-
1
-
-
0004093989
-
-
Atlanta, GA, U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry
-
ATSDR (Agency for Toxic Substances and Disease Registry), 1992. Public health assessment guidance manual. Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry.
-
(1992)
Public health assessment guidance manual
-
-
-
2
-
-
0011863439
-
-
US Agency for Toxic Substances and Disease Registry, Division of Toxicology. February 2001. Available online
-
ATSDR (Agency for Toxic Substances and Disease Registry), 2001. Guidance for the Preparation of an Interaction Profile. US Agency for Toxic Substances and Disease Registry. Division of Toxicology. February 2001. Available online: www.atsdr.cdc.gov/interactionprofiles/interaction_profile_guidance.pdf.
-
(2001)
Guidance for the Preparation of an Interaction Profile
-
-
-
3
-
-
0011865905
-
-
US Agency for Toxic Substances and Disease Registry, Division of Toxicology. May 2004. Available online
-
ATSDR (Agency for Toxic Substances and Disease Registry), 2004a. Guidance Manual for the Assessment of Joint Toxic Action of Chemical Mixtures. US Agency for Toxic Substances and Disease Registry. Division of Toxicology. May 2004. Available online: www.atsdr.cdc.gov/interactionprofiles/ipga.html.
-
(2004)
Guidance Manual for the Assessment of Joint Toxic Action of Chemical Mixtures
-
-
-
4
-
-
84886547371
-
Interaction profile for arsenic, cadmium, chromium and lead
-
Division of Toxicology, May 2004. Available online
-
ATSDR (Agency for Toxic Substances and Disease Registry), 2004b. Interaction profile for arsenic, cadmium, chromium and lead. US Agency for Toxic Substances and Disease Registry. Division of Toxicology. May 2004. Available online: www.atsdr.cdc.gov/interactionprofiles/ipmetals1/ip04-p.pdf.
-
(2004)
US Agency for Toxic Substances and Disease Registry
-
-
-
6
-
-
85078397257
-
Interaction profile for chlorpyrifos, lead, mercury and methyl-mercury
-
Division of Toxicology. August 2006
-
ATSDR (Agency for Toxic Substances and Disease Registry), 2006a. Interaction profile for chlorpyrifos, lead, mercury and methyl-mercury. US Agency for Toxic Substances and Disease Registry. Division of Toxicology. August 2006.
-
(2006)
US Agency for Toxic Substances and Disease Registry
-
-
-
7
-
-
84886498939
-
Interaction profile for atrazine, deethylatrazine, diaz inon, nitrate, and simazine
-
Division of Toxicology. August 2006
-
ATSDR (Agency for Toxic Substances and Disease Registry), 2006b. Interaction profile for atrazine, deethylatrazine, diaz inon, nitrate, and simazine. US Agency for Toxic Substances and Disease Registry. Division of Toxicology. August 2006.
-
(2006)
US Agency for Toxic Substances and Disease Registry
-
-
-
8
-
-
84946384873
-
The toxicity of poisons applied jointly
-
Bliss CI, 1939. The toxicity of poisons applied jointly. Annals of Applied Biology, 26, 585–615.
-
(1939)
Annals of Applied Biology
, vol.26
, pp. 585-615
-
-
Bliss, C.I.1
-
9
-
-
78649736009
-
PBPK modelling of inter-individual variability in the pharmacokinetics of environmental chemicals
-
Bois FY, Jamei M and Clewell HJ, 2010. PBPK modelling of inter-individual variability in the pharmacokinetics of environmental chemicals. Toxicology, 278, 256–267.
-
(2010)
Toxicology
, vol.278
, pp. 256-267
-
-
Bois, F.Y.1
Jamei, M.2
Clewell, H.J.3
-
10
-
-
79955756966
-
Critical analysis of literature on low-dose synergy for use in screening chemical mixtures for risk assessment
-
Boobis AR, Budinsky R, Collie S, Crofton K, Embry M, Felter S, Hertzberg R, Kopp D, Mihlan G, Mumtaz M, Price P, Solomon K, Teuschler L, Yang R and Zaleski R, 2011. Critical analysis of literature on low-dose synergy for use in screening chemical mixtures for risk assessment. Critical Review in Toxicology, 41, 1–14.
-
(2011)
Critical Review in Toxicology
, vol.41
, pp. 1-14
-
-
Boobis, A.R.1
Budinsky, R.2
Collie, S.3
Crofton, K.4
Embry, M.5
Felter, S.6
Hertzberg, R.7
Kopp, D.8
Mihlan, G.9
Mumtaz, M.10
Price, P.11
Solomon, K.12
Teuschler, L.13
Yang, R.14
Zaleski, R.15
-
11
-
-
38949133743
-
IPCS framework for analyzing the relevance of a non-cancer mode of action for humans
-
Boobis AR, Doe JE, Heinrich-Hirsch B, Meek ME, Munn S, Ruchirawat M, Schlatter J, Seed J and Vickers C, 2008. IPCS framework for analyzing the relevance of a non-cancer mode of action for humans. Critical Review in Toxicology, 38, 87–96.
-
(2008)
Critical Review in Toxicology
, vol.38
, pp. 87-96
-
-
Boobis, A.R.1
Doe, J.E.2
Heinrich-Hirsch, B.3
Meek, M.E.4
Munn, S.5
Ruchirawat, M.6
Schlatter, J.7
Seed, J.8
Vickers, C.9
-
12
-
-
82755162819
-
A mechanistic modeling framework for predicting metabolic interactions in complex mixtures
-
Cheng S and Bois F, 2011. A mechanistic modeling framework for predicting metabolic interactions in complex mixtures. Environmental Health Perspectives, 12, 1712–1718.
-
(2011)
Environmental Health Perspectives
, vol.12
, pp. 1712-1718
-
-
Cheng, S.1
Bois, F.2
-
13
-
-
24644478241
-
Population variability in biological adaptive responses to DNA damage and the shapes of carcinogen dose-response curves
-
Conolly RB, Gaylor DW and Lutz WK, 2005. Population variability in biological adaptive responses to DNA damage and the shapes of carcinogen dose-response curves. Toxicology and Applied Pharmacology, 207, 570–575.
