Repressed E-cadherin expression in the lower crypt of human small intestine: A cell marker of functional relevance

Experimental Cell Research

Volumn 302, Issue 2, 2005, Pages 206-220

  Escaffit, Fabrice ^a   Perreault, Nathalie ^a   Jean, Dominique ^a   Francoeur, Caroline ^a   Herring, Elizabeth ^a   Rancourt, Claudine ^a   Rivard, Nathalie ^a   Vachon, Pierre H ^a   Paré, Frédéric ^a   Boucher, Marie Pierre ^a   Auclair, Joëlle ^a   Beaulieu, Jean François ^a  

^a UNIVERSITY OF SHERBROOKE   (Canada)

Author keywords

Apoptosis; Crypt cells; Differentiation; E cadherin; HIEC; Migration; Proliferation

Indexed keywords

BETA CATENIN; CELL MARKER; PROTEIN P21; UVOMORULIN;

ANOIKIS; ARTICLE; CELL INTERACTION; CELL KINETICS; CELL MIGRATION; CELL POPULATION; CELLULAR DISTRIBUTION; COMPARATIVE STUDY; CONTROLLED STUDY; CRYPT CELL; DOWN REGULATION; EPITHELIUM CELL; FETUS; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOFLUORESCENCE; INTESTINE CRYPT; INTESTINE EPITHELIUM CELL; LABORATORY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SMALL INTESTINE; STEM CELL;

EID: 9244230606     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yexcr.2004.08.033     Document Type: Article

References (67)

