메뉴 건너뛰기




Volumn 41, Issue 5, 2011, Pages 369-383

Critical analysis of literature on low-dose synergy for use in screening chemical mixtures for risk assessment

(15)  Boobis, Alan a   Budinsky, Robert b   Collie, Shanna c   Crofton, Kevin d   Embry, Michelle e   Felter, Susan f   Hertzberg, Richard g   Kopp, David g   Mihlan, Gary h   Mumtaz, Moiz i   Price, Paul b   Solomon, Keith j   Teuschler, Linda d   Yang, Raymond k   Zaleski, Rosemary l  


Author keywords

Chemical mixtures; low dose; risk assessment; synergy; TTC

Indexed keywords

ARSENIC; CHLORPYRIFOS; CIGARETTE SMOKE; DIBENZOFURAN; DIMETHYLBENZ[A]ANTHRACENE; DIMPYLATE; DIOXIN; ETHYLBENZENE; HYDROQUINONE; MALATHION; MIREX; PESTICIDE; PHENOL; PHORBOL 13 ACETATE 12 MYRISTATE; POLYCHLORINATED BIPHENYL; TOLUENE; TOXIC SUBSTANCE; XYLENE;

EID: 79955756966     PISSN: 10408444     EISSN: 15476898     Source Type: Journal    
DOI: 10.3109/10408444.2010.543655     Document Type: Review
Times cited : (140)

