-
1
-
-
0032456709
-
Insulin resistance versus insulin deficiency in non-insulin-dependent diabetes mellitus: Problems and prospects
-
Ferrannini E (1998) Insulin resistance versus insulin deficiency in non-insulin-dependent diabetes mellitus: problems and prospects. Endocrin Rev 19: 477-490
-
(1998)
Endocrin Rev
, vol.19
, pp. 477-490
-
-
Ferrannini, E.1
-
2
-
-
0141678155
-
Metabolic and genetic influence on glucose metabolism in type 2 diabetic subjects - Experiences from relatives and twin studies
-
Beck-Nielsen H, Vaag A, Poulsen P, Gaster M (2003) Metabolic and genetic influence on glucose metabolism in type 2 diabetic subjects - experiences from relatives and twin studies. Best Pract Res Clin Endocrinol Metab 17: 445-467
-
(2003)
Best Pract Res Clin Endocrinol Metab
, vol.17
, pp. 445-467
-
-
Beck-Nielsen, H.1
Vaag, A.2
Poulsen, P.3
Gaster, M.4
-
3
-
-
0024160877
-
Banting lecture 1988. Role of insulin resistance in human disease
-
Reaven GM (1988) Banting lecture 1988. Role of insulin resistance in human disease. Diabetes 37: 1595-1607
-
(1988)
Diabetes
, vol.37
, pp. 1595-1607
-
-
Reaven, G.M.1
-
4
-
-
0842277242
-
Definition of metabolic syndrome
-
Grundy SM, Brewer HB, Cleeman JI, Smith SC, Lenfant C, for the Conference Participants (2004) Definition of metabolic syndrome. Circulation 109: 433-438
-
(2004)
Circulation
, vol.109
, pp. 433-438
-
-
Grundy, S.M.1
Brewer, H.B.2
Cleeman, J.I.3
Smith, S.C.4
Lenfant, C.5
-
5
-
-
0032934826
-
Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: A 1H NMR spectroscopy study
-
Krssak M, Falk Petersen K, Dresner A, DiPietro L, Vogel SM, Rothman DL, Roden M, Shulman GI (1999) Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a 1H NMR spectroscopy study. Diabetologia 42: 113-116
-
(1999)
Diabetologia
, vol.42
, pp. 113-116
-
-
Krssak, M.1
Falk Petersen, K.2
Dresner, A.3
DiPietro, L.4
Vogel, S.M.5
Rothman, D.L.6
Roden, M.7
Shulman, G.I.8
-
6
-
-
0036312905
-
Fat accumulation in the liver is associated with defects in insulin suppression of glucose production and serum free fatty acids independent of obesity in normal men
-
Seppala-Lindroos A, Vehkavaara S, Hakkinen AM, Goto T, Westerbacka J, Sovijarvi A, Halavaara J, Yki-Järvinen H (2002) Fat accumulation in the liver is associated with defects in insulin suppression of glucose production and serum free fatty acids independent of obesity in normal men. J Clin Endocrinol Metab 87: 3023-3028
-
(2002)
J Clin Endocrinol Metab
, vol.87
, pp. 3023-3028
-
-
Seppala-Lindroos, A.1
Vehkavaara, S.2
Hakkinen, A.M.3
Goto, T.4
Westerbacka, J.5
Sovijarvi, A.6
Halavaara, J.7
Yki-Järvinen, H.8
-
7
-
-
3843061592
-
AMP kinase and malonyl-CoA: Targets for therapy of the metabolic syndrome
-
Ruderman N, Prentki M (2004) AMP kinase and malonyl-CoA: targets for therapy of the metabolic syndrome. Nature 3: 340-351
-
(2004)
Nature
, vol.3
, pp. 340-351
-
-
Ruderman, N.1
Prentki, M.2
-
8
-
-
0037453056
-
Triglyceride accumulation protects against fatty-acid induced lipotoxicity
-
Listenberger LL, Han X, Lewis SE, Cases S, Farese RVjr, Ory DS, Schaffer JE (2003) Triglyceride accumulation protects against fatty-acid induced lipotoxicity. Proc Nat Acad Sci USA 100: 3077-3083
-
(2003)
Proc Nat Acad Sci USA