-
(2005)
Toxicology and Applied Pharmacology
, vol.207
, pp. 570-575
-
-
Conolly, R.B.1
Gaylor, D.W.2
Lutz, W.K.3
-
14
-
-
0142170682
-
-
Available online
-
COT (UK Committee on Toxicity of Chemicals in Food, Consumer Products and the Environment), 2002. Risk Assessment of Mixtures of Pesticides and Similar Substances. Available online: cot.food.gov.uk/pdfs/reportindexed.pdf.
-
(2002)
Risk Assessment of Mixtures of Pesticides and Similar Substances
-
-
-
15
-
-
79957905227
-
Bayesian nonparametric model for clustering individual co-exposure to pesticides found in the French diet
-
Crépet A and Tressou J, 2011. Bayesian nonparametric model for clustering individual co-exposure to pesticides found in the French diet. Bayesian Analysis, 6, 127–144.
-
(2011)
Bayesian Analysis
, vol.6
, pp. 127-144
-
-
Crépet, A.1
Tressou, J.2
-
16
-
-
76849112754
-
Combined Actions and Interactions of Chemicals in Mixtures
-
Fødevare Rapport
-
Danish Environmental Protection Agency & Danish Veterinary and Food Administration, 2003. Combined Actions and Interactions of Chemicals in Mixtures. The Toxicological Effects of Exposure to Mixtures of Industrial and Environmental Chemicals,Fødevare Rapport:12.
-
(2003)
The Toxicological Effects of Exposure to Mixtures of Industrial and Environmental Chemicals
, pp. 12
-
-
-
18
-
-
0141458234
-
Characterisation of the pharmacokinetics of gasoline using PBPK modeling with a complex mixtures chemical lumping approach
-
Dennison JE, Andersen ME and Yang RS, 2003. Characterisation of the pharmacokinetics of gasoline using PBPK modeling with a complex mixtures chemical lumping approach. Inhalation Toxicology, 15, 961–986.
-
(2003)
Inhalation Toxicology
, vol.15
, pp. 961-986
-
-
Dennison, J.E.1
Andersen, M.E.2
Yang, R.S.3
-
19
-
-
84934439491
-
Population effects and variability
-
Dorne JL, Amzal B, Bois F, Crépet A, Tressou J and Verger P, 2012. Population effects and variability. Methods in Molecular Biology, 929, 521–581.
-
(2012)
Methods in Molecular Biology
, vol.929
, pp. 521-581
-
-
Dorne, J.L.1
Amzal, B.2
Bois, F.3
Crépet, A.4
Tressou, J.5
Verger, P.6
-
20
-
-
68949086430
-
Combining analytical techniques, exposure assessment and biological effects for risk assessment of chemicals in food
-
Dorne JLCM, Bordajandi LR, Amzal B, Ferrari P and Verger P, 2009. Combining analytical techniques, exposure assessment and biological effects for risk assessment of chemicals in food. Trac-Trends Anal. Chem. 28, 695–707.
-
(2009)
Trac-Trends Anal. Chem
, vol.28
, pp. 695-707
-
-
Dorne, J.L.C.M.1
Bordajandi, L.R.2
Amzal, B.3
Ferrari, P.4
Verger, P.5
-
32
-
-
85060723513
-
Opinion of the Scientific Committee on a request from EFSA related to a harmonised approach for risk Assessment of substances which are both genotoxic and carcinogenic
-
EFSA Scientific Committee, 2005a. Opinion of the Scientific Committee on a request from EFSA related to a harmonised approach for risk Assessment of substances which are both genotoxic and carcinogenic. The EFSA Journal 2005, 282, 1–31. doi:10.2903/j.efsa.2005.282
-
(2005)
The EFSA Journal 2005
, vol.282
, pp. 1-31
-
-
-
33
-
-
85074865782
-
Scientific opinion on a request from the Commission related to the presence of non dioxin-like polychlorinated biphenyls (PCB) in feed and food
-
EFSA Panel on Contaminants in the Food Chain (CONTAM), 2005b. Scientific opinion on a request from the Commission related to the presence of non dioxin-like polychlorinated biphenyls (PCB) in feed and food. The EFSA Journal 2005, 284, 1–137. doi:10.2903/j.efsa.2005.284.
-
(2005)
The EFSA Journal 2005
, vol.284
, pp. 1-137
-
-
-
34
-
-
44749086017
-
Guidance of the Scientific Committee on a request from EFSA related to Uncertainties in Dietary Exposure Assessment
-
EFSA Scientific Committee, 2006. Guidance of the Scientific Committee on a request from EFSA related to Uncertainties in Dietary Exposure Assessment. The EFSA Journal 2006, 438, 1–54. doi:10.2903/j.efsa.2006.438
-
(2006)
The EFSA Journal 2006
, vol.438
, pp. 1-54
-
-
-
36
-
-
85072680785
-
Scientific opinion related to the potential increase of consumer health risk by a possible increase of the existing maximum levels for aflatoxins in almonds, hazelnuts and pistachios and derived products
-
EFSA Panel on Contaminants in the Food Chain (CONTAM), 2007b. Scientific opinion related to the potential increase of consumer health risk by a possible increase of the existing maximum levels for aflatoxins in almonds, hazelnuts and pistachios and derived products. The EFSA Journal 2007, 446, 1–127. doi:10.2903/j.efsa.2007.446
-
(2007)
The EFSA Journal 2007
, vol.446
, pp. 1-127
-
-
-
37
-
-
85073224094
-
Scientific Opinion on a request from the EFSA evaluate the suitability of existing methodologies and, if appropriate, the identification of new approaches to assess cumulative and synergistic risks from pesticides to human health with a view to set MRLs for those pesticides in the frame of Regulation (EC) 396/2005
-
EFSA Panel on Plant Protection Products and their Residues (PPR), 2008a. Scientific Opinion on a request from the EFSA evaluate the suitability of existing methodologies and, if appropriate, the identification of new approaches to assess cumulative and synergistic risks from pesticides to human health with a view to set MRLs for those pesticides in the frame of Regulation (EC) 396/2005. The EFSA Journal 2008, 704, 1–85. doi:10.2903/j.efsa.2008.705
