Cytogenetic alterations and cytokeratin expression patterns in breast cancer: Integrating a new model of breast differentiation into cytogenetic pathways of breast carcinogenesis

Laboratory Investigation

Volumn 82, Issue 11, 2002, Pages 1525-1533

  Korsching, Eberhard ^a   Packeisen, Jens ^b   Agelopoulos, Konstantin ^a   Eisenacher, Martin ^a   Voss, Reinhard ^a   Isola, Jorma ^c   Van Diest, Paul J ^d   Brandt, Burkhard ^a   Boecker, Werner ^a   Buerger, Horst ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b Institute of Pathology   (Germany)

^c UNIVERSITY OF TAMPERE   (Finland)

^d VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN A; CYTOKERATIN; CYTOKERATIN 5; CYTOKERATIN 6; ESTROGEN RECEPTOR; GROWTH FACTOR RECEPTOR; KI 67 ANTIGEN; ONCOPROTEIN; PROGESTERONE RECEPTOR; PROTEIN BCL 2; PROTEIN P21; PROTEIN P27; PROTEIN P53; UNCLASSIFIED DRUG;

ARTICLE; BREAST CANCER; BREAST CARCINOGENESIS; CHROMOSOME 16Q; CLUSTER ANALYSIS; COMPARATIVE GENOMIC HYBRIDIZATION; CONTROLLED STUDY; CYTOGENETICS; DNA MICROARRAY; GENE MUTATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SCORING SYSTEM; STEM CELL;

BREAST NEOPLASMS; CELL DIFFERENTIATION; CHROMOSOME ABERRATIONS; CLUSTER ANALYSIS; FEMALE; GENE EXPRESSION PROFILING; GENES, ERBB-2; GENES, P53; HUMANS; IMMUNOHISTOCHEMISTRY; KERATINS;

EID: 0036849017     PISSN: 00236837     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.LAB.0000038508.86221.B3     Document Type: Article

References (48)

