-
1
-
-
64649104158
-
Banting Lecture. from the triumvirate to the ominous octet: A new paradigm for the treatment of type 2 diabetes mellitus
-
DeFronzo RA. Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus. Diabetes. 2009;58(4):773-795.
-
(2009)
Diabetes.
, vol.58
, Issue.4
, pp. 773-795
-
-
DeFronzo, R.A.1
-
2
-
-
84901445280
-
B-cell failure in type 2 diabetes: Postulated mechanisms and prospects for prevention and treatment
-
Halban PA, Polonsky KS, Bowden DW, Hawkins MA, Ling C, Mather KJ, Powers AC, Rhodes CJ, Sussel L, Weir GC. b-cell failure in type 2 diabetes: postulated mechanisms and prospects for prevention and treatment. Diabetes Care. 2014;37(6):1751-1758.
-
(2014)
Diabetes Care.
, vol.37
, Issue.6
, pp. 1751-1758
-
-
Halban, P.A.1
Polonsky, K.S.2
Bowden, D.W.3
Hawkins, M.A.4
Ling, C.5
Mather, K.J.6
Powers, A.C.7
Rhodes, C.J.8
Sussel, L.9
Weir, G.C.10
-
3
-
-
70350312488
-
Genetic and biochemical pathways of beta-cell failure in type 2 diabetes
-
Talchai C, Lin HV, Kitamura T, Accili D. Genetic and biochemical pathways of beta-cell failure in type 2 diabetes. Diabetes Obes Metab. 2009;11(Suppl 4):38-45.
-
(2009)
Diabetes Obes Metab.
, vol.11
, pp. 38-45
-
-
Talchai, C.1
Lin, H.V.2
Kitamura, T.3
Accili, D.4
-
4
-
-
0141755328
-
A sustained increase in plasma free fatty acids impairs insulin secretion in nondiabetic subjects genetically predisposed to develop type 2 diabetes
-
Kashyap S, Belfort R, Gastaldelli A, Pratipanawatr T, Berria R, Pratipanawatr W, Bajaj M, Mandarino L, DeFronzo R, Cusi K. A sustained increase in plasma free fatty acids impairs insulin secretion in nondiabetic subjects genetically predisposed to develop type 2 diabetes. Diabetes. 2003;52(10):2461-2474.
-
(2003)
Diabetes.
, vol.52
, Issue.10
, pp. 2461-2474
-
-
Kashyap, S.1
Belfort, R.2
Gastaldelli, A.3
Pratipanawatr, T.4
Berria, R.5
Pratipanawatr, W.6
Bajaj, M.7
Mandarino, L.8
DeFronzo, R.9
Cusi, K.10
-
5
-
-
65749113590
-
Glucose toxicity: The leading actor in the pathogenesis and clinical history of type 2 diabetes -mechanisms and potentials for treatment
-
Giaccari A, Sorice G, Muscogiuri G. Glucose toxicity: the leading actor in the pathogenesis and clinical history of type 2 diabetes -mechanisms and potentials for treatment. Nutr Metab Cardiovasc Dis. 2009;19(5):365-377.
-
(2009)
Nutr Metab Cardiovasc Dis.
, vol.19
, Issue.5
, pp. 365-377
-
-
Giaccari, A.1
Sorice, G.2
Muscogiuri, G.3
-
6
-
-
0023571397
-
Effect of chronic hyperglycemia on in vivo insulin secretion in partially pancreatectomized rats
-
Rossetti L, Shulman GI, Zawalich W, DeFronzo RA. Effect of chronic hyperglycemia on in vivo insulin secretion in partially pancreatectomized rats. J Clin Invest. 1987;80(4):1037-1044.
-
(1987)
J Clin Invest.