, vol.100
, pp. 3077-3083
-
-
Listenberger, L.L.1
Han, X.2
Lewis, S.E.3
Cases, S.4
Farese Jr., R.V.5
Ory, D.S.6
Schaffer, J.E.7
-
9
-
-
0026002683
-
Effects of fat on insulin-stimulated carbohydrate metabolism in normal men
-
Boden G, Jadali F, White J, Liang Y, Mozzoli M, Chen X, Coleman E, Smith C (1991) Effects of fat on insulin-stimulated carbohydrate metabolism in normal men. J Clin Invest 88: 960-966
-
(1991)
J Clin Invest
, vol.88
, pp. 960-966
-
-
Boden, G.1
Jadali, F.2
White, J.3
Liang, Y.4
Mozzoli, M.5
Chen, X.6
Coleman, E.7
Smith, C.8
-
10
-
-
0042160182
-
The role of intramuscular lipid in insulin resistance
-
Hegarty BT, Furler SM, Ye J, Cooney GJ, Kraegen EW (2003) The role of intramuscular lipid in insulin resistance. Acta Physiol Scand 178: 373-383
-
(2003)
Acta Physiol Scand
, vol.178
, pp. 373-383
-
-
Hegarty, B.T.1
Furler, S.M.2
Ye, J.3
Cooney, G.J.4
Kraegen, E.W.5
-
11
-
-
0036092239
-
Banting lecture: Dysregulation of fatty acid metabolism in the etiology of type 2 diabetes
-
McGarry JD (2002) Banting lecture: dysregulation of fatty acid metabolism in the etiology of type 2 diabetes. Diabetes 51: 7-18
-
(2002)
Diabetes
, vol.51
, pp. 7-18
-
-
McGarry, J.D.1
-
12
-
-
0036182137
-
Lipotoxic diseases
-
Unger RH (2002) Lipotoxic diseases. Annu Rev Med 53: 319-336
-
(2002)
Annu Rev Med
, vol.53
, pp. 319-336
-
-
Unger, R.H.1
-
13
-
-
0030046495
-
Mitochondria and diabetes: Genetic, biochemical and clinical implications of the cellular energy circuit
-
Gerbitz KD, Gempel K, Brdiczka D (1996) Mitochondria and diabetes: genetic, biochemical and clinical implications of the cellular energy circuit. Diabetes 45: 113-126
-
(1996)
Diabetes
, vol.45
, pp. 113-126
-
-
Gerbitz, K.D.1
Gempel, K.2
Brdiczka, D.3
-
14
-
-
0035130102
-
Disease of liporegulation: New perspectives on obesity related disorders
-
Unger RH and Orci L (2001) Disease of liporegulation: new perspectives on obesity related disorders. FASEB J 15: 312-321
-
(2001)
FASEB J
, vol.15
, pp. 312-321
-
-
Unger, R.H.1
Orci, L.2
-
15
-
-
0036788293
-
Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes
-
Kelley DE, He J, Menshikova EV, Ritov VB (2002) Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes. Diabetes 51: 2944-2950
-
(2002)
Diabetes
, vol.51
, pp. 2944-2950
-
-
Kelley, D.E.1
He, J.2
Menshikova, E.V.3
Ritov, V.B.4
-
16
-
-
0029689984
-
Contractil activity-induced mitochondrial biogenesis in skeletal muscle
-
Essig DA (1996) Contractil activity-induced mitochondrial biogenesis in skeletal muscle. Exerc Sport Sci Rev 24: 289-314
-
(1996)
Exerc Sport Sci Rev
, vol.24
, pp. 289-314
-
-
Essig, D.A.1
-
17
-
-
0038025371
-
Mitochondrial dysfunction in the elderly: Possible role in insulin resistance
-
Petersen KF, Befroy D, Dufour S, Dziura J, Ariyan C, Rothman DL, Di Pietro L, Cline GW, Shulman GI (2003) Mitochondrial dysfunction in the elderly: possible role in insulin resistance. Science 300: 1140-1142
-
(2003)
Science
, vol.300
, pp. 1140-1142
-
-
Petersen, K.F.1
Befroy, D.2
Dufour, S.3
Dziura, J.4
Ariyan, C.5
Rothman, D.L.6
Di Pietro, L.7
Cline, G.W.8
Shulman, G.I.9
-
18
-
-
9144273505
-
Gene expression in humans with diabetes and prediabetes: What we learned about diabetes pathophysiology?