References (45)
  • 1
    • 79955761242 scopus 로고    scopus 로고
    • Agency for Toxic Substances and Disease Registry (ATSDR)
    • Agency for Toxic Substances and Disease Registry (ATSDR). (2004a). Assessment of joint toxic action of chemical mixtures. Available at: http://www.atsdr.cdc.gov/interactionprofles/ipga.html.
    • (2004) Assessment of Joint Toxic Action of Chemical Mixtures
  • 2
    • 50849134196 scopus 로고    scopus 로고
    • Agency for Toxic Substances and Disease Registry (ATSDR)
    • Agency for Toxic Substances and Disease Registry (ATSDR). (2004b). Interaction profle for: benzene, toluene, ethylbenzene, and xylenes. Available at: http://www.atsdr.cdc.gov/interactionprofles/ IP-btex/ip05.pdf
    • (2004) Interaction Profle For: Benzene, Toluene, Ethylbenzene, and Xylenes
  • 4
    • 40149092941 scopus 로고    scopus 로고
    • IPCS framework for analysing the relevance of a cancer mode of action for humans
    • Boobis A, et al. (2006). IPCS framework for analysing the relevance of a cancer mode of action for humans. Toxicol Lett 164(Suppl 1):S254-S255.
    • (2006) Toxicol Lett , vol.164 , Issue.SUPPL. 1
    • Boobis, A.1
  • 5
    • 0034010799 scopus 로고    scopus 로고
    • Health risk of low-dose pesticides mixtures: A review of the 1985-1998 literature on combination toxicology and health risk assessment
    • Carpy SA, Kobel W, et al. (2000). Health risk of low-dose pesticides mixtures: A review of the 1985-1998 literature on combination toxicology and health risk assessment. J Toxicol Environ Health B 3:1-25. (Pubitemid 30142353)
    • (2000) Journal of Toxicology and Environmental Health - Part B: Critical Reviews , vol.3 , Issue.1 , pp. 1-25
    • Carpy, S.A.1    Kobel, W.2    Doe, J.3
  • 6
    • 8144219718 scopus 로고    scopus 로고
    • Detecting interaction(s) and assessing the impact of component subsets in a chemical mixture using fxed-ratio mixture ray designs
    • Casey M, Gennings C, Carter JWH, Moser VC, Simmons JE. (2004). Detecting interaction(s) and assessing the impact of component subsets in a chemical mixture using fxed-ratio mixture ray designs. J Agricult Biol Environ Stat 9:339-361.
    • (2004) J Agricult Biol Environ Stat , vol.9 , pp. 339-361
    • Casey, M.1    Gennings, C.2    Carter, J.W.H.3    Moser, V.C.4    Simmons, J.E.5
  • 8
    • 0029162056 scopus 로고
    • Synergistic increase in chromosomal breakage within the euchromatin induced by an interaction of the benzene metabolites phenol and hydroquinone in mice
    • Chen H, Eastmond DA. (1995). Synergistic increase in chromosomal breakage within the euchromatin induced by an interaction of the benzene metabolites phenol and hydroquinone in mice. Carcinogenesis 16:1963-1969.
    • (1995) Carcinogenesis , vol.16 , pp. 1963-1969
    • Chen, H.1    Eastmond, D.A.2
  • 10
    • 0018079206 scopus 로고
    • Estimation of toxic hazard - A decision tree approach
    • DOI 10.1016/S0015-6264(76)80522-6
    • Cramer GM, Ford RA, Hall RL. (1978). Estimation of toxic hazard-A decision tree approach. Food Cosmet Toxicol 16: 255-276. (Pubitemid 9010193)
    • (1978) Food and Cosmetics Toxicology , vol.16 , Issue.3 , pp. 255-276
    • Cramer, G.M.1    Ford, R.A.2    Hall, R.L.3
  • 12
    • 79955768284 scopus 로고    scopus 로고
    • Available online at
    • Available online at: http://www. ehponline.org/members/2005/8195/8195. pdf.
  • 13
    • 15444364182 scopus 로고    scopus 로고
    • Evaluation of potential toxicity from co-exposure to three CNS depressants (toluene, ethylbenzene, and xylenes) under resting and working conditions using PBPK modeling
    • Dennison JE, Bigelow PL, Mumtaz MM, Andersen ME, Dobrev ID, Yang RSH. (2005). Evaluation of potential toxicity from co-exposure to three CNS depressants (toluene, ethylbenzene, and xylenes) under resting and working conditions using PBPK modeling. J Occup Environ Hyg 2:127-135.
    • (2005) J Occup Environ Hyg , vol.2 , pp. 127-135
    • Dennison, J.E.1    Bigelow, P.L.2    Mumtaz, M.M.3    Andersen, M.E.4    Dobrev, I.D.5    Yang, R.S.H.6
  • 14
    • 1542286120 scopus 로고    scopus 로고
    • Application of physiologically-based pharmacokinetic modeling to investigate the toxicological interaction between chlorpyrifos and parathion in the rat
