Alpha-1 antitrypsin-deficient macrophages have increased matriptase-mediated proteolytic activity

American Journal of Respiratory Cell and Molecular Biology

Volumn 57, Issue 2, 2017, Pages 238-247

  Krotova, Karina ^a   Marek, George W ^a   Wang, Rejean L ^a   Aslanidi, George ^a   Hoffman, Brad E ^a   Khodayari, Nazli ^a   Rouhani, Farshid N ^a   Brantly, Mark L ^a  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

Alpha 1 antitrypsin deficiency; Extracellular matrix degradation; Macrophages; Matriptase; Matrix metalloproteinase 14

Indexed keywords

ALPHA 1 ANTITRYPSIN; APROTININ; BATIMASTAT; COLONY STIMULATING FACTOR 1; ENZYME PRECURSOR; GELATINASE A; GELATINASE B; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; LIPOPOLYSACCHARIDE; MATRIPTASE; MATRIX METALLOPROTEINASE 14; N [N (3 CARBOXYOXIRANE 2 CARBONYL)LEUCYL]AGMATINE; PROTEIN DISULFIDE ISOMERASE; SCLEROPROTEIN; SERINE PROTEINASE; SERPINA1 PROTEIN, HUMAN; ST14 PROTEIN, HUMAN;

ALPHA 1 ANTITRYPSIN DEFICIENCY; ARTICLE; CELL LYSATE; CELL SURFACE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; EXTRACELLULAR MATRIX; FLUORESCENCE ACTIVATED CELL SORTING; HUMAN; HUMAN CELL; IMMUNOLOCALIZATION; IN VITRO STUDY; LUNG ALVEOLUS MACROPHAGE; PERIPHERAL BLOOD MONONUCLEAR CELL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN SECRETION; UPREGULATION; WESTERN BLOTTING; ADULT; AGED; BIOSYNTHESIS; BLOOD; CELL CULTURE; COMPLICATION; DRUG EFFECTS; ENDOPLASMIC RETICULUM; ENZYME INDUCTION; ENZYMOLOGY; FEMALE; GENETICS; MACROPHAGE; MALE; METABOLISM; MIDDLE AGED; MONOCYTE; MUTATION; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; PULMONARY EMPHYSEMA; YOUNG ADULT;

ADULT; AGED; ALPHA 1-ANTITRYPSIN; ALPHA 1-ANTITRYPSIN DEFICIENCY; CELLS, CULTURED; ENDOPLASMIC RETICULUM; ENZYME ACTIVATION; ENZYME INDUCTION; EXTRACELLULAR MATRIX PROTEINS; FEMALE; HUMANS; MACROPHAGES; MACROPHAGES, ALVEOLAR; MALE; MATRIX METALLOPROTEINASE 14; MIDDLE AGED; MONOCYTES; MUTATION; PULMONARY EMPHYSEMA; SERINE ENDOPEPTIDASES; UP-REGULATION; YOUNG ADULT;

EID: 85026874971     PISSN: 10441549     EISSN: 15354989     Source Type: Journal    
DOI: 10.1165/rcmb.2016-0366OC     Document Type: Article

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