메뉴 건너뛰기




Volumn 4, Issue DEC, 2013, Pages

Clonal exhaustion as a mechanism to protect against severe immunopathology and death from an overwhelming CD8 T cell response

Author keywords

CD8; Clonal exhaustion; Immunopathology; LCMV; Liver; Lung; T cells

Indexed keywords


EID: 84892147911     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2013.00475     Document Type: Article
Times cited : (79)

References (32)
  • 1
    • 0016137553 scopus 로고
    • T-cell-mediated immunopathology in viral infections
    • Doherty PC, Zinkernagel RM. T-cell-mediated immunopathology in viral infections. Transplant Rev (1974) 19:89-120.
    • (1974) Transplant Rev , vol.19 , pp. 89-120
    • Doherty, P.C.1    Zinkernagel, R.M.2
  • 2
    • 79954460462 scopus 로고    scopus 로고
    • Heterologous immunity: immunopathology, autoimmunity and protection during viral infections
    • doi:10.3109/08916934.2011.523277
    • Selin LK, Wlodarczyk MF, Kraft AR, Nie S, Kenney LL, Puzone R, et al. Heterologous immunity: immunopathology, autoimmunity and protection during viral infections. Autoimmunity (2011) 44(4):328-47. doi:10.3109/08916934.2011.523277
    • (2011) Autoimmunity , vol.44 , Issue.4 , pp. 328-347
    • Selin, L.K.1    Wlodarczyk, M.F.2    Kraft, A.R.3    Nie, S.4    Kenney, L.L.5    Puzone, R.6
  • 3
    • 0015502942 scopus 로고
    • Requirement for theta-bearing cells in lymphocytic choriomeningitis virus-induced central nervous system disease
    • doi:10.1038/238335a0
    • Cole GA, Nathanson N, Prendergast RA. Requirement for theta-bearing cells in lymphocytic choriomeningitis virus-induced central nervous system disease. Nature (1972) 238:335-7. doi:10.1038/238335a0
    • (1972) Nature , vol.238 , pp. 335-337
    • Cole, G.A.1    Nathanson, N.2    Prendergast, R.A.3
  • 4
    • 0032416085 scopus 로고    scopus 로고
    • Viral immune evasion due to persistence of activated T cells without effector function
    • doi:10.1084/jem.188.12.2205
    • Zajac AJ, Blattman JN, Murali-Krishna K, Sourdive DJD, Suresh M, Altman JD, et al. Viral immune evasion due to persistence of activated T cells without effector function. J Exp Med (1998) 188:2205-13. doi:10.1084/jem.188.12.2205
    • (1998) J Exp Med , vol.188 , pp. 2205-2213
    • Zajac, A.J.1    Blattman, J.N.2    Murali-Krishna, K.3    Sourdive, D.J.D.4    Suresh, M.5    Altman, J.D.6
  • 5
    • 0021225388 scopus 로고
    • Selection of genetic variants of lymphocytic choriomeningitis virus in spleens of persistently infected mice: role in suppression of cytotoxic T lymphocyte response and viral persistence
    • doi:10.1084/jem.160.2.521
    • Ahmed R, Salmi A, Butler LD, Chiller JM, Oldstone MBA. Selection of genetic variants of lymphocytic choriomeningitis virus in spleens of persistently infected mice: role in suppression of cytotoxic T lymphocyte response and viral persistence. J Exp Med (1984) 160:521-40. doi:10.1084/jem.160.2.521
    • (1984) J Exp Med , vol.160 , pp. 521-540
    • Ahmed, R.1    Salmi, A.2    Butler, L.D.3    Chiller, J.M.4    Oldstone, M.B.A.5
  • 6
    • 0037383592 scopus 로고    scopus 로고
    • Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairment
    • doi:10.1128/JVI.77.8.4911-4927.2003
    • Wherry EJ, Blattman JN, Murali-Krishna K, van der MR, Ahmed R. Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairment. J Virol (2003) 77:4911-27. doi:10.1128/JVI.77.8.4911-4927.2003
    • (2003) J Virol , vol.77 , pp. 4911-4927
    • Wherry, E.J.1    Blattman, J.N.2    Murali-Krishna, K.3    van der, M.R.4    Ahmed, R.5