-
Patti ME (2004) Gene expression in humans with diabetes and prediabetes: what we learned about diabetes pathophysiology? Curr Opin Clin Nutr&Metabolic Care 7: 383-390
-
(2004)
Curr Opin Clin Nutr&Metabolic Care
, vol.7
, pp. 383-390
-
-
Patti, M.E.1
-
19
-
-
0038271638
-
Effect of insulin on human skeletal muscle mitochondrial ATP production, protein synthesis, and mRNA transcripts
-
Stump CS, Short KR, Bigelow ML, Schimke JM, Nair SK (2003) Effect of insulin on human skeletal muscle mitochondrial ATP production, protein synthesis, and mRNA transcripts. Proc Natl Acad Sci USA 100: 7996-8001
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 7996-8001
-
-
Stump, C.S.1
Short, K.R.2
Bigelow, M.L.3
Schimke, J.M.4
Nair, S.K.5
-
20
-
-
2442477506
-
Skeletal muscle mitochondrial protein metabolism and function in aging and type 2 diabetes
-
Barazzoni R (2004) Skeletal muscle mitochondrial protein metabolism and function in aging and type 2 diabetes. Curr Opin Clin Nutr&Metabolic Care 7: 97-102
-
(2004)
Curr Opin Clin Nutr&Metabolic Care
, vol.7
, pp. 97-102
-
-
Barazzoni, R.1
-
21
-
-
1642377274
-
Impaired mitochondrial activity in the insulin-resistant offsprings of patients with type 2 diabetes
-
Petersen KF, Dufour S, Befroy D, Garcia R, Shulman GI (2004) Impaired mitochondrial activity in the insulin-resistant offsprings of patients with type 2 diabetes. N Engl J Med 350: 664-671
-
(2004)
N Engl J Med
, vol.350
, pp. 664-671
-
-
Petersen, K.F.1
Dufour, S.2
Befroy, D.3
Garcia, R.4
Shulman, G.I.5
-
22
-
-
0042266366
-
Impact of aerobic exercise training on age-related changes in insulin sensitivity and muscle oxidative capacity
-
Short KR, Vittone JL, Bigelow ML, Proctor DN, Rizza RA, Coenen-Schimke JM, Nair SK (2003) Impact of aerobic exercise training on age-related changes in insulin sensitivity and muscle oxidative capacity. Diabetes 52: 1888-1896
-
(2003)
Diabetes
, vol.52
, pp. 1888-1896
-
-
Short, K.R.1
Vittone, J.L.2
Bigelow, M.L.3
Proctor, D.N.4
Rizza, R.A.5
Coenen-Schimke, J.M.6
Nair, S.K.7
-
23
-
-
18144453903
-
Mitochondrial metabolism and type-2 diabetes: A specific target for metformin
-
Leverve XM, Guigas B, Detaille D, Batandier C, Koceir EA, Chauvin C, Fontaine E, Wiernsperger NF (2003) Mitochondrial metabolism and type-2 diabetes: a specific target for metformin. Diabetes Metab 29: 6S88-94
-
(2003)
Diabetes Metab
, vol.29
-
-
Leverve, X.M.1
Guigas, B.2
Detaille, D.3
Batandier, C.4
Koceir, E.A.5
Chauvin, C.6
Fontaine, E.7
Wiernsperger, N.F.8
-
24
-
-
12144291275
-
Thiazolidindiones, like metformin, inhibit respiratory complex I: A common mechanism contributing to their antidiabetic actions?
