-
1
-
-
84885997413
-
ESC guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD: the task force on diabetes, pre-diabetes, and cardiovascular diseases of the European Society of Cardiology (ESC) and developed in collaboration with the European Association for the Study of Diabetes (EASD)
-
Rydén L, Grant PJ, Anker SD, et al. ESC guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD: the task force on diabetes, pre-diabetes, and cardiovascular diseases of the European Society of Cardiology (ESC) and developed in collaboration with the European Association for the Study of Diabetes (EASD). Eur Heart J. 2013;34:3035-3087.
-
(2013)
Eur Heart J
, vol.34
, pp. 3035-3087
-
-
Rydén, L.1
Grant, P.J.2
Anker, S.D.3
-
2
-
-
85045241847
-
CKD in diabetes: diabetic kidney disease versus nondiabetic kidney disease
-
Anders HJ, Huber TB, Isermann B, Schiffer M. CKD in diabetes: diabetic kidney disease versus nondiabetic kidney disease. Nat Rev Nephrol. 2018;14:361-377.
-
(2018)
Nat Rev Nephrol
, vol.14
, pp. 361-377
-
-
Anders, H.J.1
Huber, T.B.2
Isermann, B.3
Schiffer, M.4
-
3
-
-
84944800184
-
Empagliflozin, cardiovascular outcomes, and mortality in type 2 diabetes
-
Zinman B, Wanner C, Lachin JM, et al. Empagliflozin, cardiovascular outcomes, and mortality in type 2 diabetes. N Engl J Med. 2015;373:2117-2128.
-
(2015)
N Engl J Med
, vol.373
, pp. 2117-2128
-
-
Zinman, B.1
Wanner, C.2
Lachin, J.M.3
-
4
-
-
85034766786
-
Canagliflozin and cardiovascular and renal events in type 2 diabetes
-
Neal B, Perkovic V, Mahaffey KW, et al. Canagliflozin and cardiovascular and renal events in type 2 diabetes. N Engl J Med. 2017;377:644-657.
-
(2017)
N Engl J Med
, vol.377
, pp. 644-657
-
-
Neal, B.1
Perkovic, V.2
Mahaffey, K.W.3
-
5
-
-
85060042753
-
Dapagliflozin and cardiovascular outcomes in type 2 diabetes
-
Wiviott SD, Raz I, Bonaca MP, et al. Dapagliflozin and cardiovascular outcomes in type 2 diabetes. N Engl J Med. 2019;380:347-357.
-
(2019)
N Engl J Med
, vol.380
, pp. 347-357
-
-
Wiviott, S.D.1
Raz, I.2
Bonaca, M.P.3
-
6
-
-
84979895487
-
Empagliflozin and progression of kidney disease in type 2 diabetes
-
Wanner C, Inzucchi SE, Lachin JM, et al. Empagliflozin and progression of kidney disease in type 2 diabetes. N Engl J Med. 2016;375:323-334.
-
(2016)
N Engl J Med
, vol.375
, pp. 323-334
-
-
Wanner, C.1
Inzucchi, S.E.2
Lachin, J.M.3
-
7
-
-
85048935795
-
Canagliflozin and renal outcomes in type 2 diabetes: results from the CANVAS program randomised clinical trials
-
Perkovic V, de Zeeuw D, Mahaffey KW, et al. Canagliflozin and renal outcomes in type 2 diabetes: results from the CANVAS program randomised clinical trials. Lancet Diabetes Endocrinol. 2018;6:691-704.
-
(2018)
Lancet Diabetes Endocrinol
, vol.6
, pp. 691-704
-
-
Perkovic, V.1
de Zeeuw, D.2
Mahaffey, K.W.3
-
8
-
-
85066483412
-
Canagliflozin and renal outcomes in type 2 diabetes and nephropathy
-
Perkovic V, Jardine MJ, Neal B, et al. Canagliflozin and renal outcomes in type 2 diabetes and nephropathy. N Engl J Med. 2019;380:2295-2306.
-
(2019)
N Engl J Med
, vol.380
, pp. 2295-2306
-
-
Perkovic, V.1
Jardine, M.J.2
Neal, B.3
-
9
-
-
85065609449
-
Albuminuria-lowering effect of dapagliflozin alone and in combination with saxagliptin and effect of dapagliflozin and saxagliptin on glycaemic control in patients with type 2 diabetes and chronic kidney disease (DELIGHT): a randomised, double-blind, placebo-controlled trial
-
Pollock C, Stefánsson B, Reyner D, et al. Albuminuria-lowering effect of dapagliflozin alone and in combination with saxagliptin and effect of dapagliflozin and saxagliptin on glycaemic control in patients with type 2 diabetes and chronic kidney disease (DELIGHT): a randomised, double-blind, placebo-controlled trial. Lancet Diabetes Endocrinol. 2019;7:429-441.
-
(2019)
Lancet Diabetes Endocrinol
, vol.7
, pp. 429-441
-
-
Pollock, C.1
Stefánsson, B.2
Reyner, D.3
-
10
-
-
85067060766
-
Effects of dapagliflozin on development and progression of kidney disease in patients with type 2 diabetes: an analysis from the DECLARE-TIMI 58 randomised trial
-
Mosenzon O, Wiviott SD, Cahn A, et al. Effects of dapagliflozin on development and progression of kidney disease in patients with type 2 diabetes: an analysis from the DECLARE-TIMI 58 randomised trial. Lancet Diabetes Endocrinol. 2019;7:606-617.
-
(2019)
Lancet Diabetes Endocrinol
, vol.7
, pp. 606-617
-
-
Mosenzon, O.1
Wiviott, S.D.2
Cahn, A.3
-
11
-
-
85061348557
-
Consensus statement by the American Association of Clinical Endocrinologists and American College of Endocrinology on the comprehensive type 2 diabetes management algorithm – 2019 executive summary
-
Garber AJ, Abrahamson MJ, Barzilay JI, et al. Consensus statement by the American Association of Clinical Endocrinologists and American College of Endocrinology on the comprehensive type 2 diabetes management algorithm – 2019 executive summary. Endocr Pract. 2019;25:69-100.
-
(2019)
Endocr Pract
, vol.25
, pp. 69-100
-
-
Garber, A.J.1
Abrahamson, M.J.2
Barzilay, J.I.3
-
12
-
-
85056802117
-
Management of hyperglycemia in type 2 diabetes, 2018. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)
-
Davies MJ, D'Alessio DA, Fradkin J, et al. Management of hyperglycemia in type 2 diabetes, 2018. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetes Care. 2018;41:2669-2701.
-
(2018)
Diabetes Care
, vol.41
, pp. 2669-2701
-
-
Davies, M.J.1
D'Alessio, D.A.2
Fradkin, J.3
-
13
-
-
85058738504
-
9. Pharmacologic approaches to glycemic treatment: Standards of Medical Care in Diabetes-2019
-
American Diabetes Association. 9. Pharmacologic approaches to glycemic treatment: Standards of Medical Care in Diabetes-2019. Diabetes Care. 2019;42(suppl 1):S90-S102.
-
(2019)
Diabetes Care
, vol.42
, pp. S90-S102
-
-
-
14
-
-
64749089393
-
Inhibition of renal glucose reabsorption: a novel strategy for achieving glucose control in type 2 diabetes mellitus
-
Abdul-Ghani MA, DeFronzo RA. Inhibition of renal glucose reabsorption: a novel strategy for achieving glucose control in type 2 diabetes mellitus. Endocr Pract. 2008;14:782-790.
-
(2008)
Endocr Pract
, vol.14
, pp. 782-790
-
-
Abdul-Ghani, M.A.1
DeFronzo, R.A.2
-
15
-
-
83655193529
-
The role of the kidneys in glucose homeostasis: a new path towards normalizing glycaemia
-
DeFronzo RA, Davidson JA, Del Prato S. The role of the kidneys in glucose homeostasis: a new path towards normalizing glycaemia. Diabetes Obes Metab. 2012;14:5-14.
