts. DU 145 prostate cells and CHRF megakaryocytes. Throm. Haemst. 86, 1094-1098
    • (2001) Throm. Haemst. , vol.86 , pp. 1094-1098
    • Huang, Y.-Q.1    Li, J.-J.2    Hu, L.3    Lee, M.4    Karpatkin, S.5
  • 56
    • 0027991781 scopus 로고
    • Phosphatidylinositol 3,4,5-triphosphate is formed from phosphatidylinositol 4,5-bis-phosphate in thrombin-stimulated platelets
    • Carter, A. N., Haung, R., Sorisk, A., Downes, C. P., and Rittenhouse, S. E. (1994) Phosphatidylinositol 3,4,5-triphosphate is formed from phosphatidylinositol 4,5-bis-phosphate in thrombin-stimulated platelets. Biochem. J. 310, 415-420
    • (1994) Biochem. J. , vol.310 , pp. 415-420
    • Carter, A.N.1    Haung, R.2    Sorisk, A.3    Downes, C.P.4    Rittenhouse, S.E.5
  • 57
    • 0025325661 scopus 로고
    • Thrombin-dependent association of phosphatidylinositol-3-kinase with p60c-src and p59fyn in human platelets
    • Gutkind, J. S., Lacal, P. M., and Robbins, K. C. (1990) Thrombin-dependent association of phosphatidylinositol-3-kinase with p60c-src and p59fyn in human platelets. Mol. Cell. Biol. 10, 3806-3809
    • (1990) Mol. Cell. Biol. , vol.10 , pp. 3806-3809
    • Gutkind, J.S.1    Lacal, P.M.2    Robbins, K.C.3
  • 58
    • 0026801172 scopus 로고
    • Alpha thrombin stimulates nuclear localization of protein kinse C isozyme in IIC9 cells
    • Leach, K., L., Ruff, V. A., Jarpe, M. B., Adams, L. D., Fabbro, D., and Raben, D. M. (1992) Alpha thrombin stimulates nuclear localization of protein kinse C isozyme in IIC9 cells. J. Biol. Chem. 267, 21816-21822
    • (1992) J. Biol. Chem. , vol.267 , pp. 21816-21822
    • Leach, K.1    Ruff, V.A.2    Jarpe, M.B.3    Adams, L.D.4    Fabbro, D.5    Raben, D.M.6
  • 59
    • 0029964035 scopus 로고    scopus 로고
    • Shc adaptor proteins are key transducers of mitogenic signaling mediated by the G protein-coupled thrombin receptor
    • Chen, Y., Grall, D., Salcini, A. E., Pelicci, P. G., Pouyssegur, J., and Van Obberghen-Schilling, E. (1996) Shc adaptor proteins are key transducers of mitogenic signaling mediated by the G protein-coupled thrombin receptor. EMBO J. 15, 1037-1044
    • (1996) EMBO J. , vol.15 , pp. 1037-1044
    • Chen, Y.1    Grall, D.2    Salcini, A.E.3    Pelicci, P.G.4    Pouyssegur, J.5    Van Obberghen-Schilling, E.6
  • 60
    • 0030612752 scopus 로고    scopus 로고
    • The G12 coupled thrombin receptor stimulates mitogenesis through the Shc SH2 domain
    • Collins, L. R., Rickets, W. A., Olefsky, J. M., and Brown, J. H. (1997) The G12 coupled thrombin receptor stimulates mitogenesis through the Shc SH2 domain. Oncogene 15, 595-600
    • (1997) Oncogene , vol.15 , pp. 595-600
    • Collins, L.R.1    Rickets, W.A.2    Olefsky, J.M.3    Brown, J.H.4
  • 61
    • 0035848665 scopus 로고    scopus 로고
    • Differential requirements for ERK1/2 and P38 MAPK activation by thrombin in T cells. Role of P59Fyn and PKC epsilon
    • Maulon, L., Mari, B., Bertolotto, C., Ricci, J. E., Luciano, F., Belhacene, N., Deckert, M., Baier, G., and Auberger, P. (2001) Differential requirements for ERK1/2 and P38 MAPK activation by thrombin in T cells. Role of P59Fyn and PKC epsilon. Oncogene 20, 1964-1972
    • (2001) Oncogene , vol.20 , pp. 1964-1972
    • Maulon, L.1    Mari, B.2    Bertolotto, C.3    Ricci, J.E.4    Luciano, F.5    Belhacene, N.6    Deckert, M.7    Baier, G.8    Auberger, P.9
  • 62
    • 0033347395 scopus 로고    scopus 로고
    • Pertussis toxin-sensitive and -insensitive thrombin stimulation of Shc phosphorylation and mitogenesis are mediated through distinct pathways
    • Ricketts, W.A., Brown, J. H., and Olefsky, J. M. (1999) Pertussis toxin-sensitive and -insensitive thrombin stimulation of Shc phosphorylation and mitogenesis are mediated through distinct pathways. Mol. Endocrinol. 13, 1988-2001
    • (1999) Mol. Endocrinol. , vol.13 , pp. 1988-2001
    • Ricketts, W.A.1    Brown, J.H.2    Olefsky, J.M.3
  • 64
    • 0035966004 scopus 로고    scopus 로고
    • Vascular endothelial growth factor induction of the angiogenic phenotype requires Ras activation
    • Meadows, K. N., Bryant, P., and Pumiglia, K. (2001) Vascular endothelial growth factor induction of the angiogenic phenotype requires Ras activation. J. Biol. Chem. 276, 49289-49298
    • (2001) J. Biol. Chem. , vol.276 , pp. 49289-49298
    • Meadows, K.N.1    Bryant, P.2    Pumiglia, K.3
  • 66
    • 0027219681 scopus 로고
    • Single point mutation in the SH2 domain impair the transforming potential of vav and fail to activate proto-vav
    • Katzav, S. (1993) Single point mutation in the SH2 domain impair the transforming potential of vav and fail to activate proto-vav. Oncogene 8, 1757-1763
    • (1993) Oncogene , vol.8 , pp. 1757-1763
    • Katzav, S.1
  • 67
    • 0028834244 scopus 로고
    • Vav and ras induce fibroblast transformation by overlapping signaling pathways which require c-Myc function
    • Katzav, S., Packham, G., Sutherland, M., Aroca, P., Santos, E., and Cleavland, J. L. (1995) Vav and ras induce fibroblast transformation by overlapping signaling pathways which require c-Myc function. Oncogene 11, 1079-1088
    • (1995) Oncogene , vol.11 , pp. 1079-1088
    • Katzav, S.1    Packham, G.2    Sutherland, M.3    Aroca, P.4    Santos, E.5    Cleavland, J.L.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.