1. Alaiya AA, Franzen B, Hagman A, Dysvik B, Roblick UJ, Becker S, Moberger B, Auer G, and Linder S (2002). Molecular classification of borderline ovarian tumours using hierarchical cluster analysis of protein expression profiles. Int J Cancer 98:895-899.
2. Alizadeh AA, Ross DT, Perou C, and van de Rijn M (2001). Towards a novel classification of human malignancies based on gene expression. J Pathol 195:41-52.
3. Bankfalvi A, Navabi H, Bier B, Bocker W, Jasani B, and Schmid KW (1994). Wet autoclave pretreatment for antigen retrieval in diagnostic immunohistochemistry. J Pathol 174: 223-228.
4. Boecker W, Moll R, Poremba C, Holland R, van Diest PJ, Dervan P, Buerger H, Wai D, Diallo R, Herbst H, Schmidt A, and Buchwallow IB (2002). Common adult stem cells in the human breast give rise to glandular and myoepithelial cell lineages: A new cell biological concept. Lab Invest 82:737-746.
5. Brandt B, Roetger A, Bidart JM, Packeisen J, Schier K, Mikesch JH, Kemming D, Boecker W, Yu D, and Buerger H (2002). Early placental insulin-like growth factor (pro-Epil) is overexpressed and secreted by c-erbB-2-positive cells with high invasion potential. Cancer Res 62:1020-1024.
6. Breast Cancer Linkage Consortium (1997). Pathology of familial breast cancer: Differences between breast cancers in carriers of BRCA1 or BRCA2 mutations and sporadic cases. Lancet 349:1505-1510.
7. Buerger H, Gebhardt F, Schmidt H, Hutmacher K, Beckmann A, Simon R, Boecker W, and Brandt B (2000a). Length and loss of heterozygosity of an intron 1 polymorphic sequence of egfr is related to cytogenetic alterations and epithelial growth factor receptor expression. Cancer Res 60:854-857.
8. Buerger H, Mommers E, Littmann R, Diallo R, Poremba C, Brinkschmidt C, Dockhorn DB, van Diest PJ, and Boecker W (2000b). Correlation of morphologic and cytogenetic parameters of genetic instability with chromosomal alterations in in situ carcinomas of the breast. Am J Clin Pathol 114:854-859.
9. Buerger H, Mommers E, Littmann R, Simon R, Diallo R, Poremba C, Dockhorn-Dworniczak B, van Diest PJ, and Boecker W (2001). Ductal invasive G2 and G3 carcinomas of the breast are the end stages of at least two different lines of genetic evolution. J Pathol 194:165-170.
10. Buerger H, Otterbach F, Simon R, Poremba C, Diallo R, Brinkschmidt C, Dockhorn-Dworniczak B, and Boecker W (1999a). Different genetic pathways in the evolution of invasive breast cancer are associated with distinct morphological subtypes. J Pathol 189:521-526.
11. Buerger H, Otterbach F, Simon R, Poremba C, Diallo R, Decker T, Riethdorf L, Brinkschmidt C, Dockhorn-Dworniczak B, and Boecker W (1999b). Comparative genomic hybridization of ductal carcinoma in situ of the breast: Evidence of multiple genetic pathways. J Pathol 187:396-402.
12. DiRenzo J, Signoretti S, Nakamura N, Rivera-Gonzalez R, Sellers W, Loda M, and Brown M (2002). Growth factor requirements and basal phenotype of an immortalized mammary epithelial cell line. Cancer Res 62:89-98.
13. Ellis IO and Elston CW (1998). Tumors of the breast. In: Fletcher CDM, editor. Diagnostic Histopathology of Tumors. New York: Churchill Livingstone, 635-689.
14. Fearon ER and Vogelstein B (1990). A genetic model for colorectal tumorigenesis. Cell 61:759-767.
15. Gruvberger S, Ringner M, Chen Y, Panavally S, Saal LH, Borg A, Ferno M, Peterson C, and Meltzer P (2001). Estrogen receptor status in breast cancer is associated with remarkably distinct gene expression patterns. Cancer Res 61:5979-5984.
16. Harris RA, Yang A, Stein RC, Lucy K, Brusten L, Herath A, Parekh RD, O'Hare MJ, Neville MA, Page MJ, and Zvelebil MJ (2002). Cluster analysis of an extensive human breast cancer cell line protein expression map database. Proteomics 2:212-223.
17. Hedenfalk I, Duggan D, Chen Y, Radmacher M, Bittner M, Simon R, Meltzer P, Esteller M, Kallioniemi OP, Wilfond B, Borg A, and Trent J (2001). Gene expression profiles in hereditary breast cancer. N Engl J Med 344:539-548.
18. Holland R, Peterse JL, Millis RR, Eusebi V, Faverly D, van de Vijver M, and Zafrani B (1994). Ductal carcinoma in situ: A proposal for a new classification. Semin Diagn Pathol 11: 167-180.
19. Isola J, Chu L, DeVries S, Matsumura K, Chew K, Ljung BM, and Waldman FM (1999). Genetic alterations in ERBB2-amplified breast carcinomas. Clin Cancer Res 5:4140-4145.
20. Jones C, Nonni AV, Fulford L, Merrett S, Chaggar R, Eusebi V, and Lakhani SR (2001). CGH analysis of ductal carcinoma of the breast with basaloid/myoepithelial cell differentiation. Br J Cancer 85:422-427.
21. Kallioniemi A, Kallioniemi OP, Piper J, Tanner M, Stokke T, Chen L, Smith HS, Pinkel D, Gray JW, and Waldman FM (1994). Detection and mapping of amplified DNA sequences in breast cancer by comparative genomic hybridization. Proc Natl Acad Sci USA 91:2156-2160.
22. Kaufman L, Hubert M, and Rousseeuw PJ (1995). Finding Groups in Data: An Introduction to Cluster Analysis. New York: Wiley.
23. Kononen J, Bubendorf L, Kallioniemi A, Barlund M, Schraml P, Leighton S, Torhorst J, Mihatsch MJ, Sauter G, and Kallioniemi OP (1998). Tissue microarrays for high-throughput molecular profiling of tumor specimens [see comments]. Nat Med 4:844-847.
24. Megha T, Ferrari F, Benvenuto A, Bellan C, Lalinga AV, Lazzi S, Bartolommei S, Cevenini G, Leoncini L, and Tosi P (2002). p53 mutation in breast cancer: Correlation with cell cycle kinetics and cell of origin. J Clin Pathol 55:461-466.
