The Polycomb group - No longer an exclusive club?

Current Opinion in Genetics and Development

Volumn 11, Issue 2, 2001, Pages 175-181

  Brock, Hugh W ^a   van Lohuizen, M ^b  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b ANTONI VAN LEEUWENHOEK HOSPITAL   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; HISTONE; POLYCOMB PROTEIN; UNCLASSIFIED DRUG;

CELL CYCLE; DNA RESPONSIVE ELEMENT; EUKARYOTE; GENE ACTIVATION; GENE LOCUS; GENE TARGETING; HOMEOSTASIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN STRUCTURE; REGULATORY MECHANISM; REVIEW; STRUCTURE ANALYSIS; TRANSCRIPTION REGULATION;

EUKARYOTA;

EID: 0035313867     PISSN: 0959437X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-437X(00)00176-3     Document Type: Review

References (69)

1. Locking in stable states of gene expression: Transcriptional control during Drosophila development
2. Murine Polycomb- and Trithorax-group genes regulate homeotic pathways and beyond
3. The Polycomb and trithorax group proteins of Drosophila: Trans regulators of homeotic gene function
4. Dosage-dependent modifiers of Polycomb and Antennapedia mutations in Drosophila
5. Polycomb group protein complexes: Do different complexes regulate distinct target genes?
6. The trithorax-group and Polycomb-group chromatin modifiers: Implications for disease
7. The Polycomb protein shares a homologous domain with a heterochromatin-associated protein in Drosophila
8. Functional analysis of the chromodomain of HP1
9. Analysis of the functional role of the Polycomb chromo domain in Drosophila melanogaster
10. Chromodomains are protein-RNA interaction modules
11. PcG complexes and chromatin silencing
12. Transcriptional repression by Drosophila and mammalian Polycomb group proteins in transfected mammalian cells
13. Transcriptional silencing by the Polycomb protein in Drosophila embryos
14. The Drosophila trithorax protein binds to specific chromosomal sites and is co-localized with Polycomb at many sites
15. The Polycomb group protein complex of Drosophila melanogaster has different compositions at different target genes
16. Regulation of polyhomeotic transcription may involve local changes in chromatin activity in Drosophila
17. E(z): A polycomb group gene or a trithorax group gene?
18. The Additional sex combs gene of Drosophila is required for activation and repression of homeotic loci, and interacts specifically with Polycomb and super sex combs
19. Genetic analysis of the Additional sex combs locus of Drosophila melanogaster
20. A screen for new trithorax group genes identified little imaginal discs, the Drosophila melanogaster homologue of human retinoblastoma binding protein 2
21. Interactions of polyhomeotic with Polycomb group genes of Drosophila melanogaster
22. Genetic interactions and dosage effects of Polycomb group genes of Drosophila
23. Functional antogonism of the Polycomb-Group genes eed and Bmi1 in hemopoietic cell proliferation
24. Stabilization of chromatin structure by PRC1, a Polycomb complex
25. Identification of Bmi1-interacting proteins as constituents of a multimeric mammalian Polycomb complex
26. Identification and characterization of interactions between the vertebrate Polycomb-Group protein BMI1 and human homologs of Polyhomeotic
27. A Drosophila ESC-E(Z) protein complex is distinct from other Polycomb group complexes and contains covalently modified ESC
28. Interaction of mouse polycomb-group (Pc-G) proteins Enx1 and Enx2 with Eed: Indication for separate Pc-G complexes
29. Characterization of interactions between the mammalian polycomb-group proteins Enx1/EZH2 and EED suggests the existence of different mammalian polycomb-group protein complexes
30. ISWI, a member of the SWI/SNF ATPase family encodes the 140 kDa subunit of the nucleosome remodelling factor
31. A Polycomb and GAGA dependent silencer adjoin the Fab-7 boundary in the Drosophila bithorax complex
32. Co-localization of Polycomb protein and GAGA factor on regulatory elements responsible for the maintenance of homeotic gene expression
33. Structure of a Polycomb response element and in vitro binding of Polycomb group complexes containing GAGA factor
34. Trithorax and Polycomb-Group response elements within an Ultrabithorax transcription maintenance unit consist of closely situated but separable sequences
35. Genetic interactions and dosage effects of Polycomb group genes in mice
36. The oncogene and Polycomb group bmi-1 regulates cell proliferation and senescence through the ink4a locus
37. Identification of Polycomb and trithorax group responsive elements in the regulatory region of the Drosophila homeotic gene sex combs reduced
38. Epigenetic inheritance of active chromatin after removal of the main transactivator
39. Functional reconstruction of trans regulation of the ultrabithorax promotor by the products of two antagonistic genes, trithorax and Polycomb
40. The binding of Trithorax and Polycomb proteins to the bithorax complex: Dynamic changes during early Drosophila embryogenesis
41. The Drosophila Polycomb Group gene pleiohomeotic encodes a DNA binding protein with homology to the transcription factor YY1
42. A conserved sequence motif in Polycomb-response elements
43. Recruitment of components of Polycomb Group chromatin complexes in Drosphila
44. The DNA-binding Polycomb group protein Pleiohomeotic mediates silencing of a Drosophila homeotic gene
45. Functional analysis of repressor binding sites in the iab-2 regulatory region of the abdominal-A homeotic gene
46. The distribution of Polycomb-group proteins during cell division and development in Drosophila embryos: Impact on models for silencing
47. The nuclear distribution of Polycomb during Drosophila melanogaster development shown with a GFP fusion protein
48. Chromatin-association of the Polycomb group protein BMI1 is cell cycle-regulated and correlates with its phosphorylation status
49. Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 proto-oncogene
50. A role for mel-18, a Polycomb group related vertebrate gene, during the anteroposterior specification of the axial skeleton
51. The role of mel-18, a mammalian Polycomb group gene, during IL-7-dependent proliferation of lymphocyte precursors
52. Altered cellular proliferation and mesoderm patterning in Polycomb-M33-deficient mice
53. Targeted disruption of the mouse homologue of the Drosophila polyhomeotic gene leads to altered anteroposterior patterning and neural crest defects
54. The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus
55. mel-18 negatively regulates cell cycle progression upon B cell antigen receptor stimulation through a cascade leading to
56. Mutations in ccf, a novel Drosophila gene encoding a chromosomal factor, affect progression through mitosis and interact with PcG mutations
57. The GAGA factor is required in the early Drosophila embryo not only for transcriptional regulation but also for nuclear division
58. Drosophila chromosome condensation proteins Topoisomerase II and Barren colocalize with Polycomb and maintain Fab-7 PRE silencing
59. Polycombing the genome: PcG, trxG and chromatin silencing
60. Drosophila Polycomb-group regulated chromatin inhibits the accessibility of a trans-activator to its target DNA
61. Hunchback-independent silencing of late Ubx enhancers by a Polycomb group response element
62. zeste, a non-essential gene, potently activates ultrabithorax transcription in the Drosophila embryo
63. Transient inhibition of histone deacetylation alters the structural and functional imprint at fission yeast centromeres
64. dMi-2, a Hunchback-interacting protein that functions in Polycomb repression
65. Transcriptional repression mediated by the human polycomb-group protein EED involves histone deacetylation
66. Multiple links between the NuA4 histone acetyltransferase complex and epigenetic control of transcription
67. The Drosophila Brahma complex is an essential coactivator for the trithorax group protein Zeste
68. Ordered recruitment of transcription and chromatin remodeling factors to a cell cycle- and developmentally regulated promoter
69. Global role for chromatin remodeling enzymes in mitotic gene expression