-
(2008)
The EFSA Journal 2008
, vol.704
, pp. 1-85
-
-
-
38
-
-
70849096709
-
Scientific Opinion on a request from the European Commission on Polycyclic Aromatic Hydrocarbons in Food
-
EFSA Panel on Contaminants in the Food Chain (CONTAM), 2008b. Scientific Opinion on a request from the European Commission on Polycyclic Aromatic Hydrocarbons in Food. The EFSA Journal 2008, 724, 1–114. doi:10.2903/j.efsa.2008.724
-
(2008)
The EFSA Journal 2008
, vol.724
, pp. 1-114
-
-
-
39
-
-
84938688212
-
Scientific Opinion on risk assessment for a selected group of pesticides from the triazole group to test possible methodologies to assess cumulative effects from exposure throughout food from these pesticides on human health on request of EFSA
-
2009;,)1167
-
EFSA Panel on Plant Protection Products and their Residues (PPR), 2009a. Scientific Opinion on risk assessment for a selected group of pesticides from the triazole group to test possible methodologies to assess cumulative effects from exposure throughout food from these pesticides on human health on request of EFSA. EFSA Journal 2009;7(9):1167, 104 pp. doi:10.2903/j.efsa.2009.1167
-
(2009)
EFSA Journal
, vol.7
, Issue.9
, pp. 104
-
-
-
40
-
-
77149171287
-
Use of the benchmark dose approach in risk assessment. Guidance of the Scientific Committee
-
EFSA Scientific Committee, 2009b. Use of the benchmark dose approach in risk assessment. Guidance of the Scientific Committee. The EFSA Journal 2009, 1150, 1–72. doi:10.2903/j.efsa.2009.1150
-
(2009)
The EFSA Journal 2009
, vol.1150
, pp. 1-72
-
-
-
41
-
-
68949089361
-
Scientific Opinion on a request from the European Commission on Marine Biotoxins in Shellfish – Saxitoxin Group
-
EFSA Panel on Contaminants in the Food Chain (CONTAM), 2009c. Scientific Opinion on a request from the European Commission on Marine Biotoxins in Shellfish – Saxitoxin Group. The EFSA Journal 2009, 1019, 1–76. doi:10.2903/j.efsa.2009.1019
-
(2009)
The EFSA Journal 2009
, vol.1019
, pp. 1-76
-
-
-
42
-
-
77956341549
-
Scientific Opinion of the Panel on Contaminants in the Food Chain on a request from the European Commission on marine biotoxins in shellfish – pectenotoxin group
-
EFSA Panel on Contaminants in the Food Chain (CONTAM), 2009d. Scientific Opinion of the Panel on Contaminants in the Food Chain on a request from the European Commission on marine biotoxins in shellfish – pectenotoxin group. The EFSA Journal 2009, 1109, 1–47. doi:10.2903/j.efsa.2009.1109
-
(2009)
The EFSA Journal 2009
, vol.1109
, pp. 1-47
-
-
-
43
-
-
85078380150
-
Application of systematic review methodology to food and feed safety assessments to support decision making
-
2010;,)1637
-
EFSA (European Food Safety Authority), 2010. Application of systematic review methodology to food and feed safety assessments to support decision making. EFSA Journal 2010;8(6):1637, 90 pp. doi:10.2903/j.efsa.2010.1637
-
(2010)
EFSA Journal
, vol.8
, Issue.6
, pp. 90
-
-
-
44
-
-
85077752327
-
Use of the EFSA Comprehensive European Food Consumption Database in Exposure Assessment
-
2011a.,)2097
-
EFSA (European Food Safety Authority), 2011a. Use of the EFSA Comprehensive European Food Consumption Database in Exposure Assessment. EFSA Journal (2011);9(3):2097, 34 pp. doi:10.2903/j.efsa.2011.2097
-
(2011)
EFSA Journal
, vol.9
, Issue.3
, pp. 34
-
-
-
45
-
-
85078390238
-
Scientific Opinion on Hexabromocyclododecanes (HBCDDs) in Food
-
2011b.,)2296
-
EFSA Panel on Contaminants in the Food Chain (CONTAM), 2011b. Scientific Opinion on Hexabromocyclododecanes (HBCDDs) in Food. EFSA Journal (2011);9(7):2296, 118 pp. doi:10.2903/j.efsa.2011.2296
-
(2011)
EFSA Journal
, vol.9
, Issue.7
, pp. 118
-
-
-
46
-
-
85021255713
-
Scientific Opinion on the science behind the development of a risk assessment of Plant Protection Products on bees (Apis mellifera, Bombus spp. and solitary bees)
-
2012a.,)2668
-
EFSA Panel on Plant Protection Products and their Residues (PPR), 2012a. Scientific Opinion on the science behind the development of a risk assessment of Plant Protection Products on bees (Apis mellifera, Bombus spp. and solitary bees). EFSA Journal (2012);10(5):2668, 275 pp. doi:10.2903/j.efsa.2012.2668
-
(2012)
EFSA Journal
, vol.10
, Issue.5
, pp. 275
-
-
-
47
-
-
85029364146
-
Guidance on the Use of Probabilistic Methodology for Modelling Dietary Exposure to Pesticide Residues
-
2012;,)2839
-
EFSA (European Food Safety Authority), 2012b. Guidance on the Use of Probabilistic Methodology for Modelling Dietary Exposure to Pesticide Residues. EFSA Journal 2012;10(10):2839, 95 pp. doi:10.2903/j.efsa.2012.2839
-
(2012)
EFSA Journal
, vol.10
, Issue.10
, pp. 95
-
-
-
48
-
-
85078396636
-
Scientific Opinion on Mineral Oil Hydrocarbons in Food
-
2012;,)2704
-
EFSA Panel on Contaminants in the Food Chain (CONTAM), 2012c. Scientific Opinion on Mineral Oil Hydrocarbons in Food. EFSA Journal 2012;10(6):2704, 185 pp. doi:10.2903/j.efsa.2012.2704
-
(2012)
EFSA Journal
, vol.10
, Issue.6
, pp. 185
-
-
-
49
-
-
84911380135
-
Scientific Opinion on Pyrrolizidine alkaloids in food and feed
-
2011;,)2406
-
EFSA Panel on Contaminants in the Food Chain (CONTAM), 2012d. Scientific Opinion on Pyrrolizidine alkaloids in food and feed. EFSA Journal 2011;9(11):2406, 134 pp. doi:10.2903/j.efsa.