, vol.80
, Issue.4
, pp. 1037-1044
-
-
Rossetti, L.1
Shulman, G.I.2
Zawalich, W.3
DeFronzo, R.A.4
-
7
-
-
58149474855
-
Hyperglycaemia but not hyperlipidaemia causes beta cell dysfunction and beta cell loss in the domestic cat
-
Zini E, Osto M, Franchini M, Guscetti F, Donath MY, Perren A, Heller RS, Linscheid P, Bouwman M, Ackermann M, Lutz TA, Reusch CE. Hyperglycaemia but not hyperlipidaemia causes beta cell dysfunction and beta cell loss in the domestic cat. Diabetologia. 2009;52(2):336-346.
-
(2009)
Diabetologia.
, vol.52
, Issue.2
, pp. 336-346
-
-
Zini, E.1
Osto, M.2
Franchini, M.3
Guscetti, F.4
Donath, M.Y.5
Perren, A.6
Heller, R.S.7
Linscheid, P.8
Bouwman, M.9
Ackermann, M.10
Lutz, T.A.11
Reusch, C.E.12
-
8
-
-
0021990787
-
The effect of insulin treatment on insulin secretion and insulin action in type II diabetes mellitus
-
Garvey WT, Olefsky JM, Griffin J, Hamman RF, Kolterman OG. The effect of insulin treatment on insulin secretion and insulin action in type II diabetes mellitus. Diabetes. 1985;34(3):222-234.
-
(1985)
Diabetes.
, vol.34
, Issue.3
, pp. 222-234
-
-
Garvey, W.T.1
Olefsky, J.M.2
Griffin, J.3
Hamman, R.F.4
Kolterman, O.G.5
-
9
-
-
84923066168
-
Effects of intensive insulin therapy upon pancreatic b cell function in patients newly diagnosed with type II diabetes
-
Wang D, Sun L, Song G, Chen S. Effects of intensive insulin therapy upon pancreatic b cell function in patients newly diagnosed with type II diabetes. Int J Clin Exp Med. 2015;8(1):1391-1395.
-
(2015)
Int J Clin Exp Med.
, vol.8
, Issue.1
, pp. 1391-1395
-
-
Wang, D.1
Sun, L.2
Song, G.3
Chen, S.4
-
10
-
-
84862832942
-
Short-term intensive therapy in newly diagnosed type 2 diabetes partially restores both insulin sensitivity and b-cell function in subjects with long-term remission
-
Hu Y, Li L, Xu Y, Yu T, Tong G, Huang H, Bi Y, Weng J, Zhu D. Short-term intensive therapy in newly diagnosed type 2 diabetes partially restores both insulin sensitivity and b-cell function in subjects with long-term remission. Diabetes Care. 2011;34(8):1848-1853.
-
(2011)
Diabetes Care.
, vol.34
, Issue.8
, pp. 1848-1853
-
-
Hu, Y.1
Li, L.2
Xu, Y.3
Yu, T.4
Tong, G.5
Huang, H.6
Bi, Y.7
Weng, J.8
Zhu, D.9
-
11
-
-
43849105857
-
Effect of intensive insulin therapy on beta-cell function and glycaemic control in patients with newly diagnosed type 2 diabetes: A multicentre randomised parallelgroup trial
-
Weng J, Li Y, Xu W, Shi L, Zhang Q, Zhu D, HuY, Zhou Z, Yan X, Tian H, Ran X, Luo Z, Xian J, Yan L, Li F, Zeng L, Chen Y, Yang L, Yan S, Liu J, Li M, Fu Z, Cheng H. Effect of intensive insulin therapy on beta-cell function and glycaemic control in patients with newly diagnosed type 2 diabetes: a multicentre randomised parallelgroup trial. Lancet. 2008;371(9626):1753-1760.
-
(2008)
Lancet.