1. M.W. Babyatsky, and D.K. Podolsky Growth and development of the gastrointestinal tract T. Yamada Textbook of Gastroenterology 1999 J.B Lippincott Philadelphia 547 584
2. C.S. Potten Stem cells in gastrointestinal epithelium: numbers, characteristics and death Philos. Trans. R. Soc. Lond., B Biol. Sci. 353 1998 821 830
3. C. Booth, and C.S. Potten Gut instincts: thoughts on intestinal epithelial stem cells J. Clin. Invest. 105 2000 1493 1499
4. A.J. Merritt, C.S. Potten, C.J. Kemp, J.A. Hickman, A. Balmain, D.P. Lane, and P.A. Hall The role of p53 in spontaneous and radiation-induced apoptosis in the gastrointestinal tract of normal and p53-deficient mice Cancer Res. 54 1994 614 617
5. D.J. Winton Stem cells in the epithelium of the small intestine and colon D.R. Marshak R. Gardner D. Gottlieb Stem. Cell Biology 2001 Cold Spring Harbor Laboratory Press Cold Spring Harbor, NY 515 536
6. M. Brittan, and N.A. Wright Gastrointestinal stem cells J. Pathol. 197 2002 492 509
7. J.P. Clatworthy, and V. Subramanian Stem cells and the regulation of proliferation, differentiation and patterning in the intestinal epithelium: emerging insights from gene expression patterns, transgenic and gene ablation studies Mech. Dev. 101 2001 3 9
8. J.A. Marrs, and W.J. Nelson Cadherin cell adhesion molecules in differentiation and embryogenesis Int. Rev. Cytol. 165 1996 159 205
9. K.A. Knudsen, C. Frankowski, K.R. Johnson, and M.J. Wheelock A role for cadherins in cellular signaling and differentiation J. Cell Biochem., Suppl. 30-31 1998 168 176
10. M. Takeichi Cadherin cell adhesion receptors as a morphogenetic regulator Science 251 1991 1451 1455
11. A. Valizadeh, A.J. Karayiannakis, I. el-Hariry, W. Kmiot, and M. Pignatelli Expression of E-cadherin-associated molecules (alpha-, beta-, and gamma-catenins and p120) in colorectal polyps Am. J. Pathol. 150 1997 1977 1984
12. G. Karatzas, A.J. Karayiannakis, K.N. Syrigos, E. Chatzigianni, S. Papanikolaou, F. Riza, and D. Papanikolaou E-cadherin expression correlates with tumor differentiation in colorectal cancer Hepato-Gastroenterology 46 1999 232 235
13. N. Gassler, C. Rohr, A. Schneider, J. Kartenbeck, A. Bach, N. Obermuller, H.F. Otto, and F. Autschbach Inflammatory bowel disease is associated with changes of enterocytic junctions Am. J. Physiol.: Gastrointest. Liver Physiol. 281 2001 G216 G228
14. M. Watabe, A. Nagafuchi, S. Tsukita, and M. Takeichi Induction of polarized cell-cell association and retardation of growth by activation of the E-cadherin-catenin adhesion system in a dispersed carcinoma line J. Cell Biol. 127 1994 247 256
15. S. Kandikonda, D. Oda, R. Niederman, and B.C. Sorkin Cadherin-mediated adhesion is required for normal growth regulation of human gingival epithelial cells Cell Adhes. Commun. 4 1996 13 24
16. K. Takahashi, and K. Suzuki Density-dependent inhibition of growth involves prevention of EGF receptor activation by E-cadherin-mediated cell-cell adhesion Exp. Cell Res. 226 1996 214 222
17. S. Pece, and J.S. Gutkind Signaling from E-cadherins to the MAPK pathway by the recruitment and activation of epidermal growth factor receptors upon cell-cell contact formation J. Biol. Chem. 275 2000 41227 41233
18. P. Laprise, P. Chailler, M. Houde, J.F. Beaulieu, M.J. Boucher, and N. Rivard Phosphatidylinositol 3-kinase controls human intestinal epithelial cell differentiation by promoting adherens junction assembly and p38 MAPK activation J. Biol. Chem. 277 2002 8226 8234
19. C. Schreider, G. Peignon, S. Thenet, J. Chambaz, and M. Pincon-Raymond Integrin-mediated functional polarization of caco-2 cells through E-cadherin-actin complexes J. Cell Sci. 115 2002 543 552
20. C.J. Gottardi, E. Wong, and B.M. Gumbiner E-cadherin suppresses cellular transformation by inhibiting beta-catenin signaling in an adhesion-independent manner J. Cell Biol. 153 2001 1049 1060
21. A. Stockinger, A. Eger, J. Wolf, H. Beug, and R. Foisner E-cadherin regulates cell growth by modulating proliferation-dependent beta-catenin transcriptional activity J. Cell Biol. 154 2001 1185 1196
22. M.H. Wong, J. Huelsken, W. Birchmeier, and J.I. Gordon Selection of multipotent stem cells during morphogenesis of small intestinal crypts of Lieberkühn is perturbed by stimulation of Lef-1/beta-catenin signaling J. Biol. Chem. 277 2002 15843 15850