  • 7
    • 0033178313 scopus 로고    scopus 로고
    • Immune deficiency, immune silencing, and clonal exhaustion of T cell responses during viral infections
    • doi:10.1016/S1369-5274(99)80067-8
    • Welsh RM, McNally JM. Immune deficiency, immune silencing, and clonal exhaustion of T cell responses during viral infections. Curr Opin Microbiol (1999) 2:382-7. doi:10.1016/S1369-5274(99)80067-8
    • (1999) Curr Opin Microbiol , vol.2 , pp. 382-387
    • Welsh, R.M.1    McNally, J.M.2
  • 8
    • 0035175549 scopus 로고    scopus 로고
    • Memory CD8+ T cells in heterologous antiviral immunity and immunopathology in the lung
    • doi:10.1038/ni727
    • Chen HD, Fraire AE, Joris I, Brehm MA, Welsh RM, Selin LK. Memory CD8+ T cells in heterologous antiviral immunity and immunopathology in the lung. Nat Immunol (2001) 2:1067-76. doi:10.1038/ni727
    • (2001) Nat Immunol , vol.2 , pp. 1067-1076
    • Chen, H.D.1    Fraire, A.E.2    Joris, I.3    Brehm, M.A.4    Welsh, R.M.5    Selin, L.K.6
  • 9
    • 0032476684 scopus 로고    scopus 로고
    • Protective heterologous antiviral immunity and enhanced immunopathogenesis mediated by memory T cell populations
    • doi:10.1084/jem.188.9.1705
    • Selin LK, Varga SM, Wong IC, Welsh RM. Protective heterologous antiviral immunity and enhanced immunopathogenesis mediated by memory T cell populations. J Exp Med (1998) 188:1705-15. doi:10.1084/jem.188.9.1705
    • (1998) J Exp Med , vol.188 , pp. 1705-1715
    • Selin, L.K.1    Varga, S.M.2    Wong, I.C.3    Welsh, R.M.4
  • 10
    • 33646412332 scopus 로고    scopus 로고
    • Narrowed TCR repertoire and viral escape as a consequence of heterologous immunity
    • doi:10.1172/JCI27804
    • Cornberg M, Chen AT, Wilkinson LA, Brehm MA, Kim SK, Calcagno C, et al. Narrowed TCR repertoire and viral escape as a consequence of heterologous immunity. J Clin Invest (2006) 116:1443-56. doi:10.1172/JCI27804
    • (2006) J Clin Invest , vol.116 , pp. 1443-1456
    • Cornberg, M.1    Chen, A.T.2    Wilkinson, L.A.3    Brehm, M.A.4    Kim, S.K.5    Calcagno, C.6
  • 11
    • 0141537227 scopus 로고    scopus 로고
    • Specific history of heterologous virus infections determines anti-viral immunity and immunopathology in the lung
    • doi:10.1016/S0002-9440(10)63493-1
    • Chen HD, Fraire AE, Joris I, Welsh RM, Selin LK. Specific history of heterologous virus infections determines anti-viral immunity and immunopathology in the lung. Am J Pathol (2003) 163:1341-55. doi:10.1016/S0002-9440(10)63493-1
    • (2003) Am J Pathol , vol.163 , pp. 1341-1355
    • Chen, H.D.1    Fraire, A.E.2    Joris, I.3    Welsh, R.M.4    Selin, L.K.5
  • 12
    • 84887133794 scopus 로고    scopus 로고
    • PC61 (Anti-CD25) treatment inhibits influenza A virus-expanded regulatory T cells and severe lung pathology during a subsequent heterologous lymphocytic choriomeningitis virus infection
    • doi:10.1128/JVI.00936-13
    • Kraft AR, Wlodarczyk MF, Kenney LL, Selin LK. PC61 (Anti-CD25) treatment inhibits influenza A virus-expanded regulatory T cells and severe lung pathology during a subsequent heterologous lymphocytic choriomeningitis virus infection. J Virol (2013) 87:12636-47. doi:10.1128/JVI.00936-13
    • (2013) J Virol , vol.87 , pp. 12636-12647
    • Kraft, A.R.1    Wlodarczyk, M.F.2    Kenney, L.L.3    Selin, L.K.4
  • 13
    • 84874863467 scopus 로고    scopus 로고
    • Anti-IFN-gamma and peptide-tolerization therapies inhibit acute lung injury induced by cross-reactive influenza a-specific memory T cells