-
(2012)
Diabetes Obes Metab
, vol.14
, pp. 5-14
-
-
DeFronzo, R.A.1
Davidson, J.A.2
Del Prato, S.3
-
16
-
-
84893214045
-
Renal hemodynamic effect of sodium-glucose cotransporter 2 inhibition in patients with type 1 diabetes mellitus
-
Cherney DZ, Perkins BA, Soleymanlou N, et al. Renal hemodynamic effect of sodium-glucose cotransporter 2 inhibition in patients with type 1 diabetes mellitus. Circulation. 2014;129:587-597.
-
(2014)
Circulation
, vol.129
, pp. 587-597
-
-
Cherney, D.Z.1
Perkins, B.A.2
Soleymanlou, N.3
-
17
-
-
84891865819
-
Characterization of renal glucose reabsorption in response to dapagliflozin in healthy subjects and subjects with type 2 diabetes
-
DeFronzo RA, Hompesch M, Kasichayanula S, et al. Characterization of renal glucose reabsorption in response to dapagliflozin in healthy subjects and subjects with type 2 diabetes. Diabetes Care. 2013;36:3169-3176.
-
(2013)
Diabetes Care
, vol.36
, pp. 3169-3176
-
-
DeFronzo, R.A.1
Hompesch, M.2
Kasichayanula, S.3
-
18
-
-
33644688031
-
Glucose transporters in human renal proximal tubular cells isolated from the urine of patients with non-insulin-dependent diabetes
-
Rahmoune H, Thompson PW, Ward JM, Smith CD, Hong G, Brown J. Glucose transporters in human renal proximal tubular cells isolated from the urine of patients with non-insulin-dependent diabetes. Diabetes. 2005;54:3427-3434.
-
(2005)
Diabetes
, vol.54
, pp. 3427-3434
-
-
Rahmoune, H.1
Thompson, P.W.2
Ward, J.M.3
Smith, C.D.4
Hong, G.5
Brown, J.6
-
19
-
-
84891534541
-
Novel hypothesis to explain why SGLT2 inhibitors inhibit only 30-50% of filtered glucose load in humans
-
Abdul-Ghani MA, DeFronzo RA, Norton L. Novel hypothesis to explain why SGLT2 inhibitors inhibit only 30-50% of filtered glucose load in humans. Diabetes. 2013;62:3324-3328.
-
(2013)
Diabetes
, vol.62
, pp. 3324-3328
-
-
Abdul-Ghani, M.A.1
DeFronzo, R.A.2
Norton, L.3
-
20
-
-
84996486377
-
Targeting renal glucose reabsorption to treat hyperglycaemia: the pleiotropic effects of SGLT2 inhibition
-
Vallon V, Thomson SC. Targeting renal glucose reabsorption to treat hyperglycaemia: the pleiotropic effects of SGLT2 inhibition. Diabetologia. 2017;60:215-225.
-
(2017)
Diabetologia
, vol.60
, pp. 215-225
-
-
Vallon, V.1
Thomson, S.C.2
-
21
-
-
85052573575
-
The actions of SGLT2 inhibitors on metabolism, renal function and blood pressure
-
Thomas MC, Cherney DZI. The actions of SGLT2 inhibitors on metabolism, renal function and blood pressure. Diabetologia. 2018;61:2098-2107.
-
(2018)
Diabetologia
, vol.61
, pp. 2098-2107
-
-
Thomas, M.C.1
Cherney, D.Z.I.2
-
22
-
-
85044240071
-
Ertugliflozin: first global approval
-
Markham A. Ertugliflozin: first global approval. Drugs. 2018;78:513-519.
-
(2018)
Drugs
, vol.78
, pp. 513-519
-
-
Markham, A.1
-
23
-
-
84915747765
-
Dapagliflozin: a review of its use in patients with type 2 diabetes
-
Plosker GL. Dapagliflozin: a review of its use in patients with type 2 diabetes. Drugs. 2014;74:2191-2209.
-
(2014)
Drugs
, vol.74
, pp. 2191-2209
-
-
Plosker, G.L.1
-
24
-
-
84901830673
-
Canagliflozin: a review of its use in patients with type 2 diabetes mellitus
-
Plosker GL. Canagliflozin: a review of its use in patients with type 2 diabetes mellitus. Drugs. 2014;74:807-824.
-
(2014)
Drugs
, vol.74
, pp. 807-824
-
-
Plosker, G.L.1
-
25
-
-
84921937734
-
Empagliflozin: a review of its use in patients with type 2 diabetes mellitus
-
Scott LJ. Empagliflozin: a review of its use in patients with type 2 diabetes mellitus. Drugs. 2014;74:1769-1784.
-
(2014)
Drugs
, vol.74
, pp. 1769-1784
-
-
Scott, L.J.1
-
26
-
-
85019731757
-
Lower risk of heart failure and death in patients initiated on sodium-glucose cotransporter-2 inhibitors versus other glucose-lowering drugs: the CVD-REAL study (comparative effectiveness of cardiovascular outcomes in new users of sodium-glucose cotransporter-2 inhibitors)
-
Kosiborod M, Cavender MA, Fu AZ, et al. Lower risk of heart failure and death in patients initiated on sodium-glucose cotransporter-2 inhibitors versus other glucose-lowering drugs: the CVD-REAL study (comparative effectiveness of cardiovascular outcomes in new users of sodium-glucose cotransporter-2 inhibitors). Circulation. 2017;136:249-259.
-
(2017)
Circulation
, vol.136
, pp. 249-259
-
-
Kosiborod, M.1
Cavender, M.A.2
Fu, A.Z.3
-
27
-
-
85028078375
-
Cardiovascular mortality and morbidity in patients with type 2 diabetes following initiation of sodium-glucose co-transporter-2 inhibitors versus other glucose-lowering drugs (CVD-REAL Nordic): a multinational observational analysis
-
Birkeland KI, Jorgensen ME, Carstensen B, et al. Cardiovascular mortality and morbidity in patients with type 2 diabetes following initiation of sodium-glucose co-transporter-2 inhibitors versus other glucose-lowering drugs (CVD-REAL Nordic): a multinational observational analysis. Lancet Diabetes Endocrinol. 2017;5:709-717.
-
(2017)
Lancet Diabetes Endocrinol
, vol.5
, pp. 709-717
-
-
Birkeland, K.I.1
Jorgensen, M.E.2
Carstensen, B.3
-
28
-
-
85047499725
-
Cardiovascular events associated with SGLT-2 inhibitors versus other glucose-lowering drugs: the CVD-REAL 2 study
-
Kosiborod M, Lam CSP, Kohsaka S, et al. Cardiovascular events associated with SGLT-2 inhibitors versus other glucose-lowering drugs: the CVD-REAL 2 study. J Am Coll Cardiol. 2018;71:2628-2639.
-
(2018)
J Am Coll Cardiol
, vol.71
, pp. 2628-2639
-
-
Kosiborod, M.1
Lam, C.S.P.2
Kohsaka, S.3
-
29
-
-
85065971899
-
Empagliflozin and the risk of heart failure hospitalization in routine clinical care: a first analysis from the EMPRISE study
-
Patorno E, Pawar A, Franklin JM, et al. Empagliflozin and the risk of heart failure hospitalization in routine clinical care: a first analysis from the EMPRISE study. Circulation. 2019;139:2822-2830.
-
(2019)
Circulation
, vol.139
, pp. 2822-2830
-
-
Patorno, E.1
Pawar, A.2
Franklin, J.M.3
-
30
-
-
85048347907
-
Cardiovascular outcomes and risks after initiation of a sodium glucose cotransporter 2 inhibitor: results from the EASEL population-based cohort study (evidence for cardiovascular outcomes with sodium glucose cotransporter 2 inhibitors in the real world)
-
Udell JA, Yuan Z, Rush T, Sicignano NM, Galitz M, Rosenthal N. Cardiovascular outcomes and risks after initiation of a sodium glucose cotransporter 2 inhibitor: results from the EASEL population-based cohort study (evidence for cardiovascular outcomes with sodium glucose cotransporter 2 inhibitors in the real world). Circulation. 2018;137:1450-1459.
