TOX reinforces the phenotype and longevity of exhausted T cells in chronic viral infection

Nature

Volumn 571, Issue 7764, 2019, Pages 265-269

  Alfei, Francesca ^a   Kanev, Kristiyan ^a   Hofmann, Maike ^b   Wu, Ming ^a   Ghoneim, Hazem E ^c,i   Roelli, Patrick ^a,d   Utzschneider, Daniel T ^e   von Hoesslin, Madlaina ^a   Cullen, Jolie G ^a   Fan, Yiping ^c   Eisenberg, Vasyl ^f   Wohlleber, Dirk ^g   Steiger, Katja ^a   Merkler, Doron ^h   Delorenzi, Mauro ^d   Knolle, Percy A ^g   Cohen, Cyrille J ^f   Thimme, Robert ^b   Youngblood, Benjamin ^c   Zehn, Dietmar ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY OF FREIBURG   (Germany)

^c ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^d UNIVERSITY OF LAUSANNE   (Switzerland)

^e UNIVERSITY OF MELBOURNE   (Australia)

^f BAR ILAN UNIVERSITY   (Israel)

^g TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^h UNIVERSITY OF GENEVA   (Switzerland)

ⁱ THE OHIO STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; NUCLEAR PROTEIN; PROGRAMMED DEATH 1 RECEPTOR; T LYMPHOCYTE RECEPTOR; THYMOCYTE SELECTION ASSOCIATED HIGH MOBILITY GROUP BOX PROTEIN; UNCLASSIFIED DRUG; CYTOKINE; HEPATOCYTE NUCLEAR FACTOR 1ALPHA; HIGH MOBILITY GROUP PROTEIN; HNF1A PROTEIN, MOUSE; HOMEODOMAIN PROTEIN; RHOX8 PROTEIN, MOUSE; TOX PROTEIN, HUMAN;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; CD8+ T LYMPHOCYTE; CELL SELECTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; FLOW CYTOMETRY; HEPATITIS C VIRUS; HISTOLOGY; HUMAN; HUMAN CELL; IMMUNOSTIMULATION; LETTER; LONGEVITY; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MALE; MICROARRAY ANALYSIS; MOUSE; NEXT GENERATION SEQUENCING; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPLEEN; T LYMPHOCYTE; VIRUS INFECTION; ANIMAL; CELL PROLIFERATION; CHRONIC DISEASE; CHRONIC HEPATITIS C; CYTOLOGY; GENE EXPRESSION REGULATION; GENETIC EPIGENESIS; GENETIC TRANSCRIPTION; HEPACIVIRUS; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; LYMPHOCYTIC CHORIOMENINGITIS; METABOLISM; PATHOLOGY; THYMOCYTE; VIROLOGY;

HEPATITIS C VIRUS; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MUS;

ANIMALS; CD8-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; CHRONIC DISEASE; CYTOKINES; EPIGENESIS, GENETIC; FEMALE; GENE EXPRESSION REGULATION; HEPACIVIRUS; HEPATITIS C, CHRONIC; HEPATOCYTE NUCLEAR FACTOR 1-ALPHA; HIGH MOBILITY GROUP PROTEINS; HOMEODOMAIN PROTEINS; HUMANS; IMMUNOLOGIC MEMORY; LYMPHOCYTIC CHORIOMENINGITIS; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MALE; MICE; PHENOTYPE; THYMOCYTES; TRANSCRIPTION, GENETIC;

EID: 85068324282     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/s41586-019-1326-9     Document Type: Article

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