메뉴 건너뛰기




Volumn 121, Issue , 2016, Pages 204-214

Effects of reducing blood pressure on cardiovascular outcomes and mortality in patients with type 2 diabetes: Focus on SGLT2 inhibitors and EMPA-REG OUTCOME

Author keywords

Blood pressure; Diuretic; Empagliflozin; Hypertension; SGLT2 inhibitor; Type 2 diabetes

Indexed keywords

ANTIHYPERTENSIVE AGENT; ATENOLOL; CANAGLIFLOZIN; CAPTOPRIL; DAPAGLIFLOZIN; DIURETIC AGENT; EMPAGLIFLOZIN; ENALAPRIL; EPLERENONE; ERTUGLIFLOZIN; HYDROCHLOROTHIAZIDE; INDAPAMIDE PLUS PERINDOPRIL; IPRAGLIFLOZIN; PLACEBO; SODIUM GLUCOSE COTRANSPORTER 2 INHIBITOR; SPIRONOLACTONE; THIAZIDE DIURETIC AGENT; ANTIDIABETIC AGENT; BENZHYDRYL DERIVATIVE; GLUCOSIDE; SLC5A2 PROTEIN, HUMAN; SODIUM GLUCOSE COTRANSPORTER 2;

EID: 84991665527     PISSN: 01688227     EISSN: 18728227     Source Type: Journal    
DOI: 10.1016/j.diabres.2016.09.016     Document Type: Review
Times cited : (47)

References (78)
  • 1
    • 84864844848 scopus 로고    scopus 로고
    • Diabetes and hypertension: the bad companions
    • [1] Ferrannini, E., Cushman, W.C., Diabetes and hypertension: the bad companions. Lancet 380 (2012), 601–610.
    • (2012) Lancet , vol.380 , pp. 601-610
    • Ferrannini, E.1    Cushman, W.C.2
  • 2
    • 84906241463 scopus 로고    scopus 로고
    • Blood pressure-lowering treatment based on cardiovascular risk: a meta-analysis of individual patient data
    • [2] Blood Pressure Lowering Treatment Trialists C, Sundstrom, J., Arima, H., Woodward, M., Jackson, R., Karmali, K., Blood pressure-lowering treatment based on cardiovascular risk: a meta-analysis of individual patient data. Lancet 384 (2014), 591–598.
    • (2014) Lancet , vol.384 , pp. 591-598
    • Sundstrom, J.1    Arima, H.2    Woodward, M.3    Jackson, R.4    Karmali, K.5
  • 3
    • 84901808693 scopus 로고    scopus 로고
    • Blood pressure and incidence of twelve cardiovascular diseases: lifetime risks, healthy life-years lost, and age-specific associations in 1.25 million people
    • [3] Rapsomaniki, E., Timmis, A., George, J., Pujades-Rodriguez, M., Shah, A.D., Denaxas, S., et al. Blood pressure and incidence of twelve cardiovascular diseases: lifetime risks, healthy life-years lost, and age-specific associations in 1.25 million people. Lancet 383 (2014), 1899–1911.
    • (2014) Lancet , vol.383 , pp. 1899-1911
    • Rapsomaniki, E.1    Timmis, A.2    George, J.3    Pujades-Rodriguez, M.4    Shah, A.D.5    Denaxas, S.6
  • 4
    • 0032511580 scopus 로고    scopus 로고
    • Tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 38
    • [4] UK Prospective Diabetes Study Group, Tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 38. BMJ 317 (1998), 703–713.
    • (1998) BMJ , vol.317 , pp. 703-713
  • 5
    • 0032511566 scopus 로고    scopus 로고
    • Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34
    • [5] UK Prospective Diabetes Study (UKPDS) Group, Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34. Lancet 352 (1998), 854–865.
    • (1998) Lancet , vol.352 , pp. 854-865
  • 6
    • 0034700790 scopus 로고    scopus 로고
    • Effects of ramipril on cardiovascular and microvascular outcomes in people with diabetes mellitus: results of the HOPE study and MICRO-HOPE substudy
    • [6] Heart Outcomes Prevention Evaluation Study Investigators, Effects of ramipril on cardiovascular and microvascular outcomes in people with diabetes mellitus: results of the HOPE study and MICRO-HOPE substudy. Lancet 355 (2000), 253–259.
    • (2000) Lancet , vol.355 , pp. 253-259
  • 7
    • 34548420712 scopus 로고    scopus 로고
    • Effects of a fixed combination of perindopril and indapamide on macrovascular and microvascular outcomes in patients with type 2 diabetes mellitus (the ADVANCE trial): a randomised controlled trial
    • [7] Patel, A., MacMahon, S., Chalmers, J., Neal, B., Woodward, M., Billot, L., et al. Effects of a fixed combination of perindopril and indapamide on macrovascular and microvascular outcomes in patients with type 2 diabetes mellitus (the ADVANCE trial): a randomised controlled trial. Lancet 370 (2007), 829–840.
    • (2007) Lancet , vol.370 , pp. 829-840
    • Patel, A.1    MacMahon, S.2    Chalmers, J.3    Neal, B.4    Woodward, M.5    Billot, L.6
  • 8
    • 84885997413 scopus 로고    scopus 로고
    • ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD: the Task Force on diabetes, pre-diabetes, and cardiovascular diseases of the European Society of Cardiology (ESC) and developed in collaboration with the European Association for the Study of Diabetes (EASD)
    • [8] Ryden, L., Grant, P.J., Anker, S.D., Berne, C., Cosentino, F., Danchin, N., et al. ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD: the Task Force on diabetes, pre-diabetes, and cardiovascular diseases of the European Society of Cardiology (ESC) and developed in collaboration with the European Association for the Study of Diabetes (EASD). Eur Heart J 34 (2013), 3035–3087.