-
(2018)
Circulation
, vol.137
, pp. 1450-1459
-
-
Udell, J.A.1
Yuan, Z.2
Rush, T.3
Sicignano, N.M.4
Galitz, M.5
Rosenthal, N.6
-
31
-
-
85054182182
-
Design and baseline characteristics of the eValuation of ERTugliflozin effIcacy and Safety CardioVascular outcomes trial (VERTIS-CV)
-
Cannon CP, McGuire DK, Pratley R, et al. Design and baseline characteristics of the eValuation of ERTugliflozin effIcacy and Safety CardioVascular outcomes trial (VERTIS-CV). Am Heart J. 2018;206:11-23.
-
(2018)
Am Heart J
, vol.206
, pp. 11-23
-
-
Cannon, C.P.1
McGuire, D.K.2
Pratley, R.3
-
32
-
-
85062326907
-
Empagliflozin reduced mortality and hospitalization for heart failure across the spectrum of cardiovascular risk in the EMPA-REG OUTCOME trial
-
Fitchett D, Inzucchi SE, Cannon CP, et al. Empagliflozin reduced mortality and hospitalization for heart failure across the spectrum of cardiovascular risk in the EMPA-REG OUTCOME trial. Circulation. 2019;139:1384-1395.
-
(2019)
Circulation
, vol.139
, pp. 1384-1395
-
-
Fitchett, D.1
Inzucchi, S.E.2
Cannon, C.P.3
-
33
-
-
85048449544
-
Canagliflozin for primary and secondary prevention of cardiovascular events: results from the CANVAS program (Canagliflozin Cardiovascular Assessment Study)
-
Mahaffey KW, Neal B, Perkovic V, et al. Canagliflozin for primary and secondary prevention of cardiovascular events: results from the CANVAS program (Canagliflozin Cardiovascular Assessment Study). Circulation. 2018;137(4):323-334.
-
(2018)
Circulation
, vol.137
, Issue.4
, pp. 323-334
-
-
Mahaffey, K.W.1
Neal, B.2
Perkovic, V.3
-
34
-
-
85063954068
-
Effects of canagliflozin on heart failure outcomes associated with preserved and reduced ejection fraction in type 2 diabetes mellitus
-
Figtree GA, Radholm K, Barrett TD, et al. Effects of canagliflozin on heart failure outcomes associated with preserved and reduced ejection fraction in type 2 diabetes mellitus. Circulation. 2019;139:2591-2593.
-
(2019)
Circulation
, vol.139
, pp. 2591-2593
-
-
Figtree, G.A.1
Radholm, K.2
Barrett, T.D.3
-
35
-
-
85063963517
-
Effect of dapagliflozin on heart failure and mortality in type 2 diabetes mellitus
-
Kato ET, Silverman MG, Mosenzon O, et al. Effect of dapagliflozin on heart failure and mortality in type 2 diabetes mellitus. Circulation. 2019;139:2528-2536.
-
(2019)
Circulation
, vol.139
, pp. 2528-2536
-
-
Kato, E.T.1
Silverman, M.G.2
Mosenzon, O.3
-
36
-
-
85067266385
-
Dapagliflozin and cardiovascular outcomes in patients with type 2 diabetes mellitus and previous myocardial infarction
-
Furtado RHM, Bonaca MP, Raz I, et al. Dapagliflozin and cardiovascular outcomes in patients with type 2 diabetes mellitus and previous myocardial infarction. Circulation. 2019;139:2516-2527.
-
(2019)
Circulation
, vol.139
, pp. 2516-2527
-
-
Furtado, R.H.M.1
Bonaca, M.P.2
Raz, I.3
-
37
-
-
85067270152
-
The serendipitous story of SGLT2 inhibitors in heart failure: new insights from DECLARE-TIMI 58
-
Verma S, McMurray JJV. The serendipitous story of SGLT2 inhibitors in heart failure: new insights from DECLARE-TIMI 58. Circulation. 2019;139:2537-2541.
-
(2019)
Circulation
, vol.139
, pp. 2537-2541
-
-
Verma, S.1
McMurray, J.J.V.2
-
38
-
-
85062762190
-
Eligibility varies among the 4 sodium-glucose cotransporter-2 inhibitor cardiovascular outcomes trials: implications for the general type 2 diabetes US population
-
Wittbrodt ET, Eudicone JM, Bell KF, Enhoffer DM, Latham K, Green JB. Eligibility varies among the 4 sodium-glucose cotransporter-2 inhibitor cardiovascular outcomes trials: implications for the general type 2 diabetes US population. Am J Manag Care. 2018;24(suppl 8):S138-S145.
-
(2018)
Am J Manag Care
, vol.24
, pp. S138-S145
-
-
Wittbrodt, E.T.1
Eudicone, J.M.2
Bell, K.F.3
Enhoffer, D.M.4
Latham, K.5
Green, J.B.6
-
39
-
-
85071388496
-
Study design, population, and key outcomes of DECLARE-TIMI 58 compared with other cardiovascular outcomes trials for sodium-glucose cotransporter-2 inhibitors
-
Atac BS. Study design, population, and key outcomes of DECLARE-TIMI 58 compared with other cardiovascular outcomes trials for sodium-glucose cotransporter-2 inhibitors. J Fam Pract. 2019;68(suppl 1):606-617.
-
(2019)
J Fam Pract
, vol.68
, pp. 606-617
-
-
Atac, B.S.1
-
40
-
-
85059501499
-
SGLT2 inhibitors for primary and secondary prevention of cardiovascular and renal outcomes in type 2 diabetes: a systematic review and meta-analysis of cardiovascular outcome trials
-
Zelniker TA, Wiviott SD, Raz I, et al. SGLT2 inhibitors for primary and secondary prevention of cardiovascular and renal outcomes in type 2 diabetes: a systematic review and meta-analysis of cardiovascular outcome trials. Lancet. 2019;393:31-39.
-
(2019)
Lancet
, vol.393
, pp. 31-39
-
-
Zelniker, T.A.1
Wiviott, S.D.2
Raz, I.3
-
41
-
-
85065306608
-
Comparison of the effects of glucagon-like peptide receptor agonists and sodium-glucose cotransporter 2 inhibitors for prevention of major adverse cardiovascular and renal outcomes in type 2 diabetes mellitus
-
Zelniker TA, Wiviott SD, Raz I, et al. Comparison of the effects of glucagon-like peptide receptor agonists and sodium-glucose cotransporter 2 inhibitors for prevention of major adverse cardiovascular and renal outcomes in type 2 diabetes mellitus. Circulation. 2019;139:2022-2031.
-
(2019)
Circulation
, vol.139
, pp. 2022-2031
-
-
Zelniker, T.A.1
Wiviott, S.D.2
Raz, I.3
-
42
-
-
85041737787
-
Cardiovascular outcomes associated with canagliflozin versus other non-gliflozin antidiabetic drugs: population based cohort study
-
Patorno E, Goldfine AB, Schneeweiss S, et al. Cardiovascular outcomes associated with canagliflozin versus other non-gliflozin antidiabetic drugs: population based cohort study. BMJ. 2018;360:k119.
-
(2018)
BMJ
, vol.360
, pp. k119
-
-
Patorno, E.1
Goldfine, A.B.2
Schneeweiss, S.3
-
43
-
-
85020040943
-
Cardiovascular protection by sodium glucose cotransporter 2 inhibitors: potential mechanisms
-
Staels B. Cardiovascular protection by sodium glucose cotransporter 2 inhibitors: potential mechanisms. Am J Med. 2017;130(suppl 6):S30-S39.
