Poorly Differentiated Breast Carcinoma is Associated with Increased Expression of the Human Polycomb Group EZH2 Gene

Neoplasia

Volumn 5, Issue 6, 2003, Pages 481-488

  Raaphorst, Frank M ^a   Meijer, Chris J L M ^a   Fieret, Elly ^a   Blokzijl, Tjasso ^a   Mommers, Ellen ^a   Buerger, Horst ^b   Packeisen, Jens ^b   Sewalt, Richard A B ^c   Otte, Arie P ^c   Van Diest, Paul J ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY OF MÜNSTER   (Germany)

^c UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

BMI 1; Breast cancer; EZH2; Polycomb; Tissue array

Indexed keywords

ADULT; ARTICLE; BMI 1 GENE; BREAST CARCINOGENESIS; BREAST CARCINOMA; CANCER INVASION; CLINICAL ARTICLE; COMPLEX FORMATION; CORRELATION ANALYSIS; DISEASE ASSOCIATION; EZH2 GENE; FEMALE; GENE; GENE EXPRESSION REGULATION; GENE FREQUENCY; GENE FUNCTION; HPC1 GENE; HPC2 GENE; HUMAN; HUMAN TISSUE; MULTIGENE FAMILY; PRIORITY JOURNAL; RING1 GENE; TUMOR DIFFERENTIATION;

EID: 9144226103     PISSN: 15228002     EISSN: None     Source Type: Journal    
DOI: 10.1016/s1476-5586(03)80032-5     Document Type: Article

References (56)