-
(2012)
EFSA Journal
, vol.9
, Issue.11
, pp. 134
-
-
-
50
-
-
85051284214
-
Scientific Opinion on Ergot alkaloids in food and feed
-
2012;,)2798
-
EFSA Panel on Contaminants in the Food Chain (CONTAM), 2012e. Scientific Opinion on Ergot alkaloids in food and feed. EFSA Journal 2012;10(7):2798, 158 pp. doi:10.2903/j.efsa.2012.2798
-
(2012)
EFSA Journal
, vol.10
, Issue.7
, pp. 158
-
-
-
51
-
-
84996465324
-
Guidance on selected default values to be used by the EFSA Scientific Committee, Scientific Panels and Units in the absence of actual measured data
-
2012;,), 2579. [,] doi, 10.2903/j.efsa.2012.2579
-
EFSA Scientific Committee, 2012f. Guidance on selected default values to be used by the EFSA Scientific Committee, Scientific Panels and Units in the absence of actual measured data. EFSA Journal 2012;10(3), 2579. [32 pp.] doi, 10.2903/j.efsa.2012.2579.
-
(2012)
EFSA Journal
, vol.10
, Issue.3
, pp. 32
-
-
-
52
-
-
85073993018
-
Scientific Opinion on the applicability of the Margin of Exposure approach for the safety assessment of impurities which are both genotoxic and carcinogenic in substances added to food/feed
-
2012;,)2578
-
EFSA Scientific Committee; 2012g. Scientific Opinion on the applicability of the Margin of Exposure approach for the safety assessment of impurities which are both genotoxic and carcinogenic in substances added to food/feed. EFSA Journal 2012;10(3):2578, 5 pp. doi:10.2903/j.efsa.2012.2578.
-
(2012)
EFSA Journal
, vol.10
, Issue.3
, pp. 5
-
-
-
53
-
-
79951500920
-
PB-PK modeling of intestinal and liver enzymes and transporters in drug absorption and sequential metabolism
-
Fan J, Chen S, Chow ECY and Pang KS, 2010. PB-PK modeling of intestinal and liver enzymes and transporters in drug absorption and sequential metabolism. Current Drug Metabolism, 11, 743–61.
-
(2010)
Current Drug Metabolism
, vol.11
, pp. 743-761
-
-
Fan, J.1
Chen, S.2
Chow, E.C.Y.3
Pang, K.S.4
-
54
-
-
0004116672
-
-
Third edition, Cambridge University Press, Food Quality Protection Act of 1996; H.R. 1627 Public Law 104–170, 3 August 1996
-
Finney DJ, 1971. Probit Analysis. Third edition. Cambridge University Press. Food Quality Protection Act of 1996; H.R. 1627 Public Law 104–170, 3 August 1996.
-
(1971)
Probit Analysis
-
-
Finney, D.J.1
-
55
-
-
0020963903
-
Physiologically based pharmacokinetic modeling, principles and applications
-
Gerlowski LE and Jain RK, 1983. Physiologically based pharmacokinetic modeling, principles and applications. Journal of Pharmaceutical Sciences, 72, 1103–1127.
-
(1983)
Journal of Pharmaceutical Sciences
, vol.72
, pp. 1103-1127
-
-
Gerlowski, L.E.1
Jain, R.K.2
-
56
-
-
0034874732
-
A PBPK modelling-based approach to account for interactions in the health risk assessment of chemical mixtures
-
Haddad S, Béliveau M, Tardif R and Krishnan K, 2001. A PBPK modelling-based approach to account for interactions in the health risk assessment of chemical mixtures. Toxicological Sciences, 63, 125–131.
-
(2001)
Toxicological Sciences
, vol.63
, pp. 125-131
-
-
Haddad, S.1
Béliveau, M.2
Tardif, R.3
Krishnan, K.4
-
57
-
-
0033572851
-
Physiological modelling of the toxicokinetic interactions in a quaternary mixture of aromatic hydrocarbons
-
Haddad S, Tardif R, Charest-Tardif G and Krishnan K, 1999. Physiological modelling of the toxicokinetic interactions in a quaternary mixture of aromatic hydrocarbons. Toxicology and Applied Pharmacology, 161, 249–257.
-
(1999)
Toxicology and Applied Pharmacology
, vol.161
, pp. 249-257
-
-
Haddad, S.1
Tardif, R.2
Charest-Tardif, G.3
Krishnan, K.4
-
60
-
-
78751685748
-
Dose-response assessment of nephrotoxicity from a 7-day combined exposure to melamine and cyanuric acid in F344 rats
-
Jacob CC, Reimschuessel R, Von Tungeln LS, Olson GR, Warbritton AR, Hattan DG, Beland FA and Gamboa da Costa G, 2011. Dose-response assessment of nephrotoxicity from a 7-day combined exposure to melamine and cyanuric acid in F344 rats. Toxicological Sciences, 119, 391–397.
-
(2011)
Toxicological Sciences
, vol.119
, pp. 391-397
-
-
Jacob, C.C.1
Reimschuessel, R.2
Von Tungeln, L.S.3
Olson, G.R.4
Warbritton, A.R.5
Hattan, D.G.6
Beland, F.A.7
Gamboa da Costa, G.8
-
61
-
-
77949621618
-
Combined exposure to endocrine disrupting pesticides impairs parturition, causes pup mortality and affects sexual differentiation in rats
-
Jacobsen PR, Christiansen S, Boberg J, Nellemann C and Hass U, 2010. Combined exposure to endocrine disrupting pesticides impairs parturition, causes pup mortality and affects sexual differentiation in rats. International Journal of Andrology, 33, 434–442.
-
(2010)
International Journal of Andrology
, vol.33
, pp. 434-442
-
-
Jacobsen, P.R.1
Christiansen, S.2
Boberg, J.3
Nellemann, C.4
Hass, U.5
-
63
-
-
85078388602
-
Casarett and Doull's Toxicology, The Basic Science of Poisons, Fifth Edition. The McGraw-Hill Companies, Inc
-
Klaassen CD, 1996. Casarett and Doull's Toxicology, The Basic Science of Poisons, Fifth Edition. The McGraw-Hill Companies, Inc. New York, 8, 201–260.