-
(2017)
Am J Med
, vol.130
, pp. S30-S39
-
-
Staels, B.1
-
44
-
-
85020107839
-
EMPA-REG OUTCOME: the nephrologist's point of view
-
Wanner C. EMPA-REG OUTCOME: the nephrologist's point of view. Am J Med. 2017;130(suppl 6):S63-S72.
-
(2017)
Am J Med
, vol.130
, pp. S63-S72
-
-
Wanner, C.1
-
45
-
-
84964773926
-
SGLT2 inhibitors and cardiovascular risk: lessons learned from the EMPA-REG OUTCOME study
-
Abdul-Ghani M, Del Prato S, Chilton R, DeFronzo RA. SGLT2 inhibitors and cardiovascular risk: lessons learned from the EMPA-REG OUTCOME study. Diabetes Care. 2016;39:717-725.
-
(2016)
Diabetes Care
, vol.39
, pp. 717-725
-
-
Abdul-Ghani, M.1
Del Prato, S.2
Chilton, R.3
DeFronzo, R.A.4
-
46
-
-
77953857048
-
Effect of dapagliflozin in patients with type 2 diabetes who have inadequate glycaemic control with metformin: a randomised, double-blind, placebo-controlled trial
-
Bailey CJ, Gross JL, Pieters A, Bastien A, List JF. Effect of dapagliflozin in patients with type 2 diabetes who have inadequate glycaemic control with metformin: a randomised, double-blind, placebo-controlled trial. Lancet. 2010;375:2223-2233.
-
(2010)
Lancet
, vol.375
, pp. 2223-2233
-
-
Bailey, C.J.1
Gross, J.L.2
Pieters, A.3
Bastien, A.4
List, J.F.5
-
47
-
-
84861781220
-
Dose-ranging effects of canagliflozin, a sodium-glucose cotransporter 2 inhibitor, as add-on to metformin in subjects with type 2 diabetes
-
Rosenstock J, Aggarwal N, Polidori D, et al. Dose-ranging effects of canagliflozin, a sodium-glucose cotransporter 2 inhibitor, as add-on to metformin in subjects with type 2 diabetes. Diabetes Care. 2012;35:1232-1238.
-
(2012)
Diabetes Care
, vol.35
, pp. 1232-1238
-
-
Rosenstock, J.1
Aggarwal, N.2
Polidori, D.3
-
48
-
-
85032196871
-
Dapagliflozin in patients with type 2 diabetes mellitus: a pooled analysis of safety data from phase IIb/III clinical trials
-
Jabbour S, Seufert J, Scheen A, Bailey CJ, Karup C, Langkilde AM. Dapagliflozin in patients with type 2 diabetes mellitus: a pooled analysis of safety data from phase IIb/III clinical trials. Diabetes Obes Metab. 2018;20:620-628.
-
(2018)
Diabetes Obes Metab
, vol.20
, pp. 620-628
-
-
Jabbour, S.1
Seufert, J.2
Scheen, A.3
Bailey, C.J.4
Karup, C.5
Langkilde, A.M.6
-
49
-
-
85010202013
-
Dapagliflozin decreases small dense low-density lipoprotein-cholesterol and increases high-density lipoprotein 2-cholesterol in patients with type 2 diabetes: comparison with sitagliptin
-
Hayashi T, Fukui T, Nakanishi N, et al. Dapagliflozin decreases small dense low-density lipoprotein-cholesterol and increases high-density lipoprotein 2-cholesterol in patients with type 2 diabetes: comparison with sitagliptin. Cardiovasc Diabetol. 2017;16:8.
-
(2017)
Cardiovasc Diabetol
, vol.16
, pp. 8
-
-
Hayashi, T.1
Fukui, T.2
Nakanishi, N.3
-
50
-
-
85044521391
-
A new class of drugs for heart failure: SGLT2 inhibitors reduce sympathetic overactivity
-
Sano M. A new class of drugs for heart failure: SGLT2 inhibitors reduce sympathetic overactivity. J Cardiol. 2018;71:471-476.
-
(2018)
J Cardiol
, vol.71
, pp. 471-476
-
-
Sano, M.1
-
51
-
-
84980320178
-
Sodium glucose cotransporter 2 inhibitors in the treatment of diabetes mellitus: cardiovascular and kidney effects, potential mechanisms, and clinical applications
-
Heerspink HJ, Perkins BA, Fitchett DH, Husain M, Cherney DZ. Sodium glucose cotransporter 2 inhibitors in the treatment of diabetes mellitus: cardiovascular and kidney effects, potential mechanisms, and clinical applications. Circulation. 2016;134:752-772.
-
(2016)
Circulation
, vol.134
, pp. 752-772
-
-
Heerspink, H.J.1
Perkins, B.A.2
Fitchett, D.H.3
Husain, M.4
Cherney, D.Z.5
-
52
-
-
84879360398
-
Diabetes mellitus is associated with adverse prognosis in chronic heart failure of ischaemic and non-ischaemic aetiology
-
Cubbon RM, Adams B, Rajwani A, et al. Diabetes mellitus is associated with adverse prognosis in chronic heart failure of ischaemic and non-ischaemic aetiology. Diab Vasc Dis Res. 2013;10:330-336.
-
(2013)
Diab Vasc Dis Res
, vol.10
, pp. 330-336
-
-
Cubbon, R.M.1
Adams, B.2
Rajwani, A.3
-
53
-
-
85020101939
-
Diabetes mellitus and heart failure
-
Lehrke M, Marx N. Diabetes mellitus and heart failure. Am J Med. 2017;130(suppl 6):S40-S50.
-
(2017)
Am J Med
, vol.130
, pp. S40-S50
-
-
Lehrke, M.1
Marx, N.2
-
54
-
-
84936999660
-
Metabolic abnormalities of the heart in type II diabetes
-
Amaral N, Okonko DO. Metabolic abnormalities of the heart in type II diabetes. Diab Vasc Dis Res. 2015;12:239-248.
-
(2015)
Diab Vasc Dis Res
, vol.12
, pp. 239-248
-
-
Amaral, N.1
Okonko, D.O.2
-
55
-
-
84876569165
-
Diabetic cardiomyopathy: pathophysiology and clinical features
-
Miki T, Yuda S, Kouzu H, Miura T. Diabetic cardiomyopathy: pathophysiology and clinical features. Heart Fail Rev. 2013;18:149-166.
-
(2013)
Heart Fail Rev
, vol.18
, pp. 149-166
-
-
Miki, T.1
Yuda, S.2
Kouzu, H.3
Miura, T.4
-
56
-
-
38349086961
-
Classification of the cardiomyopathies: a position statement from the European Society of Cardiology Working Group on Myocardial and Pericardial Diseases
-
Elliott P, Andersson B, Arbustini E, et al. Classification of the cardiomyopathies: a position statement from the European Society of Cardiology Working Group on Myocardial and Pericardial Diseases. Eur Heart J. 2008;29:270-276.
-
(2008)
Eur Heart J
, vol.29
, pp. 270-276
-
-
Elliott, P.1
Andersson, B.2
Arbustini, E.3
-
57
-
-
84897394439
-
Mitochondrial fatty acid oxidation alterations in heart failure, ischaemic heart disease and diabetic cardiomyopathy
-
Fillmore N, Mori J, Lopaschuk GD. Mitochondrial fatty acid oxidation alterations in heart failure, ischaemic heart disease and diabetic cardiomyopathy. Br J Pharmacol. 2014;171:2080-2090.
-
(2014)
Br J Pharmacol
, vol.171
, pp. 2080-2090
-
-
Fillmore, N.1
Mori, J.2
Lopaschuk, G.D.3
-
58
-
-
84975775560
-
The failing heart relies on ketone bodies as a fuel
-
Aubert G, Martin OJ, Horton JL, et al. The failing heart relies on ketone bodies as a fuel. Circulation. 2016;133:698-705.