    • (2013) Eur Heart J , vol.34 , pp. 3035-3087
    • Ryden, L.1    Grant, P.J.2    Anker, S.D.3    Berne, C.4    Cosentino, F.5    Danchin, N.6
  • 9
    • 84960094179 scopus 로고    scopus 로고
    • Blood pressure lowering for prevention of cardiovascular disease and death: a systematic review and meta-analysis
    • [9] Ettehad, D., Emdin, C.A., Kiran, A., Anderson, S.G., Callender, T., Emberson, J., et al. Blood pressure lowering for prevention of cardiovascular disease and death: a systematic review and meta-analysis. Lancet 387 (2016), 957–967.
    • (2016) Lancet , vol.387 , pp. 957-967
    • Ettehad, D.1    Emdin, C.A.2    Kiran, A.3    Anderson, S.G.4    Callender, T.5    Emberson, J.6
  • 10
    • 84959363424 scopus 로고    scopus 로고
    • Effects of intensive blood pressure lowering on cardiovascular and renal outcomes: updated systematic review and meta-analysis
    • [10] Xie, X., Atkins, E., Lv, J., Bennett, A., Neal, B., Ninomiya, T., et al. Effects of intensive blood pressure lowering on cardiovascular and renal outcomes: updated systematic review and meta-analysis. Lancet 387 (2016), 435–443.
    • (2016) Lancet , vol.387 , pp. 435-443
    • Xie, X.1    Atkins, E.2    Lv, J.3    Bennett, A.4    Neal, B.5    Ninomiya, T.6
  • 11
    • 84931261309 scopus 로고    scopus 로고
    • Benefit of blood pressure control in diabetic patients
    • [11] Kintscher, U., Benefit of blood pressure control in diabetic patients. Curr Hypertens Rep, 17, 2015, 50.
    • (2015) Curr Hypertens Rep , vol.17 , pp. 50
    • Kintscher, U.1
  • 12
    • 84899468978 scopus 로고    scopus 로고
    • Blood pressure targets for hypertension in people with diabetes mellitus
    • CD008277
    • [12] Arguedas, J.A., Leiva, V., Wright, J.M., Blood pressure targets for hypertension in people with diabetes mellitus. Cochrane Database Syst Rev, 10, 2013 CD008277.
    • (2013) Cochrane Database Syst Rev , vol.10
    • Arguedas, J.A.1    Leiva, V.2    Wright, J.M.3
  • 13
    • 84954377408 scopus 로고    scopus 로고
    • SPRINT, or false start, toward a lower universal treated blood pressure target in hypertension
    • [13] Esler, M., SPRINT, or false start, toward a lower universal treated blood pressure target in hypertension. Hypertension 67 (2016), 266–267.
    • (2016) Hypertension , vol.67 , pp. 266-267
    • Esler, M.1
  • 14
    • 84958618416 scopus 로고    scopus 로고
    • Diabetes and hypertension: a comparative review of current guidelines
    • [14] Cryer, M.J., Horani, T., DiPette, D.J., Diabetes and hypertension: a comparative review of current guidelines. J Clin Hypertens (Greenwich) 18 (2016), 95–100.
    • (2016) J Clin Hypertens (Greenwich) , vol.18 , pp. 95-100
    • Cryer, M.J.1    Horani, T.2    DiPette, D.J.3
  • 15
    • 84902551303 scopus 로고    scopus 로고
    • Effects of glucose-lowering agents on vascular outcomes in type 2 diabetes: a critical reappraisal
    • [15] Scheen, A.J., Charbonnel, B., Effects of glucose-lowering agents on vascular outcomes in type 2 diabetes: a critical reappraisal. Diabetes Metab 40 (2014), 176–185.
    • (2014) Diabetes Metab , vol.40 , pp. 176-185
    • Scheen, A.J.1    Charbonnel, B.2
  • 16
    • 84941243068 scopus 로고    scopus 로고
    • Impact of glucose-lowering drugs on cardiovascular disease in type 2 diabetes
    • [16] Ferrannini, E., DeFronzo, R.A., Impact of glucose-lowering drugs on cardiovascular disease in type 2 diabetes. Eur Heart J 36 (2015), 2288–2296.
    • (2015) Eur Heart J , vol.36 , pp. 2288-2296
    • Ferrannini, E.1    DeFronzo, R.A.2
  • 17
    • 84975292879 scopus 로고    scopus 로고
    • EMPA-REG and other cardiovascular outcome trials of glucose-lowering agents: implications for future treatment strategies in type 2 diabetes mellitus
    • [17] Schernthaner, G., Schernthaner-Reiter, M.H., Schernthaner, G.H., EMPA-REG and other cardiovascular outcome trials of glucose-lowering agents: implications for future treatment strategies in type 2 diabetes mellitus. Clin Ther 38 (2016), 1288–1298.
    • (2016) Clin Ther , vol.38 , pp. 1288-1298
    • Schernthaner, G.1    Schernthaner-Reiter, M.H.2    Schernthaner, G.H.3
  • 18
    • 84963966467 scopus 로고    scopus 로고
    • Clinical implications of cardiovascular outcome trials in type 2 diabetes: from DCCT to EMPA-REG
    • [18] Ryden, L., Shahim, B., Mellbin, L., Clinical implications of cardiovascular outcome trials in type 2 diabetes: from DCCT to EMPA-REG. Clin Ther 38 (2016), 1279–1287.
    • (2016) Clin Ther , vol.38 , pp. 1279-1287
    • Ryden, L.1    Shahim, B.2    Mellbin, L.3
  • 19
    • 84873099484 scopus 로고    scopus 로고
    • Cardiovascular effects of gliptins
    • [19] Scheen, A.J., Cardiovascular effects of gliptins. Nat Rev Cardiol 10 (2013), 73–84.
    • (2013) Nat Rev Cardiol , vol.10 , pp. 73-84
    • Scheen, A.J.1
  • 20
    • 84924961701 scopus 로고    scopus 로고
    • Safety of dipeptidyl peptidase-4 inhibitors for treating type 2 diabetes
    • [20] Scheen, A.J., Safety of dipeptidyl peptidase-4 inhibitors for treating type 2 diabetes. Expert Opin Drug Saf 14 (2015), 505–524.