-
(1996)
New York
, vol.8
, pp. 201-260
-
-
Klaassen, C.D.1
-
65
-
-
84979913846
-
Investigation of the state of the science on combined actions of chemicals in food through dissimilar modes of action and proposal for science-based approach for performing related cumulative risk assessment
-
EN-232
-
Kortenkamp A, Evans R, Faust M, Kalberlah F, Scholze M and Schuhmacher-Wolz U, 2012. Investigation of the state of the science on combined actions of chemicals in food through dissimilar modes of action and proposal for science-based approach for performing related cumulative risk assessment. EFSA External Scientific report. Supporting Publications 2012, EN-232, 233 pp.
-
(2012)
EFSA External Scientific report. Supporting Publications 2012
, pp. 233
-
-
Kortenkamp, A.1
Evans, R.2
Faust, M.3
Kalberlah, F.4
Scholze, M.5
Schuhmacher-Wolz, U.6
-
67
-
-
0036996587
-
Physiological modelling and extrapolation of pharmacokinetic interactions from binary to more complex chemical mixtures
-
Krishnan K, Haddad S, Béliveau M and Tardif R, 2002. Physiological modelling and extrapolation of pharmacokinetic interactions from binary to more complex chemical mixtures. Environmental Health Perspectives, 110 Suppl 6, 989–994.
-
(2002)
Environmental Health Perspectives
, vol.110
, pp. 989-994
-
-
Krishnan, K.1
Haddad, S.2
Béliveau, M.3
Tardif, R.4
-
68
-
-
37349006889
-
Ten years of mixing cocktails, a review of combination effects of endocrinedisrupting chemicals
-
Kortenkamp A, 2007. Ten years of mixing cocktails, a review of combination effects of endocrinedisrupting chemicals. Environmental Health Perspectives, 115, 98–105.
-
(2007)
Environmental Health Perspectives
, vol.115
, pp. 98-105
-
-
Kortenkamp, A.1
-
69
-
-
77949913992
-
Effect of in vivo nicotine exposure on chlorpyrifos pharmacokinetics and pharmacodynamics in rats
-
Lee S, Poet TS, Smith JN, Busby-Hjerpe AL and Timchalk C, 2010. Effect of in vivo nicotine exposure on chlorpyrifos pharmacokinetics and pharmacodynamics in rats. Chemical and Biological Interactions, 184(3), 449–457.
-
(2010)
Chemical and Biological Interactions
, vol.184
, Issue.3
, pp. 449-457
-
-
Lee, S.1
Poet, T.S.2
Smith, J.N.3
Busby-Hjerpe, A.L.4
Timchalk, C.5
-
71
-
-
22344452735
-
Biochemical reaction network modeling: predicting metabolism of organic chemical mixtures
-
Mayeno AN, Yang RS and Reisfeld B, 2005. Biochemical reaction network modeling: predicting metabolism of organic chemical mixtures. Environmental Science and Technology, 39, 5363–5371.
-
(2005)
Environmental Science and Technology
, vol.39
, pp. 5363-5371
-
-
Mayeno, A.N.1
Yang, R.S.2
Reisfeld, B.3
-
72
-
-
79959819248
-
Risk assessment of combined exposure to multiple chemicals, A WHO/IPCS framework
-
Meek ME, Boobis AR, Crofton KM, Heinemeyer G, Raaij MV and Vickers C, 2011. Risk assessment of combined exposure to multiple chemicals, A WHO/IPCS framework. Regulatory Toxicology and Pharmacology, 60, Supp 2, S1–S14.
-
(2011)
Regulatory Toxicology and Pharmacology
, vol.60
, pp. S1-S14
-
-
Meek, M.E.1
Boobis, A.R.2
Crofton, K.M.3
Heinemeyer, G.4
Raaij, M.V.5
Vickers, C.6
-
73
-
-
55249105682
-
Exposure to multiple chemicals, when and how to assess the risk from pesticide residues in food
-
Moretto A, 2008. Exposure to multiple chemicals, when and how to assess the risk from pesticide residues in food. Trends in Food Science & Technology, 19, S56–S63.
-
(2008)
Trends in Food Science & Technology
, vol.19
, pp. S56-S63
-
-
Moretto, A.1
-
74
-
-
0027000809
-
A weight-of-evidence scheme for assessing interactions in chemical mixtures
-
Mumtaz MM, Durkin PR, 1992. A weight-of-evidence scheme for assessing interactions in chemical mixtures. Toxicol IndusHealth, 8, 377–406.
-
(1992)
Toxicol IndusHealth
, vol.8
, pp. 377-406
-
-
Mumtaz, M.M.1
Durkin, P.R.2
-
75
-
-
84859899707
-
Existing and Developing Approaches for QSAR Analysis of Mixtures
-
Muratov EN, Victor E and Kuz'min E, 2012. Existing and Developing Approaches for QSAR Analysis of Mixtures. Molecular Informatics 31, 202–221.
-
(2012)
Molecular Informatics
, vol.31
, pp. 202-221
-
-
Muratov, E.N.1
Victor, E.2
Kuz'min, E.3
-
76
-
-
10644261949
-
-
Vol, Natl. Acad. Press, Washington, DC
-
National Research Council, 1989. Selected issues in Risk Assessment. Part II, Mixtures (Drinking Water and Health). Vol 9, pp.95–184. Natl. Acad. Press Washington, DC.
-
(1989)
Selected issues in Risk Assessment. Part II, Mixtures (Drinking Water and Health)
, vol.9
, pp. 95-184
-
-
-
78
-
-
84969859743
-
-
External Scientific Report submitted to EFSA
-
Nielsen E, Nørhede P, Boberg J, Krag Isling L, Kroghsbo S, Hadrup N, Bredsdorff L, Mortensen and Larsen JC, 2012. Identification of Cumulative Assessment Groups of Pesticides. External Scientific Report submitted to EFSA, 303 pp.