-
Brunmair B, Staniek K, Gras F, Scharf N, Althaym A, Clara R, Roden M, Gnaiger E, Nohl H, Waldhausl W, Furnsinn C (2004) Thiazolidindiones, like metformin, inhibit respiratory complex I: a common mechanism contributing to their antidiabetic actions? Diabetes 53: 1052-1059
-
(2004)
Diabetes
, vol.53
, pp. 1052-1059
-
-
Brunmair, B.1
Staniek, K.2
Gras, F.3
Scharf, N.4
Althaym, A.5
Clara, R.6
Roden, M.7
Gnaiger, E.8
Nohl, H.9
Waldhausl, W.10
Furnsinn, C.11
-
25
-
-
0028817443
-
A malonyl-CoA fuel sensing mechanism in muscle: Effects of insulin, glucose, and denervation
-
Saha AK, Kurowski TG, Colca JR, Ruderman NB (1995) A malonyl-CoA fuel sensing mechanism in muscle: effects of insulin, glucose, and denervation. Am J Physiol 269: E283-E289
-
(1995)
Am J Physiol
, vol.269
-
-
Saha, A.K.1
Kurowski, T.G.2
Colca, J.R.3
Ruderman, N.B.4
-
26
-
-
0026334132
-
Enhanced stimulation of diacylglycerol an lipid-synthesis by insulin in denervated muscle. Altered proteinkinase C activity and possible link to insulin resistance
-
Heydrick SJ, Ruderman NB, Kurowski TG, Adams HB, Chen KS (1991) Enhanced stimulation of diacylglycerol an lipid-synthesis by insulin in denervated muscle. Altered proteinkinase C activity and possible link to insulin resistance. Diabetes 40: 1707-1711
-
(1991)
Diabetes
, vol.40
, pp. 1707-1711
-
-
Heydrick, S.J.1
Ruderman, N.B.2
Kurowski, T.G.3
Adams, H.B.4
Chen, K.S.5
-
27
-
-
0026733643
-
Malonyl-CoA and long-chain Acyl-CoA esters as metabolic coupling factors in nutrient - Induced insulin secretion
-
Prentki M, Vischer S, Glennon MC, Regazzi R, Deeney JT, Corkey BE (1992) Malonyl-CoA and long-chain Acyl-CoA esters as metabolic coupling factors in nutrient - induced insulin secretion. J Biol Chem 267: 5802-5810
-
(1992)
J Biol Chem
, vol.267
, pp. 5802-5810
-
-
Prentki, M.1
Vischer, S.2
Glennon, M.C.3
Regazzi, R.4
Deeney, J.T.5
Corkey, B.E.6
-
28
-
-
0242300121
-
Hypothalamic malonyl-CoA as a mediator of feeding behavior
-
Hu Z, Cha SH, Chohnan S, Lane MD (2003) Hypothalamic malonyl-CoA as a mediator of feeding behavior. Proc Natl Acad Sci 100: 12624-12629
-
(2003)
Proc Natl Acad Sci
, vol.100
, pp. 12624-12629
-
-
Hu, Z.1
Cha, S.H.2
Chohnan, S.3
Lane, M.D.4
-
29
-
-
0038199737
-
Management of cellular energy by the AMP-activated protein kinase system
-
Hardie DG, Scott JW, Pan DA, Hudson ER (2003) Management of cellular energy by the AMP-activated protein kinase system. FEBS Lett 546: 113-120
-
(2003)
FEBS Lett
, vol.546
, pp. 113-120
-
-
Hardie, D.G.1
Scott, J.W.2
Pan, D.A.3
Hudson, E.R.4
-
30
-
-
0037122766
-
Leptin stimulates fatty-acid oxidation by activating AMP-activated proteinkinase
-
Minokoshi Y et al (2002) Leptin stimulates fatty-acid oxidation by activating AMP-activated proteinkinase. Nature 415: 339-343
-
(2002)
Nature
, vol.415
, pp. 339-343
-
-
Minokoshi, Y.1
-
31
-
-
0036851817
-
Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase
-
Yamauchi T et al (2002) Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nature Med 8: 1288-1296
-
(2002)
Nature Med
, vol.8
, pp. 1288-1296
-
-
Yamauchi, T.1
-
32
-
-
0034773404
-
Role of AMP-activated protein kinase in mechanism of metformin action
-
Zhou G et al (2001) Role of AMP-activated protein kinase in mechanism of metformin action. J Clin Invest 108: 1167-1174
-
(2001)
J Clin Invest
, vol.108
, pp. 1167-1174
-
-
Zhou, G.1
-
33
-
-
0037067666
-
The anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signalling pathways
-
Fryer LG, Parbu-Patel A, Carling D (2002) The anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signalling pathways. J Biol Chem 277: 25226-25232
-
(2002)
J Biol Chem
, vol.277
, pp. 25226-25232
-
-
Fryer, L.G.1
Parbu-Patel, A.2
Carling, D.3
-
34
-
-
0037323828
-
AMP-activated protein kinase and hepatic genes involved in glucose metabolism
-
Ferre P, Azzout-Marniche D, Foufelle F (2003) AMP-activated protein kinase and hepatic genes involved in glucose metabolism. Biochem Soc Trans 31: 220-223
-
(2003)
Biochem Soc Trans
, vol.31
, pp. 220-223
-
-
Ferre, P.1
Azzout-Marniche, D.2
Foufelle, F.3
-
35
-
-
0034883804
-
Uncoupling proteins functional characteristics and role in the pathogenesis of obesity and type II diabetes
-
Dalgaard LT, Pedersen O (2001) Uncoupling proteins functional characteristics and role in the pathogenesis of obesity and type II diabetes. Diabetologia 44: 946-965
-
(2001)
Diabetologia
, vol.44
, pp. 946-965
-
-
Dalgaard, L.T.1
Pedersen, O.2
-
36
-
-
2942532803
-
Links between fatty acids and expression of UCP2 and UCP3 mRNAs
-
Thompson MP, Kim D (2004) Links between fatty acids and expression of UCP2 and UCP3 mRNAs. FEBS Lett 568: 4-9
-
(2004)
FEBS Lett
, vol.568
, pp. 4-9
-
-
Thompson, M.P.1
Kim, D.2
-
37
-
-
0035799806
-
Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance
-
Tuomilheto J, Lindstrom J, Eriksson JG, Valle TT, Harmalainen H, Ilanne-Parikka P, Keinanen-Kiukaaniemi S, Laakso M, Louheranta A, Rastas M, Salminen V, Uusitupa M (2001) Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med 344: 1343-1350
-
(2001)
N Engl J Med
, vol.344
, pp. 1343-1350
-
-
Tuomilheto, J.1
Lindstrom, J.2
Eriksson, J.G.3
Valle, T.T.4
Harmalainen, H.5
Ilanne-Parikka, P.6
Keinanen-Kiukaaniemi, S.7
Laakso, M.8
Louheranta, A.9
Rastas, M.10
Salminen, V.11
Uusitupa, M.12
-
38
-
-
0037034257
-
Reduction in the evidence of type 2 diabetes with life-style intervention or metformin
-
Diabetes Prevention Research Group (2002) Reduction in the evidence of type 2 diabetes with life-style intervention or metformin. N Engl J Med 346: 393-403
-
(2002)
N Engl J Med
, vol.346
, pp. 393-403
-
-
-
39
-
-
0042736848
-
Regulation of mitochondrial biogenesis in muscle by endurance exercise
-
Irrcher I, Adhihetty PJ, Joseph AM, Ljubicic V, Hood DA (2003) Regulation of mitochondrial biogenesis in muscle by endurance exercise. Sports Med 33: 783-793