, vol.371
, Issue.9626
, pp. 1753-1760
-
-
Weng, J.1
Li, Y.2
Xu, W.3
Shi, L.4
Zhang, Q.5
Zhu, D.6
Hu, Y.7
Zhou, Z.8
Yan, X.9
Tian, H.10
Ran, X.11
Luo, Z.12
Xian, J.13
Yan, L.14
Li, F.15
Zeng, L.16
Chen, Y.17
Yang, L.18
Yan, S.19
Liu, J.20
Li, M.21
Fu, Z.22
Cheng, H.23
more..
-
12
-
-
84948403433
-
Renal sodium-glucose cotransporter inhibition in the management of type 2 diabetes mellitus
-
Abdul-Ghani MA, Norton L, DeFronzo RA. Renal sodium-glucose cotransporter inhibition in the management of type 2 diabetes mellitus. Am J Physiol Renal Physiol. 2015;309(11):F889-F900.
-
(2015)
Am J Physiol Renal Physiol.
, vol.309
, Issue.11
, pp. F889-F900
-
-
Abdul-Ghani, M.A.1
Norton, L.2
DeFronzo, R.A.3
-
13
-
-
84929377076
-
Dapagliflozin lowers plasma glucose concentration and improves b-cell function
-
Merovci A, Mari A, Solis C, Xiong J, Daniele G, Chavez-Velazquez A, Tripathy D, Urban McCarthy S, Abdul-Ghani M, DeFronzo RA. Dapagliflozin lowers plasma glucose concentration and improves b-cell function. J Clin Endocrinol Metab. 2015;100(5):1927-1932.
-
(2015)
J Clin Endocrinol Metab.
, vol.100
, Issue.5
, pp. 1927-1932
-
-
Merovci, A.1
Mari, A.2
Solis, C.3
Xiong, J.4
Daniele, G.5
Chavez-Velazquez, A.6
Tripathy, D.7
Urban McCarthy, S.8
Abdul-Ghani, M.9
DeFronzo, R.A.10
-
14
-
-
84893872877
-
Metabolic response to sodium-glucose cotransporter 2 inhibition in type 2 diabetic patients
-
Ferrannini E, Muscelli E, Frascerra S, Baldi S, Mari A, Heise T, Broedl UC, Woerle HJ. Metabolic response to sodium-glucose cotransporter 2 inhibition in type 2 diabetic patients. J Clin Invest. 2014;124(2):499-508.
-
(2014)
J Clin Invest.
, vol.124
, Issue.2
, pp. 499-508
-
-
Ferrannini, E.1
Muscelli, E.2
Frascerra, S.3
Baldi, S.4
Mari, A.5
Heise, T.6
Broedl, U.C.7
Woerle, H.J.8
-
15
-
-
0018520840
-
Glucose clamp technique: A method for quantifying insulin secretion and resistance
-
DeFronzo RA, Tobin JD, Andres R. Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol. 1979;237(3):E214-E223.
-
(1979)
Am J Physiol.
, vol.237
, Issue.3
, pp. E214-E223
-
-
DeFronzo, R.A.1
Tobin, J.D.2
Andres, R.3
-
16
-
-
0020684724
-
Regulation of splanchnic and peripheral glucose uptake by insulin and hyperglycemia in man
-
DeFronzo RA, Ferrannini E, Hendler R, Felig P, Wahren J. Regulation of splanchnic and peripheral glucose uptake by insulin and hyperglycemia in man. Diabetes. 1983;32(1):35-45.
-
(1983)
Diabetes.
, vol.32
, Issue.1
, pp. 35-45
-
-
DeFronzo, R.A.1
Ferrannini, E.2
Hendler, R.3
Felig, P.4
Wahren, J.5
-
17
-
-
0036615275
-
The evolution of beta-cell dysfunction and insulin resistance in type 2 diabetes
-
Bergman RN, Finegood DT, Kahn SE. The evolution of beta-cell dysfunction and insulin resistance in type 2 diabetes. Eur J Clin Invest. 2002;32(Suppl 3)35-45.
-
(2002)
Eur J Clin Invest.