    • doi:10.4049/jimmunol.1201936
    • Wlodarczyk MF, Kraft AR, Chen HD, Kenney LL, Selin LK. Anti-IFN-gamma and peptide-tolerization therapies inhibit acute lung injury induced by cross-reactive influenza a-specific memory T cells. J Immunol (2013) 190:2736-46. doi:10.4049/jimmunol.1201936
    • (2013) J Immunol , vol.190 , pp. 2736-2746
    • Wlodarczyk, M.F.1    Kraft, A.R.2    Chen, H.D.3    Kenney, L.L.4    Selin, L.K.5
  • 14
    • 79956077563 scopus 로고    scopus 로고
    • T cell exhaustion
    • doi:10.1038/ni.2035
    • Wherry EJ. T cell exhaustion. Nat Immunol (2011) 131:492-9. doi:10.1038/ni.2035
    • (2011) Nat Immunol , vol.131 , pp. 492-499
    • Wherry, E.J.1
  • 15
    • 66649114758 scopus 로고    scopus 로고
    • High antigen levels are the cause of T cell exhaustion during chronic viral infection
    • doi:10.1073/pnas.0809818106
    • Mueller SN, Ahmed R. High antigen levels are the cause of T cell exhaustion during chronic viral infection. Proc Natl Acad Sci U S A (2009) 106:8623-8. doi:10.1073/pnas.0809818106
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 8623-8628
    • Mueller, S.N.1    Ahmed, R.2
  • 16
    • 34247884612 scopus 로고    scopus 로고
    • The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection
    • doi:10.1038/ni1443
    • Sharpe AH, Wherry EJ, Ahmed R, Freeman GJ. The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection. Nat Immunol (2007) 8:239-45. doi:10.1038/ni1443
    • (2007) Nat Immunol , vol.8 , pp. 239-245
    • Sharpe, A.H.1    Wherry, E.J.2    Ahmed, R.3    Freeman, G.J.4
  • 17
    • 0032798198 scopus 로고    scopus 로고
    • Role of dendritic cells in the induction and maintenance of autoimmune diseases
    • doi:10.1111/j.1600-065X.1999.tb01305.x
    • Ludewig B, Odermatt B, Ochsenbein AF, Zinkernagel RM, Hengartner H. Role of dendritic cells in the induction and maintenance of autoimmune diseases. Immunol Rev (1999) 169:45-54. doi:10.1111/j.1600-065X.1999.tb01305.x
    • (1999) Immunol Rev , vol.169 , pp. 45-54
    • Ludewig, B.1    Odermatt, B.2    Ochsenbein, A.F.3    Zinkernagel, R.M.4    Hengartner, H.5
  • 18
    • 0033031499 scopus 로고    scopus 로고
    • General and specific immunosuppression caused by antiviral T-cell responses
    • doi:10.1111/j.1600-065X.1999.tb01300.x
    • Zinkernagel RM, Planz O, Ehl S, Battegay M, Odermatt B, Klenerman P, et al. General and specific immunosuppression caused by antiviral T-cell responses. Immunol Rev (1999) 168:305-15. doi:10.1111/j.1600-065X.1999.tb01300.x
    • (1999) Immunol Rev , vol.168 , pp. 305-315
    • Zinkernagel, R.M.1    Planz, O.2    Ehl, S.3    Battegay, M.4    Odermatt, B.5    Klenerman, P.6
  • 19
    • 1842509998 scopus 로고    scopus 로고
    • Differential tissue-specific regulation of antiviral CD8+ T-cell immune responses during chronic viral infection
    • doi:10.1128/JVI.78.3578-3600.2004
    • Zhou S, Ou R, Huang L, Price GE, Moskophidis D. Differential tissue-specific regulation of antiviral CD8+ T-cell immune responses during chronic viral infection. J Virol (2004) 78:3578-600. doi:10.1128/JVI.78.3578-3600.2004
    • (2004) J Virol , vol.78 , pp. 3578-3600
    • Zhou, S.1    Ou, R.2    Huang, L.3    Price, G.E.4    Moskophidis, D.5
  • 20
    • 0037221289 scopus 로고    scopus 로고
    • Ablation of CD8 and CD4 T cell responses by high viral loads
    • Fuller MJ, Zajac AJ. Ablation of CD8 and CD4 T cell responses by high viral loads. J Immunol (2003) 170:477-86.
