Deciding which chemical mixtures risk assessment methods work best for what mixtures

Toxicology and Applied Pharmacology

Volumn 223, Issue 2, 2007, Pages 139-147

  Teuschler, Linda K ^a  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

Additivity; Chemical mixtures risk assessment; Sufficient similarity; Toxicological interactions

Indexed keywords

DRINKING WATER; ENVIRONMENTAL CHEMICAL; HYDROCARBON; ORGANOPHOSPHORUS COMPOUND; PESTICIDE; TOXIC SUBSTANCE;

ARTICLE; CHEMICAL COMPOSITION; ENVIRONMENTAL EXPOSURE; ENZYME PHOSPHORYLATION; FOOD QUALITY; GAS CHROMATOGRAPHY; HEALTH HAZARD; MASS SPECTROMETRY; MATHEMATICAL MODEL; PRACTICE GUIDELINE; RISK ASSESSMENT; TECHNOLOGY; TOXICITY; WATER QUALITY;

ALGORITHMS; ANIMALS; DECISION MAKING; ENVIRONMENTAL EXPOSURE; FOOD CONTAMINATION; HUMANS; RISK ASSESSMENT; TOXINS, BIOLOGICAL;

EID: 34548411440     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2006.07.010     Document Type: Article

References (31)

1. ATSDR. Guidance Manual for the Assessment of Joint Toxic Action of Chemical Mixtures. Atlanta: Agency for Toxic Substances and Disease Registry, US Department of Health and Human Services (2002)
2. Chen J.J., Chen Y.J., Rice G., Teuschler L.K., Hamernik K., Protzel A., and Kodell R.L. Using dose addition to estimate cumulative risks from exposures to multiple chemicals. Regul. Toxicol. Pharmacol. 34 1 (2001) 35-41
3. Chen J.J., Chen Y.J., Teuschler L.K., Rice G., Hamernik K., Protzel A., and Kodell R.L. Cumulative risk assessment for quantitative response data. Environmetrics 14 (2003) 339-353
4. Eide I., Neverdal G., Thorvaldsen B., Grung B., and Kvalheim O.M. Toxicological evaluation of complex mixtures by pattern recognition: correlating chemical fingerprints to mutagenicity. Environ. Health Perspect. 110 6 (2002) 985-988
5. Feron V.J., and Groten J.P. Toxicological evaluation of chemical mixtures. Food Chem. Toxicol. 40 (2002) 825-839
6. Haddad S., Be'liveau M., Tardif R., and Krishnan K. A PBPK modeling-based approach to account for interactions in the health risk assessment of chemical mixtures. Toxicol. Sci. 63 (2001) 125-131
7. Hertzberg R.C., and Teuschler L.K. Evaluating quantitative formulas for dose-response assessment of chemical mixtures. Environ. Health Perspect. 110 6 (2002) 965-970
8. IPCS, 2005. IPCS framework for analyzing the relevance of a cancer mode of action for humans. Public Review Draft. April. Available at: http://www.who.int/ipcs/methods/harmonization/areas/frameworktextreview. pdf.
9. MADEP (Massachusetts Department of Environmental Protection), 2002. Characterizing risks posed by petroleum contaminated sites: implementation of the MADEP VPH/EPH approach. Massachusetts Department of Environmental Protection, Boston, MA. Available at http://www.mass.gov/dep/cleanup/laws/vph_eph.htm.
10. MADEP (Massachusetts Department of Environmental Protection), 2003. Updated petroleum hydrocarbon fraction toxicity values for the VPH/EPH/APH methodology. Massachusetts Department of Environmental Protection, Boston, MA. Available at http://www.mass.gov/dep/bwsc/vph_eph.htm.
11. Meek M.E., Bucher J.R., Cohen S.M., Dellarco V., Hill R.N., Lehman-McKeeman L.D., Longfellow D.G., Pastoor T., Seed J., and Patton D.E. A framework for human relevance analysis of information on carcinogenic modes of action. Crit. Rev. Toxicol. 33 6 (2003) 591-653
12. Mileson B.E., Chambers J.E., and Chen W.L. Common mechanism of toxicity: a case study of organophosphorous pesticides. Toxicol. Sci. 41 1 (1998) 8-10
13. Mumtaz MM., and Durkin PR. A weight-of-evidence scheme for assessing interactions in chemical mixtures. Toxicol. Ind. Health 8 (1992) 377-406