, vol.32
, pp. 35-45
-
-
Bergman, R.N.1
Finegood, D.T.2
Kahn, S.E.3
-
18
-
-
0942279564
-
Beta-cell dysfunction and glucose intolerance: Results from the San Antonio metabolism (SAM) study
-
San Antonio metabolism study.
-
Gastaldelli A, Ferrannini E, Miyazaki Y, Matsuda M, DeFronzo RA; San Antonio metabolism study. Beta-cell dysfunction and glucose intolerance: results from the San Antonio metabolism (SAM) study. Diabetologia. 2004;47(1):31-39.
-
(2004)
Diabetologia.
, vol.47
, Issue.1
, pp. 31-39
-
-
Gastaldelli, A.1
Ferrannini, E.2
Miyazaki, Y.3
Matsuda, M.4
DeFronzo, R.A.5
-
19
-
-
33746377965
-
Contributions of beta-cell dysfunction and insulin resistance to the pathogenesis of impaired glucose tolerance and impaired fasting glucose
-
Abdul-Ghani MA, Tripathy D, DeFronzo RA. Contributions of beta-cell dysfunction and insulin resistance to the pathogenesis of impaired glucose tolerance and impaired fasting glucose. Diabetes Care. 2006;29(5):1130-1139.
-
(2006)
Diabetes Care.
, vol.29
, Issue.5
, pp. 1130-1139
-
-
Abdul-Ghani, M.A.1
Tripathy, D.2
DeFronzo, R.A.3
-
20
-
-
80054090833
-
Effects of exenatide on measures of b-cell function after 3 years inmetformin-treated patients with type 2 diabetes
-
BunckMC, CornérA, Eliasson B, HeineRJ, ShaginianRM, Taskinen MR, Smith U, Yki-Järvinen H, Diamant M. Effects of exenatide on measures of b-cell function after 3 years inmetformin-treated patients with type 2 diabetes. Diabetes Care. 2011;34(9):2041-2047.
-
(2011)
Diabetes Care.
, vol.34
, Issue.9
, pp. 2041-2047
-
-
Bunck, M.C.1
Cornér, A.2
Eliasson, B.3
Heine, R.J.4
Shaginian, R.M.5
Taskinen, M.R.6
Smith, U.7
Yki-Järvinen, H.8
Diamant, M.9
-
21
-
-
33947144118
-
Thiazolidinediones improve beta-cell function in type 2 diabetic patients
-
Gastaldelli A, Ferrannini E, Miyazaki Y, Matsuda M, Mari A, DeFronzo RA. Thiazolidinediones improve beta-cell function in type 2 diabetic patients. Am J Physiol Endocrinol Metab. 2007; 292(3):E871-E883.
-
(2007)
Am J Physiol Endocrinol Metab.
, vol.292
, Issue.3
, pp. E871-E883
-
-
Gastaldelli, A.1
Ferrannini, E.2
Miyazaki, Y.3
Matsuda, M.4
Mari, A.5
DeFronzo, R.A.6
-
22
-
-
33845405222
-
Glycemic durability of rosiglitazone, metformin, or glyburide monotherapy
-
ADOPTStudy Group.
-
Kahn SE, Haffner SM, Heise MA, Herman WH, Holman RR, Jones NP, Kravitz BG, Lachin JM, O'Neill MC, Zinman B, Viberti G; ADOPTStudy Group.Glycemic durability of rosiglitazone, metformin, or glyburide monotherapy.NEngl J Med. 2006;355(23):2427-2443.
-
(2006)
N Engl J Med.