    • (2003) J Immunol , vol.170 , pp. 477-486
    • Fuller, M.J.1    Zajac, A.J.2
  • 21
    • 1642415940 scopus 로고    scopus 로고
    • Maintenance, loss, and resurgence of T cell responses during acute, protracted, and chronic viral infections
    • Fuller MJ, Khanolkar A, Tebo AE, Zajac AJ. Maintenance, loss, and resurgence of T cell responses during acute, protracted, and chronic viral infections. J Immunol (2004) 172:4204-14.
    • (2004) J Immunol , vol.172 , pp. 4204-4214
    • Fuller, M.J.1    Khanolkar, A.2    Tebo, A.E.3    Zajac, A.J.4
  • 22
    • 77949357362 scopus 로고    scopus 로고
    • T-cell exhaustion: characteristics, causes and conversion
    • doi:10.1111/j.1365-2567.2010.03255.x
    • Yi JS, Cox MA, Zajac AJ. T-cell exhaustion: characteristics, causes and conversion. Immunology (2010) 129:474-81. doi:10.1111/j.1365-2567.2010.03255.x
    • (2010) Immunology , vol.129 , pp. 474-481
    • Yi, J.S.1    Cox, M.A.2    Zajac, A.J.3
  • 23
    • 0027158798 scopus 로고
    • Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells
    • doi:10.1038/362758a0
    • Moskophidis D, Lechner F, Pircher H, Zinkernagel RM. Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells. Nature (1993) 362:758-61. doi:10.1038/362758a0
    • (1993) Nature , vol.362 , pp. 758-761
    • Moskophidis, D.1    Lechner, F.2    Pircher, H.3    Zinkernagel, R.M.4
  • 24
    • 11144317786 scopus 로고    scopus 로고
    • Vigorous response of cytotoxic T lymphocytes associated with systemic activation of CD8 T lymphocytes in fulminant hepatitis B
    • doi:10.1111/j.1478-3231.2004.0982.x
    • Kondo Y, Kobayashi K, Shiina M, Niitsuma H, Ueno Y, Kobayashi T, et al. Vigorous response of cytotoxic T lymphocytes associated with systemic activation of CD8 T lymphocytes in fulminant hepatitis B. Liver Int (2004) 24:561-7. doi:10.1111/j.1478-3231.2004.0982.x
    • (2004) Liver Int , vol.24 , pp. 561-567
    • Kondo, Y.1    Kobayashi, K.2    Shiina, M.3    Niitsuma, H.4    Ueno, Y.5    Kobayashi, T.6
  • 25
    • 44649166448 scopus 로고    scopus 로고
    • Dynamic programmed death 1 expression by virus-specific CD8 T cells correlates with the outcome of acute hepatitis B
    • doi:10.1053/j.gastro.2008.03.037
    • Zhang Z, Zhang JY, Wherry EJ, Jin B, Xu B, Zou ZS, et al. Dynamic programmed death 1 expression by virus-specific CD8 T cells correlates with the outcome of acute hepatitis B. Gastroenterology (2008) 134(1938-49):1949. doi:10.1053/j.gastro.2008.03.037
    • (2008) Gastroenterology , vol.134 , Issue.1938-1949 , pp. 1949
    • Zhang, Z.1    Zhang, J.Y.2    Wherry, E.J.3    Jin, B.4    Xu, B.5    Zou, Z.S.6
  • 26
    • 41149123861 scopus 로고    scopus 로고
    • Control of virus-specific CD8+ T-cell exhaustion and immune-mediated pathology by E3 ubiquitin ligase Cbl-b during chronic viral infection
    • doi:10.1128/JVI.01350-07
    • Ou R, Zhang M, Huang L, Moskophidis D. Control of virus-specific CD8+ T-cell exhaustion and immune-mediated pathology by E3 ubiquitin ligase Cbl-b during chronic viral infection. J Virol (2008) 82:3353-68. doi:10.1128/JVI.01350-07
    • (2008) J Virol , vol.82 , pp. 3353-3368