    • DOI 10.1016/j.etap.2003.10.002, PII S1382668903001017
    • El-Masri HA, Mumtaz MM, Yushak ML. (2004) Application of physiologically based pharmacokinetic modeling to investigate the toxicological interaction between chlorpyrifos and parathion in the rat. Environ Toxicol Pharmacol 16:57-71. (Pubitemid 38314895)
    • (2004) Environmental Toxicology and Pharmacology , vol.16 , Issue.1-2 , pp. 57-71
    • El-Masri, H.A.1    Mumtaz, M.M.2    Yushak, M.L.3
  • 15
    • 55449098865 scopus 로고    scopus 로고
    • Opinion of the Scientifc Panel on Plant Protection Products and their Residues to evaluate the suitability of existing methodologies and, if appropriate, the identifcation of new approaches to assess cumulative and synergistic risks from pesticides to human health with a view to set MRLs for those pesticides in the frame of Regulation (EC) 396/20051
    • European Food Safety Authority
    • European Food Safety Authority. (2008). Opinion of the Scientifc Panel on Plant Protection Products and their Residues to evaluate the suitability of existing methodologies and, if appropriate, the identifcation of new approaches to assess cumulative and synergistic risks from pesticides to human health with a view to set MRLs for those pesticides in the frame of Regulation (EC) 396/20051. EFSA J 704:12-84.
    • (2008) EFSA J , vol.704 , pp. 12-84
  • 16
    • 0036236038 scopus 로고    scopus 로고
    • Toxicological evaluation of chemical mixtures
    • DOI 10.1016/S0278-6915(02)00021-2, PII S0278691502000212
    • Feron VJ, Groten JP. (2002). Toxicological evaluation of chemical mixtures. Food Chem Toxicol 40:825-839. (Pubitemid 34450778)
    • (2002) Food and Chemical Toxicology , vol.40 , Issue.6 , pp. 825-839
    • Feron, V.J.1    Groten, J.P.2
  • 18
    • 0022438848 scopus 로고
    • Models of hepatocarcinogenesis in the rat-Contrasts and comparisons
    • Goldsworthy TL, Hanigan MH, Pitot HC. (1986). Models of hepatocarcinogenesis in the rat-Contrasts and comparisons. CRC Crit Rev Toxicol 17:61-89.
    • (1986) CRC Crit Rev Toxicol , vol.17 , pp. 61-89
    • Goldsworthy, T.L.1    Hanigan, M.H.2    Pitot, H.C.3
  • 19
    • 0033572851 scopus 로고    scopus 로고
    • Physiological modeling of the toxicokinetic interactions in a quaternary mixture of aromatic hydrocarbons
    • DOI 10.1006/taap.1999.8803
    • Haddad S, Tardif R, Charest-Tardif G, Krishnan K. (1999). Physiological modeling of the toxicokinetic interactions in a quaternary mixture of aromatic hydrocarbons. Toxicol Appl Pharmacol 161: 249-257. (Pubitemid 30041797)
    • (1999) Toxicology and Applied Pharmacology , vol.161 , Issue.3 , pp. 249-257
    • Haddad, S.1    Tardif, R.2    Charest-Tardif, G.3    Krishnan, K.4
  • 20
    • 23244457753 scopus 로고
    • Analysis of an interaction threshold in a mixture of drugs and/or chemicals
    • Hamm AK, Carter H Jr, Gennings C. (1995). Analysis of an interaction threshold in a mixture of drugs and/or chemicals. Stat Med 24:2493-2507.
    • (1995) Stat Med , vol.24 , pp. 2493-2507
    • Hamm, A.K.1    Carter Jr., H.2    Gennings, C.3
  • 21
    • 0028179822 scopus 로고
    • Synergistic enhancement of hepatic foci development by combined treatment of rats with 10 heterocyclic amines at low doses
    • Hasegawa R, Miyata E, Futakuchi M, Hagiwara A, Nagao M, Sugimura T, Ito N. (1994). Synergistic enhancement of hepatic foci development by combined treatment of rats with 10 heterocyclic amines at low doses. Carcinogen 15:1037-1041. (Pubitemid 24156907)
    • (1994) Carcinogenesis , vol.15 , Issue.5 , pp. 1037-1041
    • Hasegawa, R.1    Miyata, E.2    Futakuchi, M.3    Hagiwara, A.4    Nagao, M.5    Sugimura, T.6    Ito, N.7
  • 22
    • 0037041199 scopus 로고    scopus 로고
    • Synergy and other ineffective mixture risk definitions
    • DOI 10.1016/S0048-9697(01)01113-5, PII S0048969701011135
    • Hertzberg RC, MacDonell MM. (2002). Synergy and other inefective mixture risk defnitions. Sci Total Environ 288:31-42. (Pubitemid 34233691)
    • (2002) Science of the Total Environment , vol.288 , Issue.1-2 , pp. 31-42
    • Hertzberg, R.C.1    MacDonell, M.M.2