-
(2012)
Identification of Cumulative Assessment Groups of Pesticides
, pp. 303
-
-
Nielsen, E.1
Nørhede, P.2
Boberg, J.3
Krag Isling, L.4
Kroghsbo, S.5
Hadrup, N.6
Bredsdorff, L.7
Mortensen8
Larsen, J.C.9
-
81
-
-
70350491293
-
Characterising the Noncancer Toxicity of Mixtures Using Concepts from the TTC and Quantitative Models of Uncertainty in Mixture Toxicity
-
Price PS, Hollnagel HM and Zahik JM, 2009. Characterising the Noncancer Toxicity of Mixtures Using Concepts from the TTC and Quantitative Models of Uncertainty in Mixture Toxicity. Risk Analysis, 29, 1534–1548.
-
(2009)
Risk Analysis
, vol.29
, pp. 1534-1548
-
-
Price, P.S.1
Hollnagel, H.M.2
Zahik, J.M.3
-
82
-
-
80052493854
-
-
Edited by, Cornelis A.M. van Gestel, Martijs Jonker, Jan E. Kammenga, Ryszard Laskowski, Claus Svendsen CRC Press Inc
-
Ragas AMJ, Teuschler LK, Posthuma L and Cowan C, 2010. Human and ecological risk assessment of chemical mixtures in Mixture toxicity - linking approaches from ecological and human toxicology(2010) Edited by Cornelis A.M. van Gestel, Martijs Jonker, Jan E. Kammenga, Ryszard Laskowski, Claus Svendsen CRC Press Inc, 157–215.
-
(2010)
Human and ecological risk assessment of chemical mixtures in Mixture toxicity - linking approaches from ecological and human toxicology(2010)
, pp. 157-215
-
-
Ragas, A.M.J.1
Teuschler, L.K.2
Posthuma, L.3
Cowan, C.4
-
83
-
-
76849102385
-
Risk assessment of mixtures of pesticides, Current approaches and future strategies
-
Refstrup TK Larsen CJ and Meyer O, 2010. Risk assessment of mixtures of pesticides, Current approaches and future strategies. Regulatory toxicology and Pharmacology, 56, 174–192.
-
(2010)
Regulatory toxicology and Pharmacology
, vol.56
, pp. 174-192
-
-
Refstrup, T.K.1
Larsen, C.J.2
Meyer, O.3
-
84
-
-
0021234661
-
Physiologic pharmacokinetic models, relevance, experience, and future trends. Drug Metabolism
-
Rowland M, 1984. Physiologic pharmacokinetic models, relevance, experience, and future trends. Drug Metabolism. Reviews, 15, 55–74.
-
(1984)
Reviews
, vol.15
, pp. 55-74
-
-
Rowland, M.1
-
85
-
-
84863309869
-
Considering the cumulative risk of mixtures of chemicals - a challenge for policy makers
-
Sarigiannis DA and Hansen U, 2012. Considering the cumulative risk of mixtures of chemicals - a challenge for policy makers. Environ Health. 28;11 (Suppl 1), S18.
-
(2012)
Environ Health
, vol.28
, Issue.11
, pp. S18
-
-
Sarigiannis, D.A.1
Hansen, U.2
-
86
-
-
84856380055
-
Bayesian Analysis of a Lipid-Based Physiologically Based Toxicokinetic Model for a Mixture of PCBs in Rats
-
Sasso AF, Georgopoulos PG, Isukapalli SS and Krishnan K, 2012. Bayesian Analysis of a Lipid-Based Physiologically Based Toxicokinetic Model for a Mixture of PCBs in Rats. Journal of Toxicology, 2012, 895391.
-
(2012)
Journal of Toxicology
, vol.2012
, pp. 895391
-
-
Sasso, A.F.1
Georgopoulos, P.G.2
Isukapalli, S.S.3
Krishnan, K.4
-
87
-
-
84868636432
-
-
Availableo online
-
SCCS, SCENHIR, SCHER, 2012. Toxicity and Assessment of Chemical Mixtures. 50 pp. Availableo online: ec.europa.eu/health/scientific_committees/environmental_risks/docs/scher_o_155.pdf.
-
(2012)
Toxicity and Assessment of Chemical Mixtures
, pp. 50
-
-
-
88
-
-
82655174947
-
Toxicokinetics and Toxicodynamics
-
Eds, van Gestel CAM, Jonker M, Kammenga JE, Laskowski R, Svendsen C, CRC Press Inc
-
Svendsen C, Jager T, Haddad S, Yang RSH, Dorne JLCM, Broerse M and Kramarz, P, 2010. Toxicokinetics and Toxicodynamics, in Mixture Toxicity Linking Approaches from Ecological and Human Toxicology Eds van Gestel CAM, Jonker M, Kammenga JE, Laskowski R and Svendsen C. CRC Press Inc., 36–66.
-
(2010)
Mixture Toxicity Linking Approaches from Ecological and Human Toxicology
, pp. 36-66
-
-
Svendsen, C.1
Jager, T.2
Haddad, S.3
Yang, R.S.H.4
Dorne, J.L.C.M.5
Broerse, M.6
Kramarz, P.7
-
89
-
-
1942467869
-
A feasibility study of cumulative risk assessment methods for drinking water disinfection by-product mixtures
-
Teuschler LK, Rice GE, Wilkes CR, Lipscomb JC and Power FW, 2004. A feasibility study of cumulative risk assessment methods for drinking water disinfection by-product mixtures. Journal of Toxicolology and Environmental Health A, 67(8–10),755–777.
-
(2004)
Journal of Toxicolology and Environmental Health A
, vol.67
, Issue.8-10
, pp. 755-777
-
-
Teuschler, L.K.1
Rice, G.E.2
Wilkes, C.R.3
Lipscomb, J.C.4
Power, F.W.5
-
90
-
-
34548411440
-
Deciding which chemical mixtures risk assessment methods work best for what mixtures
-
Teuschler L, 2007. Deciding which chemical mixtures risk assessment methods work best for what mixtures. Toxicology and Applied Pharmacology, 223, 139–147.