    • (2015) Expert Opin Drug Saf , vol.14 , pp. 505-524
    • Scheen, A.J.1
  • 21
    • 84944800184 scopus 로고    scopus 로고
    • Empagliflozin, cardiovascular outcomes, and mortality in type 2 diabetes
    • [21] Zinman, B., Wanner, C., Lachin, J.M., Fitchett, D., Bluhmki, E., Hantel, S., et al. Empagliflozin, cardiovascular outcomes, and mortality in type 2 diabetes. N Engl J Med 373 (2015), 2117–2128.
    • (2015) N Engl J Med , vol.373 , pp. 2117-2128
    • Zinman, B.1    Wanner, C.2    Lachin, J.M.3    Fitchett, D.4    Bluhmki, E.5    Hantel, S.6
  • 23
    • 84923791994 scopus 로고    scopus 로고
    • Pharmacodynamics, efficacy and safety of sodium-glucose co-transporter type 2 (SGLT2) inhibitors for the treatment of type 2 diabetes mellitus
    • [23] Scheen, A.J., Pharmacodynamics, efficacy and safety of sodium-glucose co-transporter type 2 (SGLT2) inhibitors for the treatment of type 2 diabetes mellitus. Drugs 75 (2015), 33–59.
    • (2015) Drugs , vol.75 , pp. 33-59
    • Scheen, A.J.1
  • 24
    • 84923448295 scopus 로고    scopus 로고
    • SGLT-2 inhibitors and cardiovascular risk: proposed pathways and review of ongoing outcome trials
    • [24] Inzucchi, S.E., Zinman, B., Wanner, C., Ferrari, R., Fitchett, D., Hantel, S., et al. SGLT-2 inhibitors and cardiovascular risk: proposed pathways and review of ongoing outcome trials. Diabetes Vasc Dis Res 12 (2015), 90–100.
    • (2015) Diabetes Vasc Dis Res , vol.12 , pp. 90-100
    • Inzucchi, S.E.1    Zinman, B.2    Wanner, C.3    Ferrari, R.4    Fitchett, D.5    Hantel, S.6
  • 25
    • 84961627544 scopus 로고    scopus 로고
    • Cardiovascular outcomes of sodium-glucose cotransporter 2 inhibitors: a comprehensive review of clinical and preclinical studies
    • [25] Ghosh, R.K., Bandyopadhyay, D., Hajra, A., Biswas, M., Gupta, A., Cardiovascular outcomes of sodium-glucose cotransporter 2 inhibitors: a comprehensive review of clinical and preclinical studies. Int J Cardiol 212 (2016), 29–36.
    • (2016) Int J Cardiol , vol.212 , pp. 29-36
    • Ghosh, R.K.1    Bandyopadhyay, D.2    Hajra, A.3    Biswas, M.4    Gupta, A.5
  • 26
    • 84901198078 scopus 로고    scopus 로고
    • Blood pressure effects of sodium-glucose co-transport 2 (SGLT2) inhibitors
    • [26] Oliva, R.V., Bakris, G.L., Blood pressure effects of sodium-glucose co-transport 2 (SGLT2) inhibitors. J Am Soc Hypertens 8 (2014), 330–339.
    • (2014) J Am Soc Hypertens , vol.8 , pp. 330-339
    • Oliva, R.V.1    Bakris, G.L.2
  • 27
    • 84923108094 scopus 로고    scopus 로고
    • SGLT2 inhibitors: their potential reduction in blood pressure
    • [27] Maliha, G., Townsend, R.R., SGLT2 inhibitors: their potential reduction in blood pressure. J Am Soc Hypertens 9 (2015), 48–53.
    • (2015) J Am Soc Hypertens , vol.9 , pp. 48-53
    • Maliha, G.1    Townsend, R.R.2
  • 28
    • 84943187885 scopus 로고    scopus 로고
    • Sodium-glucose cotransporter-2 inhibitors and blood pressure decrease: a valuable effect of a novel antidiabetic class?
    • [28] Imprialos, K.P., Sarafidis, P.A., Karagiannis, A.I., Sodium-glucose cotransporter-2 inhibitors and blood pressure decrease: a valuable effect of a novel antidiabetic class?. J Hypertens 33 (2015), 2185–2197.
    • (2015) J Hypertens , vol.33 , pp. 2185-2197
    • Imprialos, K.P.1    Sarafidis, P.A.2    Karagiannis, A.I.3
  • 29
    • 84898854471 scopus 로고    scopus 로고
    • Effects of sodium-glucose co-transporter 2 inhibitors on blood pressure: a systematic review and meta-analysis
    • [29] Baker, W.L., Smyth, L.R., Riche, D.M., Bourret, E.M., Chamberlin, K.W., White, W.B., Effects of sodium-glucose co-transporter 2 inhibitors on blood pressure: a systematic review and meta-analysis. J Am Soc Hypertens, 8(262–275), 2014, e9.
    • (2014) J Am Soc Hypertens , vol.8 , Issue.262-275 , pp. e9
    • Baker, W.L.1    Smyth, L.R.2    Riche, D.M.3    Bourret, E.M.4    Chamberlin, K.W.5    White, W.B.6
  • 30
    • 84975698839 scopus 로고    scopus 로고
    • Heart failure outcomes with empagliflozin in patients with type 2 diabetes at high cardiovascular risk: results of the EMPA-REG OUTCOME® trial
    • [30] Fitchett, D., Zinman, B., Wanner, C., Lachin, J.M., Hantel, S., Salsali, A., et al. Heart failure outcomes with empagliflozin in patients with type 2 diabetes at high cardiovascular risk: results of the EMPA-REG OUTCOME® trial. Eur Heart J 37 (2016), 1526–1534.
    • (2016) Eur Heart J , vol.37 , pp. 1526-1534
    • Fitchett, D.1    Zinman, B.2    Wanner, C.3    Lachin, J.M.4    Hantel, S.5    Salsali, A.6
  • 31
    • 84964465677 scopus 로고    scopus 로고
    • Reduction in cardiovascular and all-cause mortality in the EMPA-REG OUTCOME trial: a critical analysis
    • [31] Scheen, A.J., Reduction in cardiovascular and all-cause mortality in the EMPA-REG OUTCOME trial: a critical analysis. Diabetes Metab 42 (2016), 71–76.