-
(2016)
Circulation
, vol.133
, pp. 698-705
-
-
Aubert, G.1
Martin, O.J.2
Horton, J.L.3
-
59
-
-
84975840750
-
Can a shift in fuel energetics explain the beneficial cardiorenal outcomes in the EMPA-REG OUTCOME study? A unifying hypothesis
-
Mudaliar S, Alloju S, Henry RR. Can a shift in fuel energetics explain the beneficial cardiorenal outcomes in the EMPA-REG OUTCOME study? A unifying hypothesis. Diabetes Care. 2016;39:1115-1122.
-
(2016)
Diabetes Care
, vol.39
, pp. 1115-1122
-
-
Mudaliar, S.1
Alloju, S.2
Henry, R.R.3
-
60
-
-
85030655315
-
The metabolodiuretic promise of sodium-dependent glucose cotransporter 2 inhibition: the search for the sweet spot in heart failure
-
Verma S, McMurray JJV, Cherney DZI. The metabolodiuretic promise of sodium-dependent glucose cotransporter 2 inhibition: the search for the sweet spot in heart failure. JAMA Cardiol. 2017;2:939-940.
-
(2017)
JAMA Cardiol
, vol.2
, pp. 939-940
-
-
Verma, S.1
McMurray, J.J.V.2
Cherney, D.Z.I.3
-
61
-
-
84994236427
-
Dapagliflozin enhances fat oxidation and ketone production in patients with type 2 diabetes
-
Daniele G, Xiong J, Solis-Herrera C, et al. Dapagliflozin enhances fat oxidation and ketone production in patients with type 2 diabetes. Diabetes Care. 2016;39:2036-2041.
-
(2016)
Diabetes Care
, vol.39
, pp. 2036-2041
-
-
Daniele, G.1
Xiong, J.2
Solis-Herrera, C.3
-
62
-
-
84893872877
-
Metabolic response to sodium-glucose cotransporter 2 inhibition in type 2 diabetic patients
-
Ferrannini E, Muscelli E, Frascerra S, et al. Metabolic response to sodium-glucose cotransporter 2 inhibition in type 2 diabetic patients. J Clin Invest. 2014;124:499-508.
-
(2014)
J Clin Invest
, vol.124
, pp. 499-508
-
-
Ferrannini, E.1
Muscelli, E.2
Frascerra, S.3
-
63
-
-
84975853831
-
CV protection in the EMPA-REG OUTCOME trial: a "thrifty substrate" hypothesis
-
Ferrannini E, Mark M, Mayoux E. CV protection in the EMPA-REG OUTCOME trial: a "thrifty substrate" hypothesis. Diabetes Care. 2016;39:1108-1114.
-
(2016)
Diabetes Care
, vol.39
, pp. 1108-1114
-
-
Ferrannini, E.1
Mark, M.2
Mayoux, E.3
-
64
-
-
85047345720
-
Effect of canagliflozin on left ventricular diastolic function in patients with type 2 diabetes
-
Matsutani D, Sakamoto M, Kayama Y, Takeda N, Horiuchi R, Utsunomiya K. Effect of canagliflozin on left ventricular diastolic function in patients with type 2 diabetes. Cardiovasc Diabetol. 2018;17:73.
-
(2018)
Cardiovasc Diabetol
, vol.17
, pp. 73
-
-
Matsutani, D.1
Sakamoto, M.2
Kayama, Y.3
Takeda, N.4
Horiuchi, R.5
Utsunomiya, K.6
-
65
-
-
84945455839
-
Effects of empagliflozin on blood pressure and markers of arterial stiffness and vascular resistance in patients with type 2 diabetes
-
Chilton R, Tikkanen I, Cannon CP, et al. Effects of empagliflozin on blood pressure and markers of arterial stiffness and vascular resistance in patients with type 2 diabetes. Diabetes Obes Metab. 2015;17:1180-1193.
-
(2015)
Diabetes Obes Metab
, vol.17
, pp. 1180-1193
-
-
Chilton, R.1
Tikkanen, I.2
Cannon, C.P.3
-
66
-
-
85020486808
-
Empagliflozin reduces markers of arterial stiffness, vascular resistance and cardiac workload in EMPA-REG OUTCOME
-
Chilton RJ, Gullestad L, Fitchett D, et al. Empagliflozin reduces markers of arterial stiffness, vascular resistance and cardiac workload in EMPA-REG OUTCOME. Circulation. 2016;134(suppl 1):A13520.
-
(2016)
Circulation
, vol.134
, pp. A13520
-
-
Chilton, R.J.1
Gullestad, L.2
Fitchett, D.3
-
67
-
-
85031924469
-
Dapagliflozin acutely improves endothelial dysfunction, reduces aortic stiffness and renal resistive index in type 2 diabetic patients: a pilot study
-
Solini A, Giannini L, Seghieri M, et al. Dapagliflozin acutely improves endothelial dysfunction, reduces aortic stiffness and renal resistive index in type 2 diabetic patients: a pilot study. Cardiovasc Diabetol. 2017;16:138.
-
(2017)
Cardiovasc Diabetol
, vol.16
, pp. 138
-
-
Solini, A.1
Giannini, L.2
Seghieri, M.3
-
68
-
-
84899960517
-
Efficacy and safety of canagliflozin compared with placebo in older patients with type 2 diabetes mellitus: a pooled analysis of clinical studies
-
Sinclair A, Bode B, Harris S, et al. Efficacy and safety of canagliflozin compared with placebo in older patients with type 2 diabetes mellitus: a pooled analysis of clinical studies. BMC Endocr Disord. 2014;14:37.
-
(2014)
BMC Endocr Disord
, vol.14
, pp. 37
-
-
Sinclair, A.1
Bode, B.2
Harris, S.3
-
69
-
-
85055595268
-
Mechanism of increased LDL (low-density lipoprotein) and decreased triglycerides with SGLT2 (sodium-glucose cotransporter 2) inhibition
-
Basu D, Huggins L, Scerbo D, et al. Mechanism of increased LDL (low-density lipoprotein) and decreased triglycerides with SGLT2 (sodium-glucose cotransporter 2) inhibition. Arterioscler Thromb Vasc Biol. 2018;38:2207-2216.
-
(2018)
Arterioscler Thromb Vasc Biol
, vol.38
, pp. 2207-2216
-
-
Basu, D.1
Huggins, L.2
Scerbo, D.3
-
70
-
-
84896731158
-
Type 2 diabetes mellitus and hypertension: an update
-
Lastra G, Syed S, Kurukulasuriya LR, Manrique C, Sowers JR. Type 2 diabetes mellitus and hypertension: an update. Endocrinol Metab Clin North Am. 2014;43:103-122.
-
(2014)
Endocrinol Metab Clin North Am
, vol.43
, pp. 103-122
-
-
Lastra, G.1
Syed, S.2
Kurukulasuriya, L.R.3
Manrique, C.4
Sowers, J.R.5
-
71
-
-
84928006368
-
Insulin resistance and hypertension: new insights
-
Soleimani M. Insulin resistance and hypertension: new insights. Kidney Int. 2015;87:497-499.
-
(2015)
Kidney Int
, vol.87
, pp. 497-499
-
-
Soleimani, M.1
-
72
-
-
84961794343
-
Correspondence: empagliflozin, cardiovascular outcomes, and mortality in type 2 diabetes
-
Zinman B, Lachin JM, Inzucchi SE. Correspondence: empagliflozin, cardiovascular outcomes, and mortality in type 2 diabetes. N Engl J Med. 2016;374:1094.
-
(2016)
N Engl J Med
, vol.374
, pp. 1094
-
-
Zinman, B.1
Lachin, J.M.2
Inzucchi, S.E.3
-
73
-
-
84991665527
-
Effects of reducing blood pressure on cardiovascular outcomes and mortality in patients with type 2 diabetes: focus on SGLT2 inhibitors and EMPA-REG OUTCOME
-
Scheen AJ. Effects of reducing blood pressure on cardiovascular outcomes and mortality in patients with type 2 diabetes: focus on SGLT2 inhibitors and EMPA-REG OUTCOME. Diabetes Res Clin Pract. 2016;121:204-214.