23. J.M. Mariadason, M. Bordonaro, F. Aslam, L. Shi, M. Kuraguchi, A. Velcich, and L.H. Augenlicht Down-regulation of beta-catenin TCF signaling is linked to colonic epithelial cell differentiation Cancer Res. 61 2001 3465 3471
24. M.L. Hermiston, and J.I. Gordon In vivo analysis of cadherin function in the mouse intestinal epithelium: essential roles in adhesion, maintenance of differentiation, and regulation of programmed cell death J. Cell Biol. 129 1995 489 506
25. M.L. Hermiston, M.H. Wong, and J.I. Gordon Forced expression of E-cadherin in the mouse intestinal epithelium slows cell migration and provides evidence for nonautonomous regulation of cell fate in a self-renewing system Genes Dev. 10 1996 985 996
26. J.P. Molès, and F.M. Watt The epidermal stem cell compartment: variation in expression levels of E-cadherin and catenins within the basal layer of human epidermis J. Histochem. Cytochem. 45 1997 867 874
27. N. Basora, P.H. Vachon, F.E. Herring-Gillam, N. Perreault, and J.F. Beaulieu Relation between integrin alpha7Bbeta1 expression in human intestinal cells and enterocytic differentiation Gastroenterology 113 1997 1510 1521
28. Y. Bouatrouss, F.E. Herring-Gillam, J. Gosselin, J. Poisson, and J.F. Beaulieu Altered expression of laminins in Crohn's disease small intestinal mucosa Am. J. Pathol. 156 2000 45 50
29. N. Perreault, F.E. Herring-Gillam, N. Desloges, I. Belanger, L.P. Pageot, and J.F. Beaulieu Epithelial vs. mesenchymal contribution to the extracellular matrix in the human intestine Biochem. Biophys. Res. Commun. 248 1998 121 126
30. N. Perreault, and J.F. Beaulieu Use of the dissociating enzyme thermolysin to generate viable human normal intestinal epithelial cell cultures Exp. Cell Res. 224 1996 354 364
31. N. Desloges, N. Basora, N. Perreault, Y. Bouatrouss, D. Sheppard, and J.F. Beaulieu Regulated expression of the integrin alpha9beta1 in the epithelium of the developing human gut and in intestinal cell lines: relation with cell proliferation J. Cell. Biochem. 71 1998 536 545
32. N. Perreault, and J.F. Beaulieu Primary cultures of fully differentiated and pure human intestinal epithelial cells Exp. Cell Res. 245 1998 34 42
33. N. Basora, F.E. Herring-Gillam, F. Boudreau, N. Perreault, L.P. Pageot, M. Simoneau, Y. Bouatrouss, and J.F. Beaulieu Expression of functionally distinct variants of the beta(4)A integrin subunit in relation to the differentiation state in human intestinal cells J. Biol. Chem. 274 1999 29819 29825
34. C. Deschenes, A. Vezina, J.F. Beaulieu, and N. Rivard Role of p27(Kip1) in human intestinal cell differentiation Gastroenterology 120 2001 423 438
35. A. Quaroni, and J.F. Beaulieu Cell dynamics and differentiation of conditionally immortalized human intestinal epithelial cells Gastroenterology 113 1997 1198 1213
36. L.P. Pageot, N. Perreault, N. Basora, C. Francoeur, P. Magny, and J.F. Beaulieu Human cell models to study small intestinal functions: recapitulation of the crypt-villus axis Microsc. Res. Tech. 49 2000 394 406
37. A. Nose, A. Nagafuchi, and M. Takeichi Expressed recombinant cadherins mediate cell sorting in model systems Cell 54 1988 993 1001
38. C.L. Sommers, E.P. Gelmann, R. Kemler, P. Cowin, and S.W. Byers Alterations in beta-catenin phosphorylation and plakoglobin expression in human breast cancer cells Cancer Res. 54 1994 3544 3552
39. T.C. He, S. Zhou, L.T. da Costa, J. Yu, K.W. Kinzler, and B. Vogelstein A simplified system for generating recombinant adenoviruses Proc. Natl. Acad. Sci. U. S. A. 95 1998 2509 2514
40. J.F. Beaulieu, B. Nichols, and A. Quaroni Posttranslational regulation of sucrase-isomaltase expression in intestinal crypt and villus cells J. Biol. Chem. 264 1989 20000 20011
41. P.H. Vachon, and J.F. Beaulieu Extracellular heterotrimeric laminin promotes differentiation in human enterocytes Am. J. Physiol. 268 1995 G857 G867
42. S.B. Munro, I.M. Turner, R. Farookhi, O.W. Blaschuk, and S. Jothy E-cadherin and OB-cadherin mRNA levels in normal human colon and colon carcinoma Exp. Mol. Pathol. 62 1995 118 122
43. A. Cano, M.A. Perez-Moreno, I. Rodrigo, A. Locascio, M.J. Blanco, M.G. del Barrio, F. Portillo, and M.A. Nieto The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression Nat. Cell Biol. 2 2000 76 83
44. D. Menard, and P. Arsenault Explant culture of human fetal small intestine Gastroenterology 88 1985 691 700
45. G. Roncari, and H. Zuber Thermophilic aminopeptidases from Bacillus stearothermophilus. I. Isolation, specificity, and general properties of the thermostable aminopeptidase I Int. J. Protein Res. 1 1969 45 61
