Aberrant DNA methylation and expression of SPDEF and FOXA2 in airway epithelium of patients with COPD

Clinical Epigenetics

Volumn 9, Issue 1, 2017, Pages

  Song, J ^a,b   Heijink, I H ^a   Kistemaker, L E M ^a,c   Reinders Luinge, M ^a   Kooistra, W ^a   Noordhoek, J A ^a   Gosens, R ^a,c   Brandsma, C A ^a   Timens, W ^a   Hiemstra, P S ^d   Rots, M G ^a   Hylkema, M N ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^b TIANJIN MEDICAL UNIVERSITY   (China)

^c UNIVERSITY OF GRONINGEN   (Netherlands)

^d LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

COPD; DNA methylation; FOXA2; Mucus; SPDEF

Indexed keywords

DNA; HEPATOCYTE NUCLEAR FACTOR 3BETA; INTERLEUKIN 13; SAM POINTED DOMAIN CONTAINING ETS LIKE FACTOR; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; FOXA2 PROTEIN, HUMAN; SPDEF PROTEIN, HUMAN; TRANSCRIPTION FACTOR ETS;

ADULT; AIRWAY EPITHELIUM CELL; ARTICLE; BRONCHUS TISSUE; CELL DIFFERENTIATION; CHRONIC OBSTRUCTIVE LUNG DISEASE; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; FEMALE; FOXA2 GENE; GENE; GENE EXPRESSION; GOBLET CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; MIDDLE AGED; PROMOTER REGION; PROTEIN EXPRESSION; RESPIRATORY EPITHELIUM; SPDEF GENE; TRACHEA; BRONCHUS; CELL CULTURE; CYTOLOGY; DRUG EFFECTS; EPITHELIUM CELL; GENE EXPRESSION REGULATION; GENETICS;

BRONCHI; CELL DIFFERENTIATION; CELLS, CULTURED; CPG ISLANDS; DNA METHYLATION; EPITHELIAL CELLS; FEMALE; GENE EXPRESSION REGULATION; GOBLET CELLS; HEPATOCYTE NUCLEAR FACTOR 3-BETA; HUMANS; INTERLEUKIN-13; MALE; MIDDLE AGED; PROMOTER REGIONS, GENETIC; PROTO-ONCOGENE PROTEINS C-ETS; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; TRACHEA;

EID: 85018547050     PISSN: 18687075     EISSN: 18687083     Source Type: Journal    
DOI: 10.1186/s13148-017-0341-7     Document Type: Article

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