-
(2016)
Diabetes Res Clin Pract
, vol.121
, pp. 204-214
-
-
Scheen, A.J.1
-
74
-
-
84959363424
-
Effects of intensive blood pressure lowering on cardiovascular and renal outcomes: updated systematic review and meta-analysis
-
Xie X, Atkins E, Lv J, et al. Effects of intensive blood pressure lowering on cardiovascular and renal outcomes: updated systematic review and meta-analysis. Lancet. 2016;387:435-443.
-
(2016)
Lancet
, vol.387
, pp. 435-443
-
-
Xie, X.1
Atkins, E.2
Lv, J.3
-
75
-
-
85020043362
-
EMPA-REG OUTCOME: the cardiologist's point of view
-
Pham SV, Chilton R. EMPA-REG OUTCOME: the cardiologist's point of view. Am J Med. 2017;130(suppl 6):S57-S62.
-
(2017)
Am J Med
, vol.130
, pp. S57-S62
-
-
Pham, S.V.1
Chilton, R.2
-
76
-
-
84991018034
-
Reappraisal of the diuretic effect of empagliflozin in the EMPA-REG OUTCOME trial: comparison with classic diuretics
-
Scheen AJ. Reappraisal of the diuretic effect of empagliflozin in the EMPA-REG OUTCOME trial: comparison with classic diuretics. Diabetes Metab. 2016;42:224-233.
-
(2016)
Diabetes Metab
, vol.42
, pp. 224-233
-
-
Scheen, A.J.1
-
77
-
-
84880850027
-
Dapagliflozin a glucose-regulating drug with diuretic properties in subjects with type 2 diabetes
-
Lambers Heerspink HJ, de Zeeuw D, Wie L, Leslie B, List J. Dapagliflozin a glucose-regulating drug with diuretic properties in subjects with type 2 diabetes. Diabetes Obes Metab. 2013;15:853-862.
-
(2013)
Diabetes Obes Metab
, vol.15
, pp. 853-862
-
-
Lambers Heerspink, H.J.1
de Zeeuw, D.2
Wie, L.3
Leslie, B.4
List, J.5
-
78
-
-
85071376701
-
Dapagliflozin suppresses plasma hepcidin concentrations
-
Ghanim H, Hejna JM, Abuaysheh S, et al. Dapagliflozin suppresses plasma hepcidin concentrations. Diabetes. 2018;67(suppl 1):1116-1117. Abstract 1116-P.
-
(2018)
Diabetes
, vol.67
, pp. 1116-1117
-
-
Ghanim, H.1
Hejna, J.M.2
Abuaysheh, S.3
-
79
-
-
85019367291
-
Increased hematocrit during sodium-glucose cotransporter 2 inhibitor therapy indicates recovery of tubulointerstitial function in diabetic kidneys
-
Sano M, Takei M, Shiraishi Y, Suzuki Y. Increased hematocrit during sodium-glucose cotransporter 2 inhibitor therapy indicates recovery of tubulointerstitial function in diabetic kidneys. J Clin Med Res. 2016;8:844-847.
-
(2016)
J Clin Med Res
, vol.8
, pp. 844-847
-
-
Sano, M.1
Takei, M.2
Shiraishi, Y.3
Suzuki, Y.4
-
80
-
-
84964489933
-
Sodium-glucose cotransporter 2 inhibition and cardiovascular risk reduction in patients with type 2 diabetes: the emerging role of natriuresis
-
Rajasekeran H, Lytvyn Y, Cherney DZ. Sodium-glucose cotransporter 2 inhibition and cardiovascular risk reduction in patients with type 2 diabetes: the emerging role of natriuresis. Kidney Int. 2016;89:524-526.
-
(2016)
Kidney Int
, vol.89
, pp. 524-526
-
-
Rajasekeran, H.1
Lytvyn, Y.2
Cherney, D.Z.3
-
81
-
-
84961798853
-
Empagliflozin, cardiovascular outcomes, and mortality in type 2 diabetes
-
Fischereder M, Schonermarck U. Empagliflozin, cardiovascular outcomes, and mortality in type 2 diabetes. N Engl J Med. 2016;374:1092-1093.
-
(2016)
N Engl J Med
, vol.374
, pp. 1092-1093
-
-
Fischereder, M.1
Schonermarck, U.2
-
82
-
-
85006165373
-
Factors affecting canagliflozin-induced transient urine volume increase in patients with type 2 diabetes mellitus
-
Tanaka H, Takano K, Iijima H, et al. Factors affecting canagliflozin-induced transient urine volume increase in patients with type 2 diabetes mellitus. Adv Ther. 2017;34:436-451.
-
(2017)
Adv Ther
, vol.34
, pp. 436-451
-
-
Tanaka, H.1
Takano, K.2
Iijima, H.3
-
83
-
-
78349297565
-
Oxidative stress and diabetic complications
-
Giacco F, Brownlee M. Oxidative stress and diabetic complications. Circ Res. 2010;107:1058-1070.
-
(2010)
Circ Res
, vol.107
, pp. 1058-1070
-
-
Giacco, F.1
Brownlee, M.2
-
84
-
-
84896717178
-
O-GlcNAc and the cardiovascular system
-
Dassanayaka S, Jones SP. O-GlcNAc and the cardiovascular system. Pharmacol Ther. 2014;142:62-71.
-
(2014)
Pharmacol Ther
, vol.142
, pp. 62-71
-
-
Dassanayaka, S.1
Jones, S.P.2
-
85
-
-
84906070274
-
Myocardial contractile dysfunction is associated with impaired mitochondrial function and dynamics in type 2 diabetic but not in obese patients
-
Montaigne D, Marechal X, Coisne A, et al. Myocardial contractile dysfunction is associated with impaired mitochondrial function and dynamics in type 2 diabetic but not in obese patients. Circulation. 2014;130:554-564.
-
(2014)
Circulation
, vol.130
, pp. 554-564
-
-
Montaigne, D.1
Marechal, X.2
Coisne, A.3
-
86
-
-
84995969879
-
Empagliflozin lessened cardiac injury and reduced visceral adipocyte hypertrophy in prediabetic rats with metabolic syndrome
-
Kusaka H, Koibuchi N, Hasegawa Y, Ogawa H, Kim-Mitsuyama S. Empagliflozin lessened cardiac injury and reduced visceral adipocyte hypertrophy in prediabetic rats with metabolic syndrome. Cardiovasc Diabetol. 2016;15:157.
-
(2016)
Cardiovasc Diabetol
, vol.15
, pp. 157
-
-
Kusaka, H.1
Koibuchi, N.2
Hasegawa, Y.3
Ogawa, H.4
Kim-Mitsuyama, S.5
-
87
-
-
85049855064
-
Potential mechanisms responsible for cardioprotective effects of sodium-glucose co-transporter 2 inhibitors
-
Lahnwong S, Chattipakorn SC, Chattipakorn N. Potential mechanisms responsible for cardioprotective effects of sodium-glucose co-transporter 2 inhibitors. Cardiovasc Diabetol. 2018;17:101.
-
(2018)
Cardiovasc Diabetol
, vol.17
, pp. 101
-
-
Lahnwong, S.1
Chattipakorn, S.C.2
Chattipakorn, N.3
-
88
-
-
84964696031
-
Glycemic control with empagliflozin, a novel selective SGLT2 inhibitor, ameliorates cardiovascular injury and cognitive dysfunction in obese and type 2 diabetic mice
-
Lin B, Koibuchi N, Hasegawa Y, et al. Glycemic control with empagliflozin, a novel selective SGLT2 inhibitor, ameliorates cardiovascular injury and cognitive dysfunction in obese and type 2 diabetic mice. Cardiovasc Diabetol. 2014;13:148.