25. Moll R, Franke WW, Schiller DL, Geiger B, and Krepler R (1982). The catalog of human cytokeratins: Patterns of expression in normal epithelia, tumors and cultured cells. Cell 31:11-24.
26. Mommers EC, Leonhart AM, Falix F, Michalides R, Meijer C, van Diest PJ, and Baak JP (2002). Similarity in expression of cell cycle proteins between preinvasive and invasive ductal breast lesions of sam differentiation grade. J Pathol 194:327-333.
27. Mommers E, van Diest PJ, Leonhart AM, and Meijer CBJP (1999). Balance of apoptosis and proliferation in the progression of pre-invasive breast lesions. Breast Cancer Res Treat 58:163-169.
28. Mommers EC, van Dlest PJ, Leonhart AM, Meijer CJ, and Baak JP (1998). Expression of proliferation and apoptosis-related proteins in usual ductal hyperplasia of the breast. Hum Pathol 29:1539-1545.
29. Muthuswamy SK, Li D, Lelievre S, Bissell MJ, and Brugge JS (2001). ErbB2, but not ErbB1, reinitiates proliferation and induces luminal repopulation in epithelial acini. Nat Cell Biol 3:785-791.
30. Perou C, Sorlie T, Eisen M, van de Rijn M, Jeffrey SS, Rees CA, Pollack JR, Ross DT, Johnsen H, Akslen LA, Fluge O, Pergamenschikov A, Williams C, Zhu S, Lonning PE, Borresen DA, Brown PO, and Botstein D (2000). Molecular portraits of human breast tumours. Nature 406:747-752.
31. Rennstam K, Baldetorp B, Kytölä S, Tanner M, and Isola J (2001). Chromosomal rearrangements and oncogene amplification precede aneuploidization in the genetic evolution of breast cancer. Cancer Res 61:1214-1219.
32. Ross DT, Scherf U, Eisen M, Perou C, Rees C, Spellman P, Iyer V, Jeffrey SS, van de Rijn M, Waltham M, Pergamenschikov A, Lee JCF, Shalon D, Myers TG, Weinstein JN, Botstein D, and Brown PO (2000). Systematic variation in gene expression patterns in human cancer cell lines. Nat Genet 24:227-235.
33. Roylance R, Gorman P, Harris W, Barnes D, Hanby A, and Sheer D (1999). Comparative genomic hybridization of breast tumours stratified by histological grade reveals new insights into the biological progression of breast cancer. Cancer Res 59:1433-1436.
34. Simon R, Nocito A, Hübscher T, Bucher C, Torhorst J, Schraml P, Bubendorf L, Moch H, Wilber K, Schötzau A, Kononen J, and Sauter G (2001). Patterns of HER-2/neu amplification and overexpression in primary and metastatic breast cancer. J Natl Cancer Inst 93:1141-1146.
35. Sorlie T, Perou C, Tibshirani R, Aas T, Geisler S, Johnsen H, Hastie T, Eisen M, van de Rijn M, Jeffrey SS, Thorsen T, Quist H, Matese JC, Brown PO, Botstein D, Lonning PE, and Borresen DA (2001). Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Natl Acad Sci USA 98:10869-10874.
36. Struyf A, Hubert M, and Rousseeuw PJ (2002). Integrating robust clustering techniques in S-PLUS. Comp Stat Data Anal 26:17-37.
37. Tabar L, Fagerberg G, Day NE, Duffy SB, and Kitchin RM (1992). Natural history of breast cancer. Lancet 339:810.
38. Tanner M, Gancberg D, DiLeo A, Larsimont D, Rouas G, Piccart MJ, and Isola J (2000). Chromogenic in situ hybridization: A practical approach for fluorescence in situ hybridization to detect HER-2/neu oncogene amplification in archival breast cancer samples. Am J Pathol 157:1467-1472.
39. Tirkkonen M, Johannsson O, Agnarsson BA, Olsson H, Ingvarsson S, Karhu R, Tanner M, Isola J, Barkardottir RB, Borg A, and Kallioniemi OP (1997). Distinct somatic genetic changes associated with tumor progression in carriers of BRCA1 and BRCA2 germ-line mutations. Cancer Res 57: 1222-1227.
40. Tirkkonen M, Kainu T, Loman N, Johannsson OT, Olsson H, Barkardottir RB, Kallioniemi OP, and Borg A (1999). Somatic genetic alterations in BRCA2-associated and sporadic male breast cancer. Genes Chromosomes Cancer 24:56-61.
41. Tirkkonen M, Tanner M, Karhu R, Kallioniemi A, Isola J, and Kallioniemi OP (1998). Molecular cytogenetics of primary breast cancer by CGH. Genes Chromosomes Cancer 21: 177-184.
42. Torhorst J, Bucher C, Kononen J, Haas P, Zuber M, Kochli OR, Mross F, Dieterich H, Moch H, Mihatsch MJ, and Sauter G (2001). Tissue microarrays for rapid linking of molecular changes to clinical endpoints. Am J Pathol 159:2249-2256.
43. Tsuda H, Takarabe T, Hasegawa F, Fukotomi T, and Hirohashi S (2000). Large acellular zones indicating myoepithelial tumour differentiation in high-grade invasive ductal carcinomas as markers of predisposition to lung and brain metastasis. Am J Surg Pathol 24:197-202.
44. van de Vijver M (1993). Molecular genetic changes in human breast cancer. Adv Cancer Res 61:25-56.
45. van Diest PJ (1999). Ductal carcinoma in situ in breast carcinogenesis. J Pathol 187:383-384.
46. van't Veer LJ, Dai H, van de Vijver MJ, He YD, Hart AA, Mao M, Peterse HL, van der Kooy K, Marton MJ, Witteveen AT, Schreiber GJ, Kerkhoven RM, Roberts C, Linsley PS, Bernards R, and Friend SH (2002). Gene expression profiling predicts clinical outcome of breast cancer. Nature 415:530-536.
47. Vos CB, Rosenberg C, Peterse JL, Cleton-Jansen AM, Cornelisse CJ, and van de Vijver M (2000). Genetic alterations on chromosome 16 and 17 are important features of ductal carcinoma in situ of the breast and are associated with histologic type. Br J Cancer 81:1410-1418.
48. Wetzels RH, Kuijpers HJ, Lane EB, Leigh IM, Troyanovsky SM, Holland R, van HU, and Ramaekers FC (1991). Basal cell-specific and hyperproliferation-related keratins in human breast cancer. Am J Pathol 138:751-763.