    • (2016) Diabetes Metab , vol.42 , pp. 71-76
    • Scheen, A.J.1
  • 32
    • 84951814585 scopus 로고    scopus 로고
    • The EMPA-REG study: What has it told us? A diabetologist's perspective
    • [32] DeFronzo, R.A., The EMPA-REG study: What has it told us? A diabetologist's perspective. J Diabetes Complications 30 (2016), 1–2.
    • (2016) J Diabetes Complications , vol.30 , pp. 1-2
    • DeFronzo, R.A.1
  • 33
    • 84964489933 scopus 로고    scopus 로고
    • Sodium-glucose cotransporter 2 inhibition and cardiovascular risk reduction in patients with type 2 diabetes: the emerging role of natriuresis
    • [33] Rajasekeran, H., Lytvyn, Y., Cherney, D.Z., Sodium-glucose cotransporter 2 inhibition and cardiovascular risk reduction in patients with type 2 diabetes: the emerging role of natriuresis. Kidney Int 89 (2016), 524–526.
    • (2016) Kidney Int , vol.89 , pp. 524-526
    • Rajasekeran, H.1    Lytvyn, Y.2    Cherney, D.Z.3
  • 34
    • 84960259844 scopus 로고    scopus 로고
    • Importance of inhibiting sodium-glucose cotransporter and its compelling indication in type 2 diabetes: pathophysiological hypothesis
    • [34] Kimura, G., Importance of inhibiting sodium-glucose cotransporter and its compelling indication in type 2 diabetes: pathophysiological hypothesis. J Am Soc Hypertens 10 (2016), 271–278.
    • (2016) J Am Soc Hypertens , vol.10 , pp. 271-278
    • Kimura, G.1
  • 35
    • 84943517417 scopus 로고    scopus 로고
    • Diuretic effects of sodium-glucose cotransporter 2 inhibitor in patients with type 2 diabetes mellitus and heart failure
    • [35] Takeuchi, T., Dohi, K., Omori, T., Moriwaki, K., Sato, Y., Nakamori, S., et al. Diuretic effects of sodium-glucose cotransporter 2 inhibitor in patients with type 2 diabetes mellitus and heart failure. Int J Cardiol 201 (2015), 1–3.
    • (2015) Int J Cardiol , vol.201 , pp. 1-3
    • Takeuchi, T.1    Dohi, K.2    Omori, T.3    Moriwaki, K.4    Sato, Y.5    Nakamori, S.6
  • 36
    • 84952637177 scopus 로고    scopus 로고
    • EMPA-REG - the “diuretic hypothesis”
    • [36] McMurray, J., EMPA-REG - the “diuretic hypothesis”. J Diabetes Complications 30 (2016), 3–4.
    • (2016) J Diabetes Complications , vol.30 , pp. 3-4
    • McMurray, J.1
  • 37
    • 84964507777 scopus 로고    scopus 로고
    • SGLT2 inhibition and cardiovascular events: why did EMPA-REG Outcomes surprise and what were the likely mechanisms?
    • [37] Sattar, N., McLaren, J., Kristensen, S.L., Preiss, D., McMurray, J.J., SGLT2 inhibition and cardiovascular events: why did EMPA-REG Outcomes surprise and what were the likely mechanisms?. Diabetologia 59 (2016), 1333–1339.
    • (2016) Diabetologia , vol.59 , pp. 1333-1339
    • Sattar, N.1    McLaren, J.2    Kristensen, S.L.3    Preiss, D.4    McMurray, J.J.5
  • 38
    • 84991018034 scopus 로고    scopus 로고
    • Reappraisal of the diuretic effect of empagliflozin in EMPA-REG OUTCOME: comparison with classic diuretics
    • [38] Scheen, A.J., Reappraisal of the diuretic effect of empagliflozin in EMPA-REG OUTCOME: comparison with classic diuretics. Diabetes Metab 42 (2016), 224–233.
    • (2016) Diabetes Metab , vol.42 , pp. 224-233
    • Scheen, A.J.1
  • 39
    • 84981241176 scopus 로고    scopus 로고
    • Empagliflozin: not just a glorified diuretic
    • [39] John, M., Empagliflozin: not just a glorified diuretic. Indian J Endocrinol Metab 20 (2016), 154–156.
    • (2016) Indian J Endocrinol Metab , vol.20 , pp. 154-156
    • John, M.1
  • 40
    • 84969915634 scopus 로고    scopus 로고
    • Efficacy and safety of sodium-glucose cotransporter 2 inhibitors in type 2 diabetes mellitus: systematic review and network meta-analysis
    • [40] Zaccardi, F., Webb, D.R., Htike, Z.Z., Youssef, D., Khunti, K., Davies, M.J., Efficacy and safety of sodium-glucose cotransporter 2 inhibitors in type 2 diabetes mellitus: systematic review and network meta-analysis. Diabetes Obes Metab 18 (2016), 783–794.
    • (2016) Diabetes Obes Metab , vol.18 , pp. 783-794
    • Zaccardi, F.1    Webb, D.R.2    Htike, Z.Z.3    Youssef, D.4    Khunti, K.5    Davies, M.J.6
  • 41
    • 84953638180 scopus 로고    scopus 로고
    • Reductions in mean 24-hour ambulatory blood pressure after 6-week treatment with canagliflozin in patients with type 2 diabetes mellitus and hypertension
    • [41] Townsend, R.R., Machin, I., Ren, J., Trujillo, A., Kawaguchi, M., Vijapurkar, U., et al. Reductions in mean 24-hour ambulatory blood pressure after 6-week treatment with canagliflozin in patients with type 2 diabetes mellitus and hypertension. J Clin Hypertens (Greenwich) 18 (2016), 43–52.