1. Pirrotta V (1999). Polycomb silencing and the maintenance of stable chromatin states. Results Probl Cell Differ 25, 205-28.
2. Jacobs JJ, and van Lohuizen M (2002). Polycomb repression: from cellular memory to cellular proliferation and cancer. Biochim Biophys Acta 1602, 151-61.
3. Orlando V (2003). Polycomb, epigenomes, and control of cell identity. Cell 112, 599-606.
4. Raaphorst FM, Otte AP, and Meijer CJ (2001). Polycomb-group genes as regulators of mammalian lymphopoiesis. Trends Immunol 22, 682-90.
5. van Lohuizen M (1998). Functional analysis of mouse Polycomb group genes. Cell Mol Life Sci 54, 71-79.
6. Takihara Y, and Hara J (2000). Polycomb-group genes and hematopoiesis. Int J Hematol 72, 165-72.
7. Dahiya A, Wong S, Gonzalo S, Gavin M, and Dean DC (2001). Linking the rb and polycomb pathways. Mol Cell 8, 557-69.
8. Brock HW, and van Lohuizen M (2001). The Polycomb group-no longer an exclusive club? Curr Opin Genet Dev 11, 175-81.
9. Satijn DP, and Otte AP (1999). Polycomb group protein complexes: do different complexes regulate distinct target genes? Biochim Biophys Acta 1447, 1-16.
10. van der Vlag J, and Otte AP (1999). Transcriptional repression mediated by the human polycomb-group protein EED involves histone deacetylation. Nat Genet 23, 474-78.
11. Tie F, Furuyama T, Prasad-Sinha J, Jane E, and Harte PJ (2001). The Drosophila Polycomb Group proteins ESC and E(Z) are present in a complex containing the histone-binding protein p55 and the histone deacetylase RPD3. Development 128, 275-86.
12. Muller J, Hart CM, Francis NJ, Vargas ML, Sengupta A, Wild B, Miller MB, O'Connor MB, Kingston RE, and Simon JA (2002). Histone methyltransferase activity of a Drosophila polycomb group repressor complex. Cell 11, 197-208.
13. Kuzmichev A, Nishioka K, Erdjument-Bromage H, Tempst P, and Reinberg D (2002). Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein. Genes Dev 16, 2893-905.
14. Cao R, Wang L, Wang H, Xia L, Erdjument-Bromage H, Tempst P, Jones RS, and Zhang Y (2002). Role of histone H3 lysine 27 methylation in Polycomb-group silencing. Science 298, 1039-1043.
15. Francis NJ, Saurin AJ, Shao Z, and Kingston RE (2001). Reconstitution of a functional core polycomb repressive complex. Mol Cell 8, 545-56.
16. Levine SS, Weiss A, Erdjument-Bromage H, Shao Z, Tempst P, and Kingston RE (2002). The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans. Mol Cell Biol 22, 6070-6078.
17. Duncan IM (1982). Polycomblike: a gene that appears to be required for the normal expression of the bithorax and antennapedia gene complexes of Drosophila melanogaster. Genetics 102, 49-70.
18. Satijn DP, Gunster MJ, van der Vlag J, Hamer KM, Schul W, Alkema AJ, Saurin AJ, Freemont PS, van Driel R, and Otte AP (1997). RING1 is associated with the polycomb group protein complex and acts as a transcriptional repressor. Mol Cell Biol 17, 4105-113.
19. Gunster MJ, Satijn DP, Hamer KM, den Blaauwen JL, de Bruijn D, Alkema MJ, van Lohuizen M, van Driel R, and Otte AP (1997). Identification and characterization of interactions between the vertebrate polycomb-group protein BMI1 and human homologs of polyhomeotic. Mol Cell Biol 17, 2326-335.
20. Alkema MJ, Bronk M, Verhoeven E, Otte A, van't Veer LJ, Berns A, and van Lohuizen M (1997). Identification of Bmi1-interacting proteins as constituents of a multimeric mammalian polycomb complex. Genes Dev 11, 226-40.
21. Hashimoto N, Brock HW, Nomura M, Kyba M, Hodgson J, Fujita Y, Takihara Y, Shimada K, and Higashinakagawa T (1998). RAE28, BMI1, and M33 are members of heterogeneous multimeric mammalian Polycomb group complexes. Biochem Biophys Res Commun 245, 356-65.
22. Satijn DP, and Otte AP (1999). RING1 interacts with multiple Polycombgroup proteins and displays tumorigenic activity. Mol Cell Biol 19, 57-68.
23. Ng J, Hart CM, Morgan K, and Simon JA (2000). A Drosophila ESC-E(Z) protein complex is distinct from other polycomb group complexes and contains covalently modified ESC. Mol Cell Biol 20, 3069-3078.
24. Furuyama T, Tie F, and Harte PJ (2003). Polycomb group proteins ESC and E(Z) are present in multiple distinct complexes that undergo dynamic changes during development. Genesis 35, 114-24.
25. Sewalt RG, van der Vlag J, Gunster MJ, Hamer KM, den Blaauwen JL, Satijn DP, Hendrix T, van Driel R, and Otte AP (1998). Characterization of interactions between the mammalian polycomb-group proteins Enx1/ EZH2 and EED suggests the existence of different mammalian polycomb-group protein complexes. Mol Cell Biol 18, 3586-595.
26. van Lohuizen M, Tijms M, Voncken JW, Schumacher A, Magnuson T, and Wientjens E (1998). Interaction of mouse polycomb-group (Pc-G) proteins Enx1 and Enx2 with Eed: indication for separate Pc-G complexes. Mol Cell Biol 18, 3572-579.
27. Jones CA, Ng J, Peterson AJ, Morgan K, Simon J, and Jones RS (1998). The Drosophila esc and E(z) proteins are direct partners in polycomb group-mediated repression. Mol Cell Biol 18, 2825-834.
28. Satijn DP, Hamer KM, den Blaauwen J, and Otte AP (2001). The polycomb group protein EED interacts with YY1, and both proteins induce neural tissue in Xenopus embryos. Mol Cell Biol 21, 1360-369.
29. Gunster MJ, Raaphorst FM, Hamer KM, den Blaauwen JL, Fieret E, Meijer CJ, and Otte AP (2001). Differential expression of human Polycomb group proteins in various tissues and cell types. J Cell Biochem Suppl 36, 129-43.
30. Muyrers-Chen I, and Paro R (2001). Epigenetics: unforeseen regulators in cancer. Biochim Biophys Acta 1552, 15-26.
31. Caldas C, and Aparicio S (1999). Cell memory and cancer-the story of the trithorax and Polycomb group genes. Cancer Metastasis Rev 18, 313-29.