-
(2007)
Toxicology and Applied Pharmacology
, vol.223
, pp. 139-147
-
-
Teuschler, L.1
-
91
-
-
44649149558
-
Development of a physiologically based pharmacokinetic and pharmacodynamic model to determine dosimetry and cholinesterase inhibition for a binary mixture of chlorpyrifos and diazinon in the rat
-
Timchalk C and Poet TS, 2008. Development of a physiologically based pharmacokinetic and pharmacodynamic model to determine dosimetry and cholinesterase inhibition for a binary mixture of chlorpyrifos and diazinon in the rat. Neurotoxicology, 29(3), 428–443.
-
(2008)
Neurotoxicology
, vol.29
, Issue.3
, pp. 428-443
-
-
Timchalk, C.1
Poet, T.S.2
-
93
-
-
0004044828
-
-
29 January 1999., Office of Pesticide Programs, Office of Prevention, PesticidesToxic Substances, Washington, D.C
-
US-EPA (U.S. Environmental Protection Agency), 1999. Guidance for Identifying Pesticide Chemicals and Other Substances That Have a Common Mechanism of Toxicity. 29 January 1999. Office of Pesticide Programs, Office of Prevention, Pesticides, and Toxic Substances, Washington, D.C.
-
(1999)
Guidance for Identifying Pesticide Chemicals and Other Substances That Have a Common Mechanism of Toxicity
-
-
-
95
-
-
0142201686
-
-
14 November 2001., Office of Pesticide Programs, Office of Prevention, PesticidesToxic Substances, Washington, DC
-
US-EPA (U.S. Environmental Protection Agency), 2001. General Principles For Performing Aggregate Exposure And Risk Assessments. 14 November 2001. Office of Pesticide Programs, Office of Prevention, Pesticides, and Toxic Substances. Washington, DC.
-
(2001)
General Principles For Performing Aggregate Exposure And Risk Assessments
-
-
-
96
-
-
0142042669
-
-
14 January 2001., Office of Pesticide Programs, Office of Prevention, PesticidesToxic Substances, Washington, DC
-
US-EPA (U.S. Environmental Protection Agency), 2002. Guidance on Cumulative Risk Assessment of Pesticide Chemicals That Have a Common Mechanism of Toxicity. 14 January 2001. Office of Pesticide Programs, Office of Prevention, Pesticides, and Toxic Substances. Washington, DC.
-
(2002)
Guidance on Cumulative Risk Assessment of Pesticide Chemicals That Have a Common Mechanism of Toxicity
-
-
-
97
-
-
10944269639
-
-
EPA/630/P-02/001F May 2003
-
US-EPA (U.S. Environmental Protection Agency), 2003. Framework for cumulative risk assessment. EPA/630/P-02/001F May 2003.
-
(2003)
Framework for cumulative risk assessment
-
-
-
98
-
-
55349126032
-
-
31 July 2006., Office of Pesticide Programs, Office of Prevention, PesticidesToxic Substances, Washington, DC
-
US-EPA (U.S. Environmental Protection Agency), 2006a. Organophosphorus Cumulative Risk Assessment – 2006 Update. 31 July 2006. Office of Pesticide Programs, Office of Prevention, Pesticides, and Toxic Substances. Washington, DC.
-
(2006)
Organophosphorus Cumulative Risk Assessment – 2006 Update
-
-
-
99
-
-
85078389858
-
-
Office of Pesticide Programs, Office of Prevention, PesticidesToxic Substances, Washington, DC
-
US-EPA (U.S. Environmental Protection Agency), 2006b. Triazine Cumulative Risk Assessment. 28 March 2006. Office of Pesticide Programs, Office of Prevention, Pesticides, and Toxic Substances. Washington, DC.
-
(2006)
Triazine Cumulative Risk Assessment. 28 March 2006
-
-
-
100
-
-
76849116212
-
-
Office of Pesticide Programs, Office of Prevention, PesticidesToxic Substances, Washington, DC
-
US-EPA (U.S. Environmental Protection Agency), 2006c. Cumulative Risk From Chloroacetanilide Pesticides. 8 March 2006. Office of Pesticide Programs, Office of Prevention, Pesticides, and Toxic Substances. Washington, DC.
-
(2006)
Cumulative Risk From Chloroacetanilide Pesticides. 8 March 2006
-
-
-
102
-
-
85078367960
-
-
Office of Pesticide Programs, Office of Prevention, PesticidesToxic Substances, Washington, DC
-
US-EPA (U.S. Environmental Protection Agency), 2007b. Revised N-Methyl Carbamate Cumulative Risk Assessment. 24 September 2007. Office of Pesticide Programs, Office of Prevention, Pesticides, and Toxic Substances. Washington, DC.
-
(2007)
Revised N-Methyl Carbamate Cumulative Risk Assessment. 24 September 2007
-
-
-
104
-
-
84901946386
-
-
4 October 2007., Office of Pesticide Programs, Office of Prevention, PesticidesToxic Substances, Washington, DC
-
US-EPA (U.S. Environmental Protection Agency), 2011. Pyrethrins/Pyrethroid Cumulative Risk Assessment. 4 October 2007. Office of Pesticide Programs, Office of Prevention, Pesticides, and Toxic Substances. Washington, DC.
-
(2011)
Pyrethrins/Pyrethroid Cumulative Risk Assessment
-
-
-
105
-
-
0032449610
-
Toxic Equivalency Factors (TEFs) for PCBs, PCDDs, PCDFs for humans and wildlife
-
Van den Berg M, Birnbaum L, Bosveld ATC, Brunström B, Cook P, Feeley M, Giesy JP, Hanberg A, Hasegawa R, Kennedy SW, Kubiak T, Larsen JC, Leeuwen FXR, Liem AKD, Nolt C, Peterson RE, Poellinger L, Safe S, Schrenk D, Tillitt D, Tysklind M, Younes M, Wærn F and Zacharewski T, 1998. Toxic Equivalency Factors (TEFs) for PCBs, PCDDs, PCDFs for humans and wildlife. Environmental Health Perspectives, 106, 775–792.
-
(1998)
Environmental Health Perspectives
, vol.106
, pp. 775-792
-
-
Van den Berg, M.1
Birnbaum, L.2
Bosveld, A.T.C.3
Brunström, B.4
Cook, P.5
Feeley, M.6
Giesy, J.P.7
Hanberg, A.8
Hasegawa, R.9
Kennedy, S.W.10
Kubiak, T.11
Larsen, J.C.12
Leeuwen, F.X.R.13
Liem, A.K.D.14
Nolt, C.15
Peterson, R.E.16
Poellinger, L.17
Safe, S.18
Schrenk, D.19
Tillitt, D.20
Tysklind, M.21
Younes, M.22
Wærn, F.23
Zacharewski, T.24
more..