    • (2016) J Clin Hypertens (Greenwich) , vol.18 , pp. 43-52
    • Townsend, R.R.1    Machin, I.2    Ren, J.3    Trujillo, A.4    Kawaguchi, M.5    Vijapurkar, U.6
  • 42
    • 84919681923 scopus 로고    scopus 로고
    • Effect of canagliflozin on blood pressure and adverse events related to osmotic diuresis and reduced intravascular volume in patients with type 2 diabetes mellitus
    • [42] Weir, M.R., Januszewicz, A., Gilbert, R.E., Vijapurkar, U., Kline, I., Fung, A., et al. Effect of canagliflozin on blood pressure and adverse events related to osmotic diuresis and reduced intravascular volume in patients with type 2 diabetes mellitus. J Clin Hypertens (Greenwich) 16 (2014), 875–882.
    • (2014) J Clin Hypertens (Greenwich) , vol.16 , pp. 875-882
    • Weir, M.R.1    Januszewicz, A.2    Gilbert, R.E.3    Vijapurkar, U.4    Kline, I.5    Fung, A.6
  • 43
    • 84880850027 scopus 로고    scopus 로고
    • Dapagliflozin a glucose-regulating drug with diuretic properties in subjects with type 2 diabetes
    • [43] Lambers Heerspink, H.J., de Zeeuw, D., Wie, L., Leslie, B., List, J., Dapagliflozin a glucose-regulating drug with diuretic properties in subjects with type 2 diabetes. Diabetes Obes Metab 15 (2013), 853–862.
    • (2013) Diabetes Obes Metab , vol.15 , pp. 853-862
    • Lambers Heerspink, H.J.1    de Zeeuw, D.2    Wie, L.3    Leslie, B.4    List, J.5
  • 44
    • 84959460390 scopus 로고    scopus 로고
    • Blood pressure and glycaemic effects of dapagliflozin versus placebo in patients with type 2 diabetes on combination antihypertensive therapy: a randomised, double-blind, placebo-controlled, phase 3 study
    • [44] Weber, M.A., Mansfield, T.A., Cain, V.A., Iqbal, N., Parikh, S., Ptaszynska, A., Blood pressure and glycaemic effects of dapagliflozin versus placebo in patients with type 2 diabetes on combination antihypertensive therapy: a randomised, double-blind, placebo-controlled, phase 3 study. Lancet Diabetes Endocrinol 4 (2016), 211–220.
    • (2016) Lancet Diabetes Endocrinol , vol.4 , pp. 211-220
    • Weber, M.A.1    Mansfield, T.A.2    Cain, V.A.3    Iqbal, N.4    Parikh, S.5    Ptaszynska, A.6
  • 45
    • 84938687573 scopus 로고    scopus 로고
    • Dapagliflozin lowers blood pressure in hypertensive and non-hypertensive patients with type 2 diabetes
    • [45] Sjostrom, C.D., Johansson, P., Ptaszynska, A., List, J., Johnsson, E., Dapagliflozin lowers blood pressure in hypertensive and non-hypertensive patients with type 2 diabetes. Diabetes Vasc Dis Res 12 (2015), 352–358.
    • (2015) Diabetes Vasc Dis Res , vol.12 , pp. 352-358
    • Sjostrom, C.D.1    Johansson, P.2    Ptaszynska, A.3    List, J.4    Johnsson, E.5
  • 46
    • 84928196614 scopus 로고    scopus 로고
    • Empagliflozin reduces blood pressure in patients with type 2 diabetes and hypertension
    • [46] Tikkanen, I., Narko, K., Zeller, C., Green, A., Salsali, A., Broedl, U.C., et al. Empagliflozin reduces blood pressure in patients with type 2 diabetes and hypertension. Diabetes Care 38 (2015), 420–428.
    • (2015) Diabetes Care , vol.38 , pp. 420-428
    • Tikkanen, I.1    Narko, K.2    Zeller, C.3    Green, A.4    Salsali, A.5    Broedl, U.C.6
  • 47
    • 84937818511 scopus 로고    scopus 로고
    • Blood pressure-lowering effect of the sodium glucose co-transporter-2 inhibitor ertugliflozin, assessed via ambulatory blood pressure monitoring in patients with type 2 diabetes and hypertension
    • [47] Amin, N.B., Wang, X., Mitchell, J.R., Lee, D.S., Nucci, G., Rusnak, J.M., Blood pressure-lowering effect of the sodium glucose co-transporter-2 inhibitor ertugliflozin, assessed via ambulatory blood pressure monitoring in patients with type 2 diabetes and hypertension. Diabetes Obes Metab 17 (2015), 805–808.
    • (2015) Diabetes Obes Metab , vol.17 , pp. 805-808
    • Amin, N.B.1    Wang, X.2    Mitchell, J.R.3    Lee, D.S.4    Nucci, G.5    Rusnak, J.M.6
  • 48
    • 84974727270 scopus 로고    scopus 로고
    • Circadian blood pressure rhythm as a possible key target of SGLT2 inhibitors used for the treatment of Type 2 diabetes
    • [48] Tamura, K., Wakui, H., Azushima, K., Uneda, K., Umemura, S., Circadian blood pressure rhythm as a possible key target of SGLT2 inhibitors used for the treatment of Type 2 diabetes. Hypertens Res 39 (2016), 396–398.
    • (2016) Hypertens Res , vol.39 , pp. 396-398
    • Tamura, K.1    Wakui, H.2    Azushima, K.3    Uneda, K.4    Umemura, S.5
  • 49
    • 84945455839 scopus 로고    scopus 로고
    • Effects of empagliflozin on blood pressure and markers of arterial stiffness and vascular resistance in patients with type 2 diabetes
    • [49] Chilton, R., Tikkanen, I., Cannon, C.P., Crowe, S., Woerle, H.J., Broedl, U.C., et al. Effects of empagliflozin on blood pressure and markers of arterial stiffness and vascular resistance in patients with type 2 diabetes. Diabetes Obes Metab 17 (2015), 1180–1193.