14. Pohl H.R., Roney N., Wilbur S., Hansen H., and De Rosa C.T. Six interaction profiles for simple mixtures. Chemosphere 53 (2003) 183-197
15. Seed J., et al. Overview: using mode of action and life stage information to evaluate the human relevance of animal toxicity data. Crit. Rev. Toxicol. 35 (2005) 663-672
16. Simmons J.E., Richardson S.D., Speth T.F., Miltner R.J., Rice G., Schenck K., Hunter III E.S., and Teuschler L.K. Development of a research strategy for integrated technology-based toxicological and chemical evaluation of complex mixtures of drinking water disinfection byproducts. Environ. Health Perspect. 110 6 (2002) 1013-1024
17. Sonich-Mullin C., et al. IPCS conceptual framework for evaluating a mode of action for chemical carcinogenesis. Regul. Toxicol. Pharmacol. 34 (2001) 146-152
18. Teuschler L.K., Gennings C., Stiteler W.M., Hertzberg R.C., Colman J.T., Thiyagarajah A., Lipscomb J.C., Hartley W.R., and Simmons J.E. A multiple-purpose design approach to the evaluation of risks from complex mixtures of disinfection by-products (DBPs). Drug Chem. Toxicol. 23 1 (2000) 307-321 (Erratum: Drug and Chemical Toxicology. 23 (3):511)
19. Teuschler L.K., Groten J.P., Hertzberg R.C., Mumtaz M., and Rice G. Environmental chemical mixtures risk assessment: current approaches and emerging issues. Comments Toxicol. 7 5-6 (2001) 453-493
20. Teuschler L.K., Rice G.E., Wilkes C.R., Lipscomb J.C., and Power F.W. A feasibility study of cumulative risk assessment methods for drinking water disinfection by-product mixtures. J. Toxicol. Environ. Health Part A, 2004 67 (2004) 755-777
21. U.S. Congress. 1980. Title 42-The Public Health and Welfare Chapter 103. The Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA). Available at: http://www.epa.gov/epahome/laws.htm.
22. U.S. Congress, 1996a. The Food Quality Protection Act. Public Law 104-170-Aug. 3, 1996. 104th Congress. Washington, DC. Available at: http://www.epa.gov/oppfead1/fqpa/gpogate.pdf.
23. U.S. Congress. 1996b. 1996 Amendments to the Safe Drinking Water Act-Public Law 104-182 104th Congress. Washington, DC. Available at: http://www.epa.gov/safewater/sdwa/text.html.
24. U.S. EPA. Guidelines for health risk assessment of chemical mixtures. Fed. Regist. 51 185 (1986) 34014-34025
25. U.S. EPA. Risk assessment guidance for superfund. Human Health Evaluation Manual (Part A). Vol. 1 (1989) EPA/540/1-89/002
26. U.S. EPA. Supplementary Guidance for Conducting Health Risk Assessment of Chemical Mixtures (2000) EPA/630/R-00/002. ORD/NCEA. Cincinnati, Ohio.
27. U.S. EPA, 2002a. Guidance on cumulative risk assessment of pesticide chemicals that have a common mechanism of toxicity. U.S. Environmental Protection Agency, Office of Pesticide Programs, Washington, DC. Available at http://www.epa.gov/oppfead1/trac/science/cumulative_guidance.pdf.
28. U.S. EPA, 2002b. Organophosphate pesticides: revised cumulative risk assessment. Available at http://www.epa.gov/pesticides/cumulative/rra-op/.
29. U.S. EPA. Developing Relative Potency Factors for Pesticide Mixtures: Biostatistical Analyses of Joint Dose-response. U.S. Environmental Protection Agency, Office of Research and Development, National Center for Environmental Assessment, Cincinnati, OH (2003) EPA/600/R-03/052.
30. U.S. EPA, 2006. Integrated Risk Information System (IRIS). Accessed March 9, 2006. Available at http://epa.gov/iriswebp/iris/index.html.
31. Walker N.J., Crockett P.W., Nyska A., Brix A.E., Jokinen M.P., Sells D.M., Hailey J.R., Easterling M., Haseman J.K., Yin M., Wyde M.E., Bucher J.R., and Portier C.J. Dose-additive carcinogenicity of a defined mixture of "dioxin-like compounds". Environ. Health Perspect. 113 1 (2005) 43-48