, vol.355
, Issue.23
, pp. 2427-2443
-
-
Kahn, S.E.1
Haffner, S.M.2
Heise, M.A.3
Herman, W.H.4
Holman, R.R.5
Jones, N.P.6
Kravitz, B.G.7
Lachin, J.M.8
O'Neill, M.C.9
Zinman, B.10
Viberti, G.11
-
23
-
-
23844463766
-
Vildagliptin, a dipeptidyl peptidase-IV inhibitor, improves model-assessed betacell function in patients with type 2 diabetes
-
Mari A, Sallas WM, He YL, Watson C, Ligueros-Saylan M, Dunning BE, Deacon CF, Holst JJ, Foley JE. Vildagliptin, a dipeptidyl peptidase-IV inhibitor, improves model-assessed betacell function in patients with type 2 diabetes. J Clin Endocrinol Metab. 2005;90(8):4888-4894.
-
(2005)
J Clin Endocrinol Metab.
, vol.90
, Issue.8
, pp. 4888-4894
-
-
Mari, A.1
Sallas, W.M.2
He, Y.L.3
Watson, C.4
Ligueros-Saylan, M.5
Dunning, B.E.6
Deacon, C.F.7
Holst, J.J.8
Foley, J.E.9
-
24
-
-
84903211800
-
Glycaemic durabilitywith dipeptidyl peptidase-4 inhibitors in type 2 diabetes: A systematic review and meta-analysis of long-term randomised controlled trials
-
Esposito K, Chiodini P, Maiorino MI, Bellastella G, Capuano A, Giugliano D. Glycaemic durabilitywith dipeptidyl peptidase-4 inhibitors in type 2 diabetes: a systematic review and meta-analysis of long-term randomised controlled trials. BMJ Open. 2014;4(6):e005442.
-
(2014)
BMJ Open.
, vol.4
, Issue.6
, pp. e005442
-
-
Esposito, K.1
Chiodini, P.2
Maiorino, M.I.3
Bellastella, G.4
Capuano, A.5
Giugliano, D.6
-
25
-
-
71849095372
-
Efficacy and safety comparison between the DPP-4 inhibitor vildagliptin and the sulfonylurea gliclazide after two years of monotherapy in drug-naïve patients with type 2 diabetes
-
Foley JE, Sreenan S. Efficacy and safety comparison between the DPP-4 inhibitor vildagliptin and the sulfonylurea gliclazide after two years of monotherapy in drug-naïve patients with type 2 diabetes. Horm Metab Res. 2009;41(12):905-909.
-
(2009)
Horm Metab Res.
, vol.41
, Issue.12
, pp. 905-909
-
-
Foley, J.E.1
Sreenan, S.2
-
26
-
-
84904963065
-
HARMONY 3: 104-week randomized, double-blind, placebo-and active-controlled trial assessing the efficacy and safety of albiglutide compared with placebo, sitagliptin, and glimepiride in patients with type 2 diabetes taking metformin
-
HARMONY 3 Study Group.
-
Ahrén B, Johnson SL, Stewart M, Cirkel DT, Yang F, Perry C, Feinglos MN; HARMONY 3 Study Group. HARMONY 3: 104-week randomized, double-blind, placebo-and active-controlled trial assessing the efficacy and safety of albiglutide compared with placebo, sitagliptin, and glimepiride in patients with type 2 diabetes taking metformin. Diabetes Care. 2014;37(8):2141-2148.
-
(2014)
Diabetes Care.
, vol.37
, Issue.8
, pp. 2141-2148
-
-
Ahrén, B.1
Johnson, S.L.2
Stewart, M.3
Cirkel, D.T.4
Yang, F.5
Perry, C.6
Feinglos, M.N.7
-
27
-
-
84898600889
-
Canagliflozin, a sodium glucose co-transporter 2 inhibitor, improves model-based indices of beta cell function in patients with type 2 diabetes
-
Polidori D, Mari A, Ferrannini E. Canagliflozin, a sodium glucose co-transporter 2 inhibitor, improves model-based indices of beta cell function in patients with type 2 diabetes. Diabetologia. 2014; 57(5):891-901.
-
(2014)
Diabetologia.