    • (2015) Diabetes Obes Metab , vol.17 , pp. 1180-1193
    • Chilton, R.1    Tikkanen, I.2    Cannon, C.P.3    Crowe, S.4    Woerle, H.J.5    Broedl, U.C.6
  • 50
    • 84892959743 scopus 로고    scopus 로고
    • The effect of empagliflozin on arterial stiffness and heart rate variability in subjects with uncomplicated type 1 diabetes mellitus
    • [50] Cherney, D.Z., Perkins, B.A., Soleymanlou, N., Har, R., Fagan, N., Johansen, O.E., et al. The effect of empagliflozin on arterial stiffness and heart rate variability in subjects with uncomplicated type 1 diabetes mellitus. Cardiovasc Diabetol, 13, 2014, 28.
    • (2014) Cardiovasc Diabetol , vol.13 , pp. 28
    • Cherney, D.Z.1    Perkins, B.A.2    Soleymanlou, N.3    Har, R.4    Fagan, N.5    Johansen, O.E.6
  • 51
    • 85010952053 scopus 로고    scopus 로고
    • Dapagliflozin reduces albuminuria in patients with diabetes and hypertension receiving renin-angiotensin blockers
    • [51] Heerspink, H.J., Johnsson, E., Gause-Nilsson, I., Cain, V.A., Sjostrom, C.D., Dapagliflozin reduces albuminuria in patients with diabetes and hypertension receiving renin-angiotensin blockers. Diabetes Obes Metab 18 (2016), 590–597.
    • (2016) Diabetes Obes Metab , vol.18 , pp. 590-597
    • Heerspink, H.J.1    Johnsson, E.2    Gause-Nilsson, I.3    Cain, V.A.4    Sjostrom, C.D.5
  • 52
    • 84933676007 scopus 로고    scopus 로고
    • Pharmacokinetics, pharmacodynamics and clinical use of SGLT2 inhibitors in patients with type 2 diabetes and chronic kidney disease
    • [52] Scheen, A.J., Pharmacokinetics, pharmacodynamics and clinical use of SGLT2 inhibitors in patients with type 2 diabetes and chronic kidney disease. Clin Pharmacokinet 54 (2015), 691–708.
    • (2015) Clin Pharmacokinet , vol.54 , pp. 691-708
    • Scheen, A.J.1
  • 53
    • 84897394040 scopus 로고    scopus 로고
    • Long-term study of patients with type 2 diabetes and moderate renal impairment shows that dapagliflozin reduces weight and blood pressure but does not improve glycemic control
    • [53] Kohan, D.E., Fioretto, P., Tang, W., List, J.F., Long-term study of patients with type 2 diabetes and moderate renal impairment shows that dapagliflozin reduces weight and blood pressure but does not improve glycemic control. Kidney Int 85 (2014), 962–971.
    • (2014) Kidney Int , vol.85 , pp. 962-971
    • Kohan, D.E.1    Fioretto, P.2    Tang, W.3    List, J.F.4
  • 54
    • 84922567942 scopus 로고    scopus 로고
    • Blood pressure lowering in type 2 diabetes: a systematic review and meta-analysis
    • [54] Emdin, C.A., Rahimi, K., Neal, B., Callender, T., Perkovic, V., Patel, A., Blood pressure lowering in type 2 diabetes: a systematic review and meta-analysis. JAMA 313 (2015), 603–615.
    • (2015) JAMA , vol.313 , pp. 603-615
    • Emdin, C.A.1    Rahimi, K.2    Neal, B.3    Callender, T.4    Perkovic, V.5    Patel, A.6
  • 55
    • 84959266211 scopus 로고    scopus 로고
    • Blood pressure lowering and stroke events in type 2 diabetes: a network meta-analysis of randomized controlled trials
    • [55] Xie, X.X., Liu, P., Wan, F.Y., Lin, S.G., Zhong, W.L., Yuan, Z.K., et al. Blood pressure lowering and stroke events in type 2 diabetes: a network meta-analysis of randomized controlled trials. Int J Cardiol 208 (2016), 141–146.
    • (2016) Int J Cardiol , vol.208 , pp. 141-146
    • Xie, X.X.1    Liu, P.2    Wan, F.Y.3    Lin, S.G.4    Zhong, W.L.5    Yuan, Z.K.6
  • 56
    • 84960172050 scopus 로고    scopus 로고
    • Effect of antihypertensive treatment at different blood pressure levels in patients with diabetes mellitus: systematic review and meta-analyses
    • [56] Brunstrom, M., Carlberg, B., Effect of antihypertensive treatment at different blood pressure levels in patients with diabetes mellitus: systematic review and meta-analyses. BMJ, 352, 2016, i717.
    • (2016) BMJ , vol.352 , pp. i717
    • Brunstrom, M.1    Carlberg, B.2
  • 57
    • 0032513878 scopus 로고    scopus 로고
    • Effects of intensive blood-pressure lowering and low-dose aspirin in patients with hypertension: principal results of the Hypertension Optimal Treatment (HOT) randomised trial. HOT Study Group
    • [57] Hansson, L., Zanchetti, A., Carruthers, S.G., Dahlof, B., Elmfeldt, D., Julius, S., et al. Effects of intensive blood-pressure lowering and low-dose aspirin in patients with hypertension: principal results of the Hypertension Optimal Treatment (HOT) randomised trial. HOT Study Group. Lancet 351 (1998), 1755–1762.
    • (1998) Lancet , vol.351 , pp. 1755-1762
    • Hansson, L.1    Zanchetti, A.2    Carruthers, S.G.3    Dahlof, B.4    Elmfeldt, D.5    Julius, S.6
  • 58
    • 77951735232 scopus 로고    scopus 로고
    • Effects of intensive blood-pressure control in type 2 diabetes mellitus
    • [58] ACCORD Study Group, Cushman, W.C., Evans, G.W., Byington, R.P., Goff, D.C. Jr., Grimm, R.H. Jr., et al. Effects of intensive blood-pressure control in type 2 diabetes mellitus. N Engl J Med 362 (2010), 1575–1585.