-
(2014)
Cardiovasc Diabetol
, vol.13
, pp. 148
-
-
Lin, B.1
Koibuchi, N.2
Hasegawa, Y.3
-
89
-
-
85045436396
-
Empagliflozin treatment is associated with improved β-cell function in type 2 diabetes mellitus
-
Al Jobori H, Daniele G, Adams J, et al. Empagliflozin treatment is associated with improved β-cell function in type 2 diabetes mellitus. J Clin Endocrinol Metab. 2018;103:1402-1407.
-
(2018)
J Clin Endocrinol Metab
, vol.103
, pp. 1402-1407
-
-
Al Jobori, H.1
Daniele, G.2
Adams, J.3
-
90
-
-
77955657267
-
Insulin resistance, lipotoxicity, type 2 diabetes and atherosclerosis: the missing links. The Claude Bernard Lecture 2009
-
DeFronzo RA. Insulin resistance, lipotoxicity, type 2 diabetes and atherosclerosis: the missing links. The Claude Bernard Lecture 2009. Diabetologia. 2010;53:1270-1287.
-
(2010)
Diabetologia
, vol.53
, pp. 1270-1287
-
-
DeFronzo, R.A.1
-
91
-
-
85054466162
-
Effects of SGLT2 inhibitors on systemic and tissue low-grade inflammation: the potential contribution to diabetes complications and cardiovascular disease
-
Bonnet F, Scheen AJ. Effects of SGLT2 inhibitors on systemic and tissue low-grade inflammation: the potential contribution to diabetes complications and cardiovascular disease. Diabetes Metab. 2018;44:457-464.
-
(2018)
Diabetes Metab
, vol.44
, pp. 457-464
-
-
Bonnet, F.1
Scheen, A.J.2
-
92
-
-
85010842028
-
Dapagliflozin, a selective SGLT2 inhibitor, attenuated cardiac fibrosis by regulating the macrophage polarization via STAT3 signaling in infarcted rat hearts
-
Lee TM, Chang NC, Lin SZ. Dapagliflozin, a selective SGLT2 inhibitor, attenuated cardiac fibrosis by regulating the macrophage polarization via STAT3 signaling in infarcted rat hearts. Free Radic Biol Med. 2017;104:298-310.
-
(2017)
Free Radic Biol Med
, vol.104
, pp. 298-310
-
-
Lee, T.M.1
Chang, N.C.2
Lin, S.Z.3
-
93
-
-
84929325840
-
Diabetic kidney disease: pathophysiology and therapeutic targets
-
Toth-Manikowski S, Atta MG. Diabetic kidney disease: pathophysiology and therapeutic targets. J Diabetes Res. 2015;2015:697010.
-
(2015)
J Diabetes Res
, vol.2015
, pp. 697010
-
-
Toth-Manikowski, S.1
Atta, M.G.2
-
94
-
-
85052558182
-
SGLT2 inhibitors and mechanisms of cardiovascular benefit: a state-of-the-art review
-
Verma S, McMurray JJV. SGLT2 inhibitors and mechanisms of cardiovascular benefit: a state-of-the-art review. Diabetologia. 2018;61:2108-2117.
-
(2018)
Diabetologia
, vol.61
, pp. 2108-2117
-
-
Verma, S.1
McMurray, J.J.V.2
-
95
-
-
85028338781
-
Sodium glucose cotransporter 2 in mesangial cells and retinal pericytes and its implications for diabetic nephropathy and retinopathy
-
Wakisaka M, Nagao T. Sodium glucose cotransporter 2 in mesangial cells and retinal pericytes and its implications for diabetic nephropathy and retinopathy. Glycobiology. 2017;27:691-695.
-
(2017)
Glycobiology
, vol.27
, pp. 691-695
-
-
Wakisaka, M.1
Nagao, T.2
-
96
-
-
85047818222
-
SGLT2 inhibition for the prevention and treatment of diabetic kidney disease: a review
-
Alicic RZ, Johnson EJ, Tuttle KR. SGLT2 inhibition for the prevention and treatment of diabetic kidney disease: a review. Am J Kidney Dis. 2018;72:267-277.
-
(2018)
Am J Kidney Dis
, vol.72
, pp. 267-277
-
-
Alicic, R.Z.1
Johnson, E.J.2
Tuttle, K.R.3
-
97
-
-
85019386393
-
SGLT2 inhibitors-sweet success for diabetic kidney disease?
-
de Boer IH, Kahn SE. SGLT2 inhibitors-sweet success for diabetic kidney disease? J Am Soc Nephrol. 2017;28:7-10.
-
(2017)
J Am Soc Nephrol
, vol.28
, pp. 7-10
-
-
de Boer, I.H.1
Kahn, S.E.2
-
98
-
-
85021849793
-
Canagliflozin slows progression of renal function decline independently of glycemic effects
-
Heerspink HJ, Desai M, Jardine M, Balis D, Meininger G, Perkovic V. Canagliflozin slows progression of renal function decline independently of glycemic effects. J Am Soc Nephrol. 2017;28:368-375.
-
(2017)
J Am Soc Nephrol
, vol.28
, pp. 368-375
-
-
Heerspink, H.J.1
Desai, M.2
Jardine, M.3
Balis, D.4
Meininger, G.5
Perkovic, V.6
-
99
-
-
84936085884
-
Protein- and diabetes-induced glomerular hyperfiltration: role of glucagon, vasopressin, and urea
-
Bankir L, Roussel R, Bouby N. Protein- and diabetes-induced glomerular hyperfiltration: role of glucagon, vasopressin, and urea. Am J Physiol Renal Physiol. 2015;309:F2-F23.
-
(2015)
Am J Physiol Renal Physiol
, vol.309
, pp. F2-F23
-
-
Bankir, L.1
Roussel, R.2
Bouby, N.3
-
100
-
-
85063607974
-
Retinopathy outcomes with empagliflozin versus placebo in the EMPA-REG OUTCOME trial
-
Inzucchi SE, Wanner C, Hehnke U, et al. Retinopathy outcomes with empagliflozin versus placebo in the EMPA-REG OUTCOME trial. Diabetes Care. 2019;42:e53-e55.
-
(2019)
Diabetes Care
, vol.42
, pp. e53-e55
-
-
Inzucchi, S.E.1
Wanner, C.2
Hehnke, U.3
-
101
-
-
84903175006
-
Modeling effects of SGLT-2 inhibitor dapagliflozin treatment versus standard diabetes therapy on cardiovascular and microvascular outcomes
-
Dziuba J, Alperin P, Racketa J, et al. Modeling effects of SGLT-2 inhibitor dapagliflozin treatment versus standard diabetes therapy on cardiovascular and microvascular outcomes. Diabetes Obes Metab. 2014;16:628-635.
-
(2014)
Diabetes Obes Metab
, vol.16
, pp. 628-635
-
-
Dziuba, J.1
Alperin, P.2
Racketa, J.3
-
102
-
-
84952362321
-
Cardiovascular implications of hypoglycemia in diabetes mellitus
-
Connelly KA, Yan AT, Leiter LA, Bhatt DL, Verma S. Cardiovascular implications of hypoglycemia in diabetes mellitus. Circulation. 2015;132:2345-2350.
-
(2015)
Circulation
, vol.132
, pp. 2345-2350
-
-
Connelly, K.A.1
Yan, A.T.2
Leiter, L.A.3
Bhatt, D.L.4
Verma, S.5
-
103
-
-
84865491015
-
Increased mortality of patients with diabetes reporting severe hypoglycemia
-
McCoy RG, Van Houten HK, Ziegenfuss JY, Shah ND, Wermers RA, Smith SA. Increased mortality of patients with diabetes reporting severe hypoglycemia. Diabetes Care. 2012;35:1897-1901.