, vol.57
, Issue.5
, pp. 891-901
-
-
Polidori, D.1
Mari, A.2
Ferrannini, E.3
-
28
-
-
84922032249
-
Ameliorated pancreatic b cell dysfunction in type 2 diabetic patients treated with a sodium-glucose cotransporter 2 inhibitor ipragliflozin
-
Takahara M, Shiraiwa T, Matsuoka TA, Katakami N, Shimomura I. Ameliorated pancreatic b cell dysfunction in type 2 diabetic patients treated with a sodium-glucose cotransporter 2 inhibitor ipragliflozin. Endocr J. 2015;62(1):77-86.
-
(2015)
Endocr J.
, vol.62
, Issue.1
, pp. 77-86
-
-
Takahara, M.1
Shiraiwa, T.2
Matsuoka, T.A.3
Katakami, N.4
Shimomura, I.5
-
29
-
-
0029126350
-
Reciprocal variations in insulin-stimulated glucose uptake and pancreatic insulin secretion in women with normal glucose tolerance
-
Diamond MP, Thornton K, Connolly-Diamond M, Sherwin RS, DeFronzo RA. Reciprocal variations in insulin-stimulated glucose uptake and pancreatic insulin secretion in women with normal glucose tolerance. J Soc Gynecol Investig. 1995;2(5):708-715.
-
(1995)
J Soc Gynecol Investig.
, vol.2
, Issue.5
, pp. 708-715
-
-
Diamond, M.P.1
Thornton, K.2
Connolly-Diamond, M.3
Sherwin, R.S.4
DeFronzo, R.A.5
-
30
-
-
58149467276
-
Four weeks of near-normalisation of blood glucose improves the insulin response to glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide in patients with type 2 diabetes
-
Højberg PV, Vilsbøll T, Rabøl R, Knop FK, Bache M, Krarup T, Holst JJ, Madsbad S. Four weeks of near-normalisation of blood glucose improves the insulin response to glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide in patients with type 2 diabetes. Diabetologia. 2009;52(2):199-207.
-
(2009)
Diabetologia.
, vol.52
, Issue.2
, pp. 199-207
-
-
Højberg, P.V.1
Vilsbøll, T.2
Rabøl, R.3
Knop, F.K.4
Bache, M.5
Krarup, T.6
Holst, J.J.7
Madsbad, S.8
-
31
-
-
84893827104
-
Dapagliflozin improves muscle insulin sensitivity but enhances endogenous glucose production
-
Merovci A, Solis-Herrera C, Daniele G, Eldor R, Fiorentino TV, Tripathy D, Xiong J, Perez Z, Norton L, Abdul-GhaniMA, DeFronzo RA. Dapagliflozin improves muscle insulin sensitivity but enhances endogenous glucose production. J Clin Invest. 2014;124(2):509-514.
-
(2014)
J Clin Invest.
, vol.124
, Issue.2
, pp. 509-514
-
-
Merovci, A.1
Solis-Herrera, C.2
Daniele, G.3
Eldor, R.4
Fiorentino, T.V.5
Tripathy, D.6
Xiong, J.7
Perez, Z.8
Norton, L.9
Abdul-Ghani, M.A.10
DeFronzo, R.A.11
-
32
-
-
80054091845
-
Reversal of type 2 diabetes: Normalisation of beta cell function in association with decreased pancreas and liver triacylglycerol
-
Lim EL, Hollingsworth KG, Aribisala BS, Chen MJ, Mathers JC, Taylor R. Reversal of type 2 diabetes: normalisation of beta cell function in association with decreased pancreas and liver triacylglycerol. Diabetologia. 2011;54(10):2506-2514.
-
(2011)
Diabetologia.
, vol.54
, Issue.10
, pp. 2506-2514
-
-
Lim, E.L.1
Hollingsworth, K.G.2
Aribisala, B.S.3
Chen, M.J.4
Mathers, J.C.5
Taylor, R.6
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