-
106
-
-
33748751381
-
The 2005 World Health Organization reevaluation Dioxins and DL-PCBs in foods for infants and young children of human and mammalian toxic equivalency factors for dioxins and dioxin-like compounds
-
Van den Berg M, Birnbaum LS, Denison M, De Vito M, Farland W, Feeley M, Fiedler H, Hakansson H, Hanberg A, Haws L, Rose M, Safe S, Schrenk D, Tohyama C, Tritscher A, Tuomisto J, Tysklind M, Walker N and Peterson RE, 2006. The 2005 World Health Organization reevaluation Dioxins and DL-PCBs in foods for infants and young children of human and mammalian toxic equivalency factors for dioxins and dioxin-like compounds. Toxicological Sciences, 93, 223–241.
-
(2006)
Toxicological Sciences
, vol.93
, pp. 223-241
-
-
Van den Berg, M.1
Birnbaum, L.S.2
Denison, M.3
De Vito, M.4
Farland, W.5
Feeley, M.6
Fiedler, H.7
Hakansson, H.8
Hanberg, A.9
Haws, L.10
Rose, M.11
Safe, S.12
Schrenk, D.13
Tohyama, C.14
Tritscher, A.15
Tuomisto, J.16
Tysklind, M.17
Walker, N.18
Peterson, R.E.19
-
107
-
-
0030970186
-
A proposed approach to study the toxicology of complex mixtures of petroleum products: the integrated use of QSAR, lumping analysis and PBPK/PD modeling
-
Verhaar HJ, Morroni JR, Reardon KF, Hays SM, Gaver DP Jr, Carpenter RL and Yang RS, 1997. A proposed approach to study the toxicology of complex mixtures of petroleum products: the integrated use of QSAR, lumping analysis and PBPK/PD modeling. Environmental Health Perspectives, 105 Suppl 1:179–195.
-
(1997)
Environmental Health Perspectives
, vol.105
, pp. 179-195
-
-
Verhaar, H.J.1
Morroni, J.R.2
Reardon, K.F.3
Hays, S.M.4
Gaver, D.P.5
Carpenter, R.L.6
Yang, R.S.7
-
108
-
-
84960428197
-
Norwegian Scientific Committee for Food Safety
-
Report., Available online
-
VKM, 2008. Norwegian Scientific Committee for Food Safety. Combined toxic effects of multiple chemical exposures. Report.105 pp. Available online: vkm.no/dav/15ec300082.pdf.
-
(2008)
Combined toxic effects of multiple chemical exposures
, pp. 105
-
-
-
109
-
-
84858299749
-
An in silico approach for evaluating a fraction-based, risk assessment method for total petroleum hydrocarbon mixtures
-
Epub 2012 Feb 8
-
Wang NC, Rice GE, Teuschler LK, Colman J and Yang RS, 2012. An in silico approach for evaluating a fraction-based, risk assessment method for total petroleum hydrocarbon mixtures. Journal of Toxicology, 2012, 410143. doi:10.1155/2012/410143. Epub 2012 Feb 8.
-
(2012)
Journal of Toxicology
, vol.2012
, pp. 410143
-
-
Wang, N.C.1
Rice, G.E.2
Teuschler, L.K.3
Colman, J.4
Yang, R.S.5
-
110
-
-
0003428543
-
-
WHO European Centre for Environmental Health and International Programme on Chemical Safety. World Health Organization, Geneva, Available online
-
WHO (World Health Organization), 1998. Executive summary. Assessment of the health risk of dioxins: re-evaluation of the Tolerable Daily Intake (TDI). WHO Consultation May 25–29 1998, Geneva, Switzerland. WHO European Centre for Environmental Health and International Programme on Chemical Safety. World Health Organization, Geneva, 28 pp. Available online: www.who.int/ipcs/publications/en/exe-sum-final.pdf.
-
(1998)
Executive summary. Assessment of the health risk of dioxins: re-evaluation of the Tolerable Daily Intake (TDI). WHO Consultation May 25–29 1998, Geneva, Switzerland
, pp. 28
-
-
-
114
-
-
85058656863
-
Toxicological data analysis to support grouping of pesticide active substances for cumulative risk assessment of effects on liver, on the nervous system and on reproduction and development
-
EN-392
-
Wolterink G, Van Kesteren P, Mahieu K, Van de Ven B, Ossendorp B, Laura Ruggeri, Luca Tosti, Francesca Metruccio, Schlitt C, Moretto A, Printemps N, Gouze M-E, Charles S, Angeli K, Fastier A and Mercier T, 2013. Toxicological data analysis to support grouping of pesticide active substances for cumulative risk assessment of effects on liver, on the nervous system and on reproduction and development. Supporting Publications 2013:EN-392, 88 pp.
-
(2013)
Supporting Publications
, vol.2013
, pp. 88
-
-
Wolterink, G.1
Van Kesteren, P.2
Mahieu, K.3
Van de Ven, B.4
Ossendorp, B.5
Ruggeri, L.6
Tosti, L.7
Metruccio, F.8
Schlitt, C.9
Moretto, A.10
Printemps, N.11
Gouze, M.-E.12
Charles, S.13
Angeli, K.14
Fastier, A.15
Mercier, T.16
-
115
-
-
0029090599
-
The application of physiologically based pharmacokinetic/pharmacodynamic (PBPK/PD) modeling for exploring risk assessment approaches of chemical mixtures
-
Yang RS, El-Masri HA, Thomas RS, Constan AA and Tessari JD, 1995. The application of physiologically based pharmacokinetic/pharmacodynamic (PBPK/PD) modeling for exploring risk assessment approaches of chemical mixtures. Toxicology Letters, 79(1–3), 193–200.
-
(1995)
Toxicology Letters
, vol.79
, Issue.1-3
, pp. 193-200
-
-
Yang, R.S.1
El-Masri, H.A.2
Thomas, R.S.3
Constan, A.A.4
Tessari, J.D.5
|