G972R IRS-1 Variant Impairs Insulin Regulation of Endothelial Nitric Oxide Synthase in Cultured Human Endothelial Cells

Circulation

Volumn 109, Issue 3, 2004, Pages 399-405

  Federici, Massimo ^a   Pandolfi, Assunta ^b   De Filippis, Elena Anna ^b   Pellegrini, Giuliana ^b   Menghini, Rossella ^a   Lauro, Davide ^a   Cardellini, Marina ^a   Romano, Mario ^b   Sesti, Giorgio ^c   Lauro, Renato ^a   Consoli, Agostino ^b  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

^b UNIVERSITY OF CHIETI   (Italy)

^c UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

Author keywords

Endothelium; Insulin; Nitric oxide synthase

Indexed keywords

ARGININE; CITRULLINE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; NITRIC OXIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOINOSITIDE DEPENDENT KINASE 1; PHOSPHOTYROSINE; PROTEIN KINASE; PROTEIN KINASE B; SERINE; THREONINE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; ENZYME REGULATION; G972R GENE; GENE; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; HUMAN; HUMAN CELL; INSULIN RESISTANCE; PRIORITY JOURNAL; PROTEIN VARIANT; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UMBILICAL VEIN; VASCULAR DISEASE; VASCULAR ENDOTHELIUM; VASODILATATION; WESTERN BLOTTING;

1-PHOSPHATIDYLINOSITOL 3-KINASE; CELLS, CULTURED; ENDOTHELIUM, VASCULAR; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; INSULIN; MITOGEN-ACTIVATED PROTEIN KINASES; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE III; PHOSPHOPROTEINS; PHOSPHORYLATION; POLYMORPHISM, GENETIC; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RNA, MESSENGER; SIGNAL TRANSDUCTION;

EID: 9144222572     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.0000109498.77895.6F     Document Type: Article

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