    • (2010) N Engl J Med , vol.362 , pp. 1575-1585
    • Cushman, W.C.1    Evans, G.W.2    Byington, R.P.3    Goff, D.C.4    Grimm, R.H.5
  • 59
    • 84961712297 scopus 로고    scopus 로고
    • Cardiovascular outcomes according to systolic blood pressure in patients with and without diabetes: an ACCOMPLISH substudy
    • [59] Weber, M.A., Bloch, M., Bakris, G.L., Weir, M.R., Zappe, D.H., Dahlof, B., et al. Cardiovascular outcomes according to systolic blood pressure in patients with and without diabetes: an ACCOMPLISH substudy. J Clin Hypertens (Greenwich) 18 (2016), 299–307.
    • (2016) J Clin Hypertens (Greenwich) , vol.18 , pp. 299-307
    • Weber, M.A.1    Bloch, M.2    Bakris, G.L.3    Weir, M.R.4    Zappe, D.H.5    Dahlof, B.6
  • 60
    • 84948439672 scopus 로고    scopus 로고
    • A randomized trial of intensive versus standard blood-pressure control
    • [60] SPRINT Research Group, Wright, J.T. Jr., Williamson, J.D., Whelton, P.K., Snyder, J.K., Sink, K.M., et al. A randomized trial of intensive versus standard blood-pressure control. N Engl J Med 373 (2015), 2103–2116.
    • (2015) N Engl J Med , vol.373 , pp. 2103-2116
    • Wright, J.T.1    Williamson, J.D.2    Whelton, P.K.3    Snyder, J.K.4    Sink, K.M.5
  • 61
    • 22144477948 scopus 로고    scopus 로고
    • Effects of different blood pressure-lowering regimens on major cardiovascular events in individuals with and without diabetes mellitus: results of prospectively designed overviews of randomized trials
    • [61] Turnbull, F., Neal, B., Algert, C., Chalmers, J., Chapman, N., Cutler, J., et al. Effects of different blood pressure-lowering regimens on major cardiovascular events in individuals with and without diabetes mellitus: results of prospectively designed overviews of randomized trials. Arch Intern Med 165 (2005), 1410–1419.
    • (2005) Arch Intern Med , vol.165 , pp. 1410-1419
    • Turnbull, F.1    Neal, B.2    Algert, C.3    Chalmers, J.4    Chapman, N.5    Cutler, J.6
  • 62
    • 79959504988 scopus 로고    scopus 로고
    • Blood pressure targets in subjects with type 2 diabetes mellitus/impaired fasting glucose: observations from traditional and bayesian random-effects meta-analyses of randomized trials
    • [9 p following 810]
    • [62] Bangalore, S., Kumar, S., Lobach, I., Messerli, F.H., Blood pressure targets in subjects with type 2 diabetes mellitus/impaired fasting glucose: observations from traditional and bayesian random-effects meta-analyses of randomized trials. Circulation 123 (2011), 2799–2810 [9 p following 810].
    • (2011) Circulation , vol.123 , pp. 2799-2810
    • Bangalore, S.1    Kumar, S.2    Lobach, I.3    Messerli, F.H.4
  • 63
    • 84969161167 scopus 로고    scopus 로고
    • Blood-pressure lowering in intermediate-risk persons without cardiovascular disease
    • [63] Lonn, E.M., Bosch, J., Lopez-Jaramillo, P., Zhu, J., Liu, L., Pais, P., et al. Blood-pressure lowering in intermediate-risk persons without cardiovascular disease. N Engl J Med 374 (2016), 2009–2020.
    • (2016) N Engl J Med , vol.374 , pp. 2009-2020
    • Lonn, E.M.1    Bosch, J.2    Lopez-Jaramillo, P.3    Zhu, J.4    Liu, L.5    Pais, P.6
  • 64
    • 0038312287 scopus 로고    scopus 로고
    • Health outcomes associated with various antihypertensive therapies used as first-line agents: a network meta-analysis
    • [64] Psaty, B.M., Lumley, T., Furberg, C.D., Schellenbaum, G., Pahor, M., Alderman, M.H., et al. Health outcomes associated with various antihypertensive therapies used as first-line agents: a network meta-analysis. JAMA 289 (2003), 2534–2544.
    • (2003) JAMA , vol.289 , pp. 2534-2544
    • Psaty, B.M.1    Lumley, T.2    Furberg, C.D.3    Schellenbaum, G.4    Pahor, M.5    Alderman, M.H.6
  • 65
    • 33646766401 scopus 로고    scopus 로고
    • Role of diuretics in the prevention of heart failure: the Antihypertensive and Lipid-lowering treatment to prevent heart attack trial
    • [65] Davis, B.R., Piller, L.B., Cutler, J.A., Furberg, C., Dunn, K., Franklin, S., et al. Role of diuretics in the prevention of heart failure: the Antihypertensive and Lipid-lowering treatment to prevent heart attack trial. Circulation 113 (2006), 2201–2210.
    • (2006) Circulation , vol.113 , pp. 2201-2210
    • Davis, B.R.1    Piller, L.B.2    Cutler, J.A.3    Furberg, C.4    Dunn, K.5    Franklin, S.6
  • 67
    • 68949112343 scopus 로고    scopus 로고
    • Target blood pressure attainment in diabetic hypertensive patients: need for more diuretics?
    • [67] Sweileh, W.M., Target blood pressure attainment in diabetic hypertensive patients: need for more diuretics?. Int J Clin Pharmacol Ther 47 (2009), 434–438.
    • (2009) Int J Clin Pharmacol Ther , vol.47 , pp. 434-438
    • Sweileh, W.M.1
  • 68
    • 84949991353 scopus 로고    scopus 로고
    • Cardioprotective effect of thiazide-like diuretics: a meta-analysis
    • [68] Chen, P., Chaugai, S., Zhao, F., Wang, D.W., Cardioprotective effect of thiazide-like diuretics: a meta-analysis. Am J Hypertens 28 (2015), 1453–1463.