32. Satijn DP, Olson DJ, van der Vlag J, Hamer KM, Lambrechts C, Masselink H, Gunster MJ, Sewalt RG, van Driel R, and Otte AP (1997). Interference with the expression of a novel human polycomb protein, hPc2, results in cellular transformation and apoptosis. Mol Cell Biol 17, 6076-6086.
33. Goebi MG (1991). The bmi-1 and mel-18 gene products define a new family of DNA-binding proteins involved in cell proliferation and tumorigenesis. Cell 66, 623.
34. Dimri GP, Martinez JL, Jacobs JJ, Keblusek P, Itahana K, van Lohuizen J, Campisi J, Wazer DE, and Band V (2002). The Bmi-1 oncogene induces telomerase activity and immortalizes human mammary epithelial cells. Cancer Res 62, 4736-745.
35. Jacobs JJ, Scheijen B, Voncken JW, Kieboom K, Berns A, and van Lohuizen M (1999). Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARF. Genes Dev 13, 2678-690.
36. Raaphorst FM, van Kemenade FJ; Blokzijl T, Fieret E, Hamer KM, Satijn DP, Otte AP, and Meijer CJ (2000). Coexpression of BMI-1 and EZH2 polycomb group genes in Reed-Sternberg cells of Hodgkin's disease. Am J Pathol 157, 709-15.
37. van Kemenade FJ, Raaphorst FM, Blokzijl T, Fieret E, Hamer KM, Satijn DP, Otte AP, and Meijer CJ (2001). Coexpression of BMI-1 and EZH2 polycomb-group proteins is associated with cycling cells and degree of malignancy in B-cell non-Hodgkin lymphoma. Blood 97, 3896-901.
38. Vonlanthen S, Heighway J, Altermatt HJ, Gugger M, Kappeler A, Borner M, Lohuizen M, and Betticher DC (2001). The bmi-1 oncoprotein is differentially expressed in non-small cell lung cancer and correlates with INK4A-ARF locus expression. Br J Cancer 84, 1372-376.
39. Varambally S, Dhanasekaran SM, Zhou M, Barrette TR, Kumar-Sinha MG, Sanda MG, Ghosh D, Pienta KJ, Sewalt RG, Otte AP, Rubin MA, and Chinnaiyan AM (2002). The polycomb group protein EZH2 is involved in progression of prostate cancer. Nature 419, 624-29.
40. LaTulippe E, Satagopan J, Smith A, Scher H, Scardino P, Reuter V, and Gerald WL (2002). Comprehensive gene expression analysis of prostate cancer reveals distinct transcriptional programs associated with metastatic disease. Cancer Res 62, 4499-506.
41. van Diest PJ (2002). No consent should be needed for using leftover body material for scientific purposes. BMJ 325, 648-51.
42. Page DL, Anderson TJ, and Rogers LW (1987). Carcinoma in situ. In Page DL, Anderson TJ (Eds). Diagnostic Histopathology of the Breast, pp. 157-92 Livingstone, Edinburgh, UK.
43. Page DL, Anderson TJ, and Rogers LW (1987). Epithelial hyperplasia. In Page DL, Anderson TJ (Eds). Diagnostic Histopathology of the Breast, pp. 120-56 Livingstone, Edinburgh, UK.
44. Elston CW, and Ellis, IO (1991). Pathological prognostic factors in breast cancer: I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up. Histopathology 19, 403-10.
45. Korsching E, Packeisen J, Agelopoulos K, Eisenacher M, Voss R, Isola PJ, van Diest PJ, Brandt B, Boecker W, and Buerger H (2002). Cytogenetic alterations and cytokeratin expression patterns in breast cancer: integrating a new model of breast differentiation into cytogenetic pathways of breast carcinogenesis. Lab Invest 82, 1525-533.
46. van Diest PJ (1999). Ductal carcinoma in situ in breast carcinogenesis. J Pathol 187, 383-84.
47. Bos R, Zhong H, Hanrahan CF, Mommers EC, Semenza GL, Pinedo MD, Abeloff MD, Simons JW, van Diest PJ, and van der WE. (2001). Levels of hypoxia-inducible factor-1 alpha during breast carcinogenesis. J Natl Cancer Inst 93, 309-14.
48. Jacobs JJ, Kieboom K, Marino S, DePinho RA, and van Lohuizen M (1999). The oncogene and Polycomb-group gene bmi-I regulates cell proliferation and senescence through the ink4a locus. Nature 397, 164-68.
49. Visser HP, Gunster MJ, Kluin-Nelemans HC, Manders EM, Raaphorst FM, Meijer CJ, Willemze R, and Otte AP (2001). The Polycomb group protein EZH2 is upregulated in proliferating, cultured human mantle cell lymphoma. Br J Haematol 112, 950-58.
50. Raaphorst FM, Otte AP, van Kemenade FJ, Blokzijl T, Fieret E, Hamer DP, Satijn DP, and Meijer CJ (2001). Distinct bmi-1 and ezh2 expression patterns in thymocytes and mature T cells suggest a role for polycomb genes in human T cell differentiation. J Immunol 166, 5925-934.
51. Raaphorst FM, van Kemenade FJ, Fieret E, Hamer KM, Satijn DP, Otte CJ, and Meijer CJ (2000). Cutting edge: polycomb gene expression patterns reflect distinct B cell differentiation stages in human germinal centers. J Immunol 164, 1-4.
52. Matsuo F, Yano K, Saito H, Morotomi K, Kato M, Yoshimoto M, Kasumi F, Akiyama F, Sakamoto G, and Miki Y (2002). Mutation analysis of the mel-18 gene that shows decreased expression in human breast cancer cell lines. Breast Cancer 9, 33-38.
53. Desai KV, Xiao N, Wang W, Gangi L, Greene J, Powell JI, Dickson R, Gerald WL, Hunter K, Kucherlapati R, Simon R, Liu ET, and Green JE (2002). Initiating oncogenic event determines gene-expression patterns of human breast cancer models. Proc Natl Acad Sci USA 99, 6967-972.
54. Buerger H, Mommers C, Littmann R, Simon R, Diallo R, Poremba C, Dockhom-Dwomiczak B, van Diest PJ, and Boecker W (2001). Ductal invasive G2 and G3 carcinomas of the breast are the end stages of at least two different lines of genetic evolution. J Pathol 194, 165-70.
55. Bocker W, Moll R, Poremba C, Holland R, van Diest PJ, Dervan P, Burger H, Wai D, Ina DR, Brandt B, Herbst H, Schmidt A, Lerch MM, and Buchwallow IB (2002). Common adult stem cells in the human breast give rise to glandular and myoepithelial cell lineages: a new cell biological concept. Lab Invest 82, 737-46.
56. LaTulippe E, Satagopan J, Smith A, Scher H, Scardino P, Reuter V, and Gerald WL (2002). Comprehensive gene expression analysis of prostate cancer reveals distinct transcriptional programs associated with metastatic disease. Cancer Res 62, 4499-506.