Variation in coumarin 7-hydroxylase activity associated with genetic polymorphism of cytochrome P450 2A6 and the body status of iron stores in adult Thai males and females

Pharmacogenetics

Volumn 12, Issue 3, 2002, Pages 241-249

  Ujjin, Pailin ^a   Satarug, Soisungwan ^a   Vanavanitkun, Yuvaree ^a   Daigo, Satoshi ^a   Ariyoshi, Noritaka ^a   Yamazaki, Hiroshi ^a   Reilly, Paul E B ^a   Moore, Michael R ^a   Kamataki, Tetsuya ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

Author keywords

7 hydroxylation; Body iron stores; Coumarin; Cytochrome P4502A6; Dietary cadmium; Ferritin; Gene typing; Phenotyping

Indexed keywords

CYTOCHROME P450 2A6; FERRITIN; MELILOTUS EXTRACT; UMBELLIFERONE;

ADULT; ALLELISM; ARTICLE; CONTROLLED STUDY; DRUG EXCRETION; DRUG HYDROXYLATION; DRUG METABOLISM; ENZYME ACTIVE SITE; ENZYME ACTIVITY; FEMALE; FERRITIN BLOOD LEVEL; GENE FREQUENCY; GENETIC POLYMORPHISM; GENETIC VARIABILITY; HUMAN; IRON OVERLOAD; IRON STORAGE; MAJOR CLINICAL STUDY; MALE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEX DIFFERENCE; THAILAND;

ADULT; ARYL HYDROCARBON HYDROXYLASES; CYTOCHROME P-450 ENZYME SYSTEM; FEMALE; FERRITINS; GENE FREQUENCY; GENOTYPE; HUMANS; IRON; MALE; MIDDLE AGED; MIXED FUNCTION OXYGENASES; MUTATION; PHENOTYPE; POLYMORPHISM, GENETIC; PREVALENCE; SEX FACTORS; SMOKING; THAILAND; UMBELLIFERONES; VARIATION (GENETICS);

THAIS;

EID: 0036260293     PISSN: 0960314X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00008571-200204000-00009     Document Type: Article

References (50)

1. Interindividual variability of coumarin 7-hydorxylation in healthy volunteers
2. Coumarin 7-hydroxylase activity in human liver microsomes, properties of the enzyme and interspecies comparisons
3. Identification of the human liver cytochrome P-450 responsible for coumarin 7-hydroxylase activity
4. Purification and characterization of human liver microsomal cytochrome P450 2A6
5. The pharmacology, metabolism, analysis, and applications of coumarin and coumarin-related compounds
6. Regulation of coumarin 7-hydroxylation in man
7. Genetic polymorphisms in the cytochrome P450 2A6 (CYP2A6) gene: Implications for interindividual differences in nicotine metabolism
8. Comparison of a novel thin-layer chromatographic-fluorescence detection method with a spectrofluorometric method for the determination of 7-hydroxycoumarin in human urine
9. CYP3A4 and CYP2A6 activities marked by the metabolism of lignocaine and coumarin in patients with liver and kidney diseases and epileptic patients
10. Induction of cytohrome P450 2A6 expression in humans by the carcinogenic parasite infection, opisthorchiasis viverrini
11. Hepatitis A impairs the function of human hepatic CYP2A6 in vivo
12. Comparison of in vitro and in vivo biotransformation in patients with liver disease of differing severity
13. Ethnic-related difference in coumarin 7-hydroxylation activities catalyzed by cytochrome P4502A6 in liver microsomes of Japanese and Caucasian population
14. The human drug metabolizing cytochrome P450
15. Characterization of phase I and phase II hepatic drug metabolism activities in a panel of human liver preparations
16. A genetic polymorphism in coumarin 7-hydroxylation: Sequence of the human CYP2A genes and identification of variant CYP2A6 alleles
17. Genetic polymorphism of drug metabolizing enzyme: New mutations in CYP2D6 and CYP2A6 genes in Japanese
18. A new deleted allele in the human cytochrome P450 2A6 (CYP2A6) gene found in individuals showing poor metabolic capacity to coumarin and (+)-cis-3, 5-dimethyl-2-(3-pyrydyl) thiazolidin-4-one hydrochloride (SM-12502)
19. Characterization and PCR-based detection of CYP2A6 gene deletion found at a high frequency in a Chinese population
20. Genetic polymorphism of cytochrome P450 2A6 in a case-control study on lung cancer in a French population
21. Nicotine metabolism and CYP2A6 allele frequencies in Koreans
22. Low frequency of CYP2A6 gene polymorphism as revealed by one-step polymerase chain reaction method
23. CYP2A6 gene deletion reduces susceptibility to lung cancer
24. Relationships between non-occupational cadmium exposure and expression of nine cytochrome P450 forms in human liver and kidney cortex samples
25. Sex-dependent metabolism of xenobiotics
26. Gender differences in genetic susceptibility for lung cancer
27. Liver fluke infection and cholangiocarcinoma: Model of endogenous nitric oxide and extragastric nitrosation in human carcinogenesis
28. Cross-sectional study of Opisthorchis viverritni infection and cholangiocarcinoma in communities within a high risk area in northeast Thailand
29. The role of individual susceptibility in cancer burden related to environmental exposure
30. Influence of clinicopathological variables on CYP protein expression in human liver
31. Effect of diet and nutrition on the expression of cytochromes P450
32. Iron status in Danes 1994 II: Prevalence of iron deficiency and iron overload in 1390 Danish women aged 40-70 years. Influence of blood donation, alcohol intake and iron supplementation
33. Serum ferritin and death from all causes and cardiovascular disease: The NHANES II mortality study
34. Structural characterization of a new variant of the CYP2A6 gene (CYP2A6* 1B) apparently diagnosed as heterozygotes of CYP2A6* 1A and CYP* 4C
35. A novel single nucleotide polymorphism altering stability and activity of CYP2A6
36. Relationship between interindividual differences in nicotine metabolism and CYP2A6 genetic polymorphism in humans
37. Nicotine metabolic profile in man: Comparison of cigarette smoking and transdermal nicotine
38. Cytochrome P450 2E1 and 2A6 enzymes as major catalysts for metabolic activation of N-nitrosodialkylamines and tobacco-related nitrosamines in human liver microsomes
39. CYP2A6 polymorphism, nicotine and environmental nitrosamines
40. Genetic polymorphism of CYP2A6 in relation to cancer
41. Expression of CYP2A genes in human liver and extrahepatic tissues
42. Associations between human liver and kidney cadmium content and immunochemically detected CYP4A11 apoprotein
43. Cadmium levels in the lung, liver, kidney codex and urine samples from Australians without occupational exposure to metals
44. Effects of arsenic, cadmium, chromium, and lead on gene expression regulated by a battery of 13 different promoters in recombinant HepG2 cells
45. Bioavailability of cadmium from shellfish and mixed diet in women
46. Mineral status of female rats affects the absorption and organ distribution of dietary cadmium derived from edible sunflower kernels (Helianthus annuus L)
47. Increased dietary cadmium absorption in mice and human subjects with iron deficiency
48. Intestinal absorption of dietary camium in women depends on body iron stores and fiber intake
49. Duodenal metal transporter (DMT1, Nramp-2) expression in patients with hereditary hemochromatosis