    • Ou, R.1    Zhang, M.2    Huang, L.3    Moskophidis, D.4
  • 27
    • 79956111917 scopus 로고    scopus 로고
    • Vaccination alters the balance between protective immunity, exhaustion, escape, and death in chronic infections
    • doi:10.1128/JVI.00166-11
    • Johnson PL, Kochin BF, McAfee MS, Stromnes IM, Regoes RR, Ahmed R, et al. Vaccination alters the balance between protective immunity, exhaustion, escape, and death in chronic infections. J Virol (2011) 85:5565-70. doi:10.1128/JVI.00166-11
    • (2011) J Virol , vol.85 , pp. 5565-5570
    • Johnson, P.L.1    Kochin, B.F.2    McAfee, M.S.3    Stromnes, I.M.4    Regoes, R.R.5    Ahmed, R.6
  • 28
    • 0032505708 scopus 로고    scopus 로고
    • The impact of variation in the number of CD8(+) T-cell precursors on the outcome of virus infection
    • doi:10.1006/cimm.1998.1344
    • Ehl S, Klenerman P, Zinkernagel RM, Bocharov G. The impact of variation in the number of CD8(+) T-cell precursors on the outcome of virus infection. Cell Immunol (1998) 189:67-73. doi:10.1006/cimm.1998.1344
    • (1998) Cell Immunol , vol.189 , pp. 67-73
    • Ehl, S.1    Klenerman, P.2    Zinkernagel, R.M.3    Bocharov, G.4
  • 29
    • 84855999478 scopus 로고    scopus 로고
    • Natural killer cells act as rheostats modulating antiviral T cells
    • doi:10.1038/nature10624
    • Waggoner SN, Cornberg M, Selin LK, Welsh RM. Natural killer cells act as rheostats modulating antiviral T cells. Nature (2012) 481:394-8. doi:10.1038/nature10624
    • (2012) Nature , vol.481 , pp. 394-398
    • Waggoner, S.N.1    Cornberg, M.2    Selin, L.K.3    Welsh, R.M.4
  • 30
    • 84857031449 scopus 로고    scopus 로고
    • An intermediate dose of LCMV clone 13 causes prolonged morbidity that is maintained by CD4+ T cells
    • doi:10.1016/j.virol.2012.01.005
    • Stamm A, Valentine L, Potts R, Premenko-Lanier M. An intermediate dose of LCMV clone 13 causes prolonged morbidity that is maintained by CD4+ T cells. Virology (2012) 425:122-32. doi:10.1016/j.virol.2012.01.005
    • (2012) Virology , vol.425 , pp. 122-132
    • Stamm, A.1    Valentine, L.2    Potts, R.3    Premenko-Lanier, M.4
  • 31
    • 20544443927 scopus 로고    scopus 로고
    • Insulin needs after CD3-antibody therapy in new-onset type 1 diabetes
    • doi:10.1056/NEJMoa043980
    • Keymeulen B, Vandemeulebroucke E, Ziegler AG, Mathieu C, Kaufman L, Hale G, et al. Insulin needs after CD3-antibody therapy in new-onset type 1 diabetes. N Engl J Med (2005) 352:2598-608. doi:10.1056/NEJMoa043980
    • (2005) N Engl J Med , vol.352 , pp. 2598-2608
    • Keymeulen, B.1    Vandemeulebroucke, E.2    Ziegler, A.G.3    Mathieu, C.4    Kaufman, L.5    Hale, G.6
  • 32
    • 68849130127 scopus 로고    scopus 로고
    • Progress towards the clinical use of CD3 monoclonal antibodies in the treatment of autoimmunity
    • doi:10.1097/MOT.0b013e32832ce95a
    • Chatenoud L. Progress towards the clinical use of CD3 monoclonal antibodies in the treatment of autoimmunity. Curr Opin Organ Transplant (2009) 14:351-6. doi:10.1097/MOT.0b013e32832ce95a
    • (2009) Curr Opin Organ Transplant , vol.14 , pp. 351-356
    • Chatenoud, L.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.