-
(2003)
Sports Med
, vol.33
, pp. 783-793
-
-
Irrcher, I.1
Adhihetty, P.J.2
Joseph, A.M.3
Ljubicic, V.4
Hood, D.A.5
-
40
-
-
0034846769
-
Skeletal muscle metabolism in overweight and post-overweight women: An isometric exercise study using (319P magnetic resonance spectroscopy
-
Newcomer BR, Larson-Meyer DE, Hunter GR, Weinsier RL (2001) Skeletal muscle metabolism in overweight and post-overweight women: an isometric exercise study using (319P magnetic resonance spectroscopy. Int J Obes Relat Metab Disord 25: 1309-1315
-
(2001)
Int J Obes Relat Metab Disord
, vol.25
, pp. 1309-1315
-
-
Newcomer, B.R.1
Larson-Meyer, D.E.2
Hunter, G.R.3
Weinsier, R.L.4
-
41
-
-
0032511566
-
Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS-34)
-
UK Prospective Diabetes Study (UKPDS) Group (1998) Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS-34) Lancet 352: 854-865
-
(1998)
Lancet
, vol.352
, pp. 854-865
-
-
-
42
-
-
0038644536
-
Nonalcoholic steatohepatitis: Summary of an AASLD single topic conference
-
Neuschwander-Tetri BA, Caldwell SH (2003) Nonalcoholic steatohepatitis: summary of an AASLD single topic conference. Hepatology 37: 1202-1219
-
(2003)
Hepatology
, vol.37
, pp. 1202-1219
-
-
Neuschwander-Tetri, B.A.1
Caldwell, S.H.2
-
43
-
-
1642415794
-
Treatment of PCOS with metformin and other insulin-sensitizing agents
-
Seli E, Duleby AJ (2004) Treatment of PCOS with metformin and other insulin-sensitizing agents. Curr Diab Rep 4: 61-75
-
(2004)
Curr Diab Rep
, vol.4
, pp. 61-75
-
-
Seli, E.1
Duleby, A.J.2
-
45
-
-
0035432604
-
Bezafibrate reduces mRNA levels of adipocyte markers and increases fatty acid oxidation in primary culture of adipocytes
-
Cabrero A, Alegret M, Sanchez RM, Adzet T, Laguna JC, Vasquez M (2001) Bezafibrate reduces mRNA levels of adipocyte markers and increases fatty acid oxidation in primary culture of adipocytes. Diabetes 50: 1883-1890
-
(2001)
Diabetes
, vol.50
, pp. 1883-1890
-
-
Cabrero, A.1
Alegret, M.2
Sanchez, R.M.3
Adzet, T.4
Laguna, J.C.5
Vasquez, M.6
-
46
-
-
4644298829
-
Fenofibrate impairs rat mitochondrial function by inhibition of respiratory complex I
-
Brunmait B, Lest A, Staniek K, Gras F, Scharf N, Roden M, Nohl H, Waldhausl W, Furnsinn C (2004) Fenofibrate impairs rat mitochondrial function by inhibition of respiratory complex I. J Pharmacol Exp Ther
-
(2004)
J Pharmacol Exp Ther
-
-
Brunmait, B.1
Lest, A.2
Staniek, K.3
Gras, F.4
Scharf, N.5
Roden, M.6
Nohl, H.7
Waldhausl, W.8
Furnsinn, C.9
-
47
-
-
0036838494
-
AMPkinase activation ameliorates insulin resistance induced by free fatty acids in skeletal muscle
-
Olsen GS, Hansen BF (2002) AMPkinase activation ameliorates insulin resistance induced by free fatty acids in skeletal muscle. Am J Physiol Endocrinol Metab 283: E965-970
-
(2002)
Am J Physiol Endocrinol Metab
, vol.283
-
-
Olsen, G.S.1
Hansen, B.F.2
|