  • 23
    • 0036993008 scopus 로고    scopus 로고
    • Evaluating quantitative formulas for dose-response assessment of chemical mixtures
    • Hertzberg RC, Teuschler LK. (2002). Evaluating quantitative formulas for dose-response assessment of chemical mixtures. Environ Health Perspect 110(Suppl 6):965-970. (Pubitemid 36204288)
    • (2002) Environmental Health Perspectives , vol.110 , Issue.SUPPL. 6 , pp. 965-970
    • Hertzberg, R.C.1    Teuschler, L.K.2
  • 24
    • 0031820173 scopus 로고    scopus 로고
    • Carcinogenicity of antioxidants BHA, caffeic acid, sesamol, 4-methoxyphenol and catechol at low doses, either alone or in combination, and modulation of their effects in a rat medium-term multi-organ carcinogenesis model
    • DOI 10.1093/carcin/19.1.207
    • Hirose M, Takesada Y, Tanaka H, Tamano S, Kato T, Shirai T. (1997). Carcinogenicity of antioxidants BHA, cafeic acid, sesamol, 4-methoxyphneol and catechol at low doses, either alone or in combination, and modulation of their efects in a rat medium-term multi-organ carcinogenesis model. Carcinogen 19:207-212. (Pubitemid 28376844)
    • (1998) Carcinogenesis , vol.19 , Issue.1 , pp. 207-212
    • Hirose, M.1    Takesada, Y.2    Tanaka, H.3    Tamano, S.4    Kato, T.5    Shirai, T.6
  • 25
    • 0025760019 scopus 로고
    • Enhancement of GST-P positive liver cell foci development by combined treatment of rats with fve heterocyclic amines at low doses
    • Ito N, Hasegawa R, Shirai T, Fukushima S, Hakoi K, Takaba K, et al. (1991). Enhancement of GST-P positive liver cell foci development by combined treatment of rats with fve heterocyclic amines at low doses. Carcinogenesis 12:767-772.
    • (1991) Carcinogenesis , vol.12 , pp. 767-772
    • Ito, N.1    Hasegawa, R.2    Shirai, T.3    Fukushima, S.4    Hakoi, K.5    Takaba, K.6
  • 26
    • 0032457957 scopus 로고    scopus 로고
    • Medium-term bioassays for carcinogenicity of chemical mixtures
    • Ito N, Imaida K, Hirose M, Shirai T. (1998). Medium-term bioassays for carcinogenicity of chemical mixtures. Environ Health Perspect 106(Suppl 6):1331-1336. (Pubitemid 29073875)
    • (1998) Environmental Health Perspectives , vol.106 , Issue.SUPPL. 6 , pp. 1331-1336
    • Ito, N.1    Imaida, K.2    Hirose, M.3    Shirai, T.4
  • 27
    • 79955780559 scopus 로고    scopus 로고
    • Available online at
    • Available online at: http://www. ehponline.org/members/1998/Suppl-6/1331- 1336ito/ito-full. html.
  • 28
    • 0000799553 scopus 로고
    • Assessing the toxicity of mixtures of chemicals
    • Krewski D, Franklin C, eds New York: Gordon and Breach
    • Kodell R, Pounds J. (1991). Assessing the toxicity of mixtures of chemicals. In: Krewski D, Franklin C, eds. Statistics in Toxicology. New York: Gordon and Breach, 559-591.
    • (1991) Statistics in Toxicology , pp. 559-591
    • Kodell, R.1    Pounds, J.2
  • 29
    • 0030292266 scopus 로고    scopus 로고
    • Confusion of concepts in mixture toxicology
    • DOI 10.1016/S0278-6915(97)00070-7, PII 0278691597000701
    • Könemann WH, Pieters MN. (1996). Confusion of concepts in mixture toxicology. Food Chem Toxicol 34:1025-1031. (Pubitemid 27124175)
    • (1996) Food and Chemical Toxicology , vol.34 , Issue.11-12 , pp. 1025-1031
    • Konemann, W.H.1    Pieters, M.N.2
  • 31
    • 0026695016 scopus 로고
    • Toxic efects of combined exposure to toluene and m-xylene in animals. IIII. Subchronic inhalation study
    • Korsak Z, Sokal J, Gorny R. (1992). Toxic efects of combined exposure to toluene and m-xylene in animals. IIII. Subchronic inhalation study. P J Occup Med 5:27-33.
    • (1992) P J Occup Med , vol.5 , pp. 27-33
    • Korsak, Z.1    Sokal, J.2    Gorny, R.3
  • 33
    • 34447542839 scopus 로고    scopus 로고
    • Site-specific applications of probabilistic health risk assessment: Review of the literature since 2000
    • DOI 10.1111/j.1539-6924.2007.00890.x
    • Lester RR, Green LC, Linkov I. (2007). Site-specifc applications of probabilistic health risk assessment: Review of the literature since 2000. Risk Anal 27:635-658. (Pubitemid 47064373)
    • (2007) Risk Analysis , vol.27 , Issue.3 , pp. 635-658
    • Lester, R.R.1    Green, L.C.2    Linkov, I.3