-
(2012)
Diabetes Care
, vol.35
, pp. 1897-1901
-
-
McCoy, R.G.1
Van Houten, H.K.2
Ziegenfuss, J.Y.3
Shah, N.D.4
Wermers, R.A.5
Smith, S.A.6
-
104
-
-
84994731812
-
Benefits and harms of sodium-glucose co-transporter 2 inhibitors in patients with type 2 diabetes: a systematic review and meta-analysis
-
Storgaard H, Gluud LL, Bennett C, et al. Benefits and harms of sodium-glucose co-transporter 2 inhibitors in patients with type 2 diabetes: a systematic review and meta-analysis. PLoS One. 2016;11:e0166125.
-
(2016)
PLoS One
, vol.11
-
-
Storgaard, H.1
Gluud, L.L.2
Bennett, C.3
-
105
-
-
85063572219
-
An update on the safety of SGLT2 inhibitors
-
Scheen AJ. An update on the safety of SGLT2 inhibitors. Expert Opin Drug Saf. 2019;18:295-311.
-
(2019)
Expert Opin Drug Saf
, vol.18
, pp. 295-311
-
-
Scheen, A.J.1
-
110
-
-
85054910738
-
Acute renal outcomes with sodium-glucose co-transporter-2 inhibitors: real-world data analysis
-
Cahn A, Melzer-Cohen C, Pollack R, Chodick G, Shalev V. Acute renal outcomes with sodium-glucose co-transporter-2 inhibitors: real-world data analysis. Diabetes Obes Metab. 2019;21:340-348.
-
(2019)
Diabetes Obes Metab
, vol.21
, pp. 340-348
-
-
Cahn, A.1
Melzer-Cohen, C.2
Pollack, R.3
Chodick, G.4
Shalev, V.5
-
111
-
-
85040177178
-
Initiation of dapagliflozin and treatment-emergent fractures
-
Toulis KA, Bilezikian JP, Thomas GN, et al. Initiation of dapagliflozin and treatment-emergent fractures. Diabetes Obes Metab. 2018;20:1070-1074.
-
(2018)
Diabetes Obes Metab
, vol.20
, pp. 1070-1074
-
-
Toulis, K.A.1
Bilezikian, J.P.2
Thomas, G.N.3
-
113
-
-
84962339296
-
Euglycemic diabetic ketoacidosis: a potential complication of treatment with sodium-glucose cotransporter 2 inhibition
-
Peters AL, Buschur EO, Buse JB, Cohan P, Diner JC, Hirsch IB. Euglycemic diabetic ketoacidosis: a potential complication of treatment with sodium-glucose cotransporter 2 inhibition. Diabetes Care. 2015;38:1687-1693.
-
(2015)
Diabetes Care
, vol.38
, pp. 1687-1693
-
-
Peters, A.L.1
Buschur, E.O.2
Buse, J.B.3
Cohan, P.4
Diner, J.C.5
Hirsch, I.B.6
-
114
-
-
85020403719
-
Risk of diabetic ketoacidosis after initiation of an SGLT2 inhibitor
-
Fralick M, Schneeweiss S, Patorno E. Risk of diabetic ketoacidosis after initiation of an SGLT2 inhibitor. N Engl J Med. 2017;376:2300-2302.
-
(2017)
N Engl J Med
, vol.376
, pp. 2300-2302
-
-
Fralick, M.1
Schneeweiss, S.2
Patorno, E.3
-
115
-
-
85018541396
-
Incidence of ketoacidosis in the Danish type 2 diabetes population before and after introduction of sodium-glucose cotransporter 2 inhibitors-a nationwide, retrospective cohort study, 1995-2014
-
Jensen ML, Persson F, Andersen GS, et al. Incidence of ketoacidosis in the Danish type 2 diabetes population before and after introduction of sodium-glucose cotransporter 2 inhibitors-a nationwide, retrospective cohort study, 1995-2014. Diabetes Care. 2017;40:e57-e58.
-
(2017)
Diabetes Care
, vol.40
, pp. e57-e58
-
-
Jensen, M.L.1
Persson, F.2
Andersen, G.S.3
-
116
-
-
85018539845
-
Incidence of diabetic ketoacidosis among patients with type 2 diabetes mellitus treated with SGLT2 inhibitors and other antihyperglycemic agents
-
Wang Y, Desai M, Ryan PB, et al. Incidence of diabetic ketoacidosis among patients with type 2 diabetes mellitus treated with SGLT2 inhibitors and other antihyperglycemic agents. Diabetes Res Clin Pract. 2017;128:83-90.
-
(2017)
Diabetes Res Clin Pract
, vol.128
, pp. 83-90
-
-
Wang, Y.1
Desai, M.2
Ryan, P.B.3
-
117
-
-
84942312400
-
Assessing bladder cancer risk in type 2 diabetes clinical trials: the dapagliflozin drug development program as a 'case study’
-
Ptaszynska A, Cohen SM, Messing EM, Reilly TP, Johnsson E, Johnsson K. Assessing bladder cancer risk in type 2 diabetes clinical trials: the dapagliflozin drug development program as a 'case study’. Diabetes Ther. 2015;6:357-375.
-
(2015)
Diabetes Ther
, vol.6
, pp. 357-375
-
-
Ptaszynska, A.1
Cohen, S.M.2
Messing, E.M.3
Reilly, T.P.4
Johnsson, E.5
Johnsson, K.6
-
118
-
-
85060858934
-
A study in a rat initiation-promotion bladder tumour model demonstrated no promoter/progressor potential of dapagliflozin
-
Billger M, Kirk J, Chang J, et al. A study in a rat initiation-promotion bladder tumour model demonstrated no promoter/progressor potential of dapagliflozin. Regul Toxicol Pharmacol. 2019;103:166-173.
-
(2019)
Regul Toxicol Pharmacol
, vol.103
, pp. 166-173
-
-
Billger, M.1
Kirk, J.2
Chang, J.3
-
119
-
-
85040369043
-
Direct cardiovascular impact of SGLT2 inhibitors: mechanisms and effects
-
Kaplan A, Abidi E, El-Yazbi A, Eid A, Booz GW, Zouein FA. Direct cardiovascular impact of SGLT2 inhibitors: mechanisms and effects. Heart Fail Rev. 2018;23:419-437.
-
(2018)
Heart Fail Rev
, vol.23
, pp. 419-437
-
-
Kaplan, A.1
Abidi, E.2
El-Yazbi, A.3
Eid, A.4
Booz, G.W.5
Zouein, F.A.6
-
120
-
-
85047995723
-
Rates of myocardial infarction and stroke in patients initiating treatment with SGLT2-inhibitors versus other glucose-lowering agents in real-world clinical practice: results from the CVD-REAL study
-
Kosiborod M, Birkeland KI, Cavender MA, et al. Rates of myocardial infarction and stroke in patients initiating treatment with SGLT2-inhibitors versus other glucose-lowering agents in real-world clinical practice: results from the CVD-REAL study. Diabetes Obes Metab. 2018;20:1983-1987.
-
(2018)
Diabetes Obes Metab
, vol.20
, pp. 1983-1987
-
-
Kosiborod, M.1
Birkeland, K.I.2
Cavender, M.A.3
-
121
-
-
85066254172
-
2019 ACC/AHA guideline on the primary prevention of cardiovascular disease. A report of the American College of Cardiology/American Heart Association Task Force on clinical practice guidelines
-
[Epub ahead of print]
-
Arnett DK, Blumenthal RS, Albert MA, et al. 2019 ACC/AHA guideline on the primary prevention of cardiovascular disease. A report of the American College of Cardiology/American Heart Association Task Force on clinical practice guidelines. J Am Coll Cardiol. 2019. https://doi.org/10.1016/j.jacc.2019.03.009 [Epub ahead of print].
-
(2019)
J Am Coll Cardiol
-
-
Arnett, D.K.1
Blumenthal, R.S.2
Albert, M.A.3
|