46. A. Eichholz Structural and functional organization of the brush border of intestinal epithelial cells. 3. Enzymic activities and chemical composition of various fractions of Tris-disrupted brush borders Biochim. Biophys. Acta 135 1967 475 482
47. G.L. Peterson A simplification of the protein assay method of Lowry et al. which is more generally applicable Anal. Biochem. 83 1977 346 356
48. P.H. Vachon, and J.F. Beaulieu Transient mosaic patterns of morphological and functional differentiation in the Caco-2 cell line Gastroenterology 103 1992 414 423
49. A.U. Dignass, and D.K. Podolsky Cytokine modulation of intestinal epithelial cell restitution: central role of transforming growth factor beta Gastroenterology 105 1993 1323 1332
50. D. Ménard, and J.F. Beaulieu Human intestinal brush border membrane hydrolases G. Bkaily Membrane Physiopathology 1994 Kluwer Academic Publishing Norwell 319 341
51. E.B. Mallow, A. Harris, N. Salzman, J.P. Russell, R.J. DeBerardinis, E. Ruchelli, and C.L. Bevins Human enteric defensins. Gene structure and developmental expression J. Biol. Chem. 271 1996 4038 4045
52. M.A. Perez-Moreno, A. Locascio, I. Rodrigo, G. Dhondt, F. Portillo, M.A. Nieto, and A. Cano A new role for E12/E47 in the repression of E-cadherin expression and epithelial-mesenchymal transitions J. Biol. Chem. 276 2001 27424 27431
53. R. Del Buono, and M. Pignatelli The role of the E-cadherin complex in gastrointestinal cell differentiation Cell Proliferation 32 1999 79 84
54. G. Gagliardi, O. Kandemir, D. Liu, M. Guida, S. Benvestito, T.G. Ruers, I.S. Benjamin, J.M. Northover, G.W. Stamp, and I.C. Talbot Changes in E-cadherin immunoreactivity in the adenoma-carcinoma sequence of the large bowel Virchows Arch. 426 1995 149 154
55. A.M. Hanby, R. Chinery, R. Poulsom, R.J. Playford, and M. Pignatelli Downregulation of E-cadherin in the reparative epithelium of the human gastrointestinal tract Am. J. Pathol. 148 1996 723 729
56. E. Marshman, C. Booth, and C.S. Potten The intestinal epithelial stem cell BioEssays 24 2002 91 98
57. F.M. Ruemmele, J.F. Beaulieu, J. O'Connell, M.W. Bennett, E.G. Seidman, and M.J. Lentze The susceptibility to Fas-induced apoptosis in normal enterocytes is regulated on the level of cIAP1 and 2 Biochem. Biophys. Res. Commun. 290 2002 1308 1314
58. P.H. Vachon, C. Harnois, A. Grenier, G. Dufour, V. Bouchard, J. Han, J. Landry, J.F. Beaulieu, A. Vezina, A.B. Dydensborg, R. Gauthier, A. Cote, J.F. Drolet, and F. Lareau Differentiation state-selective roles of p38 isoforms in human intestinal epithelial cell anoikis Gastroenterology 123 2002 1980 1991
59. E. Batlle, E. Sancho, C. Franci, D. Dominguez, M. Monfar, J. Baulida, and A. Garcia De Herreros The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells Nat. Cell Biol. 2 2000 84 89
60. L.C. Li, R.M. Chui, M. Sasaki, K. Nakajima, G. Perinchery, H.C. Au, D. Nojima, P. Carroll, and R. Dahiya A single nucleotide polymorphism in the E-cadherin gene promoter alters transcriptional activities Cancer Res. 60 2000 873 876
61. A. Darwanto, R. Kitazawa, S. Maeda, and S. Kitazawa MeCP2 and promoter methylation cooperatively regulate E-cadherin gene expression in colorectal carcinoma Cancer Sci. 94 2003 442 447
62. D.W. Owens, V.G. Brunton, E.K. Parkinson, and M.C. Frame E-cadherin at the cell periphery is a determinant of keratinocyte differentiation in vitro Biochem. Biophys. Res. Commun. 269 2000 369 376
63. D.D. Kaplan, T.E. Meigs, and P.J. Casey Distinct regions of the cadherin cytoplasmic domain are essential for functional interaction with Galpha 12 and beta-catenin J. Biol. Chem. 276 2001 44037 44043
64. A. Ben-Ze'ev, M. Shtutman, and J. Zhurinsky The integration of cell adhesion with gene expression: the role of beta-catenin Exp. Cell Res. 261 2000 75 82
65. A. Quaroni, J.Q. Tian, P. Seth, and C. Ap Rhys p27(Kip1) is an inducer of intestinal epithelial cell differentiation Am. J. Physiol., Cell Physiol. 279 2000 C1045 C1057
66. P. Laprise, M.J. Langlois, M.J. Boucher, C. Jobin, and N. Rivard Down-regulation of MEK/ERK signaling by E-cadherin-dependent PI3K/Akt pathway in differentiating intestinal epithelial cells J. Cell. Physiol. 199 2004 32 39
67. R.H. Don, P.T. Cox, B.J. Wainwright, K. Baker, and J.S. Mattick 'Touchdown' PCR to circumvent spurious priming during gene amplification Nucleic Acid Res. 19 1991 4008