    • (2015) Am J Hypertens , vol.28 , pp. 1453-1463
    • Chen, P.1    Chaugai, S.2    Zhao, F.3    Wang, D.W.4
  • 69
    • 84930983889 scopus 로고    scopus 로고
    • Effects of thiazide-type and thiazide-like diuretics on cardiovascular events and mortality: systematic review and meta-analysis
    • [69] Olde Engberink, R.H., Frenkel, W.J., van den Bogaard, B., Brewster, L.M., Vogt, L., van den Born, B.J., Effects of thiazide-type and thiazide-like diuretics on cardiovascular events and mortality: systematic review and meta-analysis. Hypertension 65 (2015), 1033–1040.
    • (2015) Hypertension , vol.65 , pp. 1033-1040
    • Olde Engberink, R.H.1    Frenkel, W.J.2    van den Bogaard, B.3    Brewster, L.M.4    Vogt, L.5    van den Born, B.J.6
  • 70
    • 0034079721 scopus 로고    scopus 로고
    • Efficacy of diuretics and beta-blockers in diabetic hypertensive patients. Results from a meta-analysis. The INDANA Steering Committee
    • [70] Lievre, M., Gueyffier, F., Ekbom, T., Fagard, R., Cutler, J., Schron, E., et al. Efficacy of diuretics and beta-blockers in diabetic hypertensive patients. Results from a meta-analysis. The INDANA Steering Committee. Diabetes Care 23:Suppl. 2 (2000), B65–B71.
    • (2000) Diabetes Care , vol.23 , pp. B65-B71
    • Lievre, M.1    Gueyffier, F.2    Ekbom, T.3    Fagard, R.4    Cutler, J.5    Schron, E.6
  • 71
    • 84969522637 scopus 로고    scopus 로고
    • Classes of antihypertensive agents and mortality in hypertensive patients with type 2 diabetes-Network meta-analysis of randomized trials
    • [71] Remonti, L.R., Dias, S., Leitao, C.B., Kramer, C.K., Klassman, L.P., Welton, N.J., et al. Classes of antihypertensive agents and mortality in hypertensive patients with type 2 diabetes-Network meta-analysis of randomized trials. J Diabetes Complications 30 (2016), 1192–1200.
    • (2016) J Diabetes Complications , vol.30 , pp. 1192-1200
    • Remonti, L.R.1    Dias, S.2    Leitao, C.B.3    Kramer, C.K.4    Klassman, L.P.5    Welton, N.J.6
  • 72
    • 84950246890 scopus 로고    scopus 로고
    • Effects of mineralocorticoid receptor antagonists in patients with hypertension and diabetes mellitus: a systematic review and meta-analysis
    • [72] Takahashi, S., Katada, J., Daida, H., Kitamura, F., Yokoyama, K., Effects of mineralocorticoid receptor antagonists in patients with hypertension and diabetes mellitus: a systematic review and meta-analysis. J Hum Hypertens 30 (2016), 534–542.
    • (2016) J Hum Hypertens , vol.30 , pp. 534-542
    • Takahashi, S.1    Katada, J.2    Daida, H.3    Kitamura, F.4    Yokoyama, K.5
  • 73
    • 84956772310 scopus 로고    scopus 로고
    • Efficacy and safety of mineralocorticoid receptor antagonists for patients with heart failure and diabetes mellitus: a systematic review and meta-analysis
    • [73] Chen, M.D., Dong, S.S., Cai, N.Y., Fan, M.D., Gu, S.P., Zheng, J.J., et al. Efficacy and safety of mineralocorticoid receptor antagonists for patients with heart failure and diabetes mellitus: a systematic review and meta-analysis. BMC Cardiovasc Disord, 16, 2016, 28.
    • (2016) BMC Cardiovasc Disord , vol.16 , pp. 28
    • Chen, M.D.1    Dong, S.S.2    Cai, N.Y.3    Fan, M.D.4    Gu, S.P.5    Zheng, J.J.6
  • 74
    • 84909946734 scopus 로고    scopus 로고
    • Efficacy and safety of eplerenone in the management of mild to moderate arterial hypertension: systematic review and meta-analysis
    • [74] Pelliccia, F., Patti, G., Rosano, G., Greco, C., Gaudio, C., Efficacy and safety of eplerenone in the management of mild to moderate arterial hypertension: systematic review and meta-analysis. Int J Cardiol 177 (2014), 219–228.
    • (2014) Int J Cardiol , vol.177 , pp. 219-228
    • Pelliccia, F.1    Patti, G.2    Rosano, G.3    Greco, C.4    Gaudio, C.5
  • 75
    • 84962613532 scopus 로고    scopus 로고
    • Effects of sodium-glucose cotransporter-2 inhibitors on cardiovascular events, death, and major safety outcomes in adults with type 2 diabetes: a systematic review and meta-analysis
    • [75] Wu, J.H., Foote, C., Blomster, J., Toyama, T., Perkovic, V., Sundstrom, J., et al. Effects of sodium-glucose cotransporter-2 inhibitors on cardiovascular events, death, and major safety outcomes in adults with type 2 diabetes: a systematic review and meta-analysis. Lancet Diabetes Endocrinol 4 (2016), 411–419.
    • (2016) Lancet Diabetes Endocrinol , vol.4 , pp. 411-419
    • Wu, J.H.1    Foote, C.2    Blomster, J.3    Toyama, T.4    Perkovic, V.5    Sundstrom, J.6
  • 76
    • 85010761222 scopus 로고    scopus 로고
    • Effects of SGLT-2 inhibitors on mortality and cardiovascular events: a comprehensive meta-analysis of randomized controlled trials
    • [Epub ahead of print]
    • [76] Monami, M., Dicembrini, I., Mannucci, E., Effects of SGLT-2 inhibitors on mortality and cardiovascular events: a comprehensive meta-analysis of randomized controlled trials. Acta Diabetol, 2016 [Epub ahead of print].
    • (2016) Acta Diabetol
    • Monami, M.1    Dicembrini, I.2    Mannucci, E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.