  • 34
    • 0028289181 scopus 로고
    • Synergistic interaction between the non-phorbol ester-type promoter mirex and 12-O-tetradecanoylphorbol-13-acetate in mouse skin tumor promotion
    • Meyer SA, Kim TW, Moser GJ, Monteiroriviere NA, Smart RC. (1994). Synergistic interaction between the nonphorbol ester-type promoter mirex and 12-o-tetradecanoylphorbol-13-acetate in mouse skin tumor promotion. Carcinogenesis 15:47-52. (Pubitemid 24121623)
    • (1994) Carcinogenesis , vol.15 , Issue.1 , pp. 47-52
    • Meyer, S.A.1    Kim, T.-W.2    Moser, G.J.3    Monteiro-Riviere, N.A.4    Smart, R.C.5
  • 35
    • 26944461642 scopus 로고    scopus 로고
    • Neurotoxicological and statistical analyses of a mixture of five organophosphorus pesticides using a ray design
    • DOI 10.1093/toxsci/kfi163
    • Moser VC, Casey M, Hamm A, Carter WH Jr, Simmons JE, Gennings C. (2005). Neurotoxicological and statistical analyses of a mixture of fve organophosphorus pesticides using a ray design. Toxicol Sci 86:101-115. (Pubitemid 41511355)
    • (2005) Toxicological Sciences , vol.86 , Issue.1 , pp. 101-115
    • Moser, V.C.1    Casey, M.2    Hamm, A.3    Carter Jr., W.H.4    Simmons, J.E.5    Gennings, C.6
  • 36
    • 33745617666 scopus 로고    scopus 로고
    • Neurotoxicological interactions of a five-pesticide mixture in preweanling rats
    • DOI 10.1093/toxsci/kfj189
    • Moser VC, Simmons JE, Gennings C. (2006). Neurotoxicological interactions of a fve-pesticide mixture in preweanling rats. Toxicol Sci 92:235-245. (Pubitemid 43985806)
    • (2006) Toxicological Sciences , vol.92 , Issue.1 , pp. 235-245
    • Moser, V.C.1    Simmons, J.E.2    Gennings, C.3
  • 37
    • 0027000809 scopus 로고
    • A weight-of-evidence approach for assessing interactions in chemical mixtures
    • Mumtaz MM, Durkin PR. (1992). A weight of evidence scheme for assessing interactions in chemical mixtures. Toxicol Ind Health 8:377-406. (Pubitemid 23128807)
    • (1992) Toxicology and Industrial Health , vol.8 , Issue.6 , pp. 377-406
    • Mumtaz, M.M.1    Durkin, P.R.2
  • 38
    • 0030250802 scopus 로고    scopus 로고
    • Correlation of structural class with no-observed-effect levels: A proposal for establishing a threshold of concern
    • DOI 10.1016/S0278-6915(96)00049-X, PII 027869159600049X
    • Munro I, Ford RA, Kennepohl E, Sprenger JG. (1996). Correlation of a structural class with no-observed-efect levels: A proposal for establishing a threshold of concern. Food Chem Toxicol 34:829-867. (Pubitemid 26420127)
    • (1996) Food and Chemical Toxicology , vol.34 , Issue.9 , pp. 829-867
    • Munro, I.C.1    Ford, R.A.2    Kennepohl, E.3    Sprenger, J.G.4
  • 40
    • 0029932554 scopus 로고    scopus 로고
    • Comparison of the infuence of binary mixtures versus a ternary mixture of inhaled aromatic hydrocarbons on their blood kinetics in the rat
    • Tardif R, Charest-Tardif G, Brodeur J. (1996). Comparison of the infuence of binary mixtures versus a ternary mixture of inhaled aromatic hydrocarbons on their blood kinetics in the rat. Arch Toxicol 70:405-413.
    • (1996) Arch Toxicol , vol.70 , pp. 405-413
    • Tardif, R.1    Charest-Tardif, G.2    Brodeur, J.3
  • 41
    • 0031149782 scopus 로고    scopus 로고
    • Physiologically based pharmacokinetic modeling of a ternary mixture of alkyl benzenes in rats and humans
    • DOI 10.1006/taap.1996.8096
    • Tardif R, Charest-Tardif G, Brodeur J, Krishnan K. (1997). Physiologically based pharmacokinetic modeling of a ternary mixture of alkyl benzenes in rats and humans. Toxicol Appl Pharmacol 144:120-134. (Pubitemid 27208344)
    • (1997) Toxicology and Applied Pharmacology , vol.144 , Issue.1 , pp. 120-134
    • Tardif, R.1    Charest-Tardif, G.2    Brodeur, J.3    Krishnan, K.4
  • 43
    • 84860015487 scopus 로고    scopus 로고
    • UK Committee on Carcinogenicity of Chemicals In Food, Consumer Products, and the Environment
    • UK Committee on Carcinogenicity of Chemicals In Food, Consumer Products, and the Environment (2008). Meeting minutes. Available at: http://www.iacoc.org. uk/meetings/documents/201108.pdf.
    • (2